Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,173 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06758050Recruiting
Core exercises for front knee pain
This study tests whether doing core exercises can help reduce knee pain in people with patellofemoral pain syndrome—pain at the front of the knee that comes on gradually. It is meant for young adults with a healthy weight who have had this type of knee pain for more than 3 months.
GizaAges 18–35 - NCT06758492Recruiting
Video vs direct laryngoscopy for surfactant in newborns
This study compares two ways of placing a thin tube into a newborn's windpipe to give surfactant—a medicine that helps their lungs work better. It will help doctors understand which method is safer and easier for babies needing this treatment.
RijekaAges birth–4 weeks - NCT06764511Recruiting
Biosimilar EPO for anemia in low-risk MDS
This trial tests how well a biosimilar version of erythropoietin (a drug that boosts red blood cells) works in people with low-risk myelodysplastic syndrome (MDS) who have anemia. It aims to see if this treatment can safely improve low hemoglobin levels without needing more intensive therapies.
BolognaAges 18 years+ - NCT06765265RecruitingPhase 4
Comparing two statins' effect on vitamin D after heart attack
This study compares two common statins (atorvastatin and rosuvastatin) to see how they affect vitamin D levels in people who have recently had a heart attack or unstable angina. It may help doctors choose the best statin for your heart and vitamin D health.
Lahore, Punjab ProvinceAges 18–65 - NCT06770218Recruiting
Pelvic taping for stability in Down syndrome
This trial tests whether taping the pelvic area can help children with Down syndrome feel more stable. It may improve their movement and balance.
Lahore, Punjab ProvinceAges 4–10 - NCT06771583Recruiting
Finding biomarkers for PMDD in blood samples
This study looks for chemical markers in the blood that might help diagnose PMDD. It involves blood draws and questionnaires over one or two menstrual cycles to see how your body responds to natural hormone changes.
Baltimore, MarylandAges 18–50 - NCT06774534Recruiting
SerpinB3 protein in acute respiratory distress
This study looks at a protein called SerpinB3 and its role in severe lung inflammation (ARDS). It may help doctors understand how ARDS develops and find new ways to treat it.
Padova, PDAges 18 years+ - NCT06777394Recruiting
High intensity interval training for Down syndrome
This study tests whether high intensity interval training (short bursts of intense exercise) can help children with Down syndrome. Doctors want to see if it improves strength and overall health.
Lahore, Punjab ProvinceAges 3–14 - NCT06780462RecruitingPhase 3
Steroids with or without blood thinners for Behçet's vein clots
This trial tests whether adding a blood thinner (anticoagulant) to steroid therapy is more effective than steroids alone for treating deep vein thrombosis (a blood clot in a large vein) in people with Behçet's syndrome. It aims to find the best way to prevent future clots and reduce side effects.
BordeauxAges 18 years+ - NCT06781099Recruiting
Iron removal machine for MDS or myelofibrosis with high iron
This trial tests a new way to remove extra iron from the blood using a machine (like dialysis). It is for people with myelodysplastic syndrome or myelofibrosis who have severe anemia, high iron levels, and cannot take standard iron-removal pills or injections.
Oullins-Pierre-BéniteAges 18 years+ - NCT06782373RecruitingPhase 2
Pacritinib for treating VEXAS syndrome
This trial tests a drug called pacritinib for people with VEXAS syndrome. It aims to see if pacritinib can help control inflammation and reduce the need for steroids. You may qualify if you have a specific UBA1 gene mutation and are currently on a stable steroid dose.
Scottsdale, ArizonaAges 18 years+ - NCT06783894Recruiting
Elliptical Exercise for Sexual Health in Men with IBS
This study looks at whether regular elliptical exercise can help improve sexual function in married men who have both irritable bowel syndrome (IBS) and erectile dysfunction. It may be an option if you are looking for a drug-free way to manage these issues.
