Clinical trials
Hypercholesterolemia clinical trials
Below are recruiting hypercholesterolemia clinical trials, each written for real people, not researchers. We’re tracking 80 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06894004Recruiting
Ketogenic diet and cholesterol study
This study looks at why a ketogenic diet can raise cholesterol. You'll follow a controlled keto diet for two weeks, and researchers will measure how your body processes fats.
St Louis, MissouriAges 18–39 - NCT06960902Recruiting
Study of Heart Artery Plaque in Familial Hypercholesterolemia
This study uses a heart CT scan to look for plaque buildup in the arteries of people with familial hypercholesterolemia (a genetic high-cholesterol condition). It aims to understand why some people with FH develop heart disease while others don't.
DijonAges 40 years+ - NCT07295327Recruiting
Food supplements for mild high cholesterol
This trial tests whether two different food supplements can improve cholesterol levels in people with mild high cholesterol. It aims to find a safe and natural way to help manage cholesterol without medication.
Pavia, LombardyAges 35–70 - NCT02009345Recruiting
Study for inherited high cholesterol in families
This trial focuses on people with familial hypercholesterolemia (FH), an inherited condition that causes very high cholesterol. It aims to better understand and manage severe cholesterol problems that raise heart risk, especially in families.
Montreal, QuebecAges Any age - NCT01109368Recruiting
Registry for people with inherited very high cholesterol
This trial is a registry that collects information from people with homozygous familial hypercholesterolemia (an inherited condition causing extremely high “bad” cholesterol). It may help researchers better understand the condition and support future studies.
New York, New YorkAges Any age - NCT02208869Recruiting
Registry for inherited high cholesterol (familial hypercholesterolemia)
This registry collects information from people with inherited high cholesterol to better understand the condition and care needs. You may be invited to share blood and medical test results, especially your cholesterol and related health history.
ChelyabinskAges 7–80 - NCT07404553RecruitingPhase 2/Phase 3
Study of SHR-1918 for high cholesterol not controlled by statins and PCSK9 inhibitors
This trial tests a new medicine, SHR-1918, for people whose bad cholesterol (LDL-C) stays high even when they take statins and another type of cholesterol-lowering drug called a PCSK9 inhibitor. It aims to see if this additional treatment can lower their cholesterol more effectively.
Nanjing, JiangsuAges 18–85 - NCT07421297RecruitingPhase 3
Study of SYH2053 for high cholesterol in Chinese adults
This trial tests a new medication called SYH2053 for people with high cholesterol or mixed high cholesterol and triglycerides. If you have high LDL cholesterol and are not taking strong cholesterol medicines, you may be able to join. The study will see if this drug is safe and works well.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07447648Recruiting
Evinacumab for plaque buildup in HoFH
This observational study looks at how adding evinacumab to standard cholesterol-lowering therapy affects plaque in the heart arteries of people with homozygous familial hypercholesterolemia (HoFH). It compares those who started evinacumab within the last 2 years to those on standard therapy alone, using CT scans taken before and after treatment.
ParisAges 12 years+ - NCT06112327Enrolling by invitation
Long-term follow-up for a gene editing heart therapy
This study follows people who already received an experimental gene editing treatment for cardiovascular disease in a prior Verve trial. The goal is to monitor their health and any long-term effects over time.
AucklandAges 18 years+ - NCT05750667Enrolling by invitation
Family screening for familial high cholesterol
This trial is about helping families with familial hypercholesterolemia (a genetic condition that causes very high cholesterol) get screened. It tests a way to reach close relatives so they can learn their risk and consider next steps.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05746247Enrolling by invitation
Helping diagnose and manage familial high cholesterol
This study is testing ways to improve how doctors identify and manage familial hypercholesterolemia (a strong inherited tendency to have very high cholesterol) using computer tools and behavior-focused strategies. It may help patients get earlier, more coordinated care if they are at high risk but not yet officially diagnosed.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05284513Enrolling by invitation
Care team study for families with high cholesterol
This study tests a “reach everyone” approach in primary care clinics to improve care for people with familial hypercholesterolemia (families with very high cholesterol). It may help families get recognized sooner and get the right follow-up.
Multiple Locations, PennsylvaniaAges 26 years+ - NCT06770543Recruiting
Study of Leqvio for high cholesterol in Korea
This study is for adults in Korea with high cholesterol who need a new option because statins aren't working well enough or cause side effects. It will look at how well the medication Leqvio works in everyday medical practice.
