Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,057 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06943170Recruiting
Aerobic exercise with or without a low calorie diet for teens with Down syndrome
This trial studies how aerobic exercise, alone or combined with a low calorie diet, affects body fat and weight in children with Down syndrome who are overweight or obese. The goal is to find a safe, effective way to help manage weight.
Lahore, Punjab ProvinceAges 8–16 - NCT06286878RecruitingPhase 2/Phase 3
Dapagliflozin after a heart attack: recovery study
This trial tests whether a diabetes drug called dapagliflozin (also used for heart failure) can help people recover better after a recent heart attack. It's for adults who are already on standard blood thinners and have had a heart attack in the past week.
São Paulo, São PauloAges 18 years+ - NCT07185191Recruiting
Device to treat gum shrinkage and black triangles between teeth
This trial tests a medical device (RDM36) to see if it safely and effectively treats gum shrinkage and black triangles between the front teeth, which can affect your smile.
Brescia, ItalyAges 18 years+ - NCT07186764Recruiting
Quality of life in women with MRKH syndrome
This study tracks quality of life and follow-up care in women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, a condition where the uterus and upper vagina are underdeveloped or absent. It compares their experiences to women without MRKH to improve care.
ToulouseAges 18–50 - NCT07183878Recruiting
Venetoclax with BUCY conditioning for high-risk AML or MDS transplant
This trial tests whether adding venetoclax (a pill that targets cancer cells) to the standard chemotherapy regimen before a stem cell transplant improves outcomes for people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). It is for patients aged 12–60 whose cancer has specific high-risk features and who have a matched donor.
Hangzhou, ZhejiangAges 12–60 - NCT07189936RecruitingPhase 2
Testing 2-HOBA for Immune Issues in Long COVID with POTS
This trial tests if a medication called 2-HOBA can help with ongoing immune system issues in people with Long COVID who also have POTS. It aims to reduce fatigue and other symptoms by calming overactive immune responses.
Nashville, TennesseeAges 18 years+ - NCT06721936Recruiting
Study for menopause symptoms after breast cancer
This trial tests a treatment for menopause-like vaginal symptoms that can happen after breast cancer treatment. It aims to help survivors feel more comfortable.
MadridAges 38 years+ - NCT07177729Recruiting
Tick Bite Study – Understanding Immune Reactions
This study looks at how the body reacts to tick bites, specifically to understand alpha-gal syndrome—a condition that can cause allergic reactions to red meat. If you had a recent tick bite and can provide the tick, you may be able to help researchers learn more.
LuxembourgAges 18 years+ - NCT07179406Recruiting
Spinal cord stimulators for restless leg syndrome
This study tests whether a spinal cord stimulator can help people with restless leg syndrome (RLS). It compares people with RLS to healthy volunteers to see if the device reduces symptoms.
Birmingham, AlabamaAges 18 years+ - NCT07183020Enrolling by invitation
Kappa Free Light Chains in MS and CIS
This study looks at a protein called kappa free light chains (KFLC) in the spinal fluid and blood of people with multiple sclerosis (MS) or a first MS-like episode (CIS). The goal is to better understand how this protein relates to the disease, which may help with diagnosis and monitoring.
Hanover, Lower SaxonyAges 18–70 - NCT07181018Recruiting
Metabolic syndrome study in Polish twins
This study looks at how metabolic syndrome (a cluster of conditions like high blood pressure, high blood sugar, and extra belly fat) runs in twins. It aims to better understand genetic and lifestyle factors, and may help you learn more about your own health risks.
Poznan, WielkopolskaAges 15–44 - NCT07183774Recruiting
Does muscle loss affect shoulder tear patterns?
This study looks at whether sarcopenia (age-related muscle loss) affects the type of rotator cuff tear you have. You'll get a shoulder MRI to check your rotator cuff and muscle measurements.
Istanbul, ÜsküdarAges 40–75 - NCT07176078Recruiting
Osteopathic care plus low-FODMAP diet for fibromyalgia and IBS
This trial tests whether adding osteopathic care (a hands-on therapy) to a low-FODMAP diet helps people with both fibromyalgia and irritable bowel syndrome feel better. It compares the diet alone to the diet plus osteopathic sessions.
