Clinical trials
Infectious Disease clinical trials
Below are recruiting infectious disease clinical trials, each written for real people, not researchers. We’re tracking 260 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05036707RecruitingPhase 1/Phase 2
Tick bite study in healthy adults
This study looks at how your body's immune system reacts to a tick bite. It may help doctors understand and prevent tick-borne diseases, which are illnesses spread by ticks, like Lyme disease.
Bethesda, MarylandAges 18–99 - NCT00032513Recruiting
Genetic study of chronic active Epstein-Barr virus disease
This research study looks for genetic factors that may explain why some people develop severe, long-lasting Epstein-Barr virus (EBV) infection. Researchers will study blood and tissue samples from patients with this rare condition, their healthy relatives, and unrelated volunteers to understand the disease better.
Bethesda, MarylandAges 1–120 - NCT02974595Recruiting
Study of rare inflammatory conditions to learn what causes them
This study follows people with rare “autoinflammatory” conditions and sometimes their blood relatives to understand why symptoms happen and how they change over time. It may help by improving diagnosis and care for these conditions, using stored samples and genetic testing.
Bethesda, MarylandAges Up to 99 years - NCT06732414Recruiting
Long-term study of multiple allergic diseases
This study creates a biorepository to collect and store samples (blood, nasal fluid, skin swabs) from people with allergies, asthma, sinus disorders, or immune dysregulation. It aims to better understand these conditions over time, which may help develop better treatments.
Bethesda, MarylandAges 3–100 - NCT00001230Recruiting
Understanding How Your Body Responds to Filarial Infection
This study looks at how the body's immune system reacts to filarial infections—parasitic worms that affect millions worldwide. Researchers will observe your infection and response to treatment to better understand the disease and improve future care.
Bethesda, MarylandAges 3–100 - NCT06253507Enrolling by invitationPhase 1/Phase 2
Gene Therapy for Chronic Granulomatous Disease
This study tests a new gene therapy for people with a rare immune disorder called chronic granulomatous disease (CGD), which causes repeated infections. The treatment uses a modified virus to deliver a healthy gene to your blood stem cells, potentially helping your immune system fight off bacteria and fungi. The goal is to reduce the risk of severe infections and improve overall health.
Bethesda, MarylandAges 3–65 - NCT06513156Recruiting
Care support for hospitalized patients with drug-related infections
This study is for people who are in the hospital with a serious infection caused by injection drug use. It aims to provide better care and support while you are in the hospital and after you leave.
Washington D.C., District of ColumbiaAges 18 years+ - NCT00246857Recruiting
Screening study for inherited immune system conditions
This study screens people who may have an inherited immune system condition (like problems with immune cell growth or death) and their blood relatives. The goal is to understand the condition better by collecting blood samples for testing.
Bethesda, MarylandAges 1 month–100 years - NCT01168271Recruiting
Study malaria risk factors in pregnancy and young children
This study looks at why some people get malaria during pregnancy, and how young children’s bodies respond early in life. It may help researchers understand who is more likely to get malaria and why, which could guide future prevention and care.
BamakoAges 1 day–45 years - NCT07113743Enrolling by invitationPhase 1/Phase 2
Gene therapy for x-linked chronic granulomatous disease
This trial tests a new gene therapy for X-linked chronic granulomatous disease (CGD), a condition where the immune system cannot fight certain infections. The treatment uses your own blood stem cells, which are modified in the lab to help your body produce working immune cells.
Bethesda, MarylandAges 3–60 - NCT06325709RecruitingPhase 1/Phase 2
Gene editing trial for X-linked chronic granulomatous disease
This trial tests a new gene-editing treatment for men with a specific genetic mutation that causes X-linked chronic granulomatous disease (CGD). The goal is to fix the faulty gene in your own blood stem cells to help your immune system fight infections better.
Bethesda, MarylandAges 18–75 - NCT05463133RecruitingPhase 1/Phase 2
Stem cell transplant for chronic granulomatous disease
This study tests a stem cell transplant using a special conditioning regimen to treat chronic granulomatous disease (CGD), a condition that causes repeated infections and inflammation. The transplant aims to replace faulty immune cells with healthy ones from a donor, potentially reducing infections and improving quality of life.
