Clinical trials
Infectious Disease clinical trials
Below are recruiting infectious disease clinical trials, each written for real people, not researchers. We’re tracking 260 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05336851Recruiting
Emergency breathing test study for sudden lung infections
This trial tests an emergency breathing-related approach for adults with a sudden, community-acquired respiratory infection. It may help doctors quickly sort out what’s going on and guide early care.
Hong KongAges 18–100 - NCT05272241Recruiting
Asthma registry that helps researchers learn about asthma
This study enrolls people in specific cities to collect health information that helps researchers better understand asthma and how to recruit future studies. It may help by improving knowledge about asthma types and care in real-world settings.
Aurora, ColoradoAges Any age - NCT05266222Recruiting
Collecting respiratory virus samples for a research library
This study collects samples from people who have or might have a cold/respiratory virus, then stores them for future research. It may help researchers better understand respiratory germs and develop better treatments.
Bethesda, MarylandAges 3 years+ - NCT05201469RecruitingPhase 2
VIB4920 for lupus kidney inflammation not responding well enough
This Phase 2 study tests VIB4920 to treat active lupus nephritis, a type of kidney disease caused by lupus. It may help reduce kidney inflammation and improve kidney outcomes in people with active disease despite standard care.
La Jolla, CaliforniaAges 18 years+ - NCT04876131RecruitingPhase 4
Single-dose IV antibiotics for children with complicated urinary tract infections
This trial tests whether one dose of intravenous (IV) antibiotics is as effective as the usual multiple-dose course for children with complicated urinary tract infections (UTIs) who need IV treatment in the emergency department. It aims to reduce hospital stays and the need for repeated IV lines.
Adelaide, South AustraliaAges 3 months–18 years - NCT04772170Recruiting
Study wearable and symptom monitoring during respiratory virus challenges
This observational study looks for digital health patterns during studies where people are intentionally exposed to a respiratory virus. If you join a respiratory virus challenge at NIH, you may help researchers discover better ways to monitor and understand illness using wearable devices and shared health data.
Bethesda, MarylandAges 18–65 - NCT04582903Recruiting
Send-in sample collection study for immune response to respiratory viruses
This study collects sent-in samples to better understand how your immune system responds during a COVID-19–like illness and after you recover. It may help researchers learn why some people get sick and others stay uninfected, and how immune protection works over time.
Rockville, MarylandAges 1 day–99 years - NCT04364503Enrolling by invitation
Study that analyzes de-identified patient samples and records
This trial checks how well patient samples and health records can be analyzed when names are removed (“de-identified”) and privacy rules are followed. You might be included if you agree in writing and your sample data can be used for this research and/or your doctor requests it.
Los Angeles, CaliforniaAges Any age - NCT04097561RecruitingPhase 1
Belimumab safety study for low CD4 counts and autoantibodies
This Phase 1 study tests how safe belimumab is for people with idiopathic CD4 lymphopenia (low protective white blood cells) and signs of autoantibodies. It aims to learn whether the treatment is tolerable and could be a future option for people with this immune condition.
Bethesda, MarylandAges 18–70 - NCT04047628RecruitingPhase 3
MS patients with active relapsing disease comparing two treatment plans
This Phase 3 study compares the best standard MS treatment (chosen by your doctors) versus an approach called autologous hematopoietic stem cell transplant (AHSCT) for people with highly active, treatment-resistant relapsing multiple sclerosis. It aims to see which option controls MS disease activity better and keeps you safer over time.
Palo Alto, CaliforniaAges 18–55 - NCT04052022Recruiting
Study of TB flare-ups in people without HIV
This study looks at why some people with tuberculosis (TB) get worse or develop new inflammation after they initially start improving on treatment—called a “paradoxical reaction.” It collects blood and tissue samples to better understand these flare-ups and guide future care.
Bethesda, MarylandAges 18–99 - NCT04145258RecruitingPhase 3
Stronger TB treatment for meningitis to reduce deaths
This trial tests if giving a stronger combination of TB drugs for meningitis can save more lives. It's for patients who have been diagnosed with tuberculosis meningitis and have not yet started more than 5 days of TB treatment.
