Clinical trials
Esophageal Cancer clinical trials
Below are recruiting esophageal cancer clinical trials, each written for real people, not researchers. We’re tracking 368 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02427269Enrolling by invitation
Blood and tissue sample study for esophagus conditions
This study collects blood and biopsy tissue from people who are having an upper endoscopy at UNC for Barrett’s esophagus or esophageal cancer. The samples help researchers build a biorepository to study these conditions and support future research.
Chapel Hill, North CarolinaAges 18 years+ - NCT07671625Recruiting
Prehabilitation program for esophageal or gastric cancer
This trial tests a comprehensive program that includes exercise, nutrition, and psychological support before and after surgery for patients with locally advanced esophageal or gastric cancer. It aims to improve recovery and outcomes.
BrnoAges 18 years+ - NCT07464470Recruiting
Comparing stomach cancer and brain metastasis genetics
This trial studies stomach and esophageal cancers that spread to the brain. It compares the genetic makeup of the original tumor to the brain metastasis, which may help find better treatments.
MoscowAges 18 years+ - NCT04871412RecruitingPhase 3
Surgery care program for lung or upper GI cancer patients
This trial tests an “integrative” support program around the time of cancer surgery to see if it improves care and outcomes for people having surgery for lung, stomach, or esophagus cancer. It may help by adding extra structured support during the peri-operative (around-surgery) period.
Ottawa, OntarioAges 18 years+ - NCT04958720Recruiting
Registry for esophagus and stomach cancer patients
This study keeps an organized record of people diagnosed with esophagus, gastroesophageal junction, or stomach cancer. It helps researchers learn from real-world outcomes, based on health information collected over time.
Alicante, AlicanteAges 18–100 - NCT05563766RecruitingPhase 2
Itraconazole added for treatable esophageal cancer before surgery
This study tests whether adding itraconazole (an anti-fungal medicine) to standard chemo-radiation before surgery increases the chance of complete tumor response. It’s for people with esophageal (or GE junction) cancer that can be removed with curative surgery after treatment.
Palo Alto, CaliforniaAges 18 years+ - NCT06232083RecruitingPhase 1
Study of Caronizumab with low-dose radiation for certain cancers
This trial tests a combination of an immunotherapy drug (Caronizumab) and a special type of low-dose radiation (PLDR) for people with esophageal, lung, or cervical cancer that has come back or spread after initial treatment. It aims to see if the combination can help stop the cancer from growing.
Hefei, British ColumbiaAges 18–75 - NCT07392892RecruitingPhase 2/Phase 3
Study of PF-08634404 plus chemo for stomach and esophagus cancer
This trial tests a new study drug called PF-08634404 in combination with standard chemotherapy for people with stomach, gastroesophageal junction, or esophagus cancer that has spread. It aims to see if adding this drug helps the treatment work better.
Aurora, ColoradoAges 18 years+ - NCT07181473RecruitingPhase 1
Safety of TJ101 for advanced solid tumors
This trial tests a new drug called TJ101 for people with advanced solid tumors who have tried standard treatments or have no standard options. It aims to see if the drug is safe and how well it works.
Orlando, FloridaAges 18 years+ - NCT03556228RecruitingPhase 1/Phase 2
Tested medicine for tumors with TrkA changes, alone or with pembrolizumab
This early-phase study tests VMD-928, a targeted cancer medicine, for cancers that have TrkA-related tumor changes. It may be given by itself or with pembrolizumab to see if it can shrink tumors when standard treatments have not worked.
Santa Rosa, CaliforniaAges 18–80 - NCT04846309RecruitingPhase 1
MRI scan to personalize radiation for esophageal cancer
This Phase 1 study uses specialized imaging (including MRI) to better “see” low-oxygen areas in esophageal cancer and help guide individualized radiation treatment. It aims to improve how radiation is planned and delivered while checking safety.
Salt Lake City, UtahAges 18 years+ - NCT05967910Recruiting
How stress affects immunotherapy for esophageal cancer
This study looks at whether chronic stress changes how well immunotherapy (ICI therapy) works in people with esophageal cancer. It may help doctors understand who benefits most from treatment and how stress could affect outcomes.
Changsha, HunanAges 18–75 - NCT06792786Recruiting
Study of Chemo-Immunotherapy and Radiation for Esophageal Cancer with Blood Monitoring
This study tests a combination of chemotherapy, immunotherapy, and radiation for esophageal cancer that cannot be surgically removed. It also uses a simple blood test (ctDNA) to monitor your cancer's response throughout treatment.
