Clinical trials · California
Health clinical trials in California
We’re tracking 342 recruiting health studies with a site in California — including Phase 1, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT05470023Recruiting
Imaging study of gum health and mouth biofilm
This study uses imaging to look at how healthy your gums are and how much “plaque/biofilm” is in your mouth. It may help researchers better understand gum health and how oral hygiene affects it.
Irvine, CaliforniaAges 18 years+ - NCT05428007RecruitingPhase 2
Sarilumab with three immunotherapy drugs for advanced melanoma
This Phase 2 trial tests whether adding sarilumab (an immune-blocking medicine) to three immunotherapy medicines can shrink unresectable, advanced melanoma that cannot be removed with surgery. It aims to improve how well the immune system controls the cancer, especially in Stage III or Stage IV disease.
Los Angeles, CaliforniaAges 18–100 - NCT05440851Recruiting
Testing different treatments for severe breathing failure in ICU
This platform trial studies which treatment works best for adults with sudden, severe breathing failure needing oxygen or a breathing machine in the ICU. It may help patients by matching them to the most appropriate treatment strategy and tracking outcomes to improve care.
Los Angeles, CaliforniaAges 18 years+ - NCT05452031Recruiting
Sleep program for people with dementia and their caregiver
This study tests a “dyadic” sleep health approach, meaning it works with both you and your caregiver together. It aims to improve sleep when dementia is causing frequent sleep problems, and to see whether a caregiver-involved plan helps both of you.
Los Angeles, CaliforniaAges 18 years+ - NCT05427370Recruiting
Compare bypass or stent treatment in weak heart patients
This study compares two ways to restore blood flow to the heart—bypass surgery (CABG) or stent procedure (PCI)—in people with a weak pumping heart. It looks at which approach works best when the heart muscle is not pumping well and there are multiple blocked heart arteries.
Los Angeles, CaliforniaAges 18 years+ - NCT05399537RecruitingPhase 3
Testing citrate fluid safety during kidney filtration (CRRT)
This Phase 3 study checks whether Prismocitrate 18 is safe for adults who need a kidney filtration treatment called CRRT. It is mainly for people who cannot safely use heparin (a common blood thinner) due to bleeding risk.
Los Angeles, CaliforniaAges 18 years+ - NCT05410977Recruiting
Testing blood and stool for colon cancer in Lynch syndrome
This study collects blood and stool samples to see how well they can detect colorectal cancer or advanced growths in people with Lynch syndrome (an inherited colon cancer risk) or suspected Lynch syndrome. It may help find cancer or precancer earlier, which can improve next-step decisions.
San Francisco, CaliforniaAges 18 years+ - NCT05380401Recruiting
DHA and ARA milk fats for very early preterm babies
This study looks at how adding two specific milk fats (DHA and ARA) through enteral feeding affects metabolism in very early preterm infants. It may help researchers understand what these nutrients do in babies born around 25–30 weeks gestation.
Los Angeles, CaliforniaAges Up to 8 months - NCT05362292RecruitingPhase 4
Treating bladder leakage to support mind and body health
This study tests medicines to reduce “urgency” urine leakage (when you suddenly feel you must go) and to see whether improving bladder control also helps overall mental and physical health. You may be eligible if you have had these symptoms for at least 3 months and can follow the study plan.
Palo Alto, CaliforniaAges 60 years+ - NCT05359991Recruiting
Exercise study in children and teens with lung or blood conditions
This study tests how safe and effective a structured exercise program is for children and teens. It also compares results between children with sickle cell disease, cystic fibrosis, and healthy peers (and some teens after COVID-19 infection).
Irvine, CaliforniaAges 10–17 - NCT05245695Recruiting
Endometriosis test using deep computer learning during surgery
This trial studies whether a computer (deep neural network) can better identify endometriosis in people with long-lasting pelvic pain using information from surgery. It may help doctors sort who has endometriosis more accurately when surgery is already planned.
Burbank, CaliforniaAges 14–50 - NCT05213676RecruitingPhase 4
Testing stopping inhaled nitric oxide in newborns with CDH
This trial studies whether stopping inhaled nitric oxide (a breathing medicine) can be safely used in newborns with congenital diaphragmatic hernia (CDH). It may help the team decide the best way to use this medicine during early newborn care.
Irvine, CaliforniaAges birth–1 month - NCT05145491Recruiting
Immediate or delayed surgery for vision changes from ERM
This trial compares doing ERM surgery right away versus waiting at least 4 weeks to see if your vision stays stable. It may help people decide the safest timing for surgery when the membrane in the retina (ERM) is causing symptoms.
