Clinical trials
Head and Neck Squamous Cell Carcinoma clinical trials
Below are recruiting head and neck squamous cell carcinoma clinical trials, each written for real people, not researchers. We’re tracking 484 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05621837Recruiting
Biomarker study to guide treatment for several advanced cancers
This study measures how strongly your immune system is being suppressed and uses that information to help personalize cancer treatment. It mainly looks at people with certain advanced cancers and needs tumor tissue and follow-up to check possible immune-related markers.
MilanAges 18–90 - NCT05645783Recruiting
Blood-based test for early diagnosis of head and neck cancer
This trial studies a liquid (blood) biopsy test to help identify squamous cell carcinoma in the head and neck area earlier. You may be able to help by providing additional sample(s) as part of a routine neck-lump clinic visit.
Kingston upon ThamesAges 18 years+ - NCT05668858RecruitingPhase 1/Phase 2
Test antibodies plus or minus chemo for advanced head and neck cancer
This early-phase study tests a combination of antibody medicines (with optional chemotherapy) in people with advanced or metastatic head and neck squamous cell carcinoma. The goal is to see how well the treatment controls the cancer and what side effects are like.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05669430RecruitingPhase 1/Phase 2
Testing an anti-cancer drug alone and with pembrolizumab
This early-phase study tests GV20-0251 (an anti-cancer treatment) by itself and combined with pembrolizumab, to see how well it works and how safe it is. It is for adults with advanced solid tumors that have grown despite standard treatments, or where standard treatments aren’t an option.
Los Angeles, CaliforniaAges 18 years+ - NCT05674396RecruitingPhase 2
Short-course radiation to ease symptoms from head and neck cancer
This Phase 2 trial tests a specific, shorter type of focused radiation to help relieve symptoms from head and neck squamous cell carcinoma. It compares two radiation timing/planning approaches to see which better improves comfort and quality of life.
Houston, TexasAges 18 years+ - NCT05707078Recruiting
PET/CT follow-up for head and neck cancer
This study uses a PET/CT scan (a special scan that can look for signs of cancer activity) after curative treatment for head and neck squamous cell cancer. It aims to help check how well prior treatment is working and whether cancer may come back.
CopenhagenAges 18 years+ - NCT05726370RecruitingPhase 2
Pembrolizumab plus chemo before surgery for recurrent head and neck cancer
This Phase 2 trial tests whether giving pembrolizumab (an immune therapy) plus chemotherapy before curative surgery can improve outcomes for people with resectable, recurrent head and neck squamous cell cancer. It also studies how these treatments affect the tumor and immune response using required tissue and blood samples.
Boston, MassachusettsAges 18 years+ - NCT05747625RecruitingPhase 1
PET/CT scan using panitumumab to find head and neck cancer spread
This Phase 1 study tests a new way to use a scan (PET/CT) with a drug called panitumumab to help spot where head and neck squamous cell cancer has spread. It may help doctors better target treatment by finding metastases earlier or more clearly.
Nashville, TennesseeAges 19 years+ - NCT05774483Recruiting
Check nodes in early mouth cancer using a biopsy or planned neck surgery
This trial studies two ways to check whether early oral cavity cancer has spread to nearby neck lymph nodes. It compares sentinel node biopsy versus limited elective neck dissection to see which approach is more useful for people with node-negative tongue or inner-cheek cancers.
Mumbai, MaharashtraAges 18–80 - NCT05784688RecruitingPhase 1/Phase 2
TU2218 with Keytruda for advanced solid tumors
This trial studies TU2218 taken with Keytruda (pembrolizumab) in adults with advanced solid cancers that have limited treatment options. The goal is to see if the combination can shrink tumors and is safe enough to keep using.
San Antonio, TexasAges 18 years+ - NCT05791149Recruiting
Saliva test to help diagnose oral cavity cancer
This study looks for changes in saliva (epigenetic biomarkers) that may help doctors diagnose squamous cell carcinoma in the mouth. You may be asked for saliva samples and usual clinical checks to see whether the test can help with diagnosis, especially before surgery.
Amiens, PicardieAges 18 years+ - NCT05793151Recruiting
Guided care to start cancer treatment on time after surgery
This trial tests a navigation program (help from a care coordinator) versus usual care to help people start the recommended “next-step” treatments (like radiation, sometimes with chemo) on time after surgery. It’s for certain stages of squamous cell cancer in the head and neck area where late treatment could matter.
St Louis, MissouriAges 18 years+ - NCT05808920Recruiting
Salvage surgery study for recurrent head and neck skin-cell cancer
This study looks at how well people do after “salvage” surgery (planned surgery after prior treatment) for recurrent or residual squamous cell cancer in the head and neck. It may help doctors understand which patients benefit most, including how this surgery affects survival and day-to-day function.
