Clinical trials
Functional Decline clinical trials
Below are recruiting functional decline clinical trials, each written for real people, not researchers. We’re tracking 46 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07666685Recruiting
Beetroot Extract for Health in Adults 75+
This study looks at whether taking beetroot extract can help improve quality of life and daily function in adults 75 and older. You will be asked to take the extract and complete simple health questionnaires.
Pamplona, NavarreAges 75 years+ - NCT07011680Recruiting
Dairy Extract for Memory Support in Older Adults
This study tests whether a special dairy extract (phospholipid-rich) can help support memory in people aged 55-85 who notice some forgetfulness but do not have dementia. You will be asked to take the extract daily and have periodic memory assessments.
YangsanAges 55–85 - NCT07289061Recruiting
Positive psychology for early memory changes
This trial tests whether positive psychology exercises can help improve memory and brain function in people with very early memory changes. It may be a good fit if you have noticed new memory concerns or a mild cognitive impairment.
ThessalonikiAges Any age - NCT07676435RecruitingPhase 2
Fisetin trial for healthy lung aging
This study tests whether a natural supplement called fisetin can help slow lung decline in older adults who are either lifelong nonsmokers or long-term smokers. You would take fisetin or a placebo for a period and be monitored regularly.
Los Angeles, CaliforniaAges 60 years+ - NCT07735078Recruiting
Smart balance and thinking exercise for older adults
This study tests a smart digital tool that combines balance and thinking exercises to help older adults stay steady and prevent falls. If you are 55+ and can walk a short distance, you may be able to join.
Taipei, TaipeiAges 55 years+ - NCT05339438Recruiting
Brain scan mapping before epilepsy surgery
This study uses a special MRI scan to map parts of the front-temporal brain in people with drug-resistant epilepsy who may need surgery. The goal is to better plan surgery by showing which brain areas are involved.
NancyAges 18 years+ - NCT07477561Recruiting
Healthy aging program for older adults in Singapore
This trial tests a program to help older adults stay independent and prevent frailty. It is based on the World Health Organization's ICOPE approach and is designed for Singaporeans and permanent residents aged 60 and older.
SingaporeAges 60 years+ - NCT06660706Recruiting
Exercise study for older adults with slow walking or weak grip
This study tests whether a supervised exercise program can help improve muscle strength and overall health in people aged 65 and older. It also looks for certain markers in the blood that may be linked to the benefits of exercise.
TaipeiAges 65 years+ - NCT07084454Enrolling by invitationPhase 3
Remote geriatric care for older adults starting cancer treatment
This trial tests whether remote health assessments and support can improve care for adults 65+ who are starting a new cancer treatment. You'd participate from home via telehealth visits.
Rio de Janeiro, Rio de JaneiroAges 65 years+ - NCT07535983RecruitingPhase 1/Phase 2
Chinese herbal medicine plus DHEA for low egg reserve
This trial tests whether a traditional Chinese medicine decoction combined with DHEA (a supplement) can improve ovarian function in women with diminished ovarian reserve—a condition where the ovaries produce fewer healthy eggs. The study combines two treatment approaches to see if they work better together.
Nanchang, JiangxiAges 20–40 - NCT04201600Recruiting
Study how blood sugar swings affect thinking in prediabetes
This study looks at how “blood sugar variability” (how much glucose levels bounce around) may affect thinking and memory in people with prediabetes. You may be eligible if you’re older and don’t already have diabetes or conditions that can strongly affect the brain or blood vessels.
Baltimore, MarylandAges 50 years+ - NCT05237687RecruitingPhase 2
Sirolimus to help prevent loss of daily function
This Phase 2 trial studies whether sirolimus can slow or prevent functional decline (more difficulty with daily activities) in older adults. You may be considered if you’re in the right age range and have no major heart, lung, liver, kidney, or recent bleeding/clotting problems.
