Clinical trials · Boston, MA
Heart failure clinical trials in Boston
We’re tracking 58 recruiting heart failure studies with a site in or near Boston — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Boston
- NCT06307652RecruitingPhase 3
Testing a new heart failure and kidney treatment combo
This study tests a new combination of two medicines (balcinrenone and dapagliflozin) for people with heart failure and reduced kidney function. The goal is to see if this combination helps improve heart and kidney health better than current treatments.
Boston, MassachusettsAges 18–130 - NCT06677060RecruitingPhase 3
Study of baxdrostat plus dapagliflozin for heart risk in type 2 diabetes
This study tests whether a new drug called baxdrostat, when added to the diabetes medicine dapagliflozin (Farxiga), can prevent heart failure and heart-related death in people with type 2 diabetes, high blood pressure, and existing heart or blood vessel disease. You may be able to join if you have type 2 diabetes, heart or blood vessel disease, high blood pressure, and at least one extra risk factor for heart failure.
Boston, MassachusettsAges 40 years+ - NCT06217302RecruitingPhase 3
Sotagliflozin for kidney protection in type 1 diabetes
This study tests whether sotagliflozin (a pill that helps control blood sugar and protects the kidneys) can slow down kidney function decline in people with type 1 diabetes and diabetic kidney disease. You may qualify if you have had type 1 diabetes for at least 8 years, have moderate kidney damage, and are on standard treatments.
Boston, MassachusettsAges 18–75 - NCT06736574RecruitingPhase 3
Study of omecamtiv mecarbil for chronic heart failure with very weak heart pump
This study tests an investigational medicine (omecamtiv mecarbil) for people with chronic heart failure and very low pumping strength. It looks at whether the drug can help prevent heart failure events or the need for stronger treatments.
Boston, MassachusettsAges 18–85 - NCT05180773RecruitingPhase 4
Bromocriptine for new postpartum heart weakness
This trial studies whether bromocriptine improves health outcomes in people recently diagnosed with peripartum cardiomyopathy (a weakened heart during late pregnancy or soon after delivery). You may be asked about timing after childbirth, heart strength tests, and whether you plan to keep breastfeeding.
Boston, MassachusettsAges 18 years+ - NCT06517186Recruiting
Heart failure study with preserved pumping function
This study looks at how the heart muscle works in people with a type of heart failure where the heart pumps normally but doesn't fill properly. It aims to understand the cause better, which could lead to new treatments.
Boston, MassachusettsAges 30 years+ - NCT07192952RecruitingPhase 3
Long-term safety of finerenone in children and young adults with heart failure
This study tests the long-term safety of the drug finerenone when taken alongside standard heart failure treatments in children and young adults with weakened heart pumping function (left ventricular systolic dysfunction). It includes both children already in a related study and new infants under 6 months old.
Boston, MassachusettsAges Up to 18 years - NCT05577819Recruiting
Screening for ATTR heart amyloid in older HFpEF patients
This study looks at how often a specific heart condition (ATTR amyloid) occurs in people age 65+ who have HFpEF. It also tries to predict who might have it, using a special heart scan, and may help your care team identify it earlier.
Boston, MassachusettsAges 65 years+ - NCT05934487Recruiting
Monitoring device trial for stable heart failure symptoms
This trial tests whether a wearable home monitoring system (myCordella™) can help people with moderate heart failure (NYHA class II or III) by tracking heart pressure and supporting follow-up care. It may help detect changes earlier so clinicians can adjust treatment sooner.
Boston, MassachusettsAges 18 years+ - NCT06812533Recruiting
Testing a new approach for heart failure with weak pump
This study tests a new device or procedure to help people with heart failure and a weak heart pump. If you have a low ejection fraction and are on standard medications, you may be able to join.
Boston, MassachusettsAges 18 years+ - NCT07112924Recruiting
CCM Heart Device Registry Study
This registry study follows patients who have or will get a CCM device to see how well it works and how safe it is over time. It helps doctors learn more about improving heart function in people with heart failure.
Boston, MassachusettsAges 18 years+ - NCT06169540Recruiting
Saliva test for heart failure diagnosis
This study tests whether a simple saliva sample can detect certain molecules (lncRNAs) that might help diagnose heart failure. It looks at two types of heart failure: chronic stable heart failure and acute decompensated heart failure, and compares them to people without heart failure who are having a heart procedure.
