Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,057 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07167667Recruiting
Hand therapy for carpal tunnel syndrome
This study tests two types of hand therapy for carpal tunnel syndrome: shockwave therapy (5 sessions) or warm paraffin wax (10 sessions). It compares which one better reduces nerve thickening and your symptoms.
IstanbulAges 30–60 - NCT07167368Recruiting
Exercise rehab for heart and kidney health
This trial tests whether a supervised exercise program can help people with heart failure and mild-to-moderate kidney problems. It might improve both your heart and kidney function.
Nantong, JiangsuAges 18–75 - NCT07167732Recruiting
CTNNB1 Syndrome Natural History Study
This study follows people with CTNNB1 syndrome over time to better understand the condition. It does not test any new treatment—just collects information to help future research.
SydneyAges Any age - NCT06346418Recruiting
Maternal genes and Beckwith-Wiedemann syndrome risk study
This study looks at how a mother's genes and chemical changes to DNA (called epimutations) may increase the risk of having a child with Beckwith-Wiedemann syndrome or affect a woman's ability to get pregnant and carry a baby to term. It aims to find genetic clues that could help explain these reproductive challenges.
MilanAges 18 years+ - NCT06104631Recruiting
Testing a treatment for IBS-like symptoms in Crohn's remission
This study tests whether a new treatment can reduce IBS-like symptoms, such as belly pain and bloating, in people whose Crohn's disease is in remission. It aims to improve your quality of life without targeting active Crohn's inflammation.
LiègeAges 18–75 - NCT07163338Recruiting
Antiphospholipid syndrome in older stroke patients
This study looks for a blood clotting disorder called antiphospholipid syndrome (APS) in people aged 65 and older who have had a stroke or a mini-stroke (TIA). The goal is to understand how common APS is in this group and if it affects recovery.
ReimsAges 65 years+ - NCT07163780Recruiting
Home Therapy Program for Babies With Down Syndrome
This study tests a special therapy program called HEP (home early intervention program) for babies with Down syndrome. It looks at whether this program can help your baby's development.
Istanbul, BeykozAges 4 months–1 year - NCT07163403RecruitingPhase 1
Preventing cancer in Lynch syndrome carriers with dendritic cell vaccine
This trial tests whether a personalized vaccine made from your own immune cells can help prevent cancer in people with Lynch syndrome. You must have no history of cancer and be willing to have regular colonoscopies.
Barcelona, BarcelonaAges 18 years+ - NCT07158723Recruiting
Protein and PCOS study for women
This trial tests how eating different types of protein affects women with PCOS. It may help you understand how your body responds to plant versus animal protein.
Fayetteville, ArkansasAges 18–50 - NCT06379945Recruiting
Better MDS care through a national patient registry
This study is building a national platform in Spain to better understand MDS (a bone marrow disorder) and to help tailor treatments to each person. By joining, you help researchers learn more about your condition and how to manage it.
Badalona, BarcelonaAges 18 years+ - NCT06591793RecruitingPhase 1/Phase 2
Gene therapy for Usher syndrome type 1B vision loss
This trial tests an experimental gene therapy given as an injection under the retina. It aims to slow or stop vision loss in people with Usher syndrome type 1B, a rare genetic condition that causes both hearing and vision problems.
NaplesAges 18–50 - NCT06936319Recruiting
Body movements for POTS symptom control
This study tests simple body movements (like squeezing your legs or squatting) to see if they help control POTS symptoms. It may offer a non-drug way to manage dizziness and fast heart rate when standing.
Innsbruck, TyrolAges 18–80 - NCT06955052Recruiting
Maze activity for balance and walking in Down syndrome
This study tests a fun activity program called 'Minds In Motion The Maze' to see if it helps improve balance and walking in children with Down syndrome.
Lahore, Punjab ProvinceAges 8–12 - NCT06951386Recruiting
Can a daily drink improve heart and metabolic health?
This trial tests whether taking a daily drink containing short-chain fatty acids can improve risk factors for metabolic syndrome, like belly fat, high blood sugar, or high blood pressure. It might help if you are at risk but not yet taking medications for these conditions.
Leuven, Vlaams-BrabantAges 18–65 - NCT07150013RecruitingPhase 1
Vorinostat for Rett syndrome safety study
This trial tests whether vorinostat is safe and helpful for girls and young women with Rett syndrome. Participants must have a confirmed MeCP2 mutation and be in a stable phase of the condition.
MedellínAges 6–21 - NCT07150026RecruitingPhase 1
Testing vorinostat for Pitt Hopkins syndrome
This trial tests whether vorinostat, a medication that may affect gene activity, is safe and helpful for children and young adults with Pitt Hopkins syndrome. Participants take the drug by mouth or feeding tube.
MedellínAges 3–21 - NCT07153276RecruitingPhase 4
Laser vs estrogen cream for vaginal dryness in Sjögren's
This trial compares two treatments for vaginal dryness in women with Sjögren's disease: a CO2 laser procedure versus a topical estrogen cream called promestriene. The goal is to see which option works better to relieve dryness and discomfort.
São Paulo, São PauloAges 30–65 - NCT07151248Recruiting
Earlobe stimulation for Gulf War veterans with chronic pain
This trial tests a mild electrical stimulation device (called CES) on the earlobe to see if it can reduce pain and improve brain function in veterans with Gulf War Illness. You will have brain scans and answer questions about your symptoms.
Atlanta, GeorgiaAges 40–80 - NCT07154134Recruiting
Blood markers in preterm babies with breathing problems
This study looks at two substances in the blood (endocan and copeptin) to see if they can help doctors understand breathing problems in premature babies. It may lead to better ways to care for these infants.
Tanta, El-GharbiaAges 6 months–8 months - NCT07151274Recruiting
Ehlers-Danlos syndrome and women's gynecological health
This study uses an online questionnaire to explore how Ehlers-Danlos syndrome (EDS) may affect gynecological health. It compares women with EDS to those without, to better understand any differences.
RouenAges 18–50 - NCT06960746Recruiting
Lifestyle change for sleep apnea, metabolic syndrome, and impotence
This trial tests whether changing your lifestyle can help men with sleep apnea, metabolic syndrome, and erectile dysfunction. It studies how improving diet and exercise might improve these conditions together.
Giza, DokkiAges 40–50 - NCT07144631Recruiting
Nerve stimulation for restless legs in pregnancy
This trial tests if a small nerve stimulation device can safely and effectively reduce restless legs symptoms in pregnant people. If you are between 21 and 26 weeks pregnant with a confirmed diagnosis of restless legs syndrome (RLS), you may be eligible.
Providence, Rhode IslandAges 18 years+ - NCT07142135Enrolling by invitation
Long-term follow-up for Klinefelter syndrome patients
This study follows patients with Klinefelter syndrome over time to learn more about their health. It may help doctors better understand and care for people with this condition.
CopenhagenAges Any age - NCT07139626Recruiting
Biomarker study for heart and kidney health
This study looks for blood markers that may predict heart and kidney problems in people with stable chronic heart failure. If you have heart failure and are willing to give blood samples, you may help researchers better understand and manage this condition.
Nantong, JiangsuAges 18–75
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,057 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.