Clinical trials
Glioblastoma clinical trials
Below are recruiting glioblastoma clinical trials, each written for real people, not researchers. We’re tracking 317 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05500612Recruiting
MRI oxygen scan study for glioblastoma during radiation treatment
This study uses special MRI scans to measure oxygen levels in and around glioblastoma before and during radiation treatment. It may help researchers understand how oxygen affects treatment response and timing.
St Leonards, New South WalesAges 18 years+ - NCT05565326Recruiting
Testing MR-guided radiation checks for glioblastoma
This study tests how best to measure and track glioblastoma treatment while using MRI (a body scanner) to guide radiation. It may help improve how doctors assess the radiation response during therapy.
Zurich, Canton of ZurichAges 18 years+ - NCT05577091RecruitingPhase 1
CAR-T cell therapy for recurrent glioblastoma
This early-phase trial studies a personalized immune-cell treatment (CAR-T) for glioblastoma that has come back. It aims to shrink or control the regrowing brain tumor by using your own immune cells after processing them in a lab.
Beijing, Beijing MunicipalityAges 18–70 - NCT05653622RecruitingPhase 2
FDOPA PET–guided radiation planning for glioblastoma patients
This Phase 2 trial tests a radiation “planning” approach guided by an FDOPA PET scan. It aims to better target glioblastoma tissue in people who can’t follow the standard STUPP treatment plan.
Nancy, DeAges 18 years+ - NCT05653635RecruitingPhase 2
PET-DOPA to guide repeat radiation for glioblastoma recurrence
This Phase 2 study tests whether a special brain scan called PET-DOPA can help guide repeat radiation for glioblastoma that has come back. It aims to improve treatment planning while keeping tumors within safe radiation limits near important brain structures.
Nancy, DeAges 18 years+ - NCT05664464RecruitingPhase 1/Phase 2
Glutamate drugs for newly diagnosed brain tumor treatment
This Phase 1/2 study tests whether “glutamate inhibitor” medications can be safely added for newly diagnosed glioblastoma, and how they affect treatment outcomes. It’s designed for adults who will also receive the standard chemo‑radiation plan with temozolomide.
Zurich, Canton of ZurichAges 18 years+ - NCT05669820RecruitingPhase 2/Phase 3
Study drug for aggressive brain tumor after surgery
This trial tests an “antisecretory factor” treatment in people with grade 4 glioblastoma (or astrocytoma). It aims to see whether it can improve outcomes when used alongside planned cancer treatments after surgery.
LundAges 18–75 - NCT05686798RecruitingPhase 1
Gene therapy plus radiation for recurring brain tumor
This early-phase study tests a “suicide gene” therapy delivered by a virus along with radiation for adults whose high-grade brain tumor has come back or grown again. The goal is to see if the treatment is safe and can help control the tumor.
Detroit, MichiganAges 18 years+ - NCT05708352RecruitingPhase 2
Ketogenic diet vs usual diet guidance for newly diagnosed glioblastoma
This trial tests whether a very low-carb, high-fat ketogenic diet helps people with newly diagnosed glioblastoma when combined with standard cancer treatment. You would compare this special diet guidance to the usual anti-cancer diet guidance while receiving the same standard-of-care treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT05768087Recruiting
Testing higher-dose proton radiation for new glioblastoma
This trial is testing an escalated dose of proton beam radiation, along with standard chemotherapy and MRI-guided planning, for newly diagnosed glioblastoma. It aims to see whether the higher radiation dose can improve treatment while staying safe for nearby critical brain structures.
Aarhus, Central JutlandAges 18 years+ - NCT05769660RecruitingPhase 1
Study BEY1107 plus temozolomide for recurrent glioblastoma
This Phase 1 study tests the safety and early effectiveness of BEY1107 combined with temozolomide in adults whose glioblastoma has come back or kept growing after standard treatment. If you qualify, you may be able to receive this combination while the researchers closely monitor side effects and tumor response.
SeoulAges 19 years+ - NCT05789394RecruitingPhase 1
Stem cell treatment for recurrent brain tumor surgery
This Phase 1 study tests an “allogenic” stem cell product made from donated fat tissue to treat recurrent glioblastoma or certain recurrent astrocytoma. It gives the treatment around the time of a repeat brain surgery, and focuses on safety while also studying why it might help.
