Clinical trials
Head and Neck Cancer clinical trials
Below are recruiting head and neck cancer clinical trials, each written for real people, not researchers. We’re tracking 616 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07712120Recruiting
Biofeedback to help with head and neck cancer surgery
This study tests a brief psychological support program that uses biofeedback (a tool that helps you learn to control body signals like heart rate) to help patients scheduled for head and neck cancer surgery. It aims to see if the program can improve well-being and recovery.
TurinAges 18 years+ - NCT07711626Recruiting
Foot massage and ear stimulation for head and neck cancer symptoms
This study tests whether foot massage (reflexology) and a mild nerve-stimulation device on the ear can help reduce side effects during chemotherapy and radiation for head and neck cancer.
Hualien CityAges 30–75 - NCT05156060RecruitingPhase 1/Phase 2
Gabapentin and ketamine to treat head and neck cancer pain
This early-phase study tests whether gabapentin and a ketamine nasal spray can help prevent or lessen short-term and long-term pain from locally advanced head and neck cancer. It may help by changing how the nervous system responds to pain during and after radiation and chemoradiation.
Nashville, TennesseeAges 21 years+ - NCT07690917Recruiting
New PET scanner study for people with cancer
This study tests a new PET scanner that may give clearer or more detailed pictures of cancer. It is for people who are already scheduled for a PET-CT scan at Memorial Sloan Kettering, and it could help doctors see cancer more precisely.
Basking Ridge, New JerseyAges 18 years+ - NCT07690618RecruitingPhase 1
Heat therapy for head and neck cancer
This phase 1 trial tests adding heat therapy (thermotherapy) to standard radiation (with or without chemo) for head and neck cancer. It aims to see if it is safe and effective for patients with locally advanced disease who have not had radiation before.
Rotterdam, South HollandAges 18 years+ - NCT07694726Recruiting
Vein repair during neck surgery to prevent lymphedema
This study tests whether repairing veins during head and neck cancer surgery helps prevent lymphedema (painful swelling) after treatment. It may help patients who are having lymph node removal and will receive radiation afterward.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07689019Recruiting
Heat and electrical stimulation for head and neck cancer recovery
This study tests whether applying far infrared rays (a type of heat) or mild electrical pulses to the skin can help improve short-term recovery in people with head and neck cancer who are receiving chemotherapy and radiation together. It aims to see if these treatments can reduce side effects or improve quality of life.
Hualien City, Hualien CountyAges 30–85 - NCT06662929Recruiting
Arabic quality of life measure for head and neck cancer patients
This study will test a new Arabic questionnaire to measure how radiotherapy affects the quality of life of head and neck cancer patients. If you are receiving, have received, or will receive radiation treatment for head or neck cancer, you may be able to help by filling out surveys.
RiyadhAges 18 years+ - NCT07672236RecruitingPhase 3
Comparing two mouth pain treatments for head and neck cancer patients
This trial tests a new mouthwash (BupiZenge) against a standard numbing medicine (lidocaine) for pain caused by mouth sores from radiation therapy. It may help you if you are about to start radiation for certain head and neck cancers.
CopenhagenAges 18–80 - NCT07675421Recruiting
HMB supplement for head and neck cancer surgery
This trial tests whether taking HMB (a supplement that may help reduce inflammation) can improve recovery and outcomes in people with head and neck cancer who are scheduled for surgery to remove their tumor.
Belo Horizonte, Minas GeraisAges 18 years+ - NCT07676461Recruiting
Microbiome study in advanced cancer patients starting immunotherapy
This study looks at the bacteria in your mouth, gut, and tumors to see if they affect how well first-line immunotherapy works. It is for people with advanced stomach, colorectal, breast, cervical, or head-and-neck cancer.
Bogotá, Bogota D.C.Ages 18 years+ - NCT07659678RecruitingPhase 2
Pet scan for head and neck cancer
This study tests a special PET/CT scan that may help doctors see the cancer more clearly in people with head and neck cancer, either at diagnosis or if it comes back.
