Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,173 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06410352RecruitingPhase 4
Weight loss methods for longer life with metabolic syndrome
This trial tests weight loss methods in people with type 2 diabetes, high blood pressure, and excess weight. It aims to see if losing 15-20% of body weight can help people live longer and healthier.
Astana, AstanaAges 35–65 - NCT06419634RecruitingPhase 1
New drug combo for returning AML or MDS
This study tests a new drug (BMS-986497) alone or combined with two other medicines (azacitidine and venetoclax) for people with AML or MDS that has not responded to or returned after prior treatments. The goal is to see if this combination can help control the disease.
New Haven, ConnecticutAges 18 years+ - NCT06421350Recruiting
Closed-loop spinal cord stimulation for complex regional pain syndrome
This trial tests a new type of spinal cord stimulator that automatically adjusts to your pain signals. It may help people with complex regional pain syndrome (CRPS) who have not tried this kind of therapy before.
La Jolla, CaliforniaAges 18 years+ - NCT06424522Recruiting
Enema program for bowel problems after rectal cancer surgery
This trial tests a special enema program to help people with ongoing bowel problems (called LARS) after rectal cancer surgery. If standard treatments haven't worked, this program might offer a new way to manage symptoms like urgency and leakage.
Columbus, OhioAges 18 years+ - NCT06427265Recruiting
Recovery after ICU: a long-term study
This study follows people after they leave the ICU to see how they recover over time. It uses computer programs to find patterns and create early warning tools to help doctors spot problems sooner.
Guiyang, GuizhouAges 18–100 - NCT06430385RecruitingPhase 1/Phase 2
Study of ION440 for MECP2 Duplication Syndrome
This trial tests an experimental medicine called ION440 for people with MECP2 Duplication Syndrome. The medicine is given as an injection into the spinal fluid, and the study aims to check its safety and how well it works.
San Diego, CaliforniaAges 2–65 - NCT06441942Recruiting
Women with heart attack or unstable angina study
This study is a registry that collects information about women who have had a heart attack or unstable angina. The goal is to learn more about how these conditions affect women and improve care for women with heart disease.
Milan, Italy MilanAges 18–100 - NCT06447376RecruitingPhase 1
Testing siltuximab before epcoritamab to prevent cytokine release syndrome
This trial tests whether giving siltuximab before epcoritamab can help prevent or reduce cytokine release syndrome (a possible side effect where the immune system overreacts). It is for people with certain types of non-Hodgkin lymphoma that have not responded well to at least two prior treatments.
Cleveland, OhioAges 18–65 - NCT06449534Recruiting
Does treatment setting affect shoulder pain and function?
This study tests whether the treatment setting (like a clinic or home) affects shoulder pain, function, and satisfaction in people with common shoulder problems. It could help doctors recommend the best place for therapy.
IstanbulAges 18–75 - NCT06454370Recruiting
New imaging vs standard biopsy for Sjögren's diagnosis
This trial compares a new, quick imaging method (called full-field optical coherence tomography) with the standard lab analysis of a saliva gland biopsy. It may help diagnose Sjögren's syndrome faster and with less discomfort.
Mâcon, Sâone-et-LoireAges 18–99 - NCT06455332Recruiting
Optic nerve test to predict MS after first symptoms
This study looks at how early damage to the optic nerve (the nerve that connects your eye to your brain) might predict future multiple sclerosis (MS) in people who have just had their first neurological symptoms (called a clinically isolated syndrome). You will have an MRI of your eyes and a special eye scan to see if these tests can help doctors know who is more likely to develop MS.
LilleAges 18–55 - NCT06460675Recruiting
Comparing two muscle-relaxing techniques for piriformis syndrome
This study compares two gentle muscle-relaxing techniques (called muscle energy techniques) to treat piriformis syndrome—a condition where a muscle in the buttock presses on a nerve and causes pain. If you have hip or buttock pain that’s been bothersome for at least 3 months and worsens with sitting, this trial may help find a better way to manage your pain.
