Clinical trials
Frail clinical trials
Below are recruiting frail clinical trials, each written for real people, not researchers. We’re tracking 90 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07597850RecruitingPhase 2
TCM formula versus HMB supplement for muscle strength in older adults
This study compares a traditional Chinese medicine formula with HMB (a muscle-building supplement) to see which helps preserve muscle strength and bone health in adults aged 65 and older who are starting to show signs of frailty. Both treatments aim to help you stay stronger and more active as you age.
TaipeiAges 65 years+ - NCT07573995Recruiting
Breathing and muscle training for frailty in older adults
This study tests a training program that combines breathing exercises with blood flow restriction (using bands to reduce blood flow in the arms or legs) to see if it improves strength and daily function in older adults who are frail. It may help you feel stronger and more independent.
TaipeiAges 65 years+ - NCT05946109Recruiting
Exercise program for frail older adults over 70
This trial studies whether a structured exercise program can improve health and function in frail adults age 70 and older. It may help you build strength, energy, and mobility if you meet frailty and safety requirements.
Brussels, Brussels CapitalAges 70 years+ - NCT07513701Recruiting
Building Strength and Balance in Older Adults
This study tests whether a home-based exercise program can help older adults who are experiencing physical weakness improve their strength, balance, and overall resilience. You'll do exercises online at home over several months to see if this approach helps you stay independent and active.
Hong Kong, Hong KongAges 60–90 - NCT07497334Recruiting
Improving functional outcomes in cognitively frail older adults
This study tests a program combining cognitive exercises, physical activity, and brain stimulation to improve daily function and thinking in older adults with mild cognitive or physical frailty. The goal is to help you stay independent and improve your quality of life.
Hong KongAges 60–90 - NCT07492745Recruiting
Staying active during your hospital stay
This trial tests whether a simple reminder can encourage you to stay active while you are in the hospital. It aims to help older patients maintain their strength and independence during recovery.
BrusselsAges 50 years+ - NCT06775028Recruiting
Integrated care for older adults with atrial fibrillation
This trial is testing a new approach to care for older adults with atrial fibrillation (an irregular heartbeat) who also have other health conditions. It aims to see if a more integrated, team-based care plan helps improve their overall health and quality of life.
HaskovoAges 65 years+ - NCT06208527RecruitingPhase 2
Nicotinamide Riboside for Frailty in Older Adults
This trial tests whether a daily supplement called nicotinamide riboside can help older adults who feel weak or frail to get stronger and more energetic. It lasts for several months and involves simple tests like a walking test and memory checks.
Bergen, VestlandAges 75 years+ - NCT06785740Recruiting
Statins for older stroke patients with frailty
This study looks at how well statins work in older stroke or TIA patients who are already taking them and also have some frailty. The goal is to understand if continuing statins is safe and helpful for this group.
Almere StadAges 70–120 - NCT07464730Recruiting
High-flow nasal oxygen after high-risk surgery for frail adults
This trial tests whether using high-flow nasal oxygen after surgery helps frail patients recover better and avoid breathing problems. It includes people having long abdominal, vascular, or chest surgeries who have several health risks like older age, low oxygen levels, or heart or lung conditions.
StockholmAges 18 years+ - NCT07465159Recruiting
Prehabilitation for frail patients before hip or knee replacement
This study tests whether a 'prehabilitation' program (tailored exercise and nutrition support before surgery) helps older patients who are frail recover better after hip or knee replacement. Participants will be randomly assigned to either the prehabilitation group or the usual care group.
ReykjavikAges 70 years+ - NCT07463352Recruiting
Pre-surgery nutrition for frail seniors with hip fractures
This study tests if giving a special protein drink before surgery helps frail older adults with a broken hip recover better. It might reduce complications after surgery.
DüzceAges 65 years+ - NCT07454616Recruiting
Supplement and exercise study for pre-frail adults
This study tests whether a special nutrient supplement combined with a simple exercise routine can improve health markers linked to living longer. It is designed for adults who are starting to feel less strong or energetic but are not yet frail.
