Clinical trials
Hypercholesterolemia clinical trials
Below are recruiting hypercholesterolemia clinical trials, each written for real people, not researchers. We’re tracking 71 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07102511Enrolling by invitationPhase 3
Testing a new cholesterol drug in children with high cholesterol
This trial tests if a new medicine, lerodalcibep, can safely lower cholesterol in children ages 6 to 17 who have a genetic condition called heterozygous familial hypercholesterolemia (HeFH). It aims to help children whose cholesterol stays high despite taking standard cholesterol-lowering drugs.
Cincinnati, OhioAges 6–17 - NCT07083206Recruiting
Pitavastatin/ezetimibe for high cholesterol
This trial tests a combination pill of two cholesterol-lowering medicines (pitavastatin and ezetimibe) in adults who have been taking either atorvastatin or rosuvastatin for at least 3 months. It aims to see if switching to this new combination is safe and effective.
Yongin-siAges 19 years+ - NCT06960655Enrolling by invitation
Improving heart disease treatment and cholesterol care
This program aims to improve how doctors manage cholesterol and other treatments for people with heart or blood vessel disease. It focuses on patients who also have diabetes or a genetic high-cholesterol condition, and are seen at Mass General Brigham.
Boston, MassachusettsAges 18–95 - NCT06834204Enrolling by invitation
Better care coordination for cancer survivors
This study tests a program to improve communication between your cancer team and your regular doctor. If you have heart or diabetes risks and you're being treated for breast, prostate, bladder, or endometrial cancer, this trial may help coordinate your care.
New Brunswick, New JerseyAges 18 years+ - NCT06770543Recruiting
Study of Leqvio for high cholesterol in Korea
This study is for adults in Korea with high cholesterol who need a new option because statins aren't working well enough or cause side effects. It will look at how well the medication Leqvio works in everyday medical practice.
Yangsan, Gyeongsangnam-doAges 18–100 - NCT06743659Recruiting
Decision support tool for familial high cholesterol
This trial tests a computer tool that helps doctors identify and manage people with familial high cholesterol. It aims to improve care for those who may not yet have a diagnosis.
Boston, MassachusettsAges Any age - NCT06439654Recruiting
Optimizing cholesterol treatment for heart health
This trial helps people with high cholesterol or a history of heart disease find the best treatment to lower their risk of future heart problems. It tests a program to optimize lipid-lowering therapy.
Clark, New JerseyAges 18–120 - NCT06646354Enrolling by invitationPhase 3
Study of two experimental drugs for high blood pressure and cholesterol
This trial tests whether taking two experimental drugs together can safely lower both high blood pressure and high cholesterol. It may be an option if you have both conditions and your blood pressure is not extremely high.
SeoulAges 19 years+ - NCT06568601Recruiting
Genetic testing to guide statin choice for veterans
This study looks at using a genetic test to help doctors choose the best statin medicine for veterans who need to lower their cholesterol but haven't taken a statin in the last 6 months. If you have diabetes, heart disease, or have had a stroke, this trial may help find a statin that works well for you with fewer side effects.
Indianapolis, IndianaAges 40–75 - NCT06546137Recruiting
Registry for inherited heart conditions in Brazil
This study is building a national registry in Brazil to learn more about inherited heart conditions and improve care. If you have a family-related heart disease, you may be able to join and help advance cardiovascular healthcare.
Rio Branco, AcreAges Any age - NCT06504043Enrolling by invitationPhase 1
Safety study of HST101 in healthy Chinese adults with high cholesterol
This study tests a new drug, HST101, to see if it is safe for healthy Chinese people with high cholesterol. It is an early-phase trial, so it focuses on safety first.
Chengdu, SichuanAges 18–55 - NCT06488105RecruitingPhase 2
ER Heart Risk Check for Cholesterol Study
This trial tests a new way to check heart risk and start treatment for cholesterol in people coming to the emergency room with chest pain or possible heart attack. It aims to see if early risk assessment and treatment can prevent future heart problems.