Boston, MassachusettsAges 18 years+ - NCT06051058Recruiting
App for managing health after hospital discharge
This study tests a smartphone app designed to help people with multiple health conditions manage their care after leaving the hospital. It may help you feel more supported and avoid confusion during the transition from hospital to home.
Boston, MassachusettsAges 55 years+ - NCT06147336Recruiting
Testing the V-Lap system for heart failure monitoring
This trial tests a new device called V-Lap that is placed in the heart to monitor pressure. It may help doctors better manage heart failure and reduce hospital stays. Researchers want to see if it works well in people with mild to moderate heart failure.
Boston, MassachusettsAges 22–88 - NCT07188805RecruitingPhase 3
Finerenone for children with heart failure
This study tests a new medicine called finerenone (a pill) to see if it helps children with heart failure who have a weak pumping heart. It compares finerenone to a placebo (a pill with no medicine) while both groups continue their usual heart treatments.
Boston, MassachusettsAges 6 months–17 years - NCT06052072Enrolling by invitation
Heart failure trial testing nerve treatment for lung pressure
This trial tests a new treatment that uses a device to calm overactive nerves in the lung's blood vessels. It is for heart failure patients who also have high blood pressure in their lungs, to see if it can help them breathe easier and feel better.
Boston, MassachusettsAges 22–85 - NCT07207811RecruitingPhase 3
Coramitug for heart failure caused by ATTR amyloidosis
This trial tests a new medicine called Coramitug for people with heart failure due to ATTR amyloidosis, a condition where abnormal proteins build up in the heart. The study aims to see if Coramitug can improve heart function and quality of life.
Boston, MassachusettsAges 18 years+ - NCT03524222Recruiting
Home hospital care for adults after sudden illness
This trial tests whether certain adults can safely receive hospital-level care at home instead of staying in the hospital, using a home care team. It may help you recover in your own home if your condition fits their plan and you have support at home.
Boston, MassachusettsAges 18 years+ - NCT06588452Recruiting
AI vs manual chart review for heart failure studies
This trial tests whether a computer program (AI) can help doctors review patient charts faster than doing it by hand. It looks at people with heart failure to see if AI can correctly identify who might qualify for other studies.
Boston, MassachusettsAges 18–90 - NCT06310031Recruiting
Testing BrioVAD heart pump for severe heart failure
This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.
Boston, MassachusettsAges 18–100 - NCT05443321Enrolling by invitation
Health information sharing during hospital transfers
This trial studies whether sharing patients’ health information between hospitals during transfers can improve outcomes. You may be included if you are moved from a specific partner hospital to Brigham and Women’s Hospital and admitted to certain hospital units.
Boston, MassachusettsAges 18 years+ - NCT05934565Recruiting
Using mindfulness coaching to help people move more
This trial studies a program that uses mindfulness coaching to help people with chronic lung disease (COPD) and/or heart failure (HF) be more physically active. You may benefit if you can safely start exercising and track your steps using a Fitbit.
Boston, MassachusettsAges 40 years+ - NCT07202000RecruitingPhase 2
Exercise and a drug to reduce inflammation for heart failure with preserved ejection fraction
This trial tests whether combining exercise with a medication that blocks a protein called activin can reduce inflammation, improve heart function, and help with thinking in people with heart failure with preserved ejection fraction (HFpEF).
Boston, MassachusettsAges 40 years+ - NCT06793371RecruitingPhase 2
Study of CK-4021586 for heart failure with preserved ejection fraction
This trial tests an investigational drug called CK-4021586 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug is safe and well-tolerated. You may qualify if you are 40 to 85, have heart failure symptoms, and have a heart that pumps well but shows signs of strain.
Boston, MassachusettsAges 40–85
Hear when a new Heart failure trial opens near Boston, MA
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Heart failure trials in other cities
Where these studies are running near Boston
Institutions with a site for the recruiting heart failure studies listed above.
- Massachusetts General Hospital · 9 studies
- Brigham and Women's Hospital · 6 studies
- Tufts Medical Center · 5 studies
- Boston Medical Center · 3 studies
- Boston Children's Hospital · 2 studies
- Research Site · 2 studies
- Beth Israel Deaconess Medical Center
- Brigham and Women's Faulkner Hospital
What taking part in a heart failure study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting heart failure studies in Massachusetts.
Common questions
- Are there heart failure clinical trials near Boston?
- Yes. We're currently tracking 58 recruiting heart failure studies with a site near Boston, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a heart failure study near Boston?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Boston to take part?
- Not necessarily. These studies have a site near Boston, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New heart failure studies open near Boston regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.