Jacksonville, FloridaAges 18 years+ - NCT05839379Recruiting
Targeted therapy study for children and young adults with brain tumors
This trial studies a targeted medicine approach for high-grade glioma (a fast-growing brain tumor) and some diffuse midline tumors, including DIPG. It may help by matching treatment to tumor biology using tumor testing done before or around starting standard therapy.
Aurora, ColoradoAges 1–39 - NCT05843253RecruitingPhase 2
Ribociclib plus everolimus or temozolomide for certain brain tumors
This Phase 2 study tests ribociclib with either everolimus or temozolomide, depending on the specific brain tumor type. It may help slow tumor growth in children and young adults whose tumor has specific genetic changes and who have had recent standard radiation therapy.
Aurora, ColoradoAges 1–39 - NCT05871021RecruitingPhase 2
Bevacizumab plus careful dosing for glioblastoma after surgery
This Phase 2 study tests a protective approach using bevacizumab (a medicine that blocks VEGF) while doctors carefully increase the dose in people with glioblastoma. It’s meant to help control tumor growth and possibly reduce certain risks that can happen with blood-vessel–targeting treatments.
AugsburgAges 18–70 - NCT05904119RecruitingPhase 3
Lomustine with or without re-irradiation for recurring glioblastoma
This trial studies whether adding repeat radiation (called re-irradiation) to the chemotherapy medicine lomustine can slow or control glioblastoma that has returned or progressed after standard treatment. It’s designed for people whose tumor comes back at least 6 months after their last radiation.
InnsbruckAges 18 years+ - NCT05911230Recruiting
MRI test to tell tumor return from temporary treatment effects
This study uses an advanced MRI scan to help doctors tell the difference between true tumor regrowth and “pseudoprogression,” which is a temporary treatment-related change that can look like progression. If it works, it may guide the safest next steps, including whether surgery is helpful.
BaselAges 18 years+ - NCT05941234Recruiting
Studying stem cells and blood patterns in glioblastoma
This study analyzes tissue and health-related biological data from people with glioblastoma to learn what’s happening in the tumor. The results may help improve future ways to understand and treat glioblastoma using advanced computer analysis.
RomeAges 18 years+ - NCT05990556Recruiting
Blocking blood supply to glioblastoma: safety and benefit
This study tests whether blocking the blood supply to a brain tumor (glioblastoma) can help treat it safely. It is for people who have just been diagnosed and have not had any treatment yet.
Guangzhou, GuangdongAges 18–70 - NCT06001281Recruiting
Blood test to predict treatment response in glioblastoma
This study looks at whether a blood marker called CD146 can help predict how well patients with a recurrent brain tumor (glioblastoma) respond to a treatment called bevacizumab. The goal is to see if this test can help doctors personalize care.
MarseilleAges 18 years+ - NCT06039709RecruitingPhase 1
Sound wave therapy for recurrent glioblastoma
This trial tests a new treatment called sonodynamic therapy that uses sound waves and a special drug to target brain tumors that have come back. It aims to see if this approach is safe and can shrink tumors in people who are eligible for surgery.
Charlottesville, VirginiaAges 18–80 - NCT06058988RecruitingPhase 2
T-DXd for people with brain cancer
This trial tests a drug called Trastuzumab Deruxtecan (T-DXd) for people with brain tumors that are either glioblastoma or have spread from other cancers. Doctors will see if T-DXd can shrink tumors or slow their growth, and they will collect tumor tissue during surgery or biopsy to study how the drug works.
New York, New YorkAges 18 years+ - NCT06059690RecruitingPhase 1/Phase 2
Imaging brain tumors to guide glioblastoma treatment
This trial studies a special imaging scan that combines MRI and PET to find active tumor areas in patients with glioblastoma. It aims to see if the scan can help identify the most aggressive parts of the tumor for surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT06069726RecruitingPhase 2
Testing atezolizumab for recurrent glioblastoma
This trial tests whether the immunotherapy drug atezolizumab can help people with glioblastoma that has come back after initial treatment. You will need to have a biopsy before starting the drug to confirm the tumor has returned.
San Francisco, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for glioblastoma?
- Yes. Clin2 currently lists 317 recruiting glioblastoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a glioblastoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a glioblastoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.