Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,057 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07135752Recruiting
Comparing digital tests in people with early MS or MRI signs
This trial studies whether digital tests can detect early changes in people with radiologically isolated syndrome (RIS) or multiple sclerosis (MS) who have normal neurological exams. It may help identify subtle symptoms earlier.
NiceAges 18–60 - NCT07142135Enrolling by invitation
Long-term follow-up for Klinefelter syndrome patients
This study follows patients with Klinefelter syndrome over time to learn more about their health. It may help doctors better understand and care for people with this condition.
CopenhagenAges Any age - NCT07139626Recruiting
Biomarker study for heart and kidney health
This study looks for blood markers that may predict heart and kidney problems in people with stable chronic heart failure. If you have heart failure and are willing to give blood samples, you may help researchers better understand and manage this condition.
Nantong, JiangsuAges 18–75 - NCT06819670RecruitingPhase 2
Preventing infantile spasms from coming back
This trial tests whether a longer course of steroids can keep infantile spasms from returning in babies who have already responded to standard treatment. It may help reduce the chance of relapse.
Los Angeles, CaliforniaAges 2 months–1.5 years - NCT03718936Recruiting
Study of genetic ADNP conditions in children and adults
This study looks at how people with certain disease-causing changes in the ADNP gene function using medical, genetic, and thinking/behavior assessments. It may help doctors better understand the condition and tailor support for families.
New York, New YorkAges 2 years+ - NCT06877715Recruiting
Sensory and autism traits in children with Prader-Willi syndrome
This study looks at autism-like symptoms and sensory profiles in children with Prader-Willi syndrome (PWS). It aims to better understand these traits to improve care and support.
ToulouseAges 3–16 - NCT07135050RecruitingPhase 1/Phase 2
Gene therapy study for Pitt Hopkins syndrome
This trial tests a new gene therapy called MZ-1866 for people with Pitt Hopkins syndrome. The therapy is given as a single injection into the fluid around the brain to help replace the missing or faulty TCF4 gene.
Oakland, CaliforniaAges 2–25 - NCT07134361Recruiting
Ultrasound study for carpal tunnel syndrome
This study uses hand ultrasound to evaluate carpal tunnel syndrome before and after surgery. It may help doctors understand how the wrist changes after treatment.
São Paulo, São PauloAges 18 years+ - NCT07135167RecruitingPhase 3
Epi-ON corneal crosslinking study for people with Down syndrome
This study tests a special light treatment for cornea problems in people with Down syndrome. It aims to strengthen the front of the eye and may help prevent vision loss.
Atlanta, GeorgiaAges 8 years+ - NCT07126028Enrolling by invitation
Quality of life in kids after MIS-C
This study looks at how children feel and live their daily lives after recovering from MIS-C (a severe inflammatory condition linked to COVID-19). It compares them to healthy children of the same age and gender to see if there are any lasting effects.
Rijeka, Primorje-Gorski Kotar CountyAges 1 month–18 years - NCT07133464Recruiting
CDH1 gene and BCDS syndrome registry
This registry studies people with changes in the CDH1 gene who may have blepharocheilodontic syndrome (BCDS). It collects information to better understand the condition and improve care.
Columbus, OhioAges Any age - NCT05741112Recruiting
Long COVID wearable study to track symptoms and help daily management
This study uses a wearable device to track symptoms and patterns in people with Long COVID, ME/CFS, and/or POTS. The goal is to see how wearable feedback and tracking tools may help you manage your symptoms.
La Jolla, CaliforniaAges 18 years+ - NCT07123519RecruitingPhase 1
YTS109 cell therapy for hard-to-treat autoimmune diseases
This trial tests a new cell therapy called YTS109 for people with certain severe autoimmune diseases that have not responded to standard treatments, such as lupus, Sjögren's syndrome, systemic sclerosis, inflammatory myopathy, vasculitis, and antiphospholipid syndrome. The goal is to see if it can safely reduce disease activity.
TianjinAges 18–65 - NCT07115654RecruitingPhase 2
A bispecific antibody trial for POEMS syndrome
This trial tests a new drug, BCMA/CD3 bispecific antibody, for people with POEMS syndrome. The drug helps the immune system attack abnormal plasma cells that cause the disease. It may offer a new treatment option for those who haven't had prior anti-plasma cell therapy.
TianjinAges 18–78 - NCT07119255Recruiting
PRP acupuncture for long-term neck pain from muscle tightness
This study tests whether a treatment called platelet-rich plasma (PRP) acupuncture — using your own blood proteins — can reduce chronic neck pain caused by a common muscle condition. It may be a good option if you have had neck pain for months and want a non-surgical approach.
JakartaAges 18–59 - NCT07125625Recruiting
Probiotic mixture for children with irritable bowel syndrome
This study tests whether a mixture of two friendly bacteria (probiotics) can improve belly pain and other IBS symptoms in children. If your child qualifies, they may receive the probiotic mixture or a placebo for a period of time.
Bari, BariAges 4–18 - NCT07122505Recruiting
Mouth muscle therapy for sleep apnea in kids with Down or Prader-Willi syndrome
This study tests a therapy that strengthens mouth and tongue muscles to help children with Down or Prader-Willi syndrome who have mild obstructive sleep apnea. It aims to improve breathing during sleep without surgery or machines.
GhentAges 4–18 - NCT07107126RecruitingPhase 1
Testing a new drug for relapsed AML or high-risk MDS
This trial tests a new drug called RPT1G for adults with acute myeloid leukemia or high-risk myelodysplastic syndromes that have not responded to standard treatments. The goal is to see if the drug is safe and if it shows signs of helping control the disease.
New York, New YorkAges 18 years+ - NCT07110714Recruiting
Kneipp water therapy for post-COVID recovery
This study tests if Kneipp hydrotherapy (a gentle water therapy) can help improve symptoms in people with Post-COVID Syndrome. You will use a smartphone app to track your heart rate and answer questionnaires.
Füssen, BavariaAges 18 years+ - NCT06967831Recruiting
Testing existing drugs for mitochondrial disorders
This trial looks at whether drugs already approved for other conditions might help people with Leigh syndrome, a rare mitochondrial disorder. Researchers will study cells made from your skin to see how these drugs work.
Düsseldorf, North Rhine-WestphaliaAges Any age - NCT07110961Recruiting
Heart rate test for restless legs diagnosis
This trial tests a new way to diagnose Restless Legs Syndrome (RLS) by looking at your heart rate changes during a simple leg movement test while you're in a sleep study. It may help doctors diagnose RLS more easily.
Bangkok, BangkokAges 18–70 - NCT07106996RecruitingEarly Phase 1
Red yeast rice for PCOS inflammation
This study tests if a natural supplement called red yeast rice can help reduce long-term inflammation in women with PCOS by improving how gut bacteria work. If you have PCOS and are not pregnant or using certain medications, you might be able to join.
Lishui, ZhejiangAges 18–40 - NCT07114913Recruiting
Carpal tunnel symptom location and pain study
This study looks at where carpal tunnel syndrome symptoms show up and how your body processes pain. By understanding this, doctors hope to find better ways to treat it.
Istanbul, UsküdarAges 18–65 - NCT07112365RecruitingPhase 4
Study of fenfluramine to prevent SUDEP in Dravet syndrome
This study tests whether the drug fenfluramine can reduce the risk of sudden unexpected death (SUDEP) in people with Dravet syndrome who have generalized convulsive seizures. It aims to see if a lower dose can still prevent seizures and protect the heart and breathing during a seizure.
Houston, TexasAges 16 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,057 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.