Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,057 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05904301Recruiting
Registry for autoimmune and autoinflammatory disease patients
This study builds a nationwide list (registry) of people with certain autoimmune or inflammation-related illnesses. It helps researchers understand these diseases better over time, which can guide future care.
YerevanAges Any age - NCT06143527RecruitingPhase 1
Stem cell safety trial for PCOS
This early-phase trial tests whether stem cells from donated umbilical cords are safe for people with PCOS (polycystic ovary syndrome). If you qualify, you would receive an infusion of these cells and be monitored for safety.
St John'sAges 18 years+ - NCT07216443RecruitingPhase 2
Study of orca-t for leukemia or MDS with reduced intensity chemo
This trial tests a new cell therapy, orca-t, given after a lower-intensity chemo and radiation regimen for people with acute myeloid leukemia, mixed phenotype leukemia, or myelodysplastic syndrome. It aims to help patients who cannot tolerate full-intensity transplant conditioning.
Los Angeles, CaliforniaAges 18 years+ - NCT07219485Enrolling by invitationPhase 3
Pitolisant for Prader-Willi syndrome in ongoing study
This study tests an oral medication, pitolisant, in people with Prader-Willi syndrome who have already been in a pitolisant study. It aims to see if continuing treatment is safe and effective.
Morrisville, North CarolinaAges 7 years+ - NCT07220239Recruiting
Menstrual cup for early cancer detection in Lynch syndrome
This study tests whether a menstrual cup can collect cells from the uterus to detect early endometrial cancer in women with Lynch syndrome. If you have Lynch syndrome and are due for a routine biopsy, you may be able to use a menstrual cup instead.
Boston, MassachusettsAges 18 years+ - NCT07213063Recruiting
Creatine and HMB supplements for Down syndrome
This trial tests whether taking creatine and HMB supplements can improve muscle strength, reduce inflammation, and increase muscle mass in people with Down syndrome. It may help if you or your loved one can do basic physical tests like standing from a chair and do not have kidney disease or severe mobility issues.
Burgos, BurgosAges 18 years+ - NCT07214818RecruitingPhase 2/Phase 3
SGLT2 Inhibitors for Adult Primary Nephrotic Syndrome
This trial tests whether SGLT2 inhibitors (a type of diabetes medicine) can help adults with primary nephrotic syndrome, a kidney disease that causes protein leakage and swelling. It aims to see if the drug can protect kidney function and reduce protein loss.
Al Mansurah, Dakahlia GovernorateAges 18 years+ - NCT06509464Recruiting
High-intensity interval training for women with central obesity
This study tests whether high-intensity interval training can improve the severity of metabolic syndrome in women who carry extra weight around their belly. It may help you understand how exercise affects your overall health.
GizaAges 25–45 - NCT06922370Recruiting
Study of bone and joint problems in Gitelman syndrome
This study looks at bone and joint problems in people with Gitelman syndrome, a rare kidney disorder. It aims to understand how this condition affects the body's bones and joints.
Hangzhou, ZhejiangAges Any age - NCT06923150Recruiting
MiniGo vs. standard care for bowel symptoms after rectal cancer surgery
This trial tests a small, portable device called MiniGo that uses a gentle water rinse to help control bowel symptoms after rectal cancer surgery. It may be an option for people who still have bothersome bowel problems despite trying other treatments.
AmiensAges 18 years+ - NCT05958563Recruiting
CPAP may prevent COPD flare-ups in COPD-OSA overlap
This study tests whether using continuous positive airway pressure (CPAP) can reduce acute COPD flare-ups in people who also have sleep apnea. It may help by improving breathing during sleep and lowering the chance of worsening lung symptoms.
AngersAges 40 years+ - NCT07209462RecruitingPhase 2
MRM-3379 for Fragile X Syndrome in males
This trial tests an investigational medicine called MRM-3379 in males with Fragile X syndrome. It looks at how the medicine affects thinking and behavior over time.
