Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,057 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07469345Enrolling by invitation
Teeth Grinding and Pelvic Pain in Young Men
This study looks at how teeth grinding (bruxism) is linked to pelvic pain, erectile function, and anxiety in young adult men. It aims to understand if these issues are connected, which could help develop better treatments.
KonyaAges 18–30 - NCT07465614Recruiting
Nerve stimulation study for children with cyclic vomiting syndrome
This study tests whether a gentle nerve stimulation device placed on the ear can reduce vomiting episodes in children with cyclic vomiting syndrome (CVS). It aims to find a safe, non-drug option for managing symptoms.
Milwaukee, WisconsinAges 5–18 - NCT06102733Recruiting
Pelvic pain study for women and men
This trial is testing treatments for chronic pelvic pain, sacroiliac pain, groin pain, tailbone pain, and piriformis pain. It may help people with persistent pain in these areas find relief.
Surrey, British ColumbiaAges 20–99 - NCT06793787Recruiting
AI and advanced imaging to guide treatment of borderline heart blockages
This study uses advanced CT scans and a special camera (OCT) to look at borderline blockages in heart arteries more closely. It aims to see if artificial intelligence can help decide which blockages need a stent and which can be treated with medicine alone.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06794190Recruiting
Understanding liver health in Turner syndrome
This study aims to understand why some women with Turner syndrome develop liver problems. Researchers will analyze factors that may contribute to liver changes, which could lead to better monitoring and care.
BolognaAges 18 years+ - NCT07454070Recruiting
Testing ear nerve stimulation for depression after a heart attack
This trial tests if a gentle, non-invasive ear stimulation device can help relieve depression in people who have had a heart attack and a stent placed. It aims to offer a drug-free option for those who choose not to take antidepressants or see a therapist.
Xi'an, ShaanxiAges 18 years+ - NCT07453862RecruitingPhase 1
New drug for restless legs syndrome: efficacy and safety study
This trial tests a new drug (a calcium channel modulator) to see how well it works and how safe it is for people with moderate to severe restless legs syndrome (RLS). It may offer a new treatment option for those with typical or variant RLS.
Beijing, Beijing MunicipalityAges 18–75 - NCT06789783RecruitingPhase 2/Phase 3
Lithium treatment for Cornelia de Lange syndrome
This trial tests whether lithium can help people with Cornelia de Lange syndrome (CdLS) who have a confirmed NIPBL gene mutation. It might improve their daily life and overall well-being.
Milan, MIAges 4 years+ - NCT06797414Recruiting
Pilates with or without vibration for upper cross syndrome
This study compares Pilates exercises with and without whole-body vibration (a platform that gently shakes your body) to see which better improves posture and pain in people with upper cross syndrome (a common pattern of rounded shoulders and forward head). It aims to find a more effective way to strengthen muscles and reduce discomfort.
Lahore, Punjab ProvinceAges 20–40 - NCT05966064RecruitingPhase 4
Denosumab for adult fibrous bone lesions with ongoing pain
This trial studies denosumab to reduce pain and active bone disease in adults with fibrous dysplasia / McCune-Albright syndrome. You may be eligible if your FD/MAS is causing persistent pain and has signs of active bone turnover, despite adequate pain treatment.
LeidenAges 18 years+ - NCT06801249RecruitingPhase 4
Metyrapone for heart risk in adrenal tumors with Cushing's
This trial tests if a drug called Metyrapone can lower heart risks in people who have adrenal nodules (noncancerous growths on the adrenal glands) and a mild form of Cushing's syndrome that doesn't cause obvious physical signs. You'll be given the drug and monitored to see if it helps control blood pressure and other heart risk factors.
BolognaAges 18–75 - NCT07450846Recruiting
Heart-lung interaction in severe breathing problems
This study looks at how the heart and lungs interact in patients with acute respiratory distress syndrome (a severe lung condition) who are on a breathing machine. Researchers will use ultrasound to check heart function at different times during treatment.
