Clinical trials
Intravitreal Injections clinical trials
Below are recruiting intravitreal injections clinical trials, each written for real people, not researchers. We’re tracking 29 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07235085RecruitingPhase 3
Study of OTX-TKI implant for moderate to severe NPDR
This study tests an eye implant (OTX-TKI) that slowly releases a medicine to slow or stop worsening of non-proliferative diabetic retinopathy (NPDR) — an early form of diabetic eye disease. It's for people with moderately severe to severe NPDR who haven't had significant treatments like laser or injections in that eye.
Hagerstown, MarylandAges 18 years+ - NCT03648814Recruiting
Bevacizumab eye injections for neovascular glaucoma
This study compares two ways of giving the medicine bevacizumab in the eye: into the front part (intracameral) versus deeper inside (intravitreal). It aims to see which approach better controls neovascular glaucoma and helps vision, especially when surgery (trabeculectomy) is needed.
Hat Yai, Changwat SongkhlaAges 18 years+ - NCT05706896Recruiting
Cord blood plasma injections for dry macular degeneration
This trial tests whether injections made from umbilical cord blood “platelet-rich plasma” can improve vision in people with dry age-related macular degeneration (AMD) in both eyes. It targets older adults with specific vision levels and no major other eye or medical problems that could affect the results.
RomeAges 65 years+ - NCT05728476Recruiting
Compare eye surgery plus peeling versus anti-VEGF injections
This trial compares a minimally invasive eye procedure (vitrectomy with peeling) versus anti-VEGF injections to treat new diabetic macular edema in people who have not had treatment yet. It looks at which option improves vision and eye swelling for people with diabetes.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06511700Enrolling by invitation
Nurse-led eye injections: a new care approach
This trial tests whether specially trained nurses can safely give eye injections instead of doctors. It may make treatment quicker and easier for people who need regular injections for eye conditions.
Sabadell, BarcelonaAges 18 years+ - NCT06841250Enrolling by invitation
Early eye changes after first injection for diabetic macular edema
This study looks at how the eyes of people with diabetes-related swelling in the retina change after their very first anti-VEGF injection. By measuring early changes in OCT scans, doctors hope to learn more about how well the treatment works and how to predict outcomes.
SohagAges Any age - NCT05844982RecruitingPhase 3
Eye injections or steroid implant to prevent vision loss
This trial studies ways to prevent worsening vision caused by radiation damage to the retina after plaque brachytherapy for uveal melanoma. You may be randomly assigned to a medication injection, a steroid implant, or observation to see which approach best protects vision.
Palo Alto, CaliforniaAges 18 years+ - NCT06929507Recruiting
Faricimab eye injections and kidney function in diabetes
This trial tests whether faricimab, an eye injection for certain eye conditions, affects kidney function in people with diabetes. It is for those with diabetic macular edema, wet age-related macular degeneration, or macular edema from a vein blockage, who are already taking kidney-protective medications.
Alexandroupoli, EvrosAges Any age - NCT07456826Enrolling by invitationPhase 4
Comparing two eye numbing gels for shots
This trial tests a new eye-numbing gel against the standard numbing method to see which works better for patients getting regular anti-VEGF injections in the eye.
Tyler, TexasAges 18 years+ - NCT05986864RecruitingPhase 1/Phase 2
Gene therapy injection for wet AMD
This study tests a new gene therapy injection called SKG0106 for people with wet AMD. The treatment is given as an injection into the eye and aims to reduce the need for frequent anti-VEGF shots.
St. Petersburg, FloridaAges 50 years+ - NCT06536062Recruiting
Cord blood and platelet plasma for dry macular degeneration
This trial tests if a treatment made from umbilical cord blood and platelet-rich plasma can help people with dry age-related macular degeneration. The treatment is given as an injection into the eye, and the goal is to see if it slows vision loss or improves sight.
Rome, RomeAges 65 years+ - NCT06810011Recruiting
Eye disease treatment study using medical records
This study uses a computer system to look at medical records of people who have had a certain type of eye injection. It aims to improve how information about eye treatments is shared and understood.
