Clinical trials
Hypercholesterolemia clinical trials
Below are recruiting hypercholesterolemia clinical trials, each written for real people, not researchers. We’re tracking 81 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04272697Recruiting
Registry study for familial cholesterol conditions
This trial is a global registry that collects health and genetic information from people with familial hypercholesterolemia (FH) and sometimes from their relatives. The goal is to better understand FH and how it presents, which can help improve care for families affected by high cholesterol.
LondonAges Any age - NCT04815005Recruiting
Registry study for people with HoFH
This study is a registry (a list that collects health information) for people with homozygous familial hypercholesterolemia, a genetic cholesterol condition. It helps researchers understand this condition better and connect patients with future research.
Philadelphia, PennsylvaniaAges Any age - NCT05017649Recruiting
Study of a receptor in people with high LDL cholesterol
This study looks at how a body receptor (called the A2A receptor) works in people with high “bad” cholesterol (LDL). It compares people with high LDL to people with normal LDL to better understand cholesterol-related biology.
MarseilleAges 18–80 - NCT05325034Recruiting
Lipid-lowering plan after heart attack in adults
This study tests a cholesterol-lowering treatment plan for adults admitted for a Type 1 heart attack. It may help your care team choose guideline-based cholesterol goals and treatments after the event.
Wollongong, New South WalesAges 18 years+ - NCT05348564Recruiting
Family genetic screening methods for heart rhythm risk
This study compares two ways to find relatives who may carry a specific inherited genetic change. It may help your family learn faster who should get follow-up testing and care.
Lancaster, PennsylvaniaAges 18 years+ - NCT05430828Recruiting
Study of staying on PCSK9 injections and health outcomes
This study follows people who are already taking PCSK9 inhibitor shots to see how well patients stay on treatment and how effective it is. Your participation would mainly be about consenting to provide basic information and possibly follow-up details.
ArzignanoAges 18–80 - NCT05682378RecruitingPhase 3
Long-term follow-up for inclisiran in young people with inherited high cholesterol
This study follows people with HeFH or HoFH (inherited high cholesterol) who previously took inclisiran in specific pediatric ORION studies. It mainly checks long-term safety and how well the treatment continues to be tolerated over time.
Boca Raton, FloridaAges 12–100 - NCT06287177Recruiting
Study on Inclisiran adherence and effectiveness
This study looks at how well people stick with and respond to the cholesterol-lowering drug Inclisiran. It aims to understand if the medicine works well over time in Italian patients.
NaplesAges 18 years+ - NCT06834204Enrolling by invitation
Better care coordination for cancer survivors
This study tests a program to improve communication between your cancer team and your regular doctor. If you have heart or diabetes risks and you're being treated for breast, prostate, bladder, or endometrial cancer, this trial may help coordinate your care.
New Brunswick, New JerseyAges 18 years+ - NCT06362473Recruiting
Italian Genetic Record for Lipid Disorders
This study creates a registry of people with inherited lipid disorders to better understand and track these conditions. It does not test a new treatment but helps researchers learn more about your condition.
Sesto San Giovanni, MilanoAges Any age - NCT06439654Recruiting
Optimizing cholesterol treatment for heart health
This trial helps people with high cholesterol or a history of heart disease find the best treatment to lower their risk of future heart problems. It tests a program to optimize lipid-lowering therapy.
Clark, New JerseyAges 18–120 - NCT06481020Recruiting
Plant sterols for heart health in overweight adults
This study tests whether plant sterols (natural compounds found in plants) can help improve cholesterol and other heart health markers. If you are overweight and have high LDL cholesterol, you may be able to join this study to see if adding plant sterols to your diet helps.
ValenciaAges 18–80 - NCT06488105RecruitingPhase 2
ER Heart Risk Check for Cholesterol Study
This trial tests a new way to check heart risk and start treatment for cholesterol in people coming to the emergency room with chest pain or possible heart attack. It aims to see if early risk assessment and treatment can prevent future heart problems.
