Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,051 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06952257Enrolling by invitation
Anesthesia type and safety in hip fracture surgery
This study is comparing different types of anesthesia (general vs. spinal/epidural) during hip fracture surgery to see which one is safer and reduces the risk of a rare but serious reaction called bone cement implantation syndrome. It may help you if you are scheduled for a cemented partial hip replacement.
Baltimore, MarylandAges 18 years+ - NCT06951516Recruiting
Can simple language help young kids with Down syndrome learn?
This study looks at whether using simpler language helps children with Down syndrome understand and learn better. It is for children ages 2 to 7 who speak English as their main language.
East Lansing, MichiganAges 2–7 - NCT06940596Recruiting
Comparing diets and therapies for irritable bowel syndrome
This study compares different dietary and behavioral treatments to find out which works best for different people with irritable bowel syndrome (IBS). You'll be asked to follow a specific treatment program to see how it affects your symptoms.
Melbourne, VictoriaAges 18 years+ - NCT06940609RecruitingPhase 2
Brain scan study for Long COVID brain fog
This trial studies if brain scans can help understand 'brain fog' in Long COVID. It also looks at how a gentle magnetic stimulation might affect symptoms. If you have ongoing thinking problems after COVID, this study may help find new ways to help.
Albuquerque, New MexicoAges 18–80 - NCT05786235Recruiting
Pregnant people with or without antiphospholipid antibodies
This study is looking at pregnancy outcomes in people who are pregnant and either have antiphospholipid antibody syndrome (APS) or do not have APS but do have prior full-term pregnancies. It may help doctors understand risks and how to manage pregnancies in these groups.
MilanAges 18–45 - NCT06928662RecruitingPhase 1/Phase 2
Chemo, radiation, and donor stem cell transplant for high-risk blood cancers
This trial tests a strong chemotherapy and radiation combo followed by a donor stem cell transplant for people with aggressive blood cancers (like AML or MDS) that haven't responded to earlier treatments or came back. It aims to help prevent the cancer from returning.
Seattle, WashingtonAges 18 years+ - NCT06927947Recruiting
Helping families learn about inherited cancer risk
This study tests different ways to help family members of people with inherited cancer syndromes get genetic testing. It aims to improve cancer prevention and early detection.
Ann Arbor, MichiganAges 18 years+ - NCT06923488RecruitingPhase 1/Phase 2
Leflunomide and decitabine for returning MDS
This trial tests a new combination of two drugs—leflunomide and decitabine—for people with MDS that has come back or hasn't responded to treatment. The goal is to see if this combination can help control the disease.
Morgantown, West VirginiaAges 18 years+ - NCT06929598Recruiting
Shiatsu for chronic pain in children and teens
This study tests whether Shiatsu—a gentle, hands-on therapy—can help reduce chronic, non-inflammatory pain in children and adolescents. If you or your child have had long-term pain without inflammation and are already being seen at a specific pain clinic in Tel Aviv, this trial might be a good fit.
Tel Aviv, Tel AvivAges 10–18 - NCT06918847Recruiting
Comparing myofascial release vs. cupping for restless leg and knee OA
This study compares two hands-on therapies – myofascial release (gentle stretching of connective tissue) and cupping (using suction cups on the skin) – to see which one better improves quality of life for people who have both restless leg syndrome and knee osteoarthritis. If you have both conditions, you may be able to join.
Karachi, SindhAges 40–70 - NCT06912763RecruitingPhase 2
Reversing radiation side effects in head and neck cancer
This trial tests a combined treatment (a statin and a drug that helps blood flow) to reverse long-term swelling and tissue hardening caused by head and neck radiation. It may help people who have had these side effects for more than 6 months.
Houston, TexasAges Any age - NCT06918834RecruitingPhase 2
Immediate vs bridging transplant for high-risk MDS
This trial compares getting a stem cell transplant right away versus getting other treatments first before transplant for people with high-risk myelodysplastic syndrome (MDS), a bone marrow disorder. It aims to see which approach leads to better outcomes.
