Clinical trials · St. Louis, MO
Heart failure clinical trials in St. Louis
We’re tracking 32 recruiting heart failure studies with a site in or near St. Louis — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near St. Louis
- NCT05180773RecruitingPhase 4
Bromocriptine for new postpartum heart weakness
This trial studies whether bromocriptine improves health outcomes in people recently diagnosed with peripartum cardiomyopathy (a weakened heart during late pregnancy or soon after delivery). You may be asked about timing after childbirth, heart strength tests, and whether you plan to keep breastfeeding.
St Louis, MissouriAges 18 years+ - NCT06424288RecruitingPhase 3
Testing vicadrostat plus empagliflozin for heart failure
This study tests whether adding a new study drug called vicadrostat to the standard heart failure medicine empagliflozin helps people with heart failure. It may be a good option if you have heart failure with preserved pumping function and are not already on a medicine called an MRA.
St Louis, MissouriAges 18 years+ - NCT05685303Recruiting
Testing a treatment for heart failure symptoms with normal pumping ability
This study is looking at a new treatment for people with heart failure where the heart’s pumping strength is not reduced much (HFpEF or HFmrEF), but pressure inside the heart is high during exercise. It may help relieve symptoms in people who still feel unwell during normal activity despite stable standard treatment.
St Louis, MissouriAges 40 years+ - NCT06793371RecruitingPhase 2
Study of CK-4021586 for heart failure with preserved ejection fraction
This trial tests an investigational drug called CK-4021586 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug is safe and well-tolerated. You may qualify if you are 40 to 85, have heart failure symptoms, and have a heart that pumps well but shows signs of strain.
St Louis, MissouriAges 40–85 - NCT03142152Recruiting
Mitral valve implant for heart failure with leaky mitral valve
This trial tests whether a device called the Carillon Mitral Contour System can help people with heart failure caused by a mild-to-moderate leaky mitral valve. You’d be compared against a control group, and the goal is to improve heart failure symptoms and outcomes.
St Louis, MissouriAges 18 years+ - NCT07761117RecruitingPhase 3
Heart failure treatment study for people with preserved pumping function
This study tests an investigational medication called elecoglipron to see if it can improve heart and blood vessel outcomes in people with heart failure with preserved or mildly reduced ejection fraction. If you join, you will receive either the study drug or a placebo, and your heart health will be monitored over time.
Bridgeton, MissouriAges 18 years+ - NCT05064709Recruiting
Test device for heart failure symptoms in some patients
This study tests whether a heart-related device called CCM can improve symptoms and daily function in people with heart failure and a moderately reduced pumping strength. It may help if you’ve had recent heart-failure-related hospital care or urgent treatment and your heart and overall health fit the study limits.
Bridgeton, MissouriAges 18 years+ - NCT07087613Recruiting
Detecting heart and lung pressure problems with a smart stethoscope
This study tests if a digital stethoscope and a simple 3-lead ECG (heart rhythm test) can detect two heart conditions: high blood pressure in the lungs (pulmonary hypertension) and low pumping strength of the heart (low ejection fraction). It's intended for adults who recently had a heart ultrasound or a heart catheterization.
O'Fallon, IllinoisAges 18 years+
Hear when a new Heart failure trial opens near St. Louis, MO
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Heart failure trials in other cities
Where these studies are running near St. Louis
Institutions with a site for the recruiting heart failure studies listed above.
- St. Louis Heart and Vascular · 2 studies
- Prairie Cardiovascular
- Research Site
- St. Louis Heart and Vascular, P.C.
- St. Luke's Hospital
- Washington University - St Louis
- Washington University Center for Advanced Medicine
- Washington University in St. Louis
What taking part in a heart failure study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting heart failure studies in Missouri.
Common questions
- Are there heart failure clinical trials near St. Louis?
- Yes. We're currently tracking 32 recruiting heart failure studies with a site near St. Louis, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a heart failure study near St. Louis?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in St. Louis to take part?
- Not necessarily. These studies have a site near St. Louis, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New heart failure studies open near St. Louis regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.