Clinical trials
Esophagectomy clinical trials
Below are recruiting esophagectomy clinical trials, each written for real people, not researchers. We’re tracking 41 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05865743RecruitingPhase 3
Antibiotic cloth before surgery to prevent esophagus infection
This Phase 3 trial tests whether using an antibiotic decolonization treatment around the time of esophagus surgery can reduce serious infections afterward. It may help you lower the risk of postoperative infectious complications after curative esophagectomy or esophagus reconstruction.
LeuvenAges 18 years+ - NCT04460352RecruitingPhase 3
Esophageal cancer treatment with chemoradiation plus planned surgery
This trial tests the best way to treat locally advanced squamous cell esophageal cancer: either chemoradiation followed by planned surgery, or monitoring with surgery only if needed. It may help you choose a strategy that controls the cancer while aiming to reduce unnecessary procedures.
Montreal, QuebecAges 18–80 - NCT07317609RecruitingPhase 1
Immunotherapy plus chemo before endoscopic resection for esophageal cancer
This trial tests a treatment plan that combines immunotherapy with chemotherapy before possible endoscopic surgery. It is for people with a specific type of esophageal cancer that has not been treated before and is either potentially removable or not suitable for standard surgery.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07244978RecruitingPhase 2
Immunotherapy plus chemotherapy before surgery for esophageal cancer
This trial tests whether giving a new immunotherapy drug (ivonescimab) along with standard chemotherapy before surgery can improve outcomes for people with resectable esophageal cancer. The goal is to shrink the tumor and increase the chance of successful surgery.
Hangzhou, ZhejiangAges 18–75 - NCT07187154Recruiting
Symptom management after esophagus cancer surgery
This trial tests a symptom management program using a WeChat mini program for people recovering from esophagus cancer surgery. It aims to help you track and manage your symptoms based on your own reports after the operation.
BeijingAges 18 years+ - NCT06897501Recruiting
Comparing breathing tubes for voice box protection during esophagectomy
This trial compares two types of breathing tubes used during robot-assisted esophageal cancer surgery. One tube blocks one lung (double-lumen tube) and the other tube uses a smaller blocker (bronchial blocker); researchers want to see which causes fewer voice box nerve injuries after surgery.
SeoulAges 19 years+ - NCT07043491Recruiting
Comparing scopes and X-rays after esophagus surgery
This trial compares two ways doctors check the surgical connection (anastomosis) after removing a cancerous part of the esophagus. It looks at whether a flexible tube with a camera (endoscopy) or a special X-ray (esophagram) is better for routine follow-up.
Guangzhou, GuangdongAges 18 years+ - NCT07004634Recruiting
Comparing Drain Types After Minimally Invasive Esophageal Cancer Surgery
This study compares two different ways of placing drains after minimally invasive surgery for esophageal cancer. It aims to find which method helps you recover better and with fewer complications.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05906134RecruitingPhase 1/Phase 2
Pain control plan after minimally invasive esophagus surgery
This trial tests a pain-control method (using an epidural/nerve pain-block through the back, called neuraxial anesthesia) for people having minimally invasive esophagus removal surgery. It may help reduce pain after surgery and improve comfort during recovery.
Seattle, WashingtonAges 18 years+ - NCT06576973RecruitingPhase 2
Adalimumab combo therapy for esophageal cancer before surgery
This trial tests a combination of an immunotherapy drug (adalimumab), chemotherapy, and a targeted therapy pill (apatinib) before surgery for esophageal cancer that can be removed. The goal is to see if this mix helps shrink the tumor and improve outcomes.
Hangzhou, ChinaAges 18–75 - NCT06271707RecruitingPhase 4
Nerve block for surgery pain relief
This trial tests a nerve block (stellate ganglion block) to see if it helps reduce pain after surgery to remove part or all of the lung or esophagus. It may be an option for adults aged 18-85 having these procedures.
Minneapolis, MinnesotaAges 18–85 - NCT06067438RecruitingPhase 2
Amiodarone to Prevent Irregular Heartbeat After Esophageal Cancer Surgery
This trial tests if amiodarone, a medication that helps keep your heart rhythm steady, can prevent a type of irregular heartbeat called atrial fibrillation after surgery to remove part of your esophagus. If you are having this surgery (called minimally invasive esophagectomy or MIE) for cancer or other esophagus problems, you may be able to join.
Portland, OregonAges 18 years+ - NCT05877300RecruitingPhase 1
Test a new esophagus implant to rebuild a short esophagus segment
This Phase 1 study tests the safety and feasibility of a new esophagus implant for people who need only a short (about 6 cm or less) section of their esophagus rebuilt after serious injury or scarring. If it does not work, you must be willing to have a planned “rescue” surgery later.
Los Angeles, CaliforniaAges 18 years+ - NCT05713955RecruitingPhase 2
Testing a specific stomach-esophagus connection method after esophagus surgery
This Phase 2 study tests whether a particular circular stapled connection between the esophagus and stomach is safe and works well after an Ivor Lewis esophagectomy for certain lower esophagus cancers. It may help surgeons improve how the connection is made during surgery.
Ghent, East-FlandersAges 18–75 - NCT05706558Recruiting
Study of esophageal cancer surgery records
This study looks back at past patients’ medical and pathology records from esophageal cancer surgeries. It may help improve how doctors understand which advanced tumors should be treated, by reviewing outcomes in specific tumor stages.
New York, New YorkAges 18 years+ - NCT05357846RecruitingPhase 3
Check whether PD-1 treatment helps esophagus cancer before surgery
This Phase 3 trial tests whether adding a PD-1 medicine (sintilimab) to standard chemo-radiation before surgery improves outcomes for locally advanced esophageal squamous cell cancer. It may help by strengthening the immune response while shrinking the tumor before an operation.
Guangzhou, GuangdongAges 18–70 - NCT02530983Recruiting
Survey study for people after esophagus surgery
This study is a survey. It asks people about their experiences after esophagus surgery (either removing part of the esophagus or rebuilding it). It may help doctors understand what happens to patients over time and improve future care.
Rochester, MinnesotaAges 18 years+
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Common questions
- Are there clinical trials for esophagectomy?
- Yes. Clin2 currently lists 41 recruiting esophagectomy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a esophagectomy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a esophagectomy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.