Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,173 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06534788Recruiting
Comparing two muscle therapies for piriformis syndrome
This study tests two different hands-on therapy techniques (reciprocal inhibition and post-facilitation muscle energy) along with standard physical therapy to see which works better for relieving piriformis syndrome—a condition that causes deep buttock pain. You may benefit if you have chronic hip/buttock pain and a shortened piriformis muscle.
Rawalpindi, Punjab ProvinceAges 20–50 - NCT06536075Recruiting
Salivary gland function in Sjogren's syndrome
This study looks at how well your salivary glands work and if there is a connection with a special scan called sialoscintigraphy. It may help people with or without dry mouth symptoms and a Sjogren's diagnosis.
TaipeiAges 20–70 - NCT06536543Recruiting
Lung imaging to check over-inflation in ARDS patients lying on their stomach
This trial uses a special lung imaging belt (EIT) to see if the lungs are over-inflated in patients with severe breathing problems (ARDS) when they lie on their stomach. It aims to help doctors adjust ventilator settings for better lung protection.
BayonneAges 18 years+ - NCT06539793Recruiting
Nerve stimulation for fibromyalgia pain
This trial tests if a gentle nerve stimulation treatment can reduce pain and improve daily function in people with fibromyalgia. It aims to understand how treatment affects natural pain signals.
Sadat, MenoufiaAges 25–35 - NCT06544473RecruitingPhase 4
Estrogen pill vs. patch for Turner syndrome
This trial compares oral and transdermal (patch) estrogen to find the right dose for women with Turner syndrome. It aims to see which method works best for hormone replacement.
Aarhus, Aarhus NAges 18–50 - NCT06545721Recruiting
Weight changes and hormone health in PCOS
This study looks at how weight changes affect hormone levels and insulin resistance in women with PCOS. It may help understand if weight cycling is harmful or helpful.
Beijing, Beijing MunicipalityAges 18–45 - NCT06548230RecruitingPhase 1/Phase 2
Nadunolimab plus azacitidine for MDS and AML
This trial tests a new combination of drugs (nadunolimab plus azacitidine, sometimes with venetoclax) for patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) that has not been treated much or has come back. The goal is to see if this combination can control the disease better.
Houston, TexasAges 18 years+ - NCT06550284Recruiting
Nerve sensitivity in carpal tunnel syndrome
This study tests how small nerve fibers work in people with carpal tunnel syndrome. It uses simple sensory tests to understand nerve function, which may help guide treatment.
San Antonio, TexasAges 18–65 - NCT06561815Recruiting
Body composition test in heart attack patients
This trial looks at how a simple, painless test called bioelectrical impedance analysis can measure your body's water, fat, and muscle. It may help doctors understand how these factors affect recovery from a heart attack or unstable angina.
Buenos Aires, Buenos AiresAges 18 years+ - NCT06567769RecruitingPhase 1
A study of GC1130A for Sanfilippo syndrome type A
This trial tests a new medicine called GC1130A for children with Sanfilippo syndrome type A (MPS IIIA). The goal is to see if it is safe and if it might help with symptoms.
Oakland, CaliforniaAges 1–18 - NCT06569095Recruiting
Study of stem cells in myelodysplastic syndrome
This study looks at special stem cells in the blood or bone marrow of people with myelodysplastic syndromes (MDS). It aims to better predict how the disease might progress and help guide treatment decisions.
BeijingAges 15–70 - NCT06570460RecruitingPhase 4
Estrogen pills vs. patch for Turner syndrome
This study compares two ways of taking estrogen (pills or a skin patch) in women with Turner syndrome to see which works better over time. It also includes healthy women for comparison.
Aarhus, Aarhus NAges 18–50 - NCT06573723Recruiting
Rare disease registry at Hospital Italiano
This study collects information from patients with certain rare diseases to better understand them. If you have one of these conditions and receive care at Hospital Italiano de Buenos Aires, you may be able to join.
Buenos Aires, Buenos AiresAges Any age - NCT06576375RecruitingPhase 3
Dapagliflozin vs metformin for PCOS and infertility
This trial compares two medicines, dapagliflozin and metformin, to see which works better for women with PCOS who are trying to get pregnant. Both are pills that can help with hormone balance and ovulation.
GizaAges 18–40 - NCT06577519RecruitingPhase 3
Study of vicagrel for heart attack patients getting stents
This trial tests a new medicine called vicagrel for people who have had a heart attack or unstable angina and are getting a stent. The goal is to see if it works better than standard treatments to prevent future heart problems.
Shenyang, LiaoningAges 18–80 - NCT06578390Recruiting
Testing a smartphone app for sleep apnea diagnosis
This trial tests whether a smartphone app (Apneal®) can accurately diagnose sleep apnea during a routine sleep study. If you are already going to have a sleep study, you may be able to help test this device.
Aix-en-ProvenceAges 18 years+ - NCT06582914Recruiting
Lynch syndrome genetics and health study
This study looks at the genetics and health of people with Lynch syndrome, a condition that raises the risk for certain cancers. Researchers want to learn more about how different genetic changes affect health over time.
Aurora, ColoradoAges 18 years+ - NCT06586268Recruiting
Sleep changes after surgery in people with sleep apnea
This study looks at how sleep patterns change in the first three nights after surgery for people who have obstructive sleep apnea (OSA). It aims to understand how anesthesia and sleep apnea severity affect sleep quality during recovery.
Amsterdam, North HollandAges 18 years+ - NCT06591793RecruitingPhase 1/Phase 2
Gene therapy for Usher syndrome type 1B vision loss
This trial tests an experimental gene therapy given as an injection under the retina. It aims to slow or stop vision loss in people with Usher syndrome type 1B, a rare genetic condition that causes both hearing and vision problems.
NaplesAges 18–50 - NCT06593977Recruiting
Dynavisc gel for pain after repeat carpal tunnel surgery
This trial tests a gel called Dynavisc to see if it reduces pain when placed in the wrist during a second surgery for carpal tunnel syndrome. It may help people who still have pain after their first surgery.
Leuven, BelgiumAges 18–65 - NCT06598618Recruiting
Comparing two therapies for kneecap pain
This study compares two types of hands-on treatments—Instrument-Assisted Soft Tissue Mobilization (IASTM) and Muscle Energy Technique—to see which works better for kneecap pain. It aims to find a therapy that can help reduce your pain and improve movement.
Rawalpindi, Punjab ProvinceAges 18–35 - NCT06598449RecruitingPhase 4
Safety of fenfluramine in children under 2 with Dravet syndrome
This trial tests the safety of a medicine called fenfluramine for children under 2 years old with Dravet syndrome. It aims to see if fenfluramine can help control seizures in very young children.
Aurora, ColoradoAges 1–2 - NCT06599086Recruiting
Steroid shot for carpal tunnel with split nerve
This study tests if a steroid injection helps people with carpal tunnel syndrome who also have a split median nerve (called bifid median nerve). It compares them to people without the split nerve to see if the treatment works differently.
Ankara, AnkaraAges 18–65 - NCT06599762RecruitingPhase 2
Tranexamic acid for bleeding in MDS and AML
This trial tests if tranexamic acid, a medicine that helps blood clot, can reduce bleeding in people with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) who have very low platelet counts and are receiving less-intensive chemotherapy.
Winnipeg, ManitobaAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,173 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.