Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,201 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05911620Recruiting
MRI test to measure liver scar severity in Cushing’s
This study uses a special MRI scan to measure how severe liver scarring is. It focuses on people with Cushing’s syndrome or suspected Cushing’s, or those with metabolic syndrome, to see how well the scan helps diagnose and assess severity.
NancyAges 18 years+ - NCT05924074Recruiting
Study of ferroptosis therapy in blood disorders with SF3B1 mutation
This study looks at ferroptosis (a type of cell stress that can affect blood-forming cells) in people with certain blood disorders linked to an SF3B1 gene change. It may help researchers understand whether targeting this pathway could improve outcomes.
PessacAges 18 years+ - NCT05926505RecruitingPhase 2/Phase 3
Anakinra for lingering symptoms after COVID-19
This Phase 2/3 trial studies whether anakinra can improve ongoing (post-acute) COVID-19 symptoms lasting for more than two months. It mainly looks for better safety and symptom improvement in people with specific inflammation and lung-related findings.
JenaAges 18 years+ - NCT05927688Recruiting
Using patient reports to adjust treatment for autoimmune diseases
This study looks at whether doctors consider patient “electronic reports” (completed online/phone) when deciding how often to change treatment. It may help improve how well treatment plans match how patients feel over time.
StrasbourgAges 18 years+ - NCT05935215RecruitingPhase 3
Switch from anti-C5 shots to iptacopan for aHUS
This trial tests whether people with atypical hemolytic uremic syndrome (aHUS) who are doing well on anti-C5 treatment can safely switch to iptacopan. It focuses on both effectiveness (blood counts and kidney function) and safety after the switch.
Nanjing, JiangsuAges 18–100 - NCT05935904Recruiting
Tracking how pregnancy changes metabolic risk markers
This study follows pregnant women to see how common metabolic health markers (like blood sugar, cholesterol, blood pressure, and belly size) change during pregnancy. It may help doctors better understand who is at higher risk for complications during pregnancy.
JimmaAges 18–45 - NCT05938543Recruiting
Brain stimulation and appetite in Prader-Willi syndrome
This trial studies whether targeted brain stimulation (TMS) can help with appetite and eating feelings in people with Prader-Willi syndrome. It also includes an MRI scan to measure brain-related effects, but only if you can safely have these scans.
Belmont, MassachusettsAges 18–64 - NCT05939453Recruiting
Bright light therapy for Prader-Willi sleepiness
This trial studies whether daily bright light therapy can reduce sleepiness in people with Prader-Willi syndrome. It may help by improving daytime alertness, but you must meet specific sleepiness, eye-safety, and mental health criteria to join.
Brooklyn, New YorkAges 6–88 - NCT05947955RecruitingPhase 2
Study drug for infection-related lung failure in adults
This Phase 2 trial tests Rhu-pGSN in adults with acute respiratory distress syndrome (ARDS) caused by an infection. If you qualify, the study may help determine whether the drug improves outcomes in this short-term, life-threatening lung condition.
Los Angeles, CaliforniaAges 18 years+ - NCT05950282Recruiting
Study of insulin sensitivity differences by age and PCOS status
This study looks at how well the body uses insulin (insulin sensitivity) across different ages, sexes, races, body weights, and whether someone has PCOS. It may help researchers understand why insulin function varies and how PCOS could be linked to metabolic health.
Houston, TexasAges 18 years+ - NCT05958563Recruiting
CPAP may prevent COPD flare-ups in COPD-OSA overlap
This study tests whether using continuous positive airway pressure (CPAP) can reduce acute COPD flare-ups in people who also have sleep apnea. It may help by improving breathing during sleep and lowering the chance of worsening lung symptoms.
AngersAges 40 years+ - NCT05963191Recruiting
Test camera bowel scan for early Lynch syndrome lesions
This study tests a special CAD-EYE system to help detect abnormal (potentially cancer-related) growths during colonoscopy in people with Lynch syndrome. It may improve how reliably clinicians find lesions early, when treatment can be easier.