Yangsan, Gyeongsangnam-doAges 18–100 - NCT06686615Recruiting
Study of a triple cholesterol medicine combination in high-risk patients
This study tests a cholesterol-lowering combination of three medicines: bempedoic acid, ezetimibe, and a statin (atorvastatin or rosuvastatin). It is for people with high cholesterol, especially those at high risk for heart problems, who need stronger treatment.
Braunau am InnAges 18 years+ - NCT07178769Recruiting
Testing a supplement for lowering cholesterol
This trial tests a nutritional supplement with bergamot, artichoke, and other natural ingredients to see if it can safely lower cholesterol in people with moderately high LDL. It may be an option for those not currently on other cholesterol treatments.
Madrid, MadridAges 18 years+ - NCT07591298RecruitingPhase 2
SYH2070 injection for homozygous familial high cholesterol
This study tests a new injectable medication (SYH2070) designed to lower cholesterol in people with homozygous familial hypercholesterolemia—a genetic condition that causes extremely high cholesterol levels despite treatment. The goal is to see if this drug safely reduces cholesterol better than current options.
Changsha, HunanAges 18 years+ - NCT06314919Recruiting
Study of a combination pill for high cholesterol
This study tests a single pill that combines two cholesterol-lowering medicines (pitavastatin and ezetimibe). It may be a good fit if you already take a statin or a statin plus ezetimibe and your doctor wants to adjust your treatment.
SeoulAges 19 years+ - NCT07610278RecruitingPhase 2
Blood Pressure and Cholesterol Treatment Study
This study tests a combination of two new medications (QCZ484 and inclisiran) designed to lower both blood pressure and cholesterol levels. You may be a good fit if you have high blood pressure and high cholesterol that isn't fully controlled by current treatments.
Foley, AlabamaAges 18–75 - NCT07102511Enrolling by invitationPhase 3
Testing a new cholesterol drug in children with high cholesterol
This trial tests if a new medicine, lerodalcibep, can safely lower cholesterol in children ages 6 to 17 who have a genetic condition called heterozygous familial hypercholesterolemia (HeFH). It aims to help children whose cholesterol stays high despite taking standard cholesterol-lowering drugs.
Cincinnati, OhioAges 6–17 - NCT06451770RecruitingPhase 1
Testing VERVE-201 for stubborn high cholesterol or triglycerides
This trial tests a new one-time treatment called VERVE-201 for people with very high cholesterol or triglycerides that don't get better with standard medicines. The goal is to see if it can safely lower these fats in your blood.
Clearwater, FloridaAges 18–70 - NCT07543731Recruiting
Study of how patients stick with cholesterol-lowering injection medications
This study follows people who are starting one of three injectable cholesterol medications (inclisiran, evolocumab, or alirocumab) to see how well they stick with treatment over time. Understanding medication adherence helps doctors and patients find ways to improve long-term health outcomes.
BaselAges 18–99 - NCT03480568RecruitingPhase 3
A cholesterol injection study for people on dialysis
This study tests whether a cholesterol-lowering injection (alirocumab) helps people who are on regular dialysis. It aims to improve cholesterol control in a carefully selected group and tracks safety during treatment.
Dallas, TexasAges 18–80 - NCT04272697Recruiting
Registry study for familial cholesterol conditions
This trial is a global registry that collects health and genetic information from people with familial hypercholesterolemia (FH) and sometimes from their relatives. The goal is to better understand FH and how it presents, which can help improve care for families affected by high cholesterol.
LondonAges Any age
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Common questions
- Are there clinical trials for hypercholesterolemia?
- Yes. Clin2 currently lists 80 recruiting hypercholesterolemia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hypercholesterolemia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hypercholesterolemia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Familial Hypercholesterolemia
- Heterozygous Familial Hypercholesterolemia
- Heterozygous Familial Hypercholesterolemia (HeFH)
- Homozygous Familial Hypercholesterolemia
- Primary Hypercholesterolemia
- Homozygous Familial Hypercholesterolemia (HoFH)
- Hyperlipidemia (E.G., Hypercholesterolemia)
- Non-familial Hypercholesterolemia and Mixed Hyperlipidemia
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.