Beijin, Beijing MunicipalityAges 18 years+ - NCT06908473Enrolling by invitationPhase 3
Tongmai Jiangtang capsule for heart risks in metabolic syndrome
This trial tests whether the Tongmai Jiangtang capsule can reduce serious heart and stroke problems in older adults with metabolic syndrome who are also at high risk for heart disease. It focuses on people with a specific traditional Chinese medicine pattern called Qi-deficiency and Blood Stasis.
Guangzhou, GuangdongAges 65 years+ - NCT06907849Enrolling by invitationPhase 2
Imaging amyloid in spinal stenosis and carpal tunnel
This trial tests a special scan that uses a radioactive tracer to look for amyloid protein deposits in people who have had surgery for lumbar spinal stenosis (narrowing of the spine in the lower back) or carpal tunnel syndrome. The goal is to see if the scan can detect these deposits, which may be linked to ongoing orthopedic issues.
Knoxville, TennesseeAges 60 years+ - NCT06158152Recruiting
AM3 supplement for metabolic syndrome pilot study
This study tests an oral supplement called AM3 in people with metabolic syndrome. It looks at whether the supplement can help improve sugar and fat levels in the blood.
MadridAges 18–75 - NCT05525598Recruiting
Online therapy for severe body–mind symptom disorders
This trial tests an internet-based treatment program for people with moderate-to-severe functional somatic disorders (long-lasting physical symptoms linked to how the body and brain interact). It may help reduce symptoms and improve day-to-day functioning by offering structured support online.
Aarhus C, DenmarkAges 18–60 - NCT06899178RecruitingPhase 2
Atomoxetine for genetic obesity due to MC4R changes
This trial tests a medicine called atomoxetine (Strattera) to help people with a specific genetic form of obesity lose weight. It may be an option if you have a change in the MC4R gene and have not used certain other medications recently.
New York, New YorkAges 6 years+ - NCT06900491Recruiting
Irritable Bowel Syndrome Regional Cohort Study
This study follows a group of people with irritable bowel syndrome (IBS) to learn more about the condition. You may join if you have been diagnosed with IBS and have had normal routine blood tests.
AmiensAges 18 years+ - NCT06896708Recruiting
Intensive cholesterol treatment for heart plaque in younger adults
This trial tests whether higher doses of cholesterol-lowering medication (statins) can slow down plaque buildup in the heart arteries of younger and middle-aged adults with stable chest pain. It may help prevent heart attacks and the need for procedures like stents.
Chongqing, Chongqing MunicipalityAges 18–60 - NCT06899711Recruiting
A helmet after skull surgery to prevent sunken flap
This study tests whether wearing a custom-made external helmet after a large skull removal surgery can prevent the skin from sinking in. If you've had this surgery in the last two weeks and are being treated at a Johns Hopkins hospital, you may be eligible.
Baltimore, MarylandAges 18 years+ - NCT06882603Recruiting
Steroid injections and nerve hydrodissection for carpal tunnel
This trial compares two treatments for carpal tunnel syndrome: a corticosteroid injection (which reduces swelling) and a newer technique called nerve hydrodissection (which uses fluid to free the nerve). The goal is to see which works better for relieving pain and improving hand function.
Kırşehir, City CentreAges 18–65 - NCT06887387Recruiting
Wearable devices to monitor Long QT Syndrome
This study tests whether wearable devices can help monitor Long QT Syndrome, a heart condition. It aims to make tracking your heart easier and more convenient than clinic visits.
LondonAges 18 years+ - NCT06890013Recruiting
Heart artery function test after a heart attack
This study looks at how well the blood vessels in your arm relax after a heart attack. It uses an ultrasound test on your arm, a heart ultrasound, and some blood tests to see if this can help predict future heart problems.
ThessalonikiAges 18–85 - NCT06881368Recruiting
Understanding Susac syndrome in adults
This study looks at Susac syndrome, a rare condition that affects the brain, ears, and eyes. If you have hearing loss, vision problems, or confusion, researchers want to understand what causes it and how it affects people like you.
ParisAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,051 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.