ParisAges 18–90 - NCT05965453Recruiting
Castor stent graft study for sudden type B aortic tears
This study looks at outcomes for people who had emergency (acute) type B aortic problems treated with a specific stent graft called the Castor single-branch device. It helps doctors understand how well this device works for selected patients and what factors affect results.
Xi'an, ShaanxiAges 18–95 - NCT05966064RecruitingPhase 4
Denosumab for adult fibrous bone lesions with ongoing pain
This trial studies denosumab to reduce pain and active bone disease in adults with fibrous dysplasia / McCune-Albright syndrome. You may be eligible if your FD/MAS is causing persistent pain and has signs of active bone turnover, despite adequate pain treatment.
LeidenAges 18 years+ - NCT05972317Recruiting
Study gut bacteria in IBS patients with and without treatment
This study looks at stool (poop) samples to understand differences in gut bacteria in people with irritable bowel syndrome (IBS), depending on whether they’ve had treatment. It may help researchers find better ways to explain IBS and improve care.
RehovotAges 18–70 - NCT05972837Recruiting
Home electrical stimulation for long-lasting neck muscle pain
This trial studies whether a home-based electrical stimulation device placed on the neck can reduce pain for people with long-lasting neck muscle pain. It may help if your pain has lasted at least 2 months and is moderate to severe.
New Taipei CityAges 20–60 - NCT05985486Recruiting
Lifestyle change for brain health in Down syndrome
This study looks at how a healthy lifestyle program can improve brain health in adults with Down syndrome who are overweight or obese. You will attend a medical center three times over a year for tests, and you'll need a caregiver to support you.
Kansas City, KansasAges 18–64 - NCT05994664Recruiting
Heart Coherence Training for Vascular Ehlers-Danlos
This study tests whether a breathing and heart-rate training program (called Heart Coherence Training) can help people with Vascular Ehlers-Danlos syndrome feel better. It's done from home using your phone and a computer or tablet.
Houston, TexasAges 12–45 - NCT05995600RecruitingPhase 4
Clopidogrel vs warfarin to prevent a second APS stroke
This study compares two types of blood thinners — clopidogrel (an antiplatelet) and warfarin — to prevent another stroke in people with antiphospholipid syndrome (APS). It aims to find which medicine works better for people who have already had a stroke related to APS.
AnyangAges 19 years+ - NCT06011889RecruitingPhase 2/Phase 3
Etanercept for treating SAPHO syndrome
This study tests if etanercept, a biologic drug that targets inflammation, safely reduces pain and disease activity in people with SAPHO syndrome.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT06013319RecruitingPhase 3
Esmolol for better oxygen in ARDS patients
This trial tests if esmolol, a heart-slowing drug, can improve oxygen levels in patients with acute respiratory distress syndrome (ARDS) who are on a breathing machine. It may help by adjusting heart rate to a specific range.
Jinan, ShandongAges 18–65 - NCT06014138RecruitingPhase 2/Phase 3
Volatile sedation study for ARDS patients
This trial is comparing a new type of inhaled sedative (volatile sedation) to usual IV sedatives for people with ARDS who are on a ventilator in the ICU. It aims to see if it can help patients breathe better and recover more quickly.
London, LondonAges 17 years+ - NCT06017869RecruitingPhase 2
Mitochondria therapy for Pearson Syndrome in children
This trial tests a one-time infusion of your own blood cells mixed with donated mitochondria to see if it can help children with Pearson Syndrome grow better and improve their health. It is a new approach that aims to provide the energy your cells need.
Ramat Gan, IsraelAges 1–18 - NCT06018766RecruitingPhase 2
LAM-001 for lung transplant patients with BOS
This study tests whether the drug LAM-001 can help people who have developed a condition called bronchiolitis obliterans syndrome (BOS) after a double lung transplant. BOS causes a slow decline in lung function, and this trial aims to see if LAM-001 can slow or stop that decline.
San Francisco, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,201 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.