AbidjanAges 15 years+ - NCT03949855RecruitingPhase 2
Belimumab plus rituximab for primary membranous nephropathy
This study tests whether adding belimumab to rituximab helps people with primary membranous nephropathy (a kidney disease) that has the right blood test marker and specific protein levels. The goal is to improve kidney outcomes and reduce disease activity while keeping treatment safe.
Birmingham, AlabamaAges 18–75 - NCT03835767RecruitingPhase 2
Predicting food allergy from blood IgE levels in eczema patients
This study looks for blood test patterns that may predict whether a child with eczema (atopic dermatitis) is likely to have a food allergy. If you join, you may do supervised oral food challenges with a placebo and the suspected foods to see what triggers symptoms.
Bethesda, MarylandAges 3–21 - NCT03878121RecruitingPhase 1
Ad4-HIV vaccine study for healthy adults and partners
This Phase 1 study tests whether an experimental HIV vaccine (made from a harmless viral vector) is safe and helps the body build immune defenses. It includes healthy volunteers and, in some groups, their close partners, with careful screening and follow-up visits.
Bethesda, MarylandAges 18–65 - NCT03538600Recruiting
Sample collection from healthy volunteers to improve test accuracy
This study collects multiple types of samples (like blood, stool, saliva, and swabs) from healthy people. The goal is to optimize lab tests for future research, which may help doctors and scientists run more accurate immune-related measurements.
Bethesda, MarylandAges 3–80 - NCT03206099Recruiting
Genetic testing study for people linked to other NIH research
This study collects and sequences (reads) your DNA to help researchers understand health and disease. You may be invited because you are connected to another NIH study, and you must agree to testing, sample storage, and sharing de-identified genetic data for future research.
Washington D.C., District of ColumbiaAges 1 day–100 years - NCT03109288RecruitingPhase 1/Phase 2
Biomarker-guided combination treatment for residual multiple sclerosis activity
This early-phase study tests combination treatments for multiple sclerosis (MS) based on lab “biomarkers” found in the spinal fluid. It aims to reduce ongoing MS activity and help determine which treatment combinations may work best for different people.
Bethesda, MarylandAges 18–120 - NCT02734277Recruiting
Extending a past Type 1 diabetes immune study
This study is for people who already took part in an earlier immune-tolerance program for Type 1 diabetes. It tests whether continuing follow-up and assessments can be done safely and may help learn more about long-term immune effects of treatment.
San Francisco, CaliforniaAges 8–35 - NCT02639299Recruiting
Screening healthy adults for malaria vaccines and drug studies
This study screens healthy adults to see who can join future malaria vaccine or investigational malaria drug studies, including a controlled malaria exposure. It may help researchers test safer vaccines/drugs, but participation requires good health and strict medical eligibility.
Bethesda, MarylandAges 18–50 - NCT02471378Recruiting
Testing a malaria vaccine in pregnant people with malaria
This study looks at lab tests for malaria vaccine candidates in pregnant women who currently have malaria. It may help researchers understand which vaccine approaches are safest and most promising for pregnancy.
BamakoAges 15–25 - NCT02190266Recruiting
Study genetics and cause of hard-to-treat Valley fever
This study looks at why “Valley fever” is difficult to treat or has spread beyond the lungs, and how a person’s genetics may be involved. You may be asked for blood or other samples for genetic testing and for storing samples for future research.
Bethesda, MarylandAges 2–100 - NCT02511002Enrolling by invitation
Long-term follow-up after an influenza challenge study
This study keeps track of how your body’s immune responses change over time after an influenza exposure. Researchers may use stored blood samples to study specific antibody levels, which could help improve future flu vaccines or treatments.
Bethesda, MarylandAges 18–120 - NCT02257892Recruiting
Study of rare immune system genetic disorders
This study looks for genetic causes of immune problems, such as unusually frequent infections, abnormal allergies, or autoimmune or inflammation conditions. It may help by improving how doctors understand these disorders and by matching families with possible genetic diagnoses.
Bethesda, MarylandAges 3–99
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Common questions
- Are there clinical trials for infectious disease?
- Yes. Clin2 currently lists 260 recruiting infectious disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a infectious disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a infectious disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.