Clinical trials
Glioblastoma Multiforme clinical trials
Below are recruiting glioblastoma multiforme clinical trials, each written for real people, not researchers. We’re tracking 92 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04765514RecruitingPhase 2
Chemo with radiation versus chemo alone for older brain tumor patients
This trial compares two standard treatments for newly diagnosed glioblastoma (a serious brain cancer) in older and frail patients: chemo plus radiation versus chemo alone. It may help determine which approach works best and is safest for people in your age and health group.
Calgary, AlbertaAges 65 years+ - NCT04765098RecruitingPhase 2
Tamoxifen or Etoposide for recurring brain tumor after prior treatment
This trial tests whether tamoxifen works as well as etoposide in people whose glioblastoma has come back after standard chemotherapy and radiation with temozolomide. It aims to find a better medication option for controlling the tumor after the first return.
Edmonton, AlbertaAges 18–65 - NCT04780009Recruiting
Imaging tool during brain tumor surgery
This trial tests a special camera system used during surgery to help doctors see brain tumor tissue using fluorescent light. It may help the surgeon remove more tumor while protecting healthy brain areas.
Lexington, KentuckyAges 18–90 - NCT05084430RecruitingPhase 1/Phase 2
Pembrolizumab plus M032 for recurrent brain tumors
This early-phase study tests the safety and early signs of benefit of combining pembrolizumab with M032 in people with certain aggressive brain tumors. You may be considered if you have a glioma tumor that can potentially be removed by surgery.
Birmingham, AlabamaAges 18 years+ - NCT05366179RecruitingPhase 1
Personalized CAR-T therapy for recurring brain tumor
This Phase 1 study tests a personalized immune-cell treatment (CAR-T) made from your own cells to attack a marker called B7-H3 on recurring glioblastoma. It may help shrink or control the tumor, but the main goal is to check safety and how the treatment works.
Chapel Hill, North CarolinaAges 18 years+ - NCT05474378RecruitingPhase 1
CAR T cell therapy for recurrent glioblastoma
This early-phase study tests a type of immune-cell treatment (CAR T cells) aimed at a target called B7-H3 in people with glioblastoma or related grade 4 brain tumors that have come back. It’s meant to see if the treatment can shrink the tumor or control the disease and to learn how safe it is.
Palo Alto, CaliforniaAges 18 years+ - NCT05495295RecruitingPhase 1
First test of PhOx430 for advanced solid tumors
This Phase 1 trial tests a new cancer drug, PhOx430, for people with advanced (metastatic) solid tumors that have not responded to standard treatments. It aims to find a safe dose and to see whether the drug can shrink or control cancer.
MontpellierAges 18–80 - NCT05864976Recruiting
MRI planning help for people with suspected brain tumor
This trial uses a special MRI approach and computer analysis to help plan neurosurgery for adults with a brain lesion that looks like glioblastoma. It may improve how surgeons find and navigate the target area before an operation.
St Louis, MissouriAges 18 years+ - NCT05956821RecruitingPhase 1/Phase 2
Study drug for young people with recurring brain glioma
This Phase 1/2 trial tests a study treatment for children and young adults under 22 whose brain glioma has come back or isn’t responding to prior treatment. It’s designed to see whether the treatment is safe and effective for shrinking tumors in this situation.
Miami, FloridaAges 1–21 - NCT06011109RecruitingPhase 1/Phase 2
APG-157 plus Avastin for recurrent high-grade glioma
This trial tests a combination of two drugs—APG-157 (an oral plant-based medicine) and bevacizumab (Avastin)—for people with recurrent high-grade brain tumors that have already been treated with standard therapies. The goal is to see if adding APG-157 can help control the tumor better.
Rochester, MinnesotaAges 19 years+ - NCT06016452RecruitingPhase 2
Chlorophyllin for brain radiation damage in glioma patients
This trial tests if chlorophyllin can help manage brain damage caused by radiation therapy in people with diffuse glioma. It may reduce symptoms or prevent them from getting worse.
Mumbai, MaharashtraAges 18–70 - NCT06585527RecruitingPhase 1
TS-2021 for recurrent malignant brain tumors
This trial tests the safety and effectiveness of a new drug called TS-2021 for people whose high-grade brain tumor has come back after initial treatment. It may be an option if you previously had surgery, radiation, or chemotherapy and are now facing a recurrence.
Beijing, Beijing MunicipalityAges 18–65 - NCT06687681RecruitingPhase 2
Natural killer cell therapy for brain tumors
This trial tests a new treatment using donated natural killer (NK) cells injected into the body to fight high-grade brain tumors. It might help people with certain types of aggressive gliomas that are newly diagnosed.
TehranAges 3–70 - NCT06810544RecruitingPhase 1/Phase 2
Study of TNG456 for tumors with MTAP loss
This trial tests a new drug called TNG456, alone or with another drug (abemaciclib), for people whose tumors have lost the MTAP gene. It aims to see if the combination can shrink tumors or slow their growth.
Scottsdale, ArizonaAges 18 years+ - NCT06926075RecruitingPhase 1/Phase 2
Early trial of KESONOTIDE™ for solid tumors
This trial tests a new tablet called KESONOTIDE™ for people with solid tumors that have spread. The goal is to see if it can help when other treatments have stopped working or are not an option.
Kogarah, New South WalesAges 18 years+ - NCT07391215RecruitingPhase 1/Phase 2
Paxalisib for newly diagnosed glioblastoma after standard treatment
This trial tests a drug called paxalisib in people with a newly diagnosed aggressive brain tumor (glioblastoma) who have just finished standard radiation and chemotherapy. The goal is to see if adding paxalisib can help prevent the tumor from coming back by targeting a specific pathway in the cancer cells.
SuttonAges 16 years+ - NCT01269853RecruitingPhase 1/Phase 2
Bevacizumab directly into brain arteries for recurrent brain tumors
This early-stage trial tests whether giving a targeted cancer medicine (bevacizumab) directly into brain arteries can help shrink or control certain recurrent (coming back) brain tumors. It may be an option if standard treatments are no longer working.
New York, New YorkAges 18 years+ - NCT07567196Recruiting
PET imaging to guide surgery for aggressive brain tumors
This trial tests whether using a special PET scan (a type of imaging that shows tumor activity) during brain tumor surgery helps doctors remove more of the tumor safely. You would have a high-grade glioma (an aggressive brain cancer) and be scheduled for surgery.
Torino, TurinAges 18 years+ - NCT07608003Recruiting
MRI AI model study for midline brain tumors
This study uses artificial intelligence to analyze MRI scans of midline brain tumors (gliomas) to help predict how the disease may progress and improve treatment planning. Researchers are collecting data from multiple hospitals to teach an AI system to better understand these tumors.
Changsha, HunanAges Any age - NCT06616727Enrolling by invitationPhase 1
CAR-T cell therapy for recurrent glioblastoma
This trial tests a new CAR-T cell treatment (SNC-109) for people with glioblastoma that has come back after initial treatment. The therapy uses your own immune cells, modified in a lab, to try to attack the tumor.
BeijingAges 18 years+
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Common questions
- Are there clinical trials for glioblastoma multiforme?
- Yes. Clin2 currently lists 92 recruiting glioblastoma multiforme studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a glioblastoma multiforme trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a glioblastoma multiforme trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.