Jinhua, ZhejiangAges 18–75 - NCT06829095Recruiting
Nutrition counseling for esophageal and head and neck cancer patients
This trial tests whether personalized nutrition advice can improve the health of people with esophageal cancer or head and neck cancer who are getting chemoradiation. It may help you stay stronger and better manage treatment side effects.
New Taipei CityAges 18 years+ - NCT04999761RecruitingPhase 1
Study testing new drug combinations for advanced cancers
This study tests new drug combinations for people with various advanced cancers that have progressed after standard treatment, or in some cases, as a first treatment. It aims to see if these combinations are safe and effective. The study is divided into groups based on cancer type and treatment history, so not everyone will qualify for every group.
AichiAges 18 years+ - NCT04214119Recruiting
Capsule test during endoscopy to find early esophageal cancer
This trial studies an “EsophaCap” capsule that can be swallowed during an endoscopy to help detect early esophageal cancer. It may help find cancer earlier and guide next steps, if your results are concerning.
Baltimore, MarylandAges 18 years+ - NCT05978193RecruitingPhase 2
Radiation plus chemo-immunotherapy for advanced esophageal cancer
This trial tests whether adding radiation to a combination of chemotherapy and immunotherapy can help people with stage IV esophageal cancer that has spread. It is for those who haven't had any prior treatment for their cancer.
ShanghaiAges 18 years+ - NCT06668454Recruiting
Chemoimmunotherapy before surgery for limited spread esophageal cancer
This trial tests a treatment plan that combines chemotherapy with immunotherapy, followed by surgery, for people whose esophageal or stomach cancer has spread to a few areas (oligometastatic). The goal is to see if this approach can shrink the cancer and improve outcomes.
Toronto, OntarioAges 18–80 - NCT07222657RecruitingPhase 2
Freezing spray before chemo for esophageal cancer
This trial tests a freezing spray (cryotherapy) to shrink esophageal tumors before standard chemotherapy. It may help reduce tumor size and improve treatment outcomes.
Weston, FloridaAges 18 years+ - NCT00900419Recruiting
Check biomarkers during bronchoscopy in breathing and throat pre-cancer
This study looks at “biomarkers” (measurable signals in samples) taken during bronchoscopy or related procedures in people with severe airway pre-cancer or certain lung/throat cancers, and in healthy volunteers. The goal is to better understand what these biomarkers mean and how they might help with diagnosis, staging, or monitoring.
Aurora, ColoradoAges 21–90 - NCT05937477Recruiting
AI tool study to predict chemotherapy side effects and symptoms
This study tests an artificial-intelligence (AI) tool in a phone app that helps predict side effects and symptoms from chemotherapy. It may help patients and their care team plan and respond to side effects more effectively.
Seoul, GangnamguAges 20 years+ - NCT07152678RecruitingPhase 2
Brachytherapy with radiation and immunotherapy for esophageal cancer
This trial tests combining brachytherapy (a type of internal radiation) with immunotherapy (nivolumab) for people with advanced esophageal cancer that has not fully responded to initial chemoradiation. The goal is to see if this targeted approach can improve outcomes.
Huwei, Yunlin CountyAges 18–85 - NCT06587152Enrolling by invitation
Robotic surgical system trial for chest and belly surgeries
This trial uses a robotic system to assist surgeons during chest and belly surgeries. It aims to see if the robot is safe and effective for procedures like hernia repair, gallbladder removal, or hysterectomy.
Hangzhou, ZhejiangAges 18–80 - NCT06005493RecruitingPhase 1/Phase 2
Study of AZD5863 for advanced stomach, esophagus, or pancreatic cancer
This trial is testing an investigational drug called AZD5863 for people whose stomach, esophagus, or pancreatic cancer has spread and hasn't responded to at least one previous treatment. The study aims to see if targeting a protein called Claudin 18.2 on tumor cells can help shrink or slow the cancer.
Jacksonville, FloridaAges 18 years+
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Common questions
- Are there clinical trials for esophageal cancer?
- Yes. Clin2 currently lists 368 recruiting esophageal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a esophageal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a esophageal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Non Small Cell Lung Cancer
- Esophageal Cancer (EsC)
- Gastric Cancer, Gastroesophageal Junction Cancer
- Lung Cancer Non-Small Cell Cancer (NSCLC)
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Esophageal Squamous Cell Cancer
- Gastro-esophageal Junction Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.