Clinical trials
Heterozygous Familial Hypercholesterolemia clinical trials
Below are recruiting heterozygous familial hypercholesterolemia clinical trials, each written for real people, not researchers. We’re tracking 20 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07058077RecruitingPhase 2/Phase 3
Study of oral cholesterol-lowering pill in children with HeFH
This study tests an experimental daily pill (enlicitide decanoate) that lowers LDL ('bad') cholesterol in children and teens with a genetic condition called heterozygous familial hypercholesterolemia (HeFH). It aims to see if this medicine can safely help reduce their high cholesterol levels.
Wilmington, DelawareAges 6–17 - NCT07465263RecruitingPhase 3
Study of SYH2053 Injection for High Cholesterol in HeFH
This study tests a new injection called SYH2053 for people with HeFH, a genetic condition that causes very high cholesterol. It looks at whether the injection can safely lower LDL cholesterol when added to standard statin therapy.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06164730RecruitingPhase 1
Study of VERVE-102 for high cholesterol or early heart disease
This trial tests a new medicine called VERVE-102 for people with a specific type of high cholesterol (HeFH) or early coronary artery disease. It aims to see if it can help lower cholesterol levels.
Dothan, AlabamaAges 18–70 - NCT07102511Enrolling by invitationPhase 3
Testing a new cholesterol drug in children with high cholesterol
This trial tests if a new medicine, lerodalcibep, can safely lower cholesterol in children ages 6 to 17 who have a genetic condition called heterozygous familial hypercholesterolemia (HeFH). It aims to help children whose cholesterol stays high despite taking standard cholesterol-lowering drugs.
Cincinnati, OhioAges 6–17 - NCT06597006RecruitingPhase 3
Study of inclisiran for children with homozygous familial high cholesterol
This trial tests a new medicine called inclisiran to lower very high cholesterol in children aged 2 to 12 who have a specific genetic condition (homozygous familial hypercholesterolemia, or HoFH). You may not need to change your current cholesterol treatments, and the study will check if inclisiran can help reduce your LDL cholesterol further.
San Francisco, CaliforniaAges 2–11 - NCT07491172RecruitingPhase 1
Trial of CTX310 for stubborn high cholesterol and fats
This trial tests a new medicine, CTX310, for people with persistently high levels of fats (triglycerides) and cholesterol that have not improved with standard treatments. It aims to see if the drug is safe and tolerable.
Hialeah, FloridaAges 18–75 - NCT04370899Recruiting
Early checkup for inherited high cholesterol in children
This study looks at children who may have inherited high cholesterol, especially when one parent is affected. It may help doctors detect the condition earlier and understand how it runs in families.
Reus, TarragonaAges 2–18 - NCT06568471RecruitingPhase 3
Study of HST101 for high cholesterol in Chinese patients
This study tests a new injectable medication called HST101 for lowering cholesterol in people who are already taking cholesterol pills but still have high levels. It may help if you have heart disease or are at high risk.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06597019RecruitingPhase 3
Study of inclisiran for children with high cholesterol
This trial tests a medicine called inclisiran to lower high cholesterol in children ages 6 to 12 with a genetic condition called heterozygous familial hypercholesterolemia (HeFH). It may help children who still have high cholesterol despite taking other treatments.
San Francisco, CaliforniaAges 6–11 - NCT06634160Recruiting
Fatty liver disease in people with high cholesterol
This study checks how common fatty liver disease is in people with a genetic form of high cholesterol. It may help researchers understand the link between these two conditions.
AngersAges 35 years+ - NCT07470723Recruiting
Familial Hypercholesterolemia in pregnancy and newborns study
This study looks at how familial hypercholesterolemia (a genetic condition that causes high cholesterol) affects mothers and their newborns. It aims to learn more about cholesterol levels during pregnancy and the baby's first week of life.
Madison, WisconsinAges 18 years+ - NCT06112327Enrolling by invitation
Long-term follow-up for a gene editing heart therapy
This study follows people who already received an experimental gene editing treatment for cardiovascular disease in a prior Verve trial. The goal is to monitor their health and any long-term effects over time.
AucklandAges 18 years+ - NCT04941599RecruitingPhase 2
2-HOBA to improve “good cholesterol” function in FH
This Phase 2 trial tests whether 2-HOBA can improve how “good cholesterol” (HDL) works in people with familial hypercholesterolemia (FH). If HDL works better, it may help lower heart risk markers. You would need to meet several heart, health, and medication-related safety checks.
Nashville, TennesseeAges 18–69 - NCT02208869Recruiting
Registry for inherited high cholesterol (familial hypercholesterolemia)
This registry collects information from people with inherited high cholesterol to better understand the condition and care needs. You may be invited to share blood and medical test results, especially your cholesterol and related health history.
ChelyabinskAges 7–80 - NCT07427472Recruiting
Follow-up study of heart artery changes in familial high cholesterol
This trial follows people with a genetic high-cholesterol condition (HeFH) who had a heart scan at least 5 years ago. Researchers will do a new scan to see how their heart arteries have changed over time, without any experimental treatments.
ParisAges 30–60 - NCT05682378RecruitingPhase 3
Long-term follow-up for inclisiran in young people with inherited high cholesterol
This study follows people with HeFH or HoFH (inherited high cholesterol) who previously took inclisiran in specific pediatric ORION studies. It mainly checks long-term safety and how well the treatment continues to be tolerated over time.
Boca Raton, FloridaAges 12–100 - NCT04073797Recruiting
PET scan study of inflammation and cholesterol-lowering treatment
This study uses PET/CT and related scans to measure inflammation in artery plaque and how cholesterol-lowering treatment changes it. It may help researchers understand which treatments reduce artery inflammation for people with heart or blood-vessel disease and high LDL (“bad”) cholesterol.
CambridgeAges 18–99 - NCT04272697Recruiting
Registry study for familial cholesterol conditions
This trial is a global registry that collects health and genetic information from people with familial hypercholesterolemia (FH) and sometimes from their relatives. The goal is to better understand FH and how it presents, which can help improve care for families affected by high cholesterol.
LondonAges Any age - NCT07591298RecruitingPhase 2
SYH2070 injection for homozygous familial high cholesterol
This study tests a new injectable medication (SYH2070) designed to lower cholesterol in people with homozygous familial hypercholesterolemia—a genetic condition that causes extremely high cholesterol levels despite treatment. The goal is to see if this drug safely reduces cholesterol better than current options.
Changsha, HunanAges 18 years+ - NCT07614958RecruitingPhase 3
Testing a new cholesterol medicine against bempedoic acid
This study compares two new medicines—obicetrapib and bempedoic acid—to see which one better lowers cholesterol in people whose cholesterol remains high despite taking standard medications. If your cholesterol isn't controlled well enough with current drugs, this trial may help you access an experimental treatment.
Stockton-on-TeesAges 18 years+
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Common questions
- Are there clinical trials for heterozygous familial hypercholesterolemia?
- Yes. Clin2 currently lists 20 recruiting heterozygous familial hypercholesterolemia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heterozygous familial hypercholesterolemia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heterozygous familial hypercholesterolemia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Heterozygous Familial Hypercholesterolemia (HeFH)
- Familial Hypercholesterolemia
- Homozygous Familial Hypercholesterolemia
- Homozygous Familial Hypercholesterolemia (HoFH)
- Non-familial Hypercholesterolemia and Mixed Hyperlipidemia
- Hypercholesterolemia
- Familial Mediterranean Fever
- Familial Adenomatous Polyposis
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.