Clinical trials
Gut Microbiome clinical trials
Below are recruiting gut microbiome clinical trials, each written for real people, not researchers. We’re tracking 139 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05381792Recruiting
Test of gut bacteria changes after colon tumor removal
This study looks at how the gut’s bacteria and bacterial gene signals change after doctors remove certain advanced growths in the colon using endoscopy. If you need an endoscopic procedure for an advanced adenoma or early colon cancer, your stool/bacteria samples may help researchers understand what changes after treatment.
Shatin, New TerritoriesAges 18–90 - NCT05414409RecruitingPhase 2
Gut microbiome study in young people with type 1 diabetes
This Phase 2 study looks at the gut microbiome (the bacteria in your intestines) in youth with type 1 diabetes, and how metformin may work differently through the gut. It may help researchers understand mechanisms and future treatment options.
Indianapolis, IndianaAges 11–18 - NCT05462496RecruitingPhase 2
Pembrolizumab plus gut microbiome changes after pancreatic chemo
This Phase 2 study tests whether changing the gut microbiome (the gut’s helpful bacteria) and giving pembrolizumab after chemotherapy can improve outcomes for people with operable pancreatic cancer. It aims to see if this approach can boost the immune system after standard treatment and help reduce cancer returning.
New York, New YorkAges 19 years+ - NCT05655910Recruiting
Nutrition support program for people with LVADs in the hospital
This trial tests whether an enhanced nutrition plan can improve care for adults who already have an LVAD (a heart pumping device). It’s designed for hospitalized patients and looks at who can safely eat by mouth while avoiding high-risk situations.
New York, New YorkAges 18 years+ - NCT05689255Recruiting
Study gut bacteria and gut chemistry after gallbladder treatment
This study looks at how your gut bacteria and gut chemical products change after treatment for gallstones. It may help researchers understand what drives symptoms and recovery after surgery and/or endoscopic procedures.
Singapore, SingaporeAges 21–80 - NCT05732480Recruiting
Studying how gut bacteria affect gallstone disease
This study looks at gut bacteria (your microbiome) in people with gallstones to better understand what’s going on in the body. It includes adults having gallbladder removal surgery, and it may help researchers find better ways to predict or treat gallstone disease.
Ashford, KentAges 18 years+ - NCT05873231Recruiting
Gut microbiome study for diarrhea after anti-cancer treatment
This trial looks at how changes in the gut (microbiome) relate to diarrhea that can happen after starting anti-cancer therapy. It may help doctors better predict and manage treatment-related diarrhea.
GrazAges 18 years+ - NCT06050733Recruiting
Gut bacteria and immunotherapy response in solid tumors
This study looks at how the bacteria in your gut may affect how well immunotherapy works for solid cancers that have spread or cannot be removed. It focuses on people who have been on certain immunotherapy drugs (PD-1 or PD-L1 inhibitors) for at least 3 months but less than 2 years.
Galveston, TexasAges 35–75 - NCT06051318Recruiting
Diet and gut microbiome effects on blood sugar in healthy adults
This study looks at how your gut bacteria and the foods you eat affect your blood sugar after meals. You'll wear a small sensor to track your blood sugar for 10 days and provide stool samples.
Florianópolis, Santa CatarinaAges 18–60 - NCT06072976Recruiting
How feeding affects gut health in babies with bowel conditions
This study looks at whether breast milk or formula helps babies with certain bowel problems heal faster and reach full feeds sooner. It compares how different milk affects the bacteria in a baby's gut.
Seattle, WashingtonAges birth–55 years - NCT06074250RecruitingPhase 2/Phase 3
Pregnancy, mood, and gut health study
This study tests whether a nutritional supplement can help prevent depression and anxiety during and after pregnancy. It looks at how the mother's gut bacteria may influence mood.
Toronto, OntarioAges 18–43 - NCT06100211Recruiting
HIV, gut health, and switching HIV meds study
This study looks at how changing your HIV medication affects the bacteria in your gut. You'll provide two stool samples so researchers can see what changes happen.