Winston-Salem, North CarolinaAges 40–75 - NCT06546137Recruiting
Registry for inherited heart conditions in Brazil
This study is building a national registry in Brazil to learn more about inherited heart conditions and improve care. If you have a family-related heart disease, you may be able to join and help advance cardiovascular healthcare.
Rio Branco, AcreAges Any age - NCT06568601Recruiting
Genetic testing to guide statin choice for veterans
This study looks at using a genetic test to help doctors choose the best statin medicine for veterans who need to lower their cholesterol but haven't taken a statin in the last 6 months. If you have diabetes, heart disease, or have had a stroke, this trial may help find a statin that works well for you with fewer side effects.
Indianapolis, IndianaAges 40–75 - NCT06743659Recruiting
Decision support tool for familial high cholesterol
This trial tests a computer tool that helps doctors identify and manage people with familial high cholesterol. It aims to improve care for those who may not yet have a diagnosis.
Boston, MassachusettsAges Any age - NCT06789432RecruitingPhase 4
Combination vs single cholesterol drug for Bangladeshi patients
This study tests whether a combination of two cholesterol-lowering medicines (atorvastatin and ezetimibe) works better than a higher dose of one medicine alone in Bangladeshi adults with high cholesterol and low to moderate heart risk.
Dhaka, Dhaka DivisionAges 18 years+ - NCT06858982Recruiting
Pitavastatin study for patients on this statin
This study collects information from patients who are already taking pitavastatin, a cholesterol-lowering medication, as recommended by Polish guidelines. The goal is to learn more about how it works in real-world use.
LodzAges 18 years+ - NCT06894251Recruiting
Testing a supplement for lowering cholesterol
This trial tests a dietary supplement called LIMICOL®-NG to see if it can lower LDL (bad) cholesterol in people with moderately high cholesterol. It may be an option if you are not already on cholesterol medication.
Lille, NordAges 18–70 - NCT07083206Recruiting
Pitavastatin/ezetimibe for high cholesterol
This trial tests a combination pill of two cholesterol-lowering medicines (pitavastatin and ezetimibe) in adults who have been taking either atorvastatin or rosuvastatin for at least 3 months. It aims to see if switching to this new combination is safe and effective.
Yongin-siAges 19 years+ - NCT07374861Recruiting
Study of bempedoic acid in Italy
This study is checking how well people stick with taking bempedoic acid, a cholesterol-lowering medication, and how effective it is over time.
Naples, NapoliAges 18 years+ - NCT00353782Recruiting
Study of cholesterol and triglyceride problems over time
This study looks at how cholesterol and triglyceride levels change in people with dyslipidemia (unhealthy cholesterol/fat levels). Researchers want to understand what different causes mean for long-term health.
Bethesda, MarylandAges 2–100 - NCT07427472Recruiting
Follow-up study of heart artery changes in familial high cholesterol
This trial follows people with a genetic high-cholesterol condition (HeFH) who had a heart scan at least 5 years ago. Researchers will do a new scan to see how their heart arteries have changed over time, without any experimental treatments.
ParisAges 30–60 - NCT07489209RecruitingPhase 2
Study of EDP167 for homozygous familial hypercholesterolemia
This trial tests a new drug, EDP167, for people with homozygous familial hypercholesterolemia (HoFH), a genetic condition that causes very high cholesterol. The goal is to see if EDP167 can lower 'bad' cholesterol (LDL-C).
BeijingAges 18 years+
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Common questions
- Are there clinical trials for hypercholesterolemia?
- Yes. Clin2 currently lists 81 recruiting hypercholesterolemia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hypercholesterolemia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hypercholesterolemia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Familial Hypercholesterolemia
- Heterozygous Familial Hypercholesterolemia
- Heterozygous Familial Hypercholesterolemia (HeFH)
- Homozygous Familial Hypercholesterolemia
- Primary Hypercholesterolemia
- Homozygous Familial Hypercholesterolemia (HoFH)
- Hyperlipidemia (E.G., Hypercholesterolemia)
- Non-familial Hypercholesterolemia and Mixed Hyperlipidemia
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.