Clinical trials
Head and Neck clinical trials
Below are recruiting head and neck clinical trials, each written for real people, not researchers. We’re tracking 682 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06992427RecruitingPhase 3
Gabapentin to prevent opioid use for mouth pain during cancer treatment
This trial tests if taking gabapentin during chemoradiation for head and neck cancer can reduce the need for strong painkillers like opioids. It may help manage mouth pain caused by treatment.
Gilbert, ArizonaAges 18 years+ - NCT07058805RecruitingPhase 2
Post-radiation therapy for head and neck cancer
This trial studies a standard type of radiation therapy given after surgery for head and neck cancer. It aims to see if giving radiation only to certain areas of the neck can control the cancer with fewer side effects.
BaselAges 18 years+ - NCT07213934RecruitingPhase 1/Phase 2
Immunotherapy and radiation before surgery for recurrent head and neck cancer
This trial tests a new combination for people whose head and neck cancer has come back after prior radiation. You'll receive an immunotherapy drug (pembrolizumab) plus radiation, then surgery. The goal is to see if this approach can improve how well surgery works.
Cincinnati, OhioAges 18 years+ - NCT07242859Recruiting
Rice bran for mouth sores from radiation in head and neck cancer
This trial tests whether a rice bran supplement can help prevent or reduce mouth sores caused by radiation therapy for head and neck cancer. If you're getting radiation with or without chemo, this simple addition might ease side effects.
CairoAges 18 years+ - NCT07253402Recruiting
Microbiota-guided radiation therapy for head and neck cancer
This trial is testing a new way to use radiation therapy for head and neck cancer by also looking at the bacteria in your mouth and gut. The goal is to see if adjusting the treatment based on your bacteria can improve outcomes and reduce side effects.
Milan, MilanAges 18 years+ - NCT07333274RecruitingPhase 3
Radiation plus nimotuzumab for head and neck cancer
This trial compares radiation therapy alone versus radiation therapy plus a targeted drug called nimotuzumab for people with advanced head and neck cancer who cannot take cisplatin chemotherapy. The goal is to see if adding nimotuzumab improves outcomes.
Shandong, ProvinceAges 18 years+ - NCT00568490Recruiting
Finding blood markers that show low oxygen in tumors
This study looks for substances in blood that may reflect how “low-oxygen” a tumor is. If you have head and neck cancer or non-small cell lung cancer, it may help researchers understand tumor oxygen levels and improve future care.
Stanford, CaliforniaAges 18 years+ - NCT07431099Recruiting
Skin color matching in head and neck reconstruction
This trial tests a new way to match skin color during reconstructive surgery on the head and neck. It may help improve how the surgical site looks and how you feel about your appearance.
Guilford, ConnecticutAges 18 years+ - NCT07445048RecruitingPhase 3
Radiation, targeted therapy, and immunotherapy for high-risk head and neck cancer
This trial tests if adding a targeted drug (nimotuzumab) and an immunotherapy (benmelstobart) after surgery and radiation can help prevent cancer from returning in patients with high-risk head and neck cancer who cannot take cisplatin chemotherapy.
ShanghaiAges 18 years+ - NCT07448727Recruiting
Early PET scan for head and neck cancer on immunotherapy
This trial uses a special PET/CT scan early in treatment to see if first-line immunotherapy is working for people with recurrent or metastatic head and neck cancer. It aims to learn if early response can predict outcomes and help guide care.
Rome, ItalyAges 18 years+ - NCT07462377RecruitingPhase 1
Testing EPI-326 for EGFR-mutant lung and head & neck cancers
This trial tests a new drug, EPI-326, in people with advanced lung or head & neck cancers that have certain EGFR changes. The goal is to see if it is safe and may help shrink the cancer.
Los Angeles, CaliforniaAges 18 years+ - NCT07501650RecruitingPhase 1
Pembrolizumab plus ultrasound bubbles for head and neck cancer
This trial combines the immunotherapy drug pembrolizumab (Keytruda) with a special ultrasound technique that uses tiny bubbles to make the treatment work better. It is for people with HPV-negative head and neck cancer that has come back or spread to other parts of the body.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05838729RecruitingPhase 1/Phase 2
RiMO-301 plus radiation with PD-1 therapy for head-neck cancer
This trial studies RiMO-301 injection combined with palliative radiation and a PD-1 immune therapy (pembrolizumab or nivolumab) for head and neck cancer that cannot be fully removed. It aims to see whether this approach can shrink tumors and improve outcomes safely.
