Clinical trials
Hypofractionated Radiotherapy clinical trials
Below are recruiting hypofractionated radiotherapy clinical trials, each written for real people, not researchers. We’re tracking 119 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06408584Recruiting
Short radiation plus two drugs for returning esophageal cancer
This trial tests a short course of radiation combined with two drugs (raltitrexed and tislelizumab) for people with esophageal cancer that has returned after standard treatment. The goal is to see if these combinations can shrink tumors and improve survival.
HefeiAges 18 years+ - NCT06545747RecruitingPhase 3
MRI-guided radiation for advanced lung cancer
This trial tests a new way of giving radiation therapy for advanced lung cancer that cannot be surgically removed. It uses MRI scans to guide and adjust the radiation dose, which may help target the tumor more precisely and reduce side effects.
GuangzhouAges 18–75 - NCT06593899RecruitingPhase 2
Chemotherapy and radiation before surgery for arm or leg sarcoma
This trial tests giving chemotherapy and radiation therapy together before surgery for soft tissue sarcoma in the arms or legs. The goal is to see if this approach can improve outcomes for people with larger, high-grade, or deep tumors.
Fuzhou, FujianAges 18–75 - NCT06635980RecruitingPhase 2
Radiation before or after breast cancer surgery
This trial compares two ways of giving radiation for breast cancer that has not spread: before or after surgery. It aims to see if giving radiation first might work as well or better.
Scottsdale, ArizonaAges 18 years+ - NCT06867536RecruitingPhase 2
Radiation plus glofitamab for relapsed large B-cell lymphoma with large tumors
This trial tests whether combining a short course of radiation with a targeted antibody drug (glofitamab) can help people with aggressive large B-cell lymphoma that came back after treatment, especially if they have bulky tumors. It aims to find a new option for hard-to-treat cases.
Wuhan, HubeiAges 18–75 - NCT07017816RecruitingEarly Phase 1
Gene therapy, checkpoint inhibitor, and radiation for children with brain cancer
This trial tests a new combination treatment for children and young adults with brain tumors that have come back or not responded to standard therapy. The treatment includes a gene therapy (SGT-53) that delivers a normal TP53 gene, a checkpoint inhibitor drug that helps the immune system attack the cancer, and focused radiation. The goal is to see if this combination is safe and can shrink tumors.
Washington D.C., District of ColumbiaAges 3–21 - NCT07603856RecruitingPhase 2
Combining Immunotherapy and Radiation for Advanced Lung Cancer
This study tests whether adding focused radiation therapy to immunotherapy can help patients with advanced non-small cell lung cancer whose cancer has progressed despite prior immunotherapy. The goal is to see if this combination works better than immunotherapy alone.
Chicago, IllinoisAges 18 years+ - NCT06389422RecruitingPhase 2
Radiation plus Keytruda for liver cancer with vein clots
This trial tests a combination of moderate-dose radiation therapy and the immunotherapy drug pembrolizumab (Keytruda) for liver cancer that has spread into the main veins of the liver. It aims to see if this combination can shrink tumors and improve survival.
Beijing, Beijing MunicipalityAges 18–90 - NCT05124236Recruiting
Pre-surgery vs post-surgery focused radiation for brain metastases
This trial compares two ways of giving focused radiation for brain metastases: before surgery or after surgery. It aims to see which timing works better to control tumors while keeping you safe.
InnsbruckAges 18 years+ - NCT04642027RecruitingPhase 3
PSMA scan-guided salvage radiation after prostate surgery
This trial tests whether using a specialized PSMA PET scan to guide radiation can better treat prostate cancer that returns after prostate surgery. It targets the “prostate bed” area with a shorter, stronger radiation schedule (hypofractionated) to control rising PSA levels.
Arnhem, GelderlandAges 18–80 - NCT05762900RecruitingPhase 2
Shorter breast radiation after surgery for low-risk breast cancer
This Phase 2 trial tests a shorter, focused radiation treatment after breast surgery, either alone or with an extra targeted boost. It’s for people with low-risk breast cancer and no spread to distant organs, aiming to keep results while reducing treatment time and side effects.
BeijingAges 35 years+ - NCT03853733Recruiting
Shorter radiation plan for non-surgery rectal cancer
This trial looks at a shorter radiation schedule for people with advanced rectal (or nearby sigmoid) cancer who cannot have surgery. The goal is to control the cancer while keeping treatment simpler, especially for those who cannot safely undergo an operation.
