Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,201 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06030349Recruiting
Breathing support for kids with Down syndrome and sleep apnea
This trial looks at how well non-invasive breathing machines help children with Down syndrome who have obstructive sleep apnea. It tracks their health and sleep over time to see if the treatment works and improves daily life.
DublinAges 6 months–16 years - NCT06030843RecruitingPhase 2/Phase 3
Testing empagliflozin for heart and kidney health
This trial tests if the drug empagliflozin can improve kidney function in people hospitalized with heart failure who also develop acute kidney injury. It may help protect the kidneys while treating the heart condition.
Bangkok, PathumwanAges 18 years+ - NCT06041204Recruiting
Thyroid hormone plus letrozole for PCOS and mild hypothyroidism
This trial tests whether adding a low-dose thyroid hormone (levothyroxine) to the standard fertility treatment letrozole improves pregnancy rates in women with both PCOS and mild hypothyroidism. It may help if you have trouble getting pregnant and have these two conditions.
CairoAges 20–40 - NCT06043440RecruitingPhase 2
Oxygen therapy for sleep apnea in Down syndrome
This study tests whether oxygen therapy can help children with Down syndrome who have sleep apnea. It compares oxygen treatment to no treatment to see if it improves breathing during sleep and thinking skills.
Los Angeles, CaliforniaAges 5–18 - NCT06045013RecruitingPhase 3
Dextrose injection vs. dextrose with steroid for carpal tunnel
This study tests whether adding a common steroid (methylprednisolone) to a dextrose (sugar water) injection works better than dextrose alone for carpal tunnel syndrome. Both treatments are injected into the wrist to reduce pain and numbness.
KninAges 18–80 - NCT06047574Recruiting
Team care for PCOS diagnosis and treatment
This trial studies whether a team of doctors from different specialties can better diagnose and treat PCOS. If you have PCOS and are looking for a more comprehensive approach, this study may be a good fit.
Shanghai, Shanghai MunicipalityAges 18–45 - NCT06049420Recruiting
Lifestyle medicine for rural patients with chronic disease
This trial tests whether exercise therapy can help people with two or more chronic conditions like obesity, diabetes, or heart disease. It's designed for rural patients and requires a referral from your doctor.
Lewisburg, West VirginiaAges 18–64 - NCT06051292Recruiting
Testing balloon size for lung pressure measurement in children
This study tests how much air to put in a small balloon in the esophagus (feeding tube-like device) to measure lung pressure more accurately. It is for children on a breathing machine whose settings are stable for the next 2 hours.
AydinAges 1 month–18 years - NCT06052436RecruitingPhase 1/Phase 2
Treg cell therapy for COVID-19 and acute respiratory distress
This trial tests a new cell therapy using Treg cells from thymic tissue to calm an overactive immune response in severe COVID-19 and ARDS. It aims to improve breathing and reduce inflammation.
Madrid, MadridAges 18–65 - NCT06052618RecruitingPhase 2
Pacritinib for KSHV-associated Castleman disease and KICS
This study tests a drug called pacritinib for people with KSHV-associated multicentric Castleman disease (MCD) or KSHV-associated inflammatory cytokine syndrome (KICS). It aims to see if the drug can help control symptoms and inflammation caused by these conditions.
Bethesda, MarylandAges 18–120 - NCT06053554Recruiting
Comparing two cataract surgery methods for pseudoexfoliation
This study compares two different surgical methods for placing a new artificial lens (IOL) during cataract surgery in people with pseudoexfoliation syndrome. It aims to find which method works best for these patients.
ViennaAges 60–100 - NCT06056635Recruiting
Study of special telescopes for fetal surgery
This study tests two types of small cameras (fetoscopes) to see how well they work for surgery on a baby before birth. Doctors want to learn if these tools can safely perform fetal procedures.
Boston, MassachusettsAges 18–45 - NCT06058182Recruiting
Rna biomarkers for heart attack patients
This study looks at RNA markers in the blood of people having their first heart attack to see if they can predict recovery. If you are scheduled for a procedure to open blocked arteries, you may be able to join.
Milan, MilanAges 18 years+ - NCT06061562Recruiting
Sleep Apnea and Activity in Down Syndrome
This trial looks at whether physical activity can help improve sleep apnea in people with Down syndrome. It aims to find better ways to manage breathing problems during sleep.
La TroncheAges 6 years+ - NCT06061926RecruitingPhase 2
Celery seed for metabolic syndrome
This trial tests whether celery seed can improve the key features of metabolic syndrome, such as blood sugar, cholesterol, and blood pressure. It may help people whose condition is not yet being treated with medication.
Guadalajara, JaliscoAges 30–60 - NCT06063486RecruitingPhase 2
Curcumin for inflammation and symptoms in blood disorders
This trial tests whether curcumin, a natural compound found in turmeric, can reduce inflammation and improve symptoms like fatigue in people with certain blood disorders that cause low blood counts or overproduction of blood cells. It is for patients with clonal cytopenia of uncertain significance, low-risk myelodysplastic syndrome, or myeloproliferative neoplasms (polycythemia vera, essential thrombocytosis, or myelofibrosis) who have bothersome symptoms.
Los Angeles, CaliforniaAges 18 years+ - NCT06072963RecruitingPhase 2
Combining insulin and semaglutide for memory in MCI with metabolic syndrome
This study tests if a combination of insulin and semaglutide (a diabetes drug) can improve memory and thinking in people with mild cognitive impairment (MCI) who also have metabolic syndrome (a cluster of health issues like large waist, high blood sugar, and high blood pressure). It aims to see if treating blood sugar problems helps protect the brain.
Ramat GanAges 60–90 - NCT06073860Recruiting
Safety study of Luspatercept for MDS or thalassemia in Korea
This study is checking the safety of a drug called Luspatercept (brand name Reblozyl) for people in Korea who have myelodysplastic syndrome (a blood disorder) or beta-thalassemia (a type of inherited anemia). It is designed to monitor how safe the drug is when used as prescribed by your doctor.
SeoulAges 19 years+ - NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT06079788RecruitingPhase 3
ACTH for children with frequently relapsing nephrotic syndrome
This trial tests if a hormone called ACTH can help children with nephrotic syndrome who have frequent relapses or need steroids to stay in remission. It aims to find a treatment that may reduce the need for steroids and prevent relapses.
Wuhan, HubeiAges 2–14 - NCT06090110Recruiting
Vagus nerve stimulation for irritable bowel syndrome
This study tests whether a gentle electrical device that stimulates the vagus nerve can help relieve symptoms of irritable bowel syndrome. If you have IBS and are between 18 and 75, you may be able to join.
Maastricht, LimburgAges 18–75 - NCT06102733Recruiting
Pelvic pain study for women and men
This trial is testing treatments for chronic pelvic pain, sacroiliac pain, groin pain, tailbone pain, and piriformis pain. It may help people with persistent pain in these areas find relief.
Surrey, British ColumbiaAges 20–99 - NCT06104696Recruiting
Comprehensive Geriatric Assessment in Kidney Transplant Patients Over 60
This study looks at how a full health review (geriatric assessment) can help older adults who are getting or have gotten a new kidney. It aims to improve care and outcomes for patients aged 60 and over.
PragueAges 60 years+ - NCT06115083Recruiting
Pelvic floor training for men with chronic pelvic pain
This trial tests if pelvic floor muscle training can reduce chronic pelvic pain in men. It also looks at how well patient-reported symptoms match physical exam findings.
StockholmAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,201 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.