Phoenix, ArizonaAges 13–45 - NCT07208591RecruitingPhase 3
Test of an experimental drug for severe viral lung infection (ARDS)
This study tests an experimental drug (STSA-1002) for people with severe breathing problems caused by a viral infection. It aims to see if the drug can help improve oxygen levels and reduce the need for a breathing machine.
Beijing, Beijing MunicipalityAges 18–85 - NCT06926205RecruitingPhase 2
CHOP chemo plus mosunetuzumab for Richter's syndrome first treatment
This trial tests a new immunotherapy drug (mosunetuzumab) combined with standard chemotherapy (CHOP) as the first treatment for Richter's syndrome, a fast-growing lymphoma that can arise from CLL. The goal is to see if this combination helps control the disease better than standard therapy.
Barcelona, BarcelonaAges 18–79 - NCT07208825Recruiting
Conservative care for complex regional pain syndrome
This study tests whether a conservative treatment plan can help people with complex regional pain syndrome (CRPS), a condition where pain lasts longer than expected after an injury. You may qualify if you have had CRPS symptoms for up to 5 years and are between ages 18 and 70.
Oulu, North OstrobothniaAges 18–70 - NCT01218776Recruiting
Survey study for people with acute heart symptoms
This study is an international survey about acute coronary syndromes, which are sudden signs of heart-related problems. Your answers can help researchers better understand symptoms and care needs after these events.
Bologna, Emilia-RomagnaAges 18 years+ - NCT06842524RecruitingPhase 2
Dihydroartemisinin for PCOS: A Phase 2 Trial
This trial tests if dihydroartemisinin (a medicine derived from a plant) can help women with PCOS. It may improve hormone balance and menstrual cycles.
Xiamen, FujianAges 18–40 - NCT06297941RecruitingPhase 1
Study of REM-422 for AML or high-risk MDS
This trial tests an experimental oral medication called REM-422 for people with AML (a type of blood cancer) that has not responded to treatment or has come back, or for those with high-risk MDS. The goal is to see if it is safe and effective.
Duarte, CaliforniaAges 18 years+ - NCT07202299Recruiting
Weaning preterm babies off high-frequency breathing machines
This trial tests two different ways to safely take preterm babies off a special breathing machine (HFOV). It aims to find which method works better for babies with breathing problems (respiratory distress syndrome).
Al MansurahAges Any age - NCT07199504RecruitingPhase 2/Phase 3
Dipyridamole for restless legs syndrome in dialysis patients
This trial tests if dipyridamole, a medication that affects blood flow, can help relieve restless legs syndrome (RLS) in people on hemodialysis. It may offer a new treatment option for RS related to kidney failure.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT07202650Recruiting
Guided imagery for premenstrual syndrome
This study tests whether guided imagery, a relaxation technique where you imagine calming scenes, can help reduce symptoms of premenstrual syndrome (PMS). It is for Turkish-speaking women who have regular periods, have not received treatment for PMS, and have moderate to severe symptoms.
AnkaraAges Any age - NCT07195253Recruiting
Down syndrome and sleep apnea study in infants
This study looks at mouth and face features and sleep apnea in 6-month-old infants with Down syndrome. It may help doctors understand and treat sleep problems better.
BronAges 5 months–6 months - NCT07194551Recruiting
Checking uterine cancer risk in Lynch syndrome with home sampling
This study is testing a new way to check for uterine cancer risk in people with Lynch syndrome. You would collect a vaginal sample yourself at home and fill out a health questionnaire, which may help catch warning signs early.
Vancouver, British ColumbiaAges 30 years+ - NCT06943508Recruiting
Nordic walking for balance in children with Down syndrome
This study tests whether a special walking program (Nordic walking with poles) can help children with Down syndrome improve their balance and leg strength. It may be a good fit for children who can walk but have balance difficulties.
Lahore, Punjab ProvinceAges 8–13
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,057 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.