Clinical trials
Immunodeficiency clinical trials
Below are recruiting immunodeficiency clinical trials, each written for real people, not researchers. We’re tracking 123 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06819176RecruitingPhase 1
Testing a new drug to shrink hidden HIV in people with suppressed virus
This study tests whether adding a new anti-HIV drug called lenacapavir to your regular HIV treatment can shrink the hidden reservoir of virus in your body. This could be a step toward a cure.
Bethesda, MarylandAges 18–75 - NCT06814275Recruiting
Brain health study for HIV+ stimulant users
This study uses brain scans to understand how stimulant use affects the brain in people with HIV who are on treatment. It may help find ways to improve brain health.
Winston-Salem, North CarolinaAges 18–59 - NCT06723457RecruitingPhase 2
Epcoritamab and lenalidomide for immunodeficiency-related lymphoma
This trial tests a combination of two drugs, epcoritamab and lenalidomide, for patients with a rare type of large B-cell lymphoma linked to a weakened immune system. It is for people whose lymphoma did not improve or returned after standard treatments, and who cannot get CAR-T therapy.
Chicago, IllinoisAges 18 years+ - NCT06604663Enrolling by invitation
Using data to improve HIV care in Kenya
This trial is looking at how to improve HIV care by using data and interviews to help clinics make better decisions. It doesn't require you to do anything different—your regular clinic data will be used to see how well appointments are kept.
EldoretAges 18–100 - NCT06612515Recruiting
Vaccine response in patients with weak immune systems
This study looks at how well vaccines for respiratory viruses work in people with weakened immune systems. It may help doctors give better vaccine advice to patients like you.
Cologne, North Rhine-WestphaliaAges 18 years+ - NCT06598397RecruitingPhase 4
Quit smoking help for people with HIV in NYC
This study is testing different ways to help people with HIV quit smoking. It combines medication, coaching, and text messages to find the most affordable and effective support.
New York, New YorkAges 18 years+ - NCT06554223Recruiting
HIV treatment support for people with gaps in care
This study is for people with HIV who have had a gap in care (missed an appointment or had a detectable viral load). It tests a program to help you stay on your dolutegravir-based HIV medication and keep your viral load undetectable.
Cape TownAges 18 years+ - NCT06519734Recruiting
Immune Deficiency, IUDs and Menstrual Products Study
This study looks at how well women with primary immune deficiencies can use intrauterine devices (IUDs) and other menstrual products. It aims to help doctors and patients make better choices for safe and effective period care.
ParisAges 18 years+ - NCT06408142Recruiting
HIV testing and connection to care in South African ERs
This study tests a program that offers HIV testing and connects people to prevention or care right in the Emergency Department. It aims to make it easier for anyone visiting the ER to get the HIV services they need.
Cape Town, Western CapeAges 12 years+ - NCT06213103Recruiting
Study of immune problems in mitochondrial disease
This study looks at immune system problems in people with mitochondrial diseases. It involves a blood draw to understand how the immune system works in these patients.
BordeauxAges 6 years+ - NCT05159466Recruiting
Transplant from HIV-positive donors to HIV-positive recipients
This trial studies whether it’s safe and effective for HIV-positive people to receive organ transplants from HIV-positive donors. It focuses on matching HIV treatment before and after transplant and checking for major complications.
Metairie, LouisianaAges 18 years+ - NCT06205056RecruitingPhase 1
HIV vaccine safety and immune response test
This trial tests a new combination HIV vaccine in healthy adults to see if it is safe and produces an immune response. If you are at low risk for HIV, you may help researchers learn more about future prevention strategies.
KampalaAges 18–50 - NCT06139224Recruiting
Gut Bacteria and Inflammation in HIV and Heavy Drinking
This study looks at how gut bacteria and inflammation interact in people with both HIV and heavy alcohol use. It aims to find new ways to improve health by understanding these connections.