Winston-Salem, North CarolinaAges 40–75 - NCT06451770RecruitingPhase 1
Testing VERVE-201 for stubborn high cholesterol or triglycerides
This trial tests a new one-time treatment called VERVE-201 for people with very high cholesterol or triglycerides that don't get better with standard medicines. The goal is to see if it can safely lower these fats in your blood.
Clearwater, FloridaAges 18–70 - NCT06314919Recruiting
Study of a combination pill for high cholesterol
This study tests a single pill that combines two cholesterol-lowering medicines (pitavastatin and ezetimibe). It may be a good fit if you already take a statin or a statin plus ezetimibe and your doctor wants to adjust your treatment.
SeoulAges 19 years+ - NCT06287177Recruiting
Study on Inclisiran adherence and effectiveness
This study looks at how well people stick with and respond to the cholesterol-lowering drug Inclisiran. It aims to understand if the medicine works well over time in Italian patients.
NaplesAges 18 years+ - NCT05682378RecruitingPhase 3
Long-term follow-up for inclisiran in young people with inherited high cholesterol
This study follows people with HeFH or HoFH (inherited high cholesterol) who previously took inclisiran in specific pediatric ORION studies. It mainly checks long-term safety and how well the treatment continues to be tolerated over time.
Boca Raton, FloridaAges 2–100 - NCT05430828Recruiting
Study of staying on PCSK9 injections and health outcomes
This study follows people who are already taking PCSK9 inhibitor shots to see how well patients stay on treatment and how effective it is. Your participation would mainly be about consenting to provide basic information and possibly follow-up details.
ArzignanoAges 18–80 - NCT04815005Recruiting
Registry study for people with HoFH
This study is a registry (a list that collects health information) for people with homozygous familial hypercholesterolemia, a genetic cholesterol condition. It helps researchers understand this condition better and connect patients with future research.
Philadelphia, PennsylvaniaAges Any age - NCT05325034Recruiting
Lipid-lowering plan after heart attack in adults
This study tests a cholesterol-lowering treatment plan for adults admitted for a Type 1 heart attack. It may help your care team choose guideline-based cholesterol goals and treatments after the event.
Wollongong, New South WalesAges 18 years+ - NCT05348564Recruiting
Family genetic screening methods for heart rhythm risk
This study compares two ways to find relatives who may carry a specific inherited genetic change. It may help your family learn faster who should get follow-up testing and care.
Lancaster, PennsylvaniaAges 18 years+ - NCT04798430Enrolling by invitationPhase 3
Study drug follow-up for LDL reduction in high-risk cholesterol patients
This Phase 3 study looks at the long-term safety and benefit of OLE LIB003 for people with very high cholesterol or heart disease risk who still need lower LDL (“bad cholesterol”). It’s likely a continuation study for participants who already did earlier LIB003 Phase 3 trials.
Evanston, IllinoisAges 10 years+ - NCT04272697Recruiting
Registry study for familial cholesterol conditions
This trial is a global registry that collects health and genetic information from people with familial hypercholesterolemia (FH) and sometimes from their relatives. The goal is to better understand FH and how it presents, which can help improve care for families affected by high cholesterol.
LondonAges Any age - NCT00353782Recruiting
Studying causes and course of lipid disorders
This study looks at the causes and natural history of different types of lipid disorders (abnormal cholesterol and fat levels in the blood). It aims to understand why these conditions happen and how they affect health over time.
Bethesda, MarylandAges 2–100
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Common questions
- Are there clinical trials for hypercholesterolemia?
- Yes. Clin2 currently lists 71 recruiting hypercholesterolemia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hypercholesterolemia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hypercholesterolemia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Familial Hypercholesterolemia
- Heterozygous Familial Hypercholesterolemia
- Heterozygous Familial Hypercholesterolemia (HeFH)
- Homozygous Familial Hypercholesterolemia
- Primary Hypercholesterolemia
- Homozygous Familial Hypercholesterolemia (HoFH)
- Hyperlipidemia (E.G., Hypercholesterolemia)
- Non-familial Hypercholesterolemia and Mixed Hyperlipidemia
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.