Manchester, Greater ManchesterAges 18 years+ - NCT06098404Recruiting
Cancer-related thinking and memory changes linked to gut health
This study looks at how gut bacteria might be connected to memory or thinking problems in people with cancer. If you join, you will answer surveys and provide stool samples to help researchers understand this link.
Galveston, TexasAges 18 years+ - NCT06171360Recruiting
Gut bacteria and CDK4/6 inhibitor treatment in breast cancer
This study looks at how gut bacteria affect response to a type of targeted therapy (CDK4/6 inhibitors) combined with hormone therapy in breast cancer that is hormone receptor-positive and HER2-negative. It may help find out why some people respond better to treatment and could lead to better personalized care.
BrusselsAges 18–100 - NCT06186089Recruiting
How stomach surgery affects gut bacteria and your thinking
This study looks at how having stomach cancer surgery changes your gut bacteria and thinking abilities. Researchers want to understand if these changes affect memory or brain function after the operation.
Wuhan, HubeiAges 40–80 - NCT06202183Recruiting
Home exercise for gut health in young colorectal cancer patients
This study tests whether a home-based exercise program can improve the health of your gut bacteria during chemotherapy for young-onset colorectal cancer. It aims to help you feel better and potentially improve how well your treatment works.
Boston, MassachusettsAges 18–50 - NCT06329544Recruiting
Study of a high-fructose diet and gut health
This trial tests how a high-fructose diet affects your gut bacteria and overall metabolic health. It is for people who already know they don't absorb fructose well (fructose malabsorbers) and want to understand how this sugar impacts their body.
New York, New YorkAges 25–45 - NCT06349590RecruitingPhase 1/Phase 2
Diet before colon cancer surgery to reduce recurrence
This trial tests whether a specific diet before colon cancer surgery can change the bacteria in your gut to help prevent the cancer from coming back or spreading. Patients who are eligible will follow the diet for a short time before their operation.
Chicago, IllinoisAges 18 years+ - NCT06448546Recruiting
Gut bacteria in Huntington's disease
This study looks at how gut bacteria are different in people with Huntington's disease who have unusual weight changes. You'll provide stool and blood samples to help researchers understand gut health in HD.
Orlando, FloridaAges 18 years+ - NCT06453720Recruiting
Predicting Crohn's treatment success with gut bacteria
This study analyzes your gut bacteria to see if it can predict how well you will respond to Crohn's disease treatments. If you are having a colonoscopy for routine care, you may be eligible.
Vancouver, British ColumbiaAges 19–80 - NCT06495190Recruiting
Blueberries, exercise, and memory in older adults
This study tests whether eating blueberries and doing regular exercise can help with mild memory decline. You will be assigned to one of four groups (blueberries + walking, blueberries + stretching, or similar combos) for 12 weeks.
Kannapolis, North CarolinaAges 65–85 - NCT06536881Recruiting
Diet and gut health during breast cancer chemo
This study looks at how changing your diet during chemotherapy affects side effects and your body's energy use. It involves providing stool samples to study gut bacteria.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06545123Recruiting
How different exercises affect gut health in older adults with muscle loss
This study looks at how different types of exercise can change the bacteria in your gut for older adults who have muscle loss (sarcopenia). You will be assigned to one of two exercise programs to see which one helps your muscles and gut health the most.
PortoAges 60 years+ - NCT06573892Recruiting
Gut Bacteria and Chronic Heart Failure
This study looks at how the bacteria in your gut (the microbiome) relates to chronic heart failure. Researchers want to see if certain probiotics (friendly bacteria) might help people with heart failure feel better.
AstanaAges 18 years+
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Common questions
- Are there clinical trials for gut microbiome?
- Yes. Clin2 currently lists 139 recruiting gut microbiome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a gut microbiome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a gut microbiome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.