Clinical trials
Hypercholesterolemia clinical trials
Below are recruiting hypercholesterolemia clinical trials, each written for real people, not researchers. We’re tracking 72 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06568471RecruitingPhase 3
Study of HST101 for high cholesterol in Chinese patients
This study tests a new injectable medication called HST101 for lowering cholesterol in people who are already taking cholesterol pills but still have high levels. It may help if you have heart disease or are at high risk.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06535542Recruiting
Gene testing and digital twins for high cholesterol in Emiratis
This study uses whole genome sequencing and digital twin technology to better understand and manage very high cholesterol in Emirati adults. It aims to identify genetic causes and personalize treatment.
Abu Dhabi, Abu Dhabi EmirateAges 18–55 - NCT04370899Recruiting
Early checkup for inherited high cholesterol in children
This study looks at children who may have inherited high cholesterol, especially when one parent is affected. It may help doctors detect the condition earlier and understand how it runs in families.
Reus, TarragonaAges 2–18 - NCT07470723Recruiting
Early cholesterol check for newborns of parents with lipid disorder
This study tests whether checking a newborn's blood spot for a genetic condition that causes very high cholesterol can help detect it early. It may help families understand their baby's risk and start care sooner if needed.
Madison, WisconsinAges 18 years+ - NCT04929457Enrolling by invitation
Screening to detect inherited high cholesterol
This study tests a digital screening method to help identify and diagnose familial hypercholesterolemia, an inherited condition that can cause very high cholesterol. If you participate, you may be invited to complete screening steps to see whether they can find the condition early.
StockholmAges Any age - NCT02208869Recruiting
Registry for inherited high cholesterol (familial hypercholesterolemia)
This registry collects information from people with inherited high cholesterol to better understand the condition and care needs. You may be invited to share blood and medical test results, especially your cholesterol and related health history.
ChelyabinskAges 7–80 - NCT02009345Recruiting
Study for inherited high cholesterol in families
This trial focuses on people with familial hypercholesterolemia (FH), an inherited condition that causes very high cholesterol. It aims to better understand and manage severe cholesterol problems that raise heart risk, especially in families.
Montreal, QuebecAges Any age - NCT07634484RecruitingPhase 4
Pemafibrate for high cholesterol not controlled by statins
This study tests whether pemafibrate, a new medication, can lower cholesterol better when added to statin treatment in patients whose cholesterol remains high despite taking statins regularly. The goal is to see if this combination reduces heart disease risk.
HokkaidoAges 18 years+ - NCT07491172RecruitingPhase 1
Trial of CTX310 for stubborn high cholesterol and fats
This trial tests a new medicine, CTX310, for people with persistently high levels of fats (triglycerides) and cholesterol that have not improved with standard treatments. It aims to see if the drug is safe and tolerable.
Hialeah, FloridaAges 18–75 - NCT07477704RecruitingPhase 2
Weekly alirocumab for high cholesterol study
This study tests if a weekly injection of alirocumab (Praluent) is safe and effective for people with high cholesterol. It aims to help lower LDL cholesterol that has not responded enough to current treatment.
Anniston, AlabamaAges 18–80 - NCT07473843RecruitingPhase 3
Study of zodasiran for teens with homozygous familial hypercholesterolemia
This study tests an experimental medicine called zodasiran in teenagers who have a rare inherited condition that causes very high cholesterol. The goal is to see if it can lower cholesterol levels and reduce the risk of heart problems.
St Louis, MissouriAges 12–17 - NCT07465263RecruitingPhase 3
Study of SYH2053 Injection for High Cholesterol in HeFH
This study tests a new injection called SYH2053 for people with HeFH, a genetic condition that causes very high cholesterol. It looks at whether the injection can safely lower LDL cholesterol when added to standard statin therapy.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07447648Recruiting
Evinacumab for plaque buildup in HoFH
This observational study looks at how adding evinacumab to standard cholesterol-lowering therapy affects plaque in the heart arteries of people with homozygous familial hypercholesterolemia (HoFH). It compares those who started evinacumab within the last 2 years to those on standard therapy alone, using CT scans taken before and after treatment.