Terrassa, CataloniaAges 18 years+ - NCT06163820RecruitingPhase 1/Phase 2
Bevacizumab and immunotherapy with radiation for melanoma brain metastases
This trial tests a combination of a drug that stops blood vessel growth (bevacizumab), immunotherapy, and focused radiation to treat melanoma that has spread to the brain and is causing symptoms. The goal is to see if this approach shrinks tumors and improves outcomes.
Melbourne, VictoriaAges 18 years+ - NCT04595019Recruiting
Shorter faster radiation with hormone treatment for prostate cancer
This trial studies a more sped-up radiation schedule for men with certain local prostate cancers, given together with hormone therapy. It aims to keep cancer control while possibly reducing treatment time and making care easier.
Sutton, SurreyAges 18 years+ - NCT05102747Recruiting
Surgery-like brain radiation for up to 5 metastases
This trial compares two ways of giving focused radiation to the brain for people with a limited number of brain metastases. It aims to see which schedule works best (and is likely best for costs and quality of life).
BordeauxAges 18 years+ - NCT05776147Recruiting
Review of extreme breast radiation schedules in Brazil
This study looks back at medical records to understand outcomes when breast cancer patients get a very short course of radiation after surgery. It may help doctors learn whether this “extreme hypofractionation” schedule is safe and effective for more patients.
Fortaleza, CearáAges 18 years+ - NCT04610372Recruiting
Targeted radiation plus hormone therapy for prostate cancer spread
This study compares different ways of giving radiation (SABR or brachytherapy) along with long-term hormone therapy for men whose prostate cancer has spread to a limited number of spots in the body. It aims to see which radiation approach controls the cancer as well as possible while keeping quality of life in mind.
Kelowna, British ColumbiaAges 18 years+ - NCT06538337Recruiting
Shorter radiation therapy for endometrial and cervical cancer
This trial tests a shorter, more targeted type of radiation therapy for people with endometrial or cervical cancer who have had surgery. It aims to reduce side effects by using daily scans to adjust the treatment plan.
Los Angeles, CaliforniaAges 18 years+ - NCT07343531Recruiting
Radiation and chemo for cervical cancer
This trial tests a shorter course of radiation combined with chemotherapy and brachytherapy (internal radiation) for cervical cancer that has not spread widely. It aims to make treatment more efficient while still being effective.
Cairo, Cairo GovernorateAges 18 years+ - NCT06349044Recruiting
Radiation and immunotherapy with or without probiotics for advanced digestive cancers
This trial tests if adding a probiotic (Lactobacillus rhamnosus M9) to standard radiation and immunotherapy can help people with advanced digestive system cancers. It aims to see if the combination is more effective and safer than the standard approach alone.
Hangzhou, ZhejiangAges 18–75 - NCT07173972RecruitingPhase 2
Proton radiation for inoperable soft tissue sarcoma
This trial studies a high-dose, shortened course of proton beam radiation for people with soft tissue sarcoma that cannot be removed by surgery. It aims to improve tumor control while reducing side effects.
BergenAges 18 years+ - NCT05775757Recruiting
Study of breast cancer after surgery using radiation planning
This study follows people with breast cancer who have already had surgery meant to cure the cancer. It checks how their radiation treatment is planned/handled, and whether it benefits patients compared with standard approaches.
SeoulAges 18–85 - NCT06080503Recruiting
Comparing shorter vs. standard radiation for early vocal cord cancer
This study tests if a shorter course of radiation (hypofractionated) works as well as the standard longer course for people with early-stage cancer of the vocal cords. The goal is to find a treatment that is more convenient and has similar results.
Dallas, TexasAges 18 years+ - NCT06894628Recruiting
Genomics and extreme radiation for recurrent prostate cancer
This study looks at how well a very short course of high-dose radiation works for prostate cancer that has come back after surgery. It aims to learn if genetics can help predict who benefits most from this type of radiation.
RomaAges Any age
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Common questions
- Are there clinical trials for hypofractionated radiotherapy?
- Yes. Clin2 currently lists 119 recruiting hypofractionated radiotherapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hypofractionated radiotherapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hypofractionated radiotherapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.