Chicago, IllinoisAges 18 years+ - NCT05898789Recruiting
Virtual rehab program for cancer survivors
This trial tests a virtual (online) rehabilitation and exercise program for people after breast, colorectal, head and neck, or certain blood cancers. It may help improve recovery and daily functioning by supporting safe activity and targeted rehab after treatment.
Toronto, OntarioAges 18 years+ - NCT06868433RecruitingPhase 1
TMV vaccine alone or with pembrolizumab for advanced HNSCC
This trial tests a vaccine made from your own tumor to help your immune system fight head and neck cancer that has returned or spread. It is given alone or with an immunotherapy drug (pembrolizumab) to see if it can shrink tumors or slow progression.
Atlanta, GeorgiaAges 18 years+ - NCT06997068RecruitingPhase 2
Drug combination for returning head and neck cancer
This trial tests a combination of three drugs—methotrexate, erlotinib, and celecoxib—for people whose head and neck cancer has come back or spread. It is designed for patients in the rural Midwest who have already had or chosen not to have standard first treatment.
Rochester, MinnesotaAges 18 years+ - NCT07217028RecruitingPhase 1
Safety study of a new PET tracer for head and neck cancer
This study tests a new radioactive tracer called [18F]NOTA-ABY030 to see if it's safe for people with head and neck cancer that may have spread. The tracer lights up cancer cells on a PET scan, helping doctors find tumors more clearly.
Nashville, TennesseeAges 18 years+ - NCT06672471Enrolling by invitation
Antibiotics after head and neck surgery study
This trial tests whether giving antibiotics after certain head and neck surgeries helps prevent infections. It is for people having planned (non-emergency) surgery that involves entering a normally clean area that may have some germs, like the mouth or throat.
Lahore, Punjab ProvinceAges 18 years+ - NCT07147426RecruitingPhase 2
Tislelizumab plus chemo before surgery for head and neck cancer
This trial tests whether giving the immunotherapy drug tislelizumab with chemotherapy before surgery can help people with advanced head and neck cancer. The goal is to shrink the tumor enough to remove it completely during surgery.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07560397Recruiting
Home-Based Exercise Program for Head and Neck Cancer Patients
This study tests whether patients recovering from head and neck cancer surgery can safely do supervised exercise exercises at home. The program aims to help you regain strength and function during your recovery.
RouenAges 18 years+ - NCT07090499RecruitingPhase 1
Study of PF-08046876 for advanced solid tumors
This trial tests a new medicine, PF-08046876, for people with advanced cancers of the bladder, lung, head and neck, esophagus, or pancreas. It aims to see if the drug is safe and works against these cancers.
Duarte, CaliforniaAges 18 years+ - NCT04511078RecruitingPhase 2
Panitumumab-IRDye800 during head and neck surgery
This Phase 2 study tests a targeted medicine (panitumumab-IRDye800) given around the time of surgery for head and neck squamous cell cancer. It aims to improve doctors’ ability to find and remove cancer tissue during planned surgery.
Birmingham, AlabamaAges 18 years+ - NCT04611113Recruiting
Nutrition support to help tolerance of cancer chemoradiotherapy
This trial studies whether adding special nutrition support (“immunonutrition”) can help people with head-and-neck cancer tolerate treatment with chemoradiotherapy, and possibly improve comfort and treatment completion. You may be eligible if you are starting or will have curative or extra (adjuvant) chemoradiotherapy and can complete study measurements.
PaviaAges 18 years+ - NCT04612075Recruiting
PET-MR scan study for head and neck squamous cancer
This study uses a combined PET/MR scan to better look at head and neck squamous cell cancer before or during treatment. It may help doctors see where the cancer is and how far it has spread, to support planning for curative radiation treatment.
TromsøAges 18 years+
Hear when a new Head and Neck trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for head and neck?
- Yes. Clin2 currently lists 682 recruiting head and neck studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.