Brussels, Brussels CapitalAges 18 years+ - NCT07181733Recruiting
BNP in Teens with Metabolic Syndrome
This study is looking at how heart function tests taken in the first month of life relate to metabolic syndrome (a group of conditions like high blood pressure and blood sugar) in teens. Researchers will use data already collected from when you were a baby.
Pavia, paviaAges 13–18 - NCT07182526RecruitingPhase 2
Quercetin or alpha lipoic acid for PCOS symptoms
This trial tests adding quercetin or alpha lipoic acid to standard PCOS care to see if they improve symptoms and blood markers. It may help women who have irregular periods or signs of excess androgens like acne.
Baghdad, KarkhAges 18 years+ - NCT07181655Recruiting
Fasting, calorie cutting, and exercise for metabolic syndrome
This study tests if combining intermittent fasting, calorie reduction, and physical activity can help manage metabolic syndrome (a group of risk factors that increase your chance of heart disease, stroke, and diabetes). If you have at least three of five specific health issues (like belly fat, high blood pressure, or high blood sugar) and are an adult aged 18 or older, you may be able to join.
Serdang, SelangorAges 18–80 - NCT07181837RecruitingPhase 1/Phase 2
Testing MVX-220 for Angelman Syndrome
This study tests an experimental medicine called MVX-220 to see if it is safe and effective for people with Angelman Syndrome. It includes both children (ages 4-8) and adults (ages 18-50) who can walk independently and have stable seizure medications.
Los Angeles, CaliforniaAges 4–50 - NCT06613490RecruitingEarly Phase 1
CAR NK cells for antibody syndrome and rheumatoid arthritis
This early-phase trial tests whether a new type of immune cell (CAR NK) can treat two conditions: antisynthetase antibody syndrome (a rare autoimmune disease) and rheumatoid arthritis. It's for people whose current treatments haven't worked well enough.
Nanjing, JiangsuAges 18–70 - NCT06952413RecruitingPhase 2
Rituximab for chronic fatigue syndrome (ME/CFS) trial
This trial tests if rituximab, a drug that affects the immune system, can help people with ME/CFS. You'll receive the drug in the hospital and be monitored for safety and improvement.
Kodaira, TokyoAges 18–65 - NCT06934798RecruitingPhase 4
Vasopressin vs. Noradrenaline for low blood pressure after heart surgery
This trial compares two medications, vasopressin and noradrenaline, to see which one works better at raising blood pressure in patients who develop dangerously low blood pressure (vasoplegic syndrome) within the first day after heart surgery. The goal is to find the safest and most effective treatment to stabilize blood pressure and help recovery.
São PauloAges 18 years+ - NCT07168434RecruitingPhase 3
Yeast supplement for irritable bowel syndrome (IBS)
This trial tests if a yeast supplement called Saccharomyces boulardii can help people with irritable bowel syndrome (IBS), except for those with constipation as their main symptom. Participants take the supplement and see if their symptoms improve.
BragaAges 18–65 - NCT07170449Recruiting
Ultrasound test for carpal tunnel syndrome sensation
This study uses ultrasound to measure the size of a nerve in your wrist and compares it with your sense of touch. It aims to see if the ultrasound results match how much feeling you have lost in your hand.
Üsküdar, İ̇stanbulAges 18–65 - NCT07167667Recruiting
Hand therapy for carpal tunnel syndrome
This study tests two types of hand therapy for carpal tunnel syndrome: shockwave therapy (5 sessions) or warm paraffin wax (10 sessions). It compares which one better reduces nerve thickening and your symptoms.
IstanbulAges 30–60 - NCT07170527Recruiting
Metabolic signs, recovery, and physical function after ICU stay
This study looks at whether certain molecules in the blood (metabolic signatures) are linked to how well people recover physically after a serious illness requiring intensive care. By understanding these links, doctors might be able to better predict and support recovery.
Ede, GelderlandAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,057 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.