Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,173 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07545772RecruitingPhase 2
Testing Brenipatide for Constipation-Focused IBS
This trial tests a new medicine called brenipatide to see if it can help people with IBS-C (irritable bowel syndrome with constipation). The study focuses on whether the drug reduces belly pain and improves bowel movements in people whose main symptom is hard or infrequent stools.
Mesa, ArizonaAges 18–75 - NCT07216443RecruitingPhase 2
Study of orca-t for leukemia or MDS with reduced intensity chemo
This trial tests a new cell therapy, orca-t, given after a lower-intensity chemo and radiation regimen for people with acute myeloid leukemia, mixed phenotype leukemia, or myelodysplastic syndrome. It aims to help patients who cannot tolerate full-intensity transplant conditioning.
Los Angeles, CaliforniaAges 18 years+ - NCT06712810RecruitingPhase 1
Q702 for blood cancers and histiocytic disorders
This study tests an experimental pill called Q702 for people with certain blood cancers and related disorders (like histiocytoses, myelofibrosis, and lymphomas) that have not responded to standard treatments. It aims to see if Q702 is safe and effective.
Scottsdale, ArizonaAges 18 years+ - NCT06715735Recruiting
A health coaching program for metabolic syndrome with kidney disease
This trial tests if a personalized health coaching program can help people with metabolic syndrome and chronic kidney disease make lasting lifestyle changes. If you have both conditions and are not yet on dialysis, this program may help you manage your health.
Chengdu, SichuanAges 18 years+ - NCT06716411Recruiting
Acupuncture for Gulf War Illness relief
This study tests whether acupuncture can help relieve Gulf War Illness symptoms like fatigue, mood or thinking problems, and muscle or joint pain. You may be able to join if you were deployed to the Gulf region and have had these symptoms for more than 6 months.
Berkeley, CaliforniaAges 18 years+ - NCT06718179RecruitingPhase 4
Short vs. 12-month prasugrel and aspirin after a heart attack with a stent
This trial compares taking a shorter course of prasugrel (a blood thinner) plus aspirin after a heart attack versus the standard 12-month course. It aims to see if a shorter duration is just as effective and safer for people who got a specific type of stent (everolimus-eluting).
AalborgAges 18 years+ - NCT06720571Recruiting
Nerve stimulation for emotion and thinking in Prader-Willi syndrome
This trial tests whether a gentle, non-invasive nerve stimulation (like a small device on the neck) can help people with Prader-Willi syndrome regulate emotions and improve planning and focus. It may be a new option if you have trouble with emotional control or daily organization.
BordeauxAges 18 years+ - NCT06720818Recruiting
Infection-fighting cells in severe lung injury
This study looks at a type of immune cell (MAIT cell) in patients with severe lung problems caused by infections, pancreatitis, head injury, burns, or major surgery. It aims to understand how these cells change during illness, which may lead to better treatments.
ToursAges 18 years+ - NCT06721936Recruiting
Study for menopause symptoms after breast cancer
This trial tests a treatment for menopause-like vaginal symptoms that can happen after breast cancer treatment. It aims to help survivors feel more comfortable.
MadridAges 38 years+ - NCT06722534Recruiting
Celecoxib to prevent polyps from growing in Peutz-Jeghers Syndrome
This trial is testing if the medication celecoxib can stop or slow the growth of polyps in people with Peutz-Jeghers Syndrome (PJS). It may help reduce the need for surgery and lower the risk of complications.
Xi'an, ShaanxiAges 8 years+ - NCT06726785Recruiting
Gene changes in nasal cells of RLS patients on long-term dopamine agonist
This study looks at changes in a gene (DRD2) in nasal cells of people with Restless Legs Syndrome who are taking a dopamine agonist medication for a long time. It aims to understand how this gene might be involved in RLS.
San Francisco, CaliforniaAges 18–60 - NCT06728228Recruiting
Amnioinfusion for fetal kidney failure
This trial is testing whether adding fluid back into the womb (amnioinfusion) can help babies whose kidneys are not working and who have no amniotic fluid early in pregnancy. It may improve the baby's chances of survival and lung development.
