Clinical trials
Hypofractionated Radiotherapy clinical trials
Below are recruiting hypofractionated radiotherapy clinical trials, each written for real people, not researchers. We’re tracking 115 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06936748RecruitingPhase 2
Radiation plus immunotherapy for large relapsed solid tumors
This trial tests a new combination of radiation therapy and two immunotherapy drugs (Iparomlimab and Tuvonralimab) for people whose solid tumors have returned or spread and are too large for standard surgery. The goal is to shrink the tumor and control the cancer.
Nanchang, JiangxiAges 18–75 - NCT06542757Recruiting
Focused radiation to main prostate tumor using MRI guidance
This trial tests a stronger, more focused radiation dose to the main tumor inside the prostate using MRI guidance. It aims to improve control of intermediate-risk prostate cancer while possibly reducing side effects.
New York, New YorkAges 18 years+ - NCT06830083Recruiting
Shorter radiation schedule after mastectomy with implant reconstruction
This trial is testing a shorter, higher-dose radiation schedule (hypofractionation) for women who have had a mastectomy and immediate breast reconstruction with implants. The goal is to see if this approach works as well as standard radiation while possibly being more convenient and causing fewer side effects.
Nanjing, JiangsuAges 18–65 - NCT07835139Recruiting
Shorter radiation schedule after breast implant reconstruction surgery
This trial compares a shorter course of radiation (fewer, larger doses) with the standard longer course for women who have had breast cancer surgery with implant-based reconstruction. It aims to see if the shorter schedule is just as safe and effective for the chest area, while being more convenient.
ShanghaiAges 18 years+ - NCT06615466Recruiting
Short radiation course for early stage breast cancer
This trial tests a shorter, more intense radiation schedule for women with early stage breast cancer after lumpectomy. It aims to provide effective treatment with fewer visits, which may be more convenient for patients.
Beijing, Beijing MunicipalityAges 45–74 - NCT05344235Recruiting
Study of very short radiation schedules for prostate cancer
This observational study looks at how well men with localized prostate cancer do when treated with an unusually short radiation approach. It may help doctors understand which patients benefit most by tracking outcomes and imaging over time.
Leuven, Vlaams BrabantAges Any age - NCT06905132RecruitingPhase 2
Short radiation before surgery for soft tissue sarcoma
This study tests a 5-day course of radiation before surgery instead of the usual 5 weeks. It may help people who face challenges like travel or tumor growth that make the longer schedule difficult.
Charleston, South CarolinaAges 18 years+ - NCT06885671Recruiting
Shorter vs fewer radiation sessions for breast cancer
This trial compares two types of partial breast radiation: one session versus several shorter sessions. It aims to see if a single treatment is as effective and more convenient for women with early-stage breast cancer.
Prince George, British ColumbiaAges 40 years+ - NCT07169344RecruitingPhase 2
Short course radiation before sarcoma surgery
This trial tests a shorter, 3-week course of radiation therapy (using protons or standard X-rays) given before surgery for localized soft tissue sarcoma. It aims to see if this approach is safe and effective for treating the tumor while reducing side effects.
BergenAges 18 years+ - NCT05313815Recruiting
Test a stronger prostate radiation boost for high-risk prostate cancer
This trial studies whether giving a moderate “boost” dose of radiation to the prostate—along with radiation to the pelvic area—can better control high-risk localized prostate cancer. You may benefit if you have high-risk disease and can safely receive radiation.
Toronto, OntarioAges 18 years+ - NCT05183074Recruiting
MRI-guided focused radiation for prostate cancer
This trial tests a newer way to plan and deliver radiation for prostate cancer using real-time MRI guidance. It may help by aiming high-dose treatment precisely while treating nearby disease and (in some cases) limited metastatic spots.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06409910RecruitingPhase 2
Comparing shorter radiation treatments for prostate cancer
This study tests two slightly different short-course radiation schedules for men who have had their prostate removed and are now getting follow-up radiation. The goal is to see if one is more effective or has fewer side effects.
London, OntarioAges 18 years+ - NCT06141070RecruitingPhase 3
Adding high-dose radiation to standard treatment for advanced lung cancer
This trial tests whether adding a high, focused dose of radiation to the usual first treatment (chemo and/or immunotherapy) can help people with non-small cell lung cancer that has spread to a limited number of spots (up to 5). The goal is to see if this approach improves how well the treatment works.
GothenburgAges 18 years+ - NCT07189598Recruiting
High-dose radiation therapy for high-risk prostate cancer
This trial tests whether giving a higher dose of radiation therapy (called SBRT) can safely and effectively treat high-risk prostate cancer that hasn't spread. It's for men who have not yet been treated for their cancer.
RennesAges 18 years+ - NCT07227610RecruitingPhase 2
Radiation for larger brain tumors that have spread
This study tests a type of radiation treatment for people with one or more brain tumors that are larger than usual (2 to 5 centimeters). It aims to see if this approach is safe and effective, and may be an option if you are not having immediate surgery.
Charleston, South CarolinaAges 18 years+ - NCT07188532Recruiting
Personalized high-dose radiation for Ewing sarcoma
This trial tests a personalized radiation therapy that adjusts the dose based on your tumor. It aims to improve treatment for Ewing sarcoma while limiting side effects.
Phoenix, ArizonaAges 2 years+ - NCT07609121RecruitingPhase 2
Radiation, Chemotherapy, and Immunotherapy for Advanced Lung Cancer
This trial tests a combination of radiation therapy, chemotherapy, and two newer cancer-fighting drugs (tislelizumab and surufatinib) for patients with Stage III non-small cell lung cancer that cannot be surgically removed. The goal is to see if this combination works better than standard treatment.
Guangzhou, GuangdongAges 18–75 - NCT04172532RecruitingPhase 1/Phase 2
New targeted drug with radiation for locally advanced pancreatic cancer
This Phase 1/2 trial tests adding peposertib, a targeted anti-cancer drug, to standard radiation for people with locally advanced pancreatic adenocarcinoma. It aims to improve control of the cancer after initial chemotherapy and determine whether the combo is safe and effective.
Duarte, CaliforniaAges 18 years+ - NCT07343349Recruiting
Adding a higher radiation dose to prostate tumors during standard radiotherapy
This trial tests whether giving an extra, focused dose of radiation to the visible tumor inside the prostate can improve results for men with intermediate or high-risk prostate cancer that has not spread. The total treatment is given in 12 or 20 sessions.
AarhusAges 18 years+
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Common questions
- Are there clinical trials for hypofractionated radiotherapy?
- Yes. Clin2 currently lists 115 recruiting hypofractionated radiotherapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hypofractionated radiotherapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hypofractionated radiotherapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.