Clinical trials
Head and Neck clinical trials
Below are recruiting head and neck clinical trials, each written for real people, not researchers. We’re tracking 682 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04805528Recruiting
Electrical stimulation to reduce dry mouth after head-neck radiation
This trial tests a non-invasive, acupuncture-like electrical stimulation treatment (ALTENS) to help reduce dry mouth after radiation for head and neck cancers. You may qualify if you have bothersome dry mouth and had significant head-neck radiation, with no signs of active cancer and if you can come for treatments over 12 weeks.
Rochester, New YorkAges 18 years+ - NCT07672236RecruitingPhase 3
Comparing two mouth pain treatments for head and neck cancer patients
This trial tests a new mouthwash (BupiZenge) against a standard numbing medicine (lidocaine) for pain caused by mouth sores from radiation therapy. It may help you if you are about to start radiation for certain head and neck cancers.
CopenhagenAges 18–80 - NCT05025813RecruitingPhase 2
Pembrolizumab before surgery or radiation for high-risk skin SCC
This Phase 2 trial tests pembrolizumab (an immune therapy) given before surgery to see if it can help control high-risk invasive cutaneous squamous cell carcinoma. The goal is to improve outcomes by treating cancer earlier and then following with standard surgery and radiation if needed.
Camperdown, New South WalesAges 18 years+ - NCT05382585Recruiting
Study of new treatment targets for head and neck cancers
This study looks at new ways to target head and neck cancers. It may help researchers learn which treatment ideas could work better for people with these cancers.
Varanasi, Uttar PradeshAges 18–100 - NCT05595590RecruitingPhase 2
Radiation plus immunotherapy for recurrent head and neck cancer
This study tests whether adding an immunotherapy medicine called tislelizumab to radiation can better control recurrent (coming back) head and neck squamous cell cancer. It is aimed at people whose cancer can’t be fully removed by surgery or can’t be safely removed.
Chengdu, SichuanAges 18–75 - NCT05644457Recruiting
Testing early blood or tissue signals to track head and neck treatment
This study looks for early “biomarkers” (signals in blood or tissue) to see how well head and neck cancer treatments are working over time. It may help doctors adjust treatment sooner based on those early signals.
LondonAges 18 years+ - NCT05808920Recruiting
Salvage surgery study for recurrent head and neck skin-cell cancer
This study looks at how well people do after “salvage” surgery (planned surgery after prior treatment) for recurrent or residual squamous cell cancer in the head and neck. It may help doctors understand which patients benefit most, including how this surgery affects survival and day-to-day function.
DerbyAges 18 years+ - NCT06725368RecruitingPhase 2
Chemo plus cetuximab after pembrolizumab for head and neck cancer
This trial tests a combination of two chemotherapy drugs (carboplatin and paclitaxel) plus a targeted therapy (cetuximab) for people with advanced head and neck cancer that has gotten worse after treatment with pembrolizumab (with or without initial chemotherapy). The goal is to see if this new combination can shrink tumors or slow the cancer's growth.
Ars-LaquenexyAges 18 years+ - NCT07285564Recruiting
Using a special PET scan to check cancer removal during head and neck surgery
This study tests whether a special PET scan (micro-PET-CT) taken just after tumor removal can help confirm that no cancer cells are left behind. It is for patients with head and neck cancers who are scheduled for surgery.
RouenAges 18 years+ - NCT07625423RecruitingPhase 1
Gene therapy injection for advanced head and neck cancer
This trial tests a new treatment where a specially designed virus carrying an anti-cancer gene is injected directly into tumors in the head and neck area. It's for patients whose cancer has come back or spread after prior chemotherapy and who cannot have surgery or radiation.
Chengdu, ChinaAges 18–65 - NCT07635641Recruiting
Proton Therapy for Recurring Head and Neck Cancer
This study tracks how well proton therapy (a precise radiation treatment) works when head and neck cancer comes back after previous treatment. Proton therapy uses high-energy particles instead of traditional X-rays, which may reduce side effects.
Rozzano, MilanoAges 18 years+ - NCT06627270RecruitingPhase 2
Antibiotics before surgery for oral cancer
This trial tests if taking antibiotics and using a mouth rinse before surgery can help treat oral cancer by targeting bacteria inside the tumor. It is for people with a new diagnosis of oral cancer who are scheduled for surgery.