Dokki, Giza GovernorateAges 30–50 - NCT06785532Recruiting
Brain stimulation for hard-to-treat Tourette's syndrome
This trial tests a brain stimulation device (RNS) for people with Tourette's syndrome whose symptoms haven't improved with standard treatments. It aims to see if this approach can reduce tics and improve quality of life.
BeijingAges 18–65 - NCT06788444Recruiting
Esketamine for irritable bowel syndrome with anxiety or depression
This study tests if esketamine, a fast-acting medication, can help people with irritable bowel syndrome who also have anxiety or depression. It is given during a colonoscopy to see if it reduces your IBS symptoms.
Beijing, Beijing MunicipalityAges 18–60 - NCT06789783RecruitingPhase 2/Phase 3
Lithium treatment for Cornelia de Lange syndrome
This trial tests whether lithium can help people with Cornelia de Lange syndrome (CdLS) who have a confirmed NIPBL gene mutation. It might improve their daily life and overall well-being.
Milan, MIAges 4 years+ - NCT06793098Recruiting
Functional proteins in polycystic ovary syndrome
This study measures proteins in the blood that may be linked to polycystic ovary syndrome (PCOS). It aims to find differences between women with PCOS and those without, which could lead to better understanding and diagnosis.
KrakowAges 18–45 - NCT06793787Recruiting
AI and advanced imaging to guide treatment of borderline heart blockages
This study uses advanced CT scans and a special camera (OCT) to look at borderline blockages in heart arteries more closely. It aims to see if artificial intelligence can help decide which blockages need a stent and which can be treated with medicine alone.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06793930Recruiting
A personalized program to improve health in metabolic syndrome
This study tests a personalized program that helps people with metabolic syndrome make healthy changes to their diet and activity. It is designed for Chinese adults who live at home and can use a digital device.
Hong KongAges 18 years+ - NCT06794008RecruitingPhase 2
CAR-T cell therapy for hard-to-treat autoimmune diseases
This trial tests a new treatment using your own immune cells (called CAR-T cells) designed to target and attack cells that cause autoimmune diseases. It is for people with lupus, Sjögren's syndrome, inflammatory myopathy, scleroderma, Behcet's disease, ANCA-associated vasculitis, IgG4-related disease, antiphospholipid syndrome, or thrombotic thrombocytopenic purpura who have not improved with standard therapies.
Beijing, Beijing MunicipalityAges 18–65 - NCT06794190Recruiting
Understanding liver health in Turner syndrome
This study aims to understand why some women with Turner syndrome develop liver problems. Researchers will analyze factors that may contribute to liver changes, which could lead to better monitoring and care.
BolognaAges 18 years+ - NCT06801249RecruitingPhase 4
Metyrapone for heart risk in adrenal tumors with Cushing's
This trial tests if a drug called Metyrapone can lower heart risks in people who have adrenal nodules (noncancerous growths on the adrenal glands) and a mild form of Cushing's syndrome that doesn't cause obvious physical signs. You'll be given the drug and monitored to see if it helps control blood pressure and other heart risk factors.
BolognaAges 18–75 - NCT06801769Recruiting
Fat in the pancreas and its link to metabolic health
This study uses a special ultrasound technique (eco-elastography) to measure fat inside the pancreas and see how it relates to metabolic syndrome and the cells that produce insulin. It might help understand why some people develop diabetes or other metabolic issues.
Rome, LazioAges 18–80 - NCT06802315RecruitingPhase 2
Radiation therapy before stem cell transplant for high-risk blood cancers
This trial tests a precise type of radiation called intensity modulated total marrow irradiation before a stem cell transplant. It aims to destroy cancer cells while reducing side effects for patients with high-risk leukemia or myelodysplastic syndrome.
Chicago, IllinoisAges 18–65 - NCT06806891Recruiting
Walking meditation for restless legs in dialysis
This trial tests if Buddhist walking meditation can help restless leg syndrome in people on hemodialysis. If you have both conditions and are not obese, you may qualify.
Dokki, Giza GovernorateAges 35–65
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,173 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.