Dallas, TexasAges Any age - NCT06729151Recruiting
Botox vs. standard care for bladder pain and sexual health
This study compares the effect of Botox injections into the bladder versus standard care (without injections) on sexual function in women with bladder pain syndrome. It aims to see if Botox can improve both pain and sexual health.
Bethesda, MarylandAges 18–99 - NCT06730126RecruitingPhase 2
Soquelitinib for ALPS-FAS-related swelling and low blood counts
This trial tests an investigational drug called soquelitinib to see if it can shrink enlarged lymph nodes and improve low blood cell counts in people with ALPS-FAS. It may offer a new treatment option for those who have active symptoms.
Bethesda, MarylandAges 16–120 - NCT06732713Recruiting
Swiss ball vs. Frenkel exercises for Down syndrome
This trial compares using a Swiss ball versus Frenkel exercises to improve balance and coordination in children with Down syndrome. It may help children who can stand and walk on their own.
Lahore, Punjab ProvinceAges 8–13 - NCT06736665Recruiting
Comparing two ways to treat hardened calcium in heart arteries
This trial compares two techniques (orbital atherectomy and intravascular lithotripsy) to break up tough calcium deposits in the heart's arteries that can block blood flow. If you have a calcified nodule and are having a non-emergency procedure to open a blocked artery, this study may help guide which method works best.
Alicante, AlicanteAges 18 years+ - NCT06737718Recruiting
Eye tracking study for children with Angelman syndrome
This trial uses eye tracking to understand how children with Angelman syndrome perceive social cues. Participation helps researchers learn more about social perception for future treatments.
ParisAges 3–17 - NCT06738758Recruiting
Early intensive cholesterol-lowering study for acute coronary syndrome
This study tests whether starting strong cholesterol-lowering treatment early in the hospital can improve outcomes for people with acute coronary syndrome (a serious heart condition like a heart attack or unstable angina). It may help if you have high LDL cholesterol.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06739759Recruiting
Preventing OHSS in PCOS women having ICSI
This trial tests a way to prevent a side effect called ovarian hyperstimulation syndrome (OHSS) in women with PCOS who are having ICSI (a type of IVF). The goal is to make fertility treatment safer for you.
GizaAges 19–42 - NCT06747741Recruiting
Stretching vs. physical therapy for restless leg syndrome in seniors
This study compares a special stretching technique (PNF) with standard physical therapy to see which better relieves restless leg syndrome symptoms in people aged 60 and older. It may help reduce the uncomfortable urge to move your legs at night.
IslamabadAges 60 years+ - NCT06747949RecruitingPhase 3
Long term extension study of dazodalibep for Sjogren's syndrome
This study gives continued access to the study drug dazodalibep for people with Sjogren's syndrome who completed a prior phase 3 study. The goal is to see how safe and effective the medication is over a longer period.
Avondale, ArizonaAges 18 years+ - NCT06748248Recruiting
Suspension therapy for mobility and balance in Down syndrome
This trial tests if suspension therapy (a type of physical therapy using supportive straps or harnesses) can help children with Down syndrome improve their ability to move and keep their balance. It may be a helpful option for children who can already stand and walk but want to get stronger and more stable.
Lahore, Punjab ProvinceAges 3–6 - NCT06753487Recruiting
Comparing two gentle therapies for piriformis syndrome in women
This trial tests two hands-on treatments (Facilitated Positional Release and Manual Myofascial Release) to see which works better for women with piriformis syndrome. If you're a woman aged 25–50 with buttock or hip pain for at least 2 months, this study might help you find relief.
Rawalpindi, Punjab ProvinceAges 25–50 - NCT06757491Recruiting
Low frequency brain stimulation for diarrhea-predominant IBS pain
This trial tests if a type of brain stimulation called low-frequency repetitive transcranial magnetic stimulation (lf-rTMS) can reduce belly pain in people with irritable bowel syndrome that causes diarrhea (IBS-D). It is a non-invasive treatment that uses magnetic pulses to target areas of the brain involved in pain perception.
Suzhou, JiangsuAges 18–75
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,173 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.