St Louis, MissouriAges 18 years+ - NCT07662746RecruitingPhase 2
Paclitaxel micelles for advanced head and neck cancer
This trial tests a new form of chemotherapy called paclitaxel polymeric micelles for people with head and neck cancer that has come back or spread. It is for patients who have already tried one line of treatment and may benefit from a different option.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07662681RecruitingPhase 1/Phase 2
Camrelizumab plus famitinib for rare head and neck cancers
This trial tests a combination of two drugs—camrelizumab (an immunotherapy) and famitinib (a targeted therapy)—for people with rare head and neck tumors that cannot be removed by surgery or have spread. It may be an option if you have not had a prior PD-1 inhibitor and have had at most one prior systemic treatment.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07644585Recruiting
Ultra-High Dose Rate Radiation for Recurrent Head and Neck Cancer
This trial tests a new type of radiation therapy called ConformalFLASH that delivers radiation extremely quickly to treat head and neck cancer that has come back after previous radiation. It may help patients who cannot have surgery or have declined it.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07630168RecruitingPhase 2
Does infusion timing affect treatment response in solid tumors?
This trial tests whether the time of day you receive your infusion (morning vs. afternoon) affects how well your cancer treatment works. It is for people with advanced lung cancer or head and neck cancer that can be surgically removed.
Chapel Hill, North CarolinaAges 18 years+ - NCT07635420RecruitingPhase 4
Testing a Dye to Check Blood Flow in Neck Reconstruction Surgery
This study compares a special imaging dye (indocyanine green) that helps surgeons see blood flow in reconstructed tissue during head and neck surgery. The goal is to see if using this dye helps surgeons make better decisions about whether the reconstructed tissue will survive and heal properly.
MalmöAges 18 years+ - NCT07631650RecruitingPhase 2
Bevonescein to help surgeons see nerves during thyroid surgery
This study tests a special dye called bevonescein that helps surgeons see nerves better during thyroid removal surgery. The goal is to protect your voice by preventing nerve damage during the procedure.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07632339RecruitingPhase 2
New drug combination for recurrent head and neck cancer
This trial tests two drugs—becotatug vedotin and pucotenlimab—given before surgery to treat head and neck cancer that has come back in the same area. The goal is to shrink the tumor and help your body's immune system fight the cancer.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07635641Recruiting
Proton Therapy for Recurring Head and Neck Cancer
This study tracks how well proton therapy (a precise radiation treatment) works when head and neck cancer comes back after previous treatment. Proton therapy uses high-energy particles instead of traditional X-rays, which may reduce side effects.
Rozzano, MilanoAges 18 years+ - NCT07623369RecruitingPhase 1
First-in-Human Study of HH160 for Advanced Solid Tumors
This is an early-stage trial testing a new drug called HH160 in patients with advanced cancer (solid tumors). Researchers want to find the right dose and learn how well it works and what side effects it causes.
Waratah, New South WalesAges 18–75 - NCT07622914Recruiting
Dietary fiber and muscle health in head and neck cancer
This study tests whether eating more fiber can help prevent muscle loss in people newly diagnosed with head and neck cancer. Researchers will track your nutrition and muscle strength over time to see if dietary fiber makes a difference.
Oklahoma City, OklahomaAges 18 years+ - NCT07622381Recruiting
Specialist Nurse Care for Head and Neck Cancer Surgery
This trial tests whether extra support from specially trained nurses helps patients recover better after head and neck cancer surgery. The study focuses on improving care, managing side effects, and supporting your overall recovery.
TianjinAges 18–70 - NCT07625423RecruitingPhase 1
Gene therapy injection for advanced head and neck cancer
This trial tests a new treatment where a specially designed virus carrying an anti-cancer gene is injected directly into tumors in the head and neck area. It's for patients whose cancer has come back or spread after prior chemotherapy and who cannot have surgery or radiation.
Chengdu, ChinaAges 18–65
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Common questions
- Are there clinical trials for head and neck cancer?
- Yes. Clin2 currently lists 616 recruiting head and neck cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.