Clinical trials
Esophageal Diseases clinical trials
Below are recruiting esophageal diseases clinical trials, each written for real people, not researchers. We’re tracking 57 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT00260585Recruiting
Esophageal risk and tissue registry study
This study collects information and, if you already need blood tests or procedures, may take extra small tissue samples (biopsies) to better understand esophageal-related conditions. It may help researchers learn about risk and future management for people with certain esophagus or reflux-related diagnoses.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05252078RecruitingPhase 2
Anlotinib plus an injection after esophageal cancer surgery
This Phase 2 study tests whether anlotinib tablets combined with an injection (TQB2450) can lower the risk of esophageal squamous cell cancer coming back after surgery. It may help by targeting cancer growth signals and blood-vessel formation to reduce recurrence.
Nanchang, JiangxiAges 18 years+ - NCT07585214Recruiting
Screening for lung and heart disease using chest X-rays
This study uses chest X-rays to screen for early signs of lung and heart disease in people without known serious disease. Researchers want to understand how well routine chest imaging can catch health problems early.
Dazhou, SichuanAges 18 years+ - NCT06514079Recruiting
Steroid injection for stubborn esophageal strictures in children
This trial tests whether adding a steroid injection to esophageal dilation helps children with narrowings that keep coming back. If you have a child with a stubborn narrowing that has already needed dilation, this treatment might help keep it open longer.
Cairo, SelectAges 2–14 - NCT06564558Recruiting
Posture correction for GERD symptoms
This study tests whether teaching people with GERD to improve their posture can reduce their symptoms. It is for people with a rounded upper back (kyphosis) and a GERD diagnosis.
BeirutAges 18–60 - NCT06721520RecruitingPhase 2/Phase 3
Botox vs. Pyloromyotomy for stomach drainage after esophageal surgery
This trial compares two ways to help the stomach drain properly after surgery to remove part of the esophagus. One uses Botox injected into the stomach outlet, the other is a surgical cut of the muscle. The goal is to see which method works better at preventing stomach emptying problems.
Cleveland, OhioAges 18 years+ - NCT07506746Recruiting
Study on esophagus movement
This study tracks patients with reflux, swallowing problems, or other esophageal symptoms to understand how the esophagus moves. It may help if you have heartburn, regurgitation, or related issues like cough or chest pain.
Milan, LombardyAges 18 years+ - NCT04255693Recruiting
Real-life reflux study of diet and behavior changes
This study looks at how following specific diet and behavior changes affects symptoms of acid reflux (heartburn/regurgitation) in everyday life. It may help you understand what lifestyle steps improve reflux and how symptoms change over time.
MoscowAges 18–80 - NCT04312633Recruiting
Testing a new throat biopsy mapping method for Barrett’s disease
This study follows people for 5 years to see how well a new biopsy-mapping test (WATS3D) works during routine upper endoscopy. It may help doctors find Barrett’s esophagus changes earlier and better guide follow-up after treatment.
Bethpage, New YorkAges 18 years+ - NCT05624099RecruitingPhase 2
Camrelizumab plus chemoradiotherapy for advanced esophageal cancer
This study tests whether adding camrelizumab (an immune treatment) to standard chemoradiotherapy can control advanced esophageal squamous cell cancer. It is meant for people who have not had any prior whole-course cancer medicines for this cancer stage.
FuzhouAges 18–75 - NCT05877300RecruitingPhase 1
Test a new esophagus implant to rebuild a short esophagus segment
This Phase 1 study tests the safety and feasibility of a new esophagus implant for people who need only a short (about 6 cm or less) section of their esophagus rebuilt after serious injury or scarring. If it does not work, you must be willing to have a planned “rescue” surgery later.
Los Angeles, CaliforniaAges 18 years+ - NCT03596476Recruiting
Test for reflux causes after proton pump pills fail
This study checks whether a special test of the esophagus after meals can find the exact reason for ongoing reflux symptoms when proton pump pills (PPIs) don’t help. It may help doctors choose the right next treatment for people whose reflux symptoms keep coming back.