DerbyAges 18 years+ - NCT05837221Recruiting
Study of the mouth microbiome in oral cancer
This study looks at the types of bacteria in the mouth (the microbiome) in people with oral squamous cell cancer and compares them to people without this cancer. It may help researchers understand what’s different in oral cancer and what could be useful for diagnosis or treatment planning.
Aurora, ColoradoAges 18–100 - NCT05854823Recruiting
Reduced radiation after surgery for advanced head and neck cancer
This trial looks at whether giving less (de-escalated) radiation after surgery is as effective and safer for people with locally advanced head and neck squamous cell carcinoma who had a strong response to treatment before surgery. If you had no remaining cancer or only very small amounts of cancer left in the surgical specimen, this approach may help reduce side effects while keeping control of the disease.
Zhuhai, GuangdongAges 18–70 - NCT05859074RecruitingPhase 1
Testing MQ710 injections alone or with pembrolizumab for advanced cancers
This early-phase study tests MQ710, a medicine given by injection into a reachable tumor, to see how well it can control advanced cancers. Some participants also receive pembrolizumab, an immunotherapy, to help the immune system fight the cancer.
Basking Ridge, New JerseyAges 18 years+ - NCT05862168RecruitingPhase 2
Tislelizumab with chemotherapy before surgery for oral cancer
This trial studies giving tislelizumab (an immune treatment) plus chemotherapy before surgery to shrink and treat locally advanced oral squamous cell cancer. It aims to improve tumor response and outcomes, while checking safety.
HangzhouAges 18–75 - NCT05872880Recruiting
Oral cancer treatment with chemo, then surgery and radiation
This trial studies giving chemotherapy first, then removing the tumor with surgery and follow-up radiation for certain cases of oral squamous cell carcinoma. It may help shrink and control the cancer before and after surgery, depending on how well the tumor can be fully removed.
Changsha, HunanAges 18–65 - NCT05889091Recruiting
Fat flap surgery to protect the neck after cancer treatment
This trial studies whether using a “fat flap” (a piece of your own fatty tissue, moved to the neck) during certain neck surgeries can reduce neck injury after head and neck cancer treatment. It is for people who need a salvage neck dissection because of persistent or returning cancer in the neck lymph nodes.
New York, New YorkAges 18 years+ - NCT05901545RecruitingPhase 1
Test an iodine-labeled drug to map neck lymph nodes
This Phase 1 study tests a labelling of panitumumab with iodine (111In) to see how well it can identify lymph nodes in head and neck cancer before surgery. The goal is to improve lymph node staging (which can help guide treatment), with the main focus on safety and early performance.
Nashville, TennesseeAges 19 years+ - NCT05902988RecruitingPhase 1/Phase 2
Study of VLS-1488 for advanced cancers
This early-phase study tests VLS-1488, a new cancer medicine, in people with advanced cancers that have limited treatment options. It may help by finding a safe dose and whether it can shrink or control tumors.
Los Angeles, CaliforniaAges 18 years+ - NCT05910827RecruitingPhase 1/Phase 2
Study of a HER3 antibody with cetuximab and possibly docetaxel
This Phase 1/2 trial tests whether an antibody that targets HER3 (with cetuximab, and possibly docetaxel) can help treat advanced squamous cell cancers that have already been treated or cannot use standard options. It mainly looks at safety first, and also whether the treatment can shrink tumors.
Sydney, New South WalesAges 18 years+ - NCT05913388RecruitingPhase 2
Testing a new drug plus pembrolizumab versus pembrolizumab alone
This Phase 2 trial studies whether adding GB1211 to pembrolizumab works better than pembrolizumab with a placebo in people with metastatic melanoma or metastatic head and neck squamous cell cancer. It may help shrink tumors and improve outcomes, but it also carries risks from immune-based treatment.
Portland, OregonAges 18 years+ - NCT05918510Recruiting
Blood and tumor study for virus markers in throat cancer
This study looks at virus-related markers and tiny gene regulators (microRNAs) in tumor tissue from people with certain throat cancers caused by human papilloma virus (HPV). It’s observational, meaning it does not change your treatment, but results may help doctors better understand these cancers and how they behave.
RomeAges 18 years+
Hear when a new Head and Neck Squamous Cell Carcinoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for head and neck squamous cell carcinoma?
- Yes. Clin2 currently lists 484 recruiting head and neck squamous cell carcinoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck squamous cell carcinoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck squamous cell carcinoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Recurrent Head and Neck Squamous Cell Carcinoma
- Metastatic Head and Neck Squamous Cell Carcinoma
- Locally Advanced Head and Neck Squamous Cell Carcinoma
- Head and Neck Cancer Squamous Cell Carcinoma
- Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
- Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
- Resectable Head and Neck Squamous Cell Carcinoma
- Cutaneous Squamous Cell Carcinoma of the Head and Neck
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.