Chemnitz, SaxonyAges 18 years+ - NCT00346814RecruitingPhase 2/Phase 3
Bevacizumab injections for severe eye vessel disease in premature babies
This trial studies whether an anti–blood vessel medicine (bevacizumab, given by eye injection) can improve the structure of the retina in very premature babies with advanced retinopathy of prematurity. It may help when standard treatments like laser or freezing cannot be used.
Mexico City, Mexico DFAges 1 month–1 year - NCT05803785RecruitingPhase 1
Safety study of an injection for wet macular degeneration
This Phase 1 trial tests whether BBC1501, an injection given into the eye, is safe for people with wet age-related macular degeneration (nAMD). It mainly looks at side effects and whether the study injections can be given safely in patients who still have active disease despite prior anti-VEGF treatments.
Sydney, New South WalesAges 50 years+ - NCT06595355RecruitingPhase 2/Phase 3
Study of eye injections with or without curcumin for diabetic eye swelling
This trial tests whether adding oral curcumin (a natural supplement) to standard eye injections (bevacizumab) improves treatment for diabetic macular edema, a swelling in the back of the eye that can affect vision.
Isfahan, Isfahan University of Medical SciencesAges 40 years+ - NCT07002372Recruiting
Watching a video before your first eye injection
This study tests whether watching a short video before your first eye injection helps you feel more at ease. It is for people who have never had this injection before.
Hangzhou, ZhejiangAges 18 years+ - NCT07133438RecruitingPhase 4
Vitamin B12 with eye injections for blocked retinal vein
This trial tests if adding mecobalamin (a form of vitamin B12) to standard anti-VEGF eye injections helps people with vision loss caused by a blocked vein in the retina. You must have swelling in the back of the eye and have had no prior treatments for this condition.
ChongqingAges 18–80 - NCT07215234RecruitingPhase 1/Phase 2
Study of an injection for geographic atrophy in AMD
This study tests a single injection of an experimental drug (SAR446597) into the eye for people with geographic atrophy, a late-stage form of dry age-related macular degeneration. The goal is to see if it can safely slow vision loss.
Peoria, ArizonaAges 60 years+ - NCT02669953Recruiting
Aflibercept injections for persistent wet macular degeneration
This trial studies whether aflibercept injections can help when “wet” age-related macular degeneration is recurring or not fully going away. It focuses on adults who have already had ranibizumab and still have measurable vision in the study eye.
ViennaAges 50 years+ - NCT07439887RecruitingPhase 1/Phase 2
Study of an injection for Stargardt disease
This trial tests a single injection of a new medicine, RTx-021, into the eye for people with Stargardt disease. The goal is to see if it is safe and to find the right dose.
Bakersfield, CaliforniaAges 16 years+ - NCT06962709Enrolling by invitation
Warmed lidocaine for less pain during eye injections
This trial tests whether warming the numbing medicine (lidocaine) before an eye injection reduces pain. If you're already getting an eye injection for any reason, you may be able to join.
Columbia, MissouriAges Any age - NCT05921162Enrolling by invitation
Long-term follow-up after a vision gene eye injection
This study checks how people who previously received a gene therapy eye injection (vMCO-I) are doing over the long term. It may help researchers understand long-lasting effects and safety.
Cuttack, OdishaAges 18 years+ - NCT07064759RecruitingPhase 3
Gene therapy injection for wet age-related macular degeneration
This trial tests a one-time gene therapy injection (4D-150) for wet AMD. It might help reduce the need for frequent anti-VEGF eye injections by targeting the underlying cause of new blood vessel growth.
Scottsdale, ArizonaAges 50 years+ - NCT06894017Recruiting
Same-Day Eye Injections: Patient Preferences Study
This study asks patients who have had a dexamethasone implant in their eye about their preferences for having injections in both eyes on the same day versus separate days. The goal is to understand what patients prefer, which could help make treatment more convenient in the future.
Glostrup MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for intravitreal injections?
- Yes. Clin2 currently lists 29 recruiting intravitreal injections studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a intravitreal injections trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a intravitreal injections trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.