SingaporeAges 50–80 - NCT07441382Recruiting
Comparing treatments for frail older adults with atrial fibrillation
This study tests whether combining a heart procedure (catheter ablation) with a device to close the left atrial appendage (LAAO) is safer or better than blood thinners alone for frail patients 75 years or older with atrial fibrillation and high stroke risk. It aims to find a treatment that reduces stroke while lowering bleeding risks.
Guangzhou, GuangdongAges 75 years+ - NCT07442773Recruiting
Support for partners and family caregivers of frail RA patients
This trial tests a support program for people who care for a loved one with rheumatoid arthritis. The program aims to reduce the burden on caregivers and help them feel more supported.
Glostrup Municipality, Capital RegionAges 18 years+ - NCT06202118Recruiting
Alpha radiation therapy for breast cancer in older or frail patients
This trial tests a new type of radiation therapy (DaRT) that uses tiny, implantable seeds to deliver targeted alpha radiation to breast tumors. It is designed for older patients (65+) or those who are too frail for surgery, offering a less invasive option for controlling the cancer.
JerusalemAges 65–120 - NCT07433153Recruiting
Phone vs. class for fall prevention in older adults
This trial compares two ways to do fall-prevention exercises: using a smartphone app or joining a community class. It may help older adults who are at risk of falling improve their balance and strength.
Binghamton, New YorkAges 55 years+ - NCT07416890RecruitingPhase 2
Study of thiotepa, pirtobrutinib, and sintilimab for CNS lymphoma
This trial tests a combination of three drugs for people with central nervous system (CNS) lymphoma that has come back or not responded to treatment, or for those who cannot take standard chemotherapy. The goal is to see if this new combination is safe and effective.
Hangzhou, ZhejiangAges 18–80 - NCT06040801Recruiting
Geriatric care for older adults with advanced stomach, bile duct, or pancreatic cancer
This study tests a special geriatric (older-adult) care program for people over 65 with advanced stomach, bile duct, or pancreatic cancer who are receiving palliative chemotherapy. The goal is to see if extra support from a geriatric team can help improve quality of life and treatment outcomes.
Taoyuan, TaiwanAges 65 years+ - NCT07396077Recruiting
Pre-op health boost for elderly spine surgery patients
This trial tests if a 6-week prehabilitation program (exercise and nutrition) before spine surgery helps elderly patients recover better. It is for people 75 or older with long-term lower back problems who need spinal fusion surgery.
Beijing, Beijing MunicipalityAges 75 years+ - NCT07392515Recruiting
Digital rehab for hip fracture recovery in older adults
This trial tests whether a digital rehabilitation program can help older adults recover their thinking and movement skills after hip fracture surgery. It uses sensors and digital tools to guide therapy, making it easier to do from a rehabilitation ward.
Messina, ItalyAges 65–89 - NCT06836167Recruiting
Integrated care for frail older adults
This study tests a program called +AGIL Barcelona that provides integrated care for older adults living at home who show signs of frailty. It aims to help them stay independent and healthy.
BarcelonaAges 65 years+ - NCT06628895Recruiting
Modified Poco-Poco exercise for pre-frailty
This study tests whether a special exercise routine called Modified Poco-Poco can improve frailty and certain biological markers (DNA changes, GDF15, and Lamin A). It may help people who are beginning to feel weaker and want to try a gentle exercise program.
Bandung, West JavaAges 60 years+ - NCT07335120Recruiting
Data & Sample Collection for Frail or Relapsed Large B-cell Lymphoma
This study collects information and samples from people with large B-cell lymphoma who are either too frail for standard chemo, or whose disease has come back after one prior treatment. The goal is to better understand how to treat these situations.
Liverpool, MerseysideAges 17 years+
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Common questions
- Are there clinical trials for frail?
- Yes. Clin2 currently lists 90 recruiting frail studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a frail trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a frail trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.