ParisAges 12 years+ - NCT06810466Recruiting
Dietary supplements for mild high cholesterol
This study tests two dietary supplements to see if they can improve cholesterol levels in people with mildly high cholesterol who are otherwise healthy and at low risk for heart disease.
Bologna, ItalyAges 18–69 - NCT06634160Recruiting
Fatty liver disease in people with high cholesterol
This study checks how common fatty liver disease is in people with a genetic form of high cholesterol. It may help researchers understand the link between these two conditions.
AngersAges 35 years+ - NCT07421297RecruitingPhase 3
Study of SYH2053 for high cholesterol in Chinese adults
This trial tests a new medication called SYH2053 for people with high cholesterol or mixed high cholesterol and triglycerides. If you have high LDL cholesterol and are not taking strong cholesterol medicines, you may be able to join. The study will see if this drug is safe and works well.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07404553RecruitingPhase 2/Phase 3
Study of SHR-1918 for high cholesterol not controlled by statins and PCSK9 inhibitors
This trial tests a new medicine, SHR-1918, for people whose bad cholesterol (LDL-C) stays high even when they take statins and another type of cholesterol-lowering drug called a PCSK9 inhibitor. It aims to see if this additional treatment can lower their cholesterol more effectively.
Nanjing, JiangsuAges 18–85 - NCT07295327Recruiting
Food supplements for mild high cholesterol
This trial tests whether two different food supplements can improve cholesterol levels in people with mild high cholesterol. It aims to find a safe and natural way to help manage cholesterol without medication.
Pavia, LombardyAges 35–70 - NCT06458010RecruitingEarly Phase 1
Gene therapy trial for inherited high cholesterol
This trial tests a new gene therapy called YOLT-101 for people with familial hypercholesterolemia, a genetic condition that causes very high cholesterol. The treatment aims to lower cholesterol levels and reduce heart risks.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07058077RecruitingPhase 2/Phase 3
Study of oral cholesterol-lowering pill in children with HeFH
This study tests an experimental daily pill (enlicitide decanoate) that lowers LDL ('bad') cholesterol in children and teens with a genetic condition called heterozygous familial hypercholesterolemia (HeFH). It aims to see if this medicine can safely help reduce their high cholesterol levels.
Wilmington, DelawareAges 6–17 - NCT06960902Recruiting
Study of Heart Artery Plaque in Familial Hypercholesterolemia
This study uses a heart CT scan to look for plaque buildup in the arteries of people with familial hypercholesterolemia (a genetic high-cholesterol condition). It aims to understand why some people with FH develop heart disease while others don't.
DijonAges 40 years+ - NCT06894004Recruiting
Ketogenic diet and cholesterol study
This study looks at why a ketogenic diet can raise cholesterol. You'll follow a controlled keto diet for two weeks, and researchers will measure how your body processes fats.
St Louis, MissouriAges 18–39 - NCT06833944Recruiting
High-intensity exercise for inherited high cholesterol
This trial tests whether a program of high-intensity interval training can help people with familial hypercholesterolemia (an inherited condition that causes very high cholesterol). It aims to see if exercise can improve cholesterol levels and heart health.
Granada, GranadaAges 18–70 - NCT06597006RecruitingPhase 3
Study of inclisiran for children with homozygous familial high cholesterol
This trial tests a new medicine called inclisiran to lower very high cholesterol in children aged 2 to 12 who have a specific genetic condition (homozygous familial hypercholesterolemia, or HoFH). You may not need to change your current cholesterol treatments, and the study will check if inclisiran can help reduce your LDL cholesterol further.
San Francisco, CaliforniaAges 2–11
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Hypercholesterolemia trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for hypercholesterolemia?
- Yes. Clin2 currently lists 72 recruiting hypercholesterolemia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hypercholesterolemia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hypercholesterolemia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Familial Hypercholesterolemia
- Heterozygous Familial Hypercholesterolemia
- Heterozygous Familial Hypercholesterolemia (HeFH)
- Homozygous Familial Hypercholesterolemia
- Primary Hypercholesterolemia
- Homozygous Familial Hypercholesterolemia (HoFH)
- Hyperlipidemia (E.G., Hypercholesterolemia)
- Non-familial Hypercholesterolemia and Mixed Hyperlipidemia
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.