Le Kremlin-BicêtreAges 18 years+ - NCT07446712Recruiting
Oxygen Therapy for Complex Regional Pain Syndrome
This trial tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help reduce pain from Complex Regional Pain Syndrome (CRPS) Type I. If you have this condition, the therapy may improve your symptoms.
Ostrava, Moravian-Silesian RegionAges 18 years+ - NCT07450664Enrolling by invitation
Observational study of VYKAT XR for Prader-Willi syndrome
This study follows people with Prader-Willi syndrome who are already taking or starting VYKAT XR, including those switching from an earlier version of the drug (DCCR). It aims to understand how the treatment works in everyday life.
Phoenix, ArizonaAges 4 years+ - NCT01950624Recruiting
DS-Connect registry for people with Down syndrome
This is a study registry that collects information from people with Down syndrome (or certain forms like mosaic or partial trisomy 21) and their families. It helps researchers learn about health and needs over time and makes it easier to contact people for future studies.
Aurora, ColoradoAges Any age - NCT06806891Recruiting
Walking meditation for restless legs in dialysis
This trial tests if Buddhist walking meditation can help restless leg syndrome in people on hemodialysis. If you have both conditions and are not obese, you may qualify.
Dokki, Giza GovernorateAges 35–65 - NCT07442669Recruiting
Lung ultrasound for surfactant decision in premature babies
This trial uses a lung ultrasound score, a type of ultrasound, to decide when to give surfactant (a medicine that helps lungs work) to premature babies born between 27 and 35 weeks of pregnancy. It aims to reduce the need for more breathing support and avoid side effects.
Hackensack, New JerseyAges 6 months–8 months - NCT07444112Recruiting
Myofascial release for text neck in university students
This trial tests if a hands-on therapy called myofascial release can help university students with text neck (neck pain from looking down at phones). It aims to reduce pain and improve neck function.
Lahore, Punjab ProvinceAges 18–30 - NCT07440706Recruiting
Glucose monitor for late dumping symptoms after bypass
This study tests a continuous glucose monitor (a small sensor that tracks your blood sugar) to see if it helps manage symptoms of late dumping syndrome—a condition causing low blood sugar after meals—in people who had gastric bypass surgery at least a year ago.
São José do Rio Preto, São PauloAges 18–65 - NCT06550284Recruiting
Nerve sensitivity in carpal tunnel syndrome
This study tests how small nerve fibers work in people with carpal tunnel syndrome. It uses simple sensory tests to understand nerve function, which may help guide treatment.
San Antonio, TexasAges 18–65 - NCT07432191Recruiting
Testing a new ventilator for safe breathing support
This study tests a new breathing machine (INBENTUS VERSATILE ventilator) for people who need help breathing. It checks if the machine is safe and works well for patients who need a ventilator and then slowly come off it.
MurciaAges 18 years+ - NCT07428863Recruiting
Jump rope for foot health in Down syndrome
This study tests if jumping rope can help improve foot arch alignment in children with Down syndrome who have flat feet. It may offer a simple, fun way to strengthen feet and reduce foot problems.
Lahore, Punjab ProvinceAges 4–15 - NCT07426016Recruiting
Comparing two ways to give surfactant to premature babies
This study compares two methods—video laryngoscopy and direct laryngoscopy—to give surfactant (a medicine that helps babies' lungs work better) to very premature infants. It aims to find which method is safer and easier for babies born at 28 weeks or earlier who need surfactant within the first 36 hours after birth.
Dallas, TexasAges birth–3 days - NCT07430046RecruitingPhase 2
Testing mirtazapine for breathing problems in Rett syndrome
This study tests whether the drug mirtazapine can reduce breathing issues in females with Rett syndrome. Participants must have a confirmed MECP2 mutation and specific breathing dysfunction like breath holding or hyperventilation.
GenovaAges 5–40
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,057 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.