Chicago, IllinoisAges 45–75 - NCT06117163Recruiting
Mental health care for pregnant women with HIV in Kenya
This study tests a program that provides integrated mental health care for pregnant women living with HIV in Kenya. The goal is to improve both mental health and HIV treatment outcomes during pregnancy.
NairobiAges 15 years+ - NCT06092346Recruiting
Understanding rare purine and pyrimidine metabolism disorders
This study aims to learn more about rare disorders of purine and pyrimidine metabolism (DPPM), which can affect the brain, immune system, kidneys, and muscles. Researchers will study people with these disorders, their family members, and healthy volunteers to better understand the condition over time.
Bethesda, MarylandAges 1 month–100 years - NCT06088277Recruiting
Texting to reduce HIV risk for dental patients
This study tests if daily text messages can help people lower their risk of getting HIV. You'll receive texts for a few months and complete surveys to see if the messages help.
Boston, MassachusettsAges 18 years+ - NCT05858034Recruiting
Study of aging and frailty in people with HIV over 50
This study looks at what makes some people with HIV become “pre-frail” or frail as they get older. It uses questionnaires and other checks to understand challenges to healthy aging and may help improve future support and care.
Winston-Salem, North CarolinaAges 50 years+ - NCT04232085RecruitingPhase 2
Stem cell transplant to rebuild immunity in genetic immune disorders
This Phase 2 trial tests a stem cell (bone marrow) transplant approach to restore bone marrow function and immune function in people with certain inherited immune problems. If you have one of these conditions and a suitable donor, the study may offer a path to rebuild blood and immune systems.
Baltimore, MarylandAges 4 months–50 years - NCT05587894RecruitingPhase 2
Testing optimized COVID antiviral treatment in immunocompromised adults
This study tests the best combination and timing of antiviral medicines for people with COVID-19 who have weakened immune systems. It aims to improve outcomes in people with mild to moderate illness.
Bordeaux, BordeauxAges 16 years+ - NCT03311503RecruitingPhase 1/Phase 2
Gene therapy for X-linked SCID in young children
This trial tests a gene therapy using a lentivirus to give missing immune system instructions in children with X-linked SCID (SCID-X1). It also uses a low dose of targeted chemotherapy (busulfan) to help the new genes work, and it requires long-term follow-up for safety.
Los Angeles, CaliforniaAges birth–5 years - NCT05537935RecruitingPhase 4
Low-dose naltrexone for nerve pain in people with HIV
This trial studies whether a low dose of naltrexone can reduce long-lasting nerve-related pain in adults living with HIV. It may help if your pain has been ongoing and you have stable HIV control.
Atlanta, GeorgiaAges 18–75 - NCT01962415RecruitingPhase 2
Reduced-intensity stem cell transplant for non-cancer disorders
This trial tests whether a gentler (reduced-intensity) conditioning treatment before a stem cell transplant works for non-cancer diseases. It uses specific donor stem cell matches and checks heart, lung, liver, and kidney function to help lower transplant stress while still aiming for benefit.
Pittsburgh, PennsylvaniaAges 2 months–55 years - NCT05495906RecruitingPhase 4
Lower-dose HPV vaccine study for women with HIV
This trial tests whether giving a lower dose of the HPV vaccine can still be effective and safe for women living with HIV. It may be helpful if you need HPV protection and the study’s dose schedule could reduce vaccine burden.
Surrey, British ColumbiaAges 18–45 - NCT05452564RecruitingPhase 2
Baricitinib to help reduce HIV in the brain
This Phase 2 study tests baricitinib to see if it can lower HIV activity in the brain (CNS) for people already on stable HIV treatment. If you have well-controlled HIV in your blood, this trial looks for additional benefit inside the nervous system.
Atlanta, GeorgiaAges 18–65
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Common questions
- Are there clinical trials for immunodeficiency?
- Yes. Clin2 currently lists 123 recruiting immunodeficiency studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a immunodeficiency trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a immunodeficiency trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.