Chambray-lès-ToursAges 18 years+ - NCT04068480Recruiting
Robotic magnetic capsule to check the small bowel
This trial tests a capsule camera that doctors can steer using magnets to look at the small intestine. It may help patients who need small-bowel endoscopy when a standard approach isn’t enough, but several safety checks are required.
Székesfehérvár, --None---Ages 18 years+ - NCT05678491Enrolling by invitation
Endoscopic treatment for reflux after gastric sleeve surgery
This trial studies an endoscopic procedure to treat gastroesophageal reflux disease (GERD) in people who had gastric sleeve surgery. It may help if reflux symptoms are not controlled on once-daily acid medicine (PPI) or if you cannot tolerate it and want an alternative.
TrondheimAges 18–70 - NCT06315179Recruiting
Spatial gene study for inflammatory bowel disease
This study looks at tissue samples from people with suspected Crohn's disease, ulcerative colitis, or indeterminate colitis. The goal is to understand these conditions better and may lead to improved treatments.
Seattle, WashingtonAges 6–21 - NCT06835374Recruiting
Comparing esophagitis in people with and without motility issues
This study looks at patients who have a swallowing disorder called achalasia and also show signs of acid reflux damage (esophagitis). It compares these patients to those without motility problems to better understand the link.
Hyderabad, TelanganaAges 18–75 - NCT07700342Recruiting
Could an evening gel improve sleep for nighttime reflux?
This trial tests a topical therapy you apply at night to see if it can improve sleep for people with non-erosive GERD who still have nighttime symptoms even while taking a morning acid reducer.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT05708885Recruiting
Testing a tool to change esophagus muscle movement
This study looks at how a device affects how the esophagus muscles squeeze and relax. It may help people better understand swallowing problems, even if their usual esophagus test looks normal.
Milwaukee, WisconsinAges 18–90 - NCT06693622Recruiting
Patient preferences for Barrett's esophagus screening tests
This study asks people at risk for Barrett's esophagus (a condition that can lead to esophageal cancer) to share which screening test they prefer. Your answers help researchers understand what matters most to patients when choosing a screening method.
Aurora, ColoradoAges 18–89 - NCT04150640RecruitingPhase 2
Chemo drug combination for advanced stomach or esophagus cancer
This Phase 2 trial tests whether a combination of chemo drugs (oxaliplatin and liposomal irinotecan) plus trastuzumab works better for people with advanced stomach or esophagus adenocarcinoma that has specific tumor markers (HER2 and PDL1). It may help shrink tumors and improve control of the cancer in people who have not had prior treatment for advanced disease.
Madison, WisconsinAges 18 years+ - NCT02530983Recruiting
Survey study for people after esophagus surgery
This study is a survey. It asks people about their experiences after esophagus surgery (either removing part of the esophagus or rebuilding it). It may help doctors understand what happens to patients over time and improve future care.
Rochester, MinnesotaAges 18 years+ - NCT00574327Recruiting
Barrett’s and reflux registry at the Kansas City VA
This study follows people with confirmed Barrett’s esophagus (with or without concerning cell changes) and people who have reflux symptoms, to better understand how these conditions progress. It may help by building a Barrett’s registry so doctors can learn which factors predict worsening over time.
Kansas City, MissouriAges 18 years+ - NCT06870630Recruiting
Comparing two myotomy methods for type 2 achalasia
This trial tests two muscle-cutting procedures for people newly diagnosed with type 2 achalasia (a swallowing disorder). The goal is to see if a more complex myotomy works better than the standard one.
Hyderabad, TelanganaAges 18–75 - NCT02526095Recruiting
Esophagus or stomach cancer registry for treatment and outcomes
This trial is a cancer data and blood-sample registry. It collects information from people newly diagnosed with esophagus or stomach (or the stomach–esophagus junction) cancer to help researchers understand treatment patterns and outcomes.
AmiensAges 18–90
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Common questions
- Are there clinical trials for esophageal diseases?
- Yes. Clin2 currently lists 57 recruiting esophageal diseases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a esophageal diseases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a esophageal diseases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.