Dallas, TexasAges 65–80 - NCT06205147Recruiting
Elastic band exercise for strength and mood in older hospital patients
This study tests whether using elastic bands for resistance exercises can help older adults in the hospital improve their muscle strength and reduce symptoms of depression. If you are 65 or older, staying in the hospital for more than a week, and able to follow simple instructions, this might be a good fit.
Taipei, TaiwanAges 65 years+ - NCT06208527RecruitingPhase 2
Nicotinamide Riboside for Frailty in Older Adults
This trial tests whether a daily supplement called nicotinamide riboside can help older adults who feel weak or frail to get stronger and more energetic. It lasts for several months and involves simple tests like a walking test and memory checks.
Bergen, VestlandAges 75 years+ - NCT06217302RecruitingPhase 3
Sotagliflozin for kidney protection in type 1 diabetes
This study tests whether sotagliflozin (a pill that helps control blood sugar and protects the kidneys) can slow down kidney function decline in people with type 1 diabetes and diabetic kidney disease. You may qualify if you have had type 1 diabetes for at least 8 years, have moderate kidney damage, and are on standard treatments.
Stanford, CaliforniaAges 18–75 - NCT06616246Recruiting
HealthyLifetime coach training for Michigan adults
This trial trains community members to become coaches for the HealthyLifetime program, which helps people learn to take better care of their health. It's for Michigan residents 30 or older with up to three mild long-term health conditions who have Medicare or Medicaid.
Ann Arbor, MichiganAges 30 years+ - NCT06676839Recruiting
Testing the ICOPE program to prevent age-related decline
This study tests a program called ICOPE, designed by the World Health Organization, to help older adults stay healthy and independent. It will check if the program can slow down age‐related declines in areas like mobility, memory, and nutrition.
Castres, FranceAges 65 years+ - NCT06842459Recruiting
Helping older adults with diabetes stay mobile
This study tests a program to help older adults with diabetes who have trouble moving around. The goal is to see if a special care plan can help them stay independent and avoid getting worse.
Cagliari, CagliariAges 75–110 - NCT07121660Recruiting
Changes after spine or hip surgery in children
This study looks at how children with severe neurological impairments recover after major spine or hip surgery. It compares their recovery to children without these impairments, to understand different recovery paths.
Vancouver, British ColumbiaAges 5–18 - NCT02504788Recruiting
Protect the brain’s memory area during whole-brain radiation
This study tests whether avoiding the hippocampus (a part of the brain important for memory) during whole-brain radiotherapy can slow down thinking and memory decline. It may help some people preserve neurocognitive function while still treating brain metastases.
TaoyuanAges 18–84 - NCT07531836Recruiting
Exercise and wellness program before breast cancer surgery
This trial tests whether a personalized exercise and wellness program before surgery helps older adults with breast cancer recover better and stay stronger. You would work with a team to prepare your body for surgery over several weeks.
Pamplona, NavarreAges 65 years+ - NCT07245186Enrolling by invitation
Healthy living program for kidney decline
This study tests a program to help people with chronic kidney disease (CKD) stay healthy through diet tracking and other proactive steps. It focuses on people whose kidney function has declined but who are not yet on dialysis.
Shanghai, Shanghai MunicipalityAges 18–90 - NCT07547319Recruiting
Accelerated rTMS to improve cognitive function
This study tests whether repeated magnetic pulses to the brain (called rTMS) can help improve thinking and memory in older adults with mild to moderate cognitive decline. The treatment is non-invasive and may help slow cognitive changes.
San Francisco, CaliforniaAges 50–90 - NCT05861999RecruitingPhase 4
Risdiplam for young children with SMA after gene therapy plateau
This trial studies whether risdiplam is safe and helpful for children under 2 with spinal muscular atrophy (SMA) whose function has leveled off or declined after gene therapy. It may be an option if you saw benefits from gene therapy but then noticed a stop or setback in key abilities.
Little Rock, ArkansasAges 3 months–2 years
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Common questions
- Are there clinical trials for functional decline?
- Yes. Clin2 currently lists 46 recruiting functional decline studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a functional decline trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a functional decline trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.