Bethesda, MarylandAges 4–65 - NCT02979951Recruiting
IV fosfomycin for serious bacterial infections
This trial studies whether IV (through a vein) fosfomycin can treat severe bacterial infections in adults. It may help people whose infection is covered by the standard fosfomycin use and who need hospital-level care.
Hall in TirolAges 18 years+ - NCT07262983RecruitingPhase 1
Baricitinib for Job syndrome with lupus or eczema
This study tests if baricitinib, a pill that changes how your immune system works, is safe and tolerable for people with Job syndrome who also have lupus-like disease or severe eczema. It might offer a new treatment option for these skin and immune problems.
Bethesda, MarylandAges 12–120 - NCT06908096RecruitingPhase 1
EBV nanoparticle vaccine study for healthy adults
This study tests two experimental vaccines against Epstein-Barr virus (EBV), the germ that causes mono. You may be able to join if you are a healthy adult aged 18–29 and haven't had an EBV vaccine before. The trial will check if the vaccines are safe and trigger an immune response.
Bethesda, MarylandAges 18–29 - NCT00044122Recruiting
Study of mast cell growth in people with mastocytosis
This study looks at what causes mast cells to grow too much in people with mastocytosis. It may help researchers find better ways to diagnose or treat this condition. You can take part in person or by telehealth.
Bethesda, MarylandAges 1 day–80 years - NCT03610802Recruiting
Send blood samples to study genetic and immune differences
This study collects blood (and sometimes related samples) to learn how genes and the immune system work in people with primary immunodeficiency (PID) or in family members who may not have it. The goal is to improve understanding of rare immune conditions and help guide future care.
Bethesda, MarylandAges 1 day–99 years - NCT00001467Recruiting
Study of genes in immune disorders
This research looks at how inherited (genetic) changes may affect the immune system in people with immune problems. It may help by improving understanding of these conditions and, in some cases, guiding faster care for a baby after birth.
Bethesda, MarylandAges 1 day–101 years - NCT07775313Enrolling by invitationPhase 1/Phase 2
Gene therapy for WHIM syndrome
This trial tests a one-time gene therapy treatment for WHIM syndrome, a rare immune disorder. It aims to fix the genetic cause to improve your body's ability to fight infections. Your stem cells will be collected, edited in a lab, and given back to you after some chemotherapy to prepare your body.
Bethesda, MarylandAges 3–75 - NCT07215858RecruitingPhase 2
Testing a new flu vaccine against H1N1 flu
This study tests an experimental flu vaccine (BPL-1357) in healthy volunteers who will later be exposed to H1N1 flu virus in a controlled setting, to see if the vaccine can prevent or reduce illness.
Bethesda, MarylandAges 18–55 - NCT03895645Enrolling by invitation
Research study using stored human samples
This study uses stored blood or other human samples that were saved from earlier medical research or care. It helps researchers answer new questions without needing you to give a new sample right now.
Bethesda, MarylandAges 18–116 - NCT06479837Recruiting
Study using tonsil tissue to understand infections
This study uses tonsil tissue that is removed during a routine tonsillectomy to grow tiny 'organoids' in the lab. Researchers will study how germs interact with human cells, which could lead to better treatments for infections.
Bethesda, MarylandAges 2–120 - NCT07027826Recruiting
String test for eosinophilic esophagitis in African patients
This study tests a new, less invasive way (the Esophageal String Test) to look for signs of eosinophilic esophagitis—an allergic condition that can make swallowing painful or difficult. It is for people of African descent who have trouble swallowing and are already having an endoscopy.
Bethesda, MarylandAges 18–65 - NCT07875218Enrolling by invitation
Hepatitis B care within Zambia's HIV programme
This study looks at how to bring hepatitis B testing and care into the same clinics that already provide HIV services in Zambia. It aims to make it easier for people to get the hepatitis B help they need.
Lusaka, Lusaka ProvinceAges 18 years+
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Common questions
- Are there clinical trials for infectious disease?
- Yes. Clin2 currently lists 260 recruiting infectious disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a infectious disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a infectious disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.