Clinical trials
Gender Dysphoria clinical trials
Below are recruiting gender dysphoria clinical trials, each written for real people, not researchers. We’re tracking 26 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06351501RecruitingPhase 3
Hormone treatment for gender dysphoria in teenagers
This study tests whether hormone therapy (such as testosterone or estrogen) helps reduce distress in teenagers who feel their gender does not match their body. It aims to see if starting hormones at this age improves mental well-being and overall quality of life.
ParisAges 13–14 - NCT06565663Enrolling by invitation
Decision aid for gender-affirming surgeries
This study tests an online decision tool for people considering metoidioplasty or phalloplasty. The tool helps patients compare surgical options to make informed choices.
Hanover, New HampshireAges 18 years+ - NCT06953908Recruiting
The Copenhagen Gender Identity Study
This trial follows all patients referred to the Center for Gender Identity in Copenhagen to learn more about their experiences and needs. If you are referred there and can read Danish, you may join.
CopenhagenAges 18 years+ - NCT05649605Recruiting
Testing early response to gender-affirming hormone treatment
This study looks at how people respond early after starting gender-confirming hormones. It may help doctors understand what changes happen soon after treatment starts and how to manage it safely.
StockholmAges 18–99 - NCT06245681Recruiting
How Hormone Therapy Affects the Heart and Liver
This study looks at how cross-sex hormone treatment affects the heart and fat in the liver. It aims to help understand the safety of hormone therapy in transgender individuals.
Vienna, State of ViennaAges 18–99 - NCT06670053Recruiting
Testosterone and brain development in teens
This study looks at how starting testosterone therapy affects brain development in transgender and gender-diverse youth. It may help you and your doctor understand the changes to expect.
Aurora, ColoradoAges 12–20 - NCT04979338RecruitingPhase 3
Opioid-sparing pain control for gender-affirming surgery
This Phase 3 study tests ways to manage pain during and after gender-affirming surgery while using less opioid medicine. It may help improve comfort after surgery and reduce opioid-related side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT04993469Recruiting
Tracking genital comfort after gender-affirming surgery
This study asks people who are planning genital gender-affirming surgery to report how their genital sensitivity and sexual function feel afterward. It helps doctors understand what changes patients experience and improve follow-up care.
Ghent, East-FlandersAges 18–110 - NCT07147166Recruiting
Testing a device to prevent raised scars after top surgery
This study tests a special bandage-like device (Brijjit) that may help reduce thick, raised scars after gender-affirming mastectomy (top surgery). If you are having double incision top surgery and want to see if this device can give you flatter, less noticeable scars, this trial may be a good fit.
San Francisco, CaliforniaAges 19 years+ - NCT04935164Recruiting
Study of gender dysphoria versus a control group
This study compares people with gender dysphoria to people without it. It looks at differences in symptoms or outcomes and may help researchers better understand how gender dysphoria affects mental well-being.
PoitiersAges 18–60 - NCT06291675Recruiting
Hormone therapy's effect on heart and organ fat
This study uses MRI scans to see how gender-affirming hormone therapy affects heart muscle, heart function, and fat in the heart, liver, and pancreas. It may help us understand long-term health effects of hormone therapy.
Vienna, State of ViennaAges 18 years+ - NCT07252687Recruiting
How Gender-Affirming Care Affects Breast Perception in Trans Men
This study looks at how gender-affirming treatments (like hormone therapy or chest surgery) affect how trans men feel about their chest. It aims to help understand the best timing for these treatments.
InnsbruckAges 16 years+ - NCT07286123Recruiting
Vaginoplasty using fish skin graft for transgender women
This trial tests a new surgical technique for gender-affirming vaginoplasty that uses a fish skin graft (Kerecis) to create the vaginal lining. It may be an option for transgender women planning this type of surgery for the first time.
Cleveland, OhioAges 19–99 - NCT07480590Recruiting
Gender-Affirming Care and Mental Health Study
This study follows adults who are referred to a gender dysphoria assessment clinic in southern Sweden to see how gender-affirming care affects quality of life, work life, and overall health over time.
Malmö, MalmöAges 18 years+ - NCT04064671Recruiting
Study of a specific erectile implant after sex reassignment surgery
This study looks at surgical outcomes after placing the Zephyr ZSI 475 FTM inflatable penile implant in people who had female-to-male (transmasculine) sex reassignment surgery. It may help improve how well this specific implant works and how patients do after surgery.
Ghent, Oost-VlaanderenAges 18–100 - NCT04596592Recruiting
Puberty blockers and estradiol effects on heart health
This study looks at how puberty blockers and then estradiol (estrogen) may affect heart and metabolism health in teens. It may help doctors understand risks and benefits for transgender youth starting gender-affirming hormone care.
Aurora, ColoradoAges 13–16 - NCT05097820Recruiting
Study of silicone gel testicular implants after placement
This is an observational study that follows people who receive silicone gel-filled testicular implants. It aims to collect real-world information about safety and healing to help improve future care.
Ghent, East-FlandersAges birth–110 years - NCT05883553Recruiting
Erection device vs cover after gender-affirming penis surgery
This trial compares two options to help people who have had phalloplasty have penetrative sex: an erection prosthesis (an implanted device) versus an epithesis (a removable cover/prosthetic). It aims to see which option works better and is acceptable for restoring sensation, function, and sexual penetration.
Ghent, East-FlandersAges 18 years+ - NCT06428669RecruitingPhase 4
Nitropaste for chest masculinizing surgery
This study tests if applying nitropaste to the chest before surgery improves blood flow to the nipple grafts, which may help them heal better. It is for people having chest masculinizing surgery with a specific technique called double incision and free nipple grafting.
Charlottesville, VirginiaAges 18 years+ - NCT06439290Recruiting
Voice Changes After Vocal Cord Surgery
This study looks at how different types of voice surgery affect the voice. Researchers will record and analyze voices before and after surgery to understand the results better.
Ghent, East-FlandersAges 18–70 - NCT06639763Recruiting
Erectile aid use after gender-affirming surgery
This study looks at how transgender men and their partners use erectile aids after phalloplasty or metoidioplasty. It hopes to improve sexual health and satisfaction after surgery.
Ghent, East-FlandersAges 18 years+ - NCT06639776Recruiting
Sexual function after erectile implant in transgender people
This study looks at how well erection prostheses (implants that help with erections) work for transgender people after phalloplasty surgery. It aims to understand sexual functioning for both you and your partner.
Ghent, East-FlandersAges 18 years+ - NCT06969326RecruitingPhase 3
Estrogen cream after hysterectomy for transgender men
This study tests whether using a topical estrogen cream after hysterectomy surgery can help transgender men have a better recovery. Participants will be randomly assigned to use the cream or not, and researchers will follow up by text message.
Providence, Rhode IslandAges 18 years+ - NCT07624747Recruiting
Brain Health Study for Transgender Adults Starting Hormone Therapy
This study looks at how gender-affirming hormone therapy affects brain health and function in transgender adults. Researchers want to understand the effects of these hormones on the brain before and after treatment begins.
Madison, WisconsinAges 18–45
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Common questions
- Are there clinical trials for gender dysphoria?
- Yes. Clin2 currently lists 26 recruiting gender dysphoria studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a gender dysphoria trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a gender dysphoria trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.