Rawalpindi, Punjab ProvinceAges 25–45 - NCT06465823RecruitingPhase 2
Bumetanide for thinking skills in Down syndrome
This trial tests whether a medication called bumetanide can improve thinking and learning skills in teenagers with Down syndrome. It is a 10-week study that compares bumetanide to a placebo (a pill with no medicine).
RomeAges 10–17 - NCT06466317Recruiting
Honey and walking for children with metabolic syndrome
This study tests if adding honey to daily walking can help children with metabolic syndrome feel healthier. It's a simple, low-cost way to see if a natural sweetener plus regular movement can make a difference.
GizaAges 9–12 - NCT06469931Recruiting
Ozone therapy for carpal tunnel syndrome
This trial tests if ozone injections can help people with mild to moderate carpal tunnel syndrome. It may offer a new way to treat hand numbness and pain without surgery.
ElâzığAges 18–65 - NCT06473454Recruiting
Physiotherapy for irritable bowel syndrome
This study is testing whether a special physiotherapy program focused on posture and movement can help ease symptoms of Irritable Bowel Syndrome. It is for people who want a non-drug treatment option and are willing to participate in exercise sessions.
IstanbulAges 18–65 - NCT06477653RecruitingPhase 2
Dupilumab for hypereosinophilic syndrome with ongoing symptoms
This trial tests if dupilumab, added to your current treatment, can help with remaining symptoms of hypereosinophilic syndrome (HES) like asthma, eczema, nasal polyps, or eosinophilic esophagitis. You may qualify if you're already on a biologic therapy that lowers eosinophils but still have bothersome symptoms.
Bethesda, MarylandAges 18–99 - NCT06481176Recruiting
How exercise affects blood in restless legs syndrome
This trial studies how a single session of exercise changes blood markers in people with restless legs syndrome (RLS) who are not currently being treated. If you have moderate to severe RLS and are not regularly active, this study may help us understand how exercise affects your condition.
Stanford, CaliforniaAges 18 years+ - NCT06484647Recruiting
Stenting methods for blocked artery forks
This trial compares two techniques for placing stents in the tricky area where a coronary artery splits into two branches (a bifurcation). The goal is to see which method leads to better blood flow and fewer complications for people with blockages there.
Rivoli, TurinAges 18 years+ - NCT07693634Recruiting
Online rehab for knee pain in active adults
This study tests a home-based tele-rehabilitation program for people with front knee pain (patellofemoral pain syndrome) who are recreational athletes. It aims to see if online guided exercises can reduce pain and improve function.
Faisalābad, PunjanAges 18–35 - NCT05419492RecruitingPhase 1/Phase 2
ETX101 for children with SCN1A Dravet syndrome
This early-phase study tests how safe ETX101 is and whether it can help reduce seizures in young children with Dravet syndrome caused by an SCN1A gene change. It mainly enrolls infants and children with a specific type of seizure history and genetic result.
San Francisco, CaliforniaAges 6 months–17 years - NCT07632534Recruiting
Serum Eye Drops for Severe Dry Eye Study
This study tests a new eye drop treatment made from your own blood serum for severe dry eye that hasn't improved with standard treatments. Researchers will analyze proteins in your tears to understand why this treatment works and who benefits most.
Saint-EtienneAges 18 years+ - NCT06489444Recruiting
Fecal amino acids, gut taste receptors, and IBS
This study looks at how amino acids in stool and taste receptors in the gut relate to irritable bowel syndrome (IBS). It aims to better understand IBS and may help find new ways to manage symptoms.
Xi'an, ShaanxiAges 18–80 - NCT06496997RecruitingPhase 2/Phase 3
Steroid treatment for acute lung failure (ARDS) trial
This study tests if adding a type of steroid (glucocorticoid) to standard treatment helps people on a breathing machine recover from severe lung failure (ARDS). It compares different doses to see which works best.
Al FayyumAges Any age
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,173 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.