Cleveland, OhioAges 18 years+ - NCT04870762RecruitingTeam says not enrollingPhase 2
3D-printed tongue stents during head and neck radiation
This Phase 2 study tests whether customized 3D-printed stents can be used safely during head and neck radiotherapy. If you’re having radiation (with or without chemotherapy), the stent may help make treatment easier and more precise, potentially improving the experience and outcomes.
Phoenix, ArizonaAges 18 years+ - NCT06959082RecruitingPhase 2
Testing an experimental drug with chemoradiation for head and neck cancer
This trial tests an experimental drug called VS-101 combined with standard radiation and chemotherapy for people with advanced head and neck cancer that hasn't been surgically removed. The goal is to see if adding this drug helps the treatment work better while keeping side effects manageable.
New Haven, ConnecticutAges 18 years+ - NCT07457346RecruitingPhase 2
Testing emactinib with chemo and immunotherapy before head and neck cancer surgery
This trial tests whether combining the drug emactinib with chemotherapy and immunotherapy before surgery helps treat advanced head and neck cancer. It aims to shrink tumors and make surgery more effective.
Hangzhou, ZhejiangAges 18–75 - NCT05874908Enrolling by invitation
Strep throat and head/neck infection study with hospital samples
This study looks at germs (microbiology) in people with a new, short-term head and neck infection caused by streptococcus bacteria. Your sample would help researchers learn more about these infections and how they behave.
NorthamptonAges 18 years+ - NCT07227792Recruiting
Tongue-out radiation therapy for head and neck cancer
This trial tests if sticking your tongue out during radiation therapy can reduce side effects. It is for people with certain types of head and neck cancer who are getting radiation to the main tumor.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07487636Enrolling by invitation
4DryField PH in head and neck surgery
This trial tests if 4DryField PH, a substance used to control bleeding, helps patients having head and neck surgery. It aims to see if it reduces complications.
Taichung, TaiwanAges 18 years+ - NCT07058116RecruitingPhase 1
BNCT radiation therapy for head and neck cancer
This trial tests a type of radiation therapy called BNCT (boron neutron capture therapy) for people with head and neck cancer that cannot be surgically removed. It may be an option if you have already had radiation or chemo and have no distant spread of cancer.
HelsinkiAges 18 years+ - NCT03483337Recruiting
MRI scan tests new markers for head and neck cancers
This trial tests special MRI scans to find warning signs of cancer that has returned or spread in the head and neck area. It may help doctors see these changes more clearly, which could improve treatment planning.
New York, New YorkAges 18 years+ - NCT04428515Recruiting
Photoacoustic scans for untreated head and neck cancer
This study tests a special imaging scan (photoacoustic imaging) to help doctors look at head and neck cancer before treatment. It’s for people who have not had first-line therapy yet and will be starting radiotherapy.
Toronto, OntarioAges Any age - NCT05053230Recruiting
At-home integrative program for people living with cancer
This study tests an at-home integrative medicine program (supportive, whole-person care) to see if it helps symptoms like fatigue for people affected by cancer. You may be assigned to the program or a comparison group, and you’ll complete questionnaires and study check-ins from home.
Basking Ridge, New JerseyAges 18 years+ - NCT05200650RecruitingPhase 1
Test gel with cisplatin injected into head and neck tumors
This trial studies an anti-cancer gel that delivers cisplatin directly into a head and neck tumor with a single injection. It mainly checks safety and side effects, and also looks for early signs that the tumor responds in people whose cancer is progressing or no longer responds to standard treatment.
JerusalemAges 18–80 - NCT05348486Recruiting
Adaptive radiation planning using FMISO imaging for head and neck cancer
This trial tests a way to personalize radiation treatment using a special scan (FMISO) to improve targeting in certain head and neck cancers. It is designed for people who are newly diagnosed and ready for standard curative (definitive) chemoradiation or faster radiation schedules.
BrnoAges 18 years+
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Common questions
- Are there clinical trials for head and neck?
- Yes. Clin2 currently lists 682 recruiting head and neck studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.