Glendale, CaliforniaAges 50 years+ - NCT04763980Recruiting
Health coaching to help Black men get prostate germline genetic testing
This study tests a community health coach to help Black men with prostate cancer understand and access genetic testing that looks for inherited cancer risk. It may help you talk with your care team about testing and reduce barriers to getting results.
San Francisco, CaliforniaAges 18 years+ - NCT05059444Recruiting
Blood test to catch cancer early after treatment
This study looks for signs of cancer left in the body after treatment using a simple blood test (called a liquid biopsy). It aims to see if the test can catch cancer that might come back earlier than regular scans.
Sacramento, CaliforniaAges 18 years+ - NCT05008848RecruitingPhase 3
Text-based quit smoking program for rural cancer survivors
This trial tests a text message program to help people who have had cancer quit smoking. It is designed for those living in rural areas and aims to see if this program can support them in stopping smoking.
St. Helena, CaliforniaAges 18 years+ - NCT05006482RecruitingPhase 3
Geriatric education and care support for older cancer survivors
This study tests whether a structured health education and “older adult care” approach—done with your oncology team—can improve support for people after cancer. It includes older cancer survivors and a chosen caregiver, using in-person or video visits for follow-up.
Fremont, CaliforniaAges 18 years+ - NCT04970056Recruiting
Pancreatic cancer risk and early-detection registry study
This study builds a database of people at higher risk for pancreatic cancer (or certain early warning findings) to help find better ways to detect the disease early. You may be asked to complete health questionnaires and possibly donate a blood/saliva/swab sample.
Burbank, CaliforniaAges 18–90 - NCT03968393RecruitingPhase 4
Blood thinner to prevent stroke after stress-related irregular heartbeats
This trial tests whether taking a blood thinner can lower the risk of stroke in people who had atrial fibrillation (an irregular heartbeat) that happened temporarily around a stressful illness or surgery. It looks especially at people at higher risk for stroke after that episode.
Los Angeles, CaliforniaAges 55 years+ - NCT04742608Recruiting
Liquid blood tests to diagnose thyroid nodules or cancer
This study tests whether a blood “liquid biopsy” can help diagnose thyroid cancer or hard-to-tell thyroid nodules without needing extra procedures. It may help confirm what’s going on before or around planned thyroid surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT04732065RecruitingPhase 1
ONC206 for certain brain tumors in children and young adults
This Phase 1 study tests ONC206, a new targeted medicine, for diffuse midline gliomas (DMG) with a specific gene change (H3K27 altered) and for some other recurrent brain/spinal cord cancers. It is designed to find the right dose and see whether it can control or shrink tumors after initial treatment or when the cancer returns.
San Francisco, CaliforniaAges 2–21 - NCT04743765Recruiting
Faster hip fracture care for people with heart stress signs
This study looks at an “accelerated” hospital plan to get surgery and treatment started sooner for some people with a hip fracture who also show signs of heart stress in blood tests. It may help reduce delays and improve safety during urgent hip fracture care.
Davis, CaliforniaAges 45 years+ - NCT04765150Recruiting
AI helps classify prostate cancer using MRI images
This trial studies whether a computer (AI) can better sort MRI results to improve prostate cancer diagnosis or classification. You may benefit by getting your multi-part MRI looked at in a new, more precise way, while helping researchers refine decision-making.
Los Angeles, CaliforniaAges 18 years+ - NCT04712461Recruiting
Support program to reduce therapist burnout
This trial tests whether adding specific implementation supports can reduce burnout in therapists who provide evidence-based care for children who have experienced trauma. It may help therapists feel more supported while delivering these child trauma treatments.
San Diego, CaliforniaAges 3–99
Where these studies are running in California
Institutions with a site for the recruiting health studies listed above.
- University of California, San Francisco · 6 studies
- Cedars-Sinai Medical Center · 3 studies
- UC San Diego Moores Cancer Center · 3 studies
- University of California, Irvine · 3 studies
- University of California, Los Angeles (UCLA) · 3 studies
- UCLA Jonsson Comprehensive Cancer Center · 2 studies
- University of California, Los Angeles · 2 studies
- Beckman Laser Institute and Medical Clinic
What taking part in a health study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Common questions
- Are there health clinical trials in California?
- Yes. We're currently tracking 342 recruiting health studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a health study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a health trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New health studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.