Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,201 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06830655Enrolling by invitation
Climbing performance and body factors study
This study looks at how mobility, balance, and fatigue affect climbing performance. If you are a healthy climber, you may help researchers understand what makes a better climber.
Gdansk, GdańskAges 15–45 - NCT06761040Recruiting
Hip and foot strength training for overweight women
This study tests whether adding hip-strengthening exercises to foot-strengthening exercises helps overweight women with flat feet. If you have foot pronation and are in your early 30s, you may be able to join.
Lahore, Punjab ProvinceAges 30–35 - NCT06721884RecruitingPhase 1/Phase 2
Artemisia annua for small intestinal bacterial overgrowth (SIBO)
This trial tests whether a supplement made from Artemisia annua (sweet wormwood) can help people with SIBO, a gut condition. You will take the supplement or a placebo for 5 weeks and have breath tests and blood draws to see how it affects your symptoms.
Portland, OregonAges 18 years+ - NCT06735664RecruitingPhase 1
Zanubrutinib and odronextamab for Richter's transformation
This trial tests a combination of two targeted drugs for people with Richter's transformation, an aggressive lymphoma that can develop from CLL. The goal is to see if this combination can help control the disease.
Duarte, CaliforniaAges 18 years+ - NCT06642285Recruiting
Preventing nasal injuries in preterm babies on breathing support
This study tests if using special care steps can prevent nose sores in preterm babies who need breathing support through a mask or nasal prongs. It may help protect your baby's delicate nose from injury.
Kafr ash Shaykh, Kafr el-Sheikh GovernorateAges 7 months–9 months - NCT06554275Recruiting
CCHS research health hub
This study creates a secure health information hub for people with Congenital Central Hypoventilation Syndrome (CCHS) to help researchers better understand the condition and find new ways to treat it. Being part of this hub may help advance future studies and care options for CCHS.
Chicago, IllinoisAges Any age - NCT06387706Recruiting
Web-based pain program for older adults
This study tests a fun, web-based program (GAP) to help older adults manage chronic pain through light exercise and coping skills. It's designed for Cantonese speakers who can use a smartphone.
Hong KongAges 60 years+ - NCT06456099Recruiting
Home exercises with a steroid shot for hip pain
This trial tests whether adding a steroid injection to a home exercise program helps people with long-term pain on the outside of the hip. It aims to find a better way to manage your pain and improve daily function.
GistrupAges 35 years+ - NCT06447818Recruiting
Airway changes after sleep apnea surgery
This study looks at how surgery for obstructive sleep apnea (a condition where breathing stops and starts during sleep) may affect your airway. The goal is to understand if the surgery makes it easier to manage your airway in the future.
Kocaeli, IzmıtAges 18–65 - NCT06283095Recruiting
Expanding the palate to help sleep apnea
This surgery expands the palate to treat obstructive sleep apnea caused by a narrow upper airway. It may help people with mild to moderate sleep apnea who have a specific type of airway collapse seen on a sleep-endoscopy test.
AsyutAges 18–70 - NCT06244433Recruiting
Genetic testing for sudden infant death
This study looks for gene changes that might be linked to sudden unexpected infant death. It compares the DNA of babies who died suddenly with DNA from their parents, to find possible inherited causes.
Nantes, Loire-AtlantiqueAges Any age - NCT06307535Recruiting
Meaning-centered therapy for cancer caregivers
This study tests a type of therapy that helps caregivers find meaning and cope with the stress of caring for someone with advanced cancer. It is done online, so you can join from home.
Miami, FloridaAges 18 years+ - NCT06265519Recruiting
Urine markers for enlarged prostate check
This study looks at two natural substances in urine (BDNF and NGF) to see if they can help doctors understand how the lower urinary tract is working in men with an enlarged prostate. It is a simple, non-invasive test that may lead to better ways to diagnose and treat bladder problems.
IstanbulAges 50–80 - NCT06198816Recruiting
Ultrasound and balloon treatment for old leg clots
This study tests a new way to treat long-standing blood clots in the leg using ultrasound waves and a balloon procedure. It aims to improve blood flow and reduce symptoms like swelling and pain for people who haven't gotten better with standard treatments.
Milan, ItalyAges 18–75 - NCT06083363Recruiting
Recovery after severe lung infection
This study follows patients who had severe pneumonia or acute respiratory distress syndrome (ARDS) in the intensive care unit (ICU) to understand how they recover over time. It aims to identify factors that affect recovery trajectories.
Tortosa, TarragonaAges 18 years+ - NCT06026436Recruiting
Predicting clot and bleeding risk in kidney disease patients after a heart attack
This trial tests whether a blood test looking at platelets and tiny cell particles can help predict future blood clots or bleeding in people who have both chronic kidney disease and a recent heart attack. The goal is to improve treatment safety.
MarseilleAges 18–90 - NCT06121466RecruitingPhase 4
Belly wall injections for abdominal pain study
This study tests whether anesthetic injections into the belly wall can help relieve abdominal pain that feels like it's coming from the muscles or tissues of the belly wall itself. It may be a good option if you have localized pain and haven't tried these injections yet.
Portland, OregonAges 18–100 - NCT05885646Recruiting
Sulthiame study using sleep EEG in children with epilepsy
This trial tests whether sulthiame changes sleep-related brain wave activity (EEG) in children with certain epilepsy syndromes. It may help doctors understand how sulthiame affects the brain’s electrical patterns between seizures.
AngersAges 6–15 - NCT05656105RecruitingEarly Phase 1
PET scan study of brain inflammation after COVID
This early-phase study uses a special PET scan to look for signs of brain inflammation in people with ongoing (long-term) nervous system symptoms after COVID-19. It may help researchers understand what is driving symptoms and whether this imaging approach can detect inflammation.
Birmingham, AlabamaAges 18–65 - NCT05674630RecruitingPhase 4
Drug-coated balloon for coronary artery blockages
This trial studies whether a drug-coated balloon can treat certain coronary artery narrowings in adults with chronic (long-term) coronary disease. It may help prevent re-narrowing after the procedure for people whose tests show the blockage is significant and needs treatment.
LuganoAges 18 years+ - NCT05873712RecruitingPhase 2
Zanubrutinib plus CAR-T for Richter syndrome
This Phase 2 trial tests whether a combination of zanubrutinib (an oral medicine) and CAR-T cell therapy can treat Richter syndrome, a type of lymphoma that develops in people with CLL/SLL. It may help shrink tumors and improve outcomes after the disease comes back or doesn’t respond to prior treatment.
New York, New YorkAges 18 years+ - NCT05280028Recruiting
Hormone treatment for overactive bladder and mood symptoms
This trial studies whether hormone treatment can improve overactive bladder symptoms, sexual well-being, mood (depressive symptoms), and body “autonomic” function (automatic body functions like heart rate and sweating) in post-menopausal women. It may help by targeting menopausal changes that can affect these symptoms.
Banqiao District, New TaipeiAges 20 years+ - NCT05329935Recruiting
Registry for children with congenital thymus missing
This registry follows children born with congenital athymia (a missing or non-working thymus). It collects information around treatment with RETHYMIC, which may help researchers better understand how care and outcomes look over time.
Durham, North CarolinaAges birth–21 years - NCT05133245Enrolling by invitation
Study of genes in people with PHACE syndrome
This study looks at genetic (DNA) differences in people who have PHACE syndrome. It also includes an eye exam, and results may help doctors better understand the condition.
Nashville, TennesseeAges Any age
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,201 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.