Clinical trials
Knee Pain Arthritis clinical trials
Below are recruiting knee pain arthritis clinical trials, each written for real people, not researchers. We’re tracking 86 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07226258RecruitingPhase 3
Testing SL1002 for knee pain caused by osteoarthritis
This trial tests a study drug called SL1002 to see if it reduces knee pain from osteoarthritis. It may be an option for people with chronic knee pain who haven't found enough relief from current treatments.
Roseville, CaliforniaAges 40 years+ - NCT03048201Recruiting
Total Knee Replacement Registry Study for a Specific Knee Implant
This study tracks outcomes for people getting a total knee replacement using a specific knee implant system. It may help doctors understand which patients do best and how the implant performs over time.
Rancho Mirage, CaliforniaAges 22 years+ - NCT03877653Recruiting
Freedom-1 treatment for long-term knee pain in adults
This study tests a procedure called Freedom-1 to reduce long-term, limiting knee pain from knee arthritis. It may help if other non-surgical options didn’t work and you meet specific knee and health requirements.
Placentia, CaliforniaAges 18 years+ - NCT06105788Recruiting
Exercise and pain relief for knee arthritis
This study looks at how moving your arms and legs might help reduce pain for people with knee osteoarthritis. If you join, you will do some light exercise so researchers can see if it helps your knee feel better.
El Paso, TexasAges 45–90 - NCT06514755Recruiting
Nerve block before artery treatment for knee pain
This study tests a two-step procedure for long-term knee pain that hasn't improved with other treatments. First, the nerves around the knee are numbed, and then the small arteries feeding the painful area are blocked. The goal is to see if doing the nerve treatment before the artery treatment works better for reducing pain.
ZagazigAges 18–80 - NCT07286513Enrolling by invitation
Study of a new knee replacement implant
This study follows patients who receive a specific type of knee replacement implant called the Persona® SoluTion® PPS, to see how well it works over time. If your surgeon recommends this implant and you meet standard health requirements, you may be able to join.
Denver, ColoradoAges 18 years+ - NCT05700682Recruiting
MRI-guided artery blockage procedure for long-term joint pain
This study tests whether an MRI scan that looks at blood flow can help target a joint embolization procedure to reduce chronic shoulder, hip, or knee pain. It first uses MRI to find signs of increased blood flow, then may use the findings to guide treatment if you qualify.
Palo Alto, CaliforniaAges 25–80 - NCT07198750Recruiting
Pulsed magnetic field therapy for knee osteoarthritis in older adults
This trial tests two types of high-intensity pulsed electromagnetic field therapy (one using two modes, another using one mode) to see if they can reduce pain and improve function in older adults with knee osteoarthritis. You would attend 9 treatment sessions and do exercises at home.
Guadalajara, JaliscoAges 60 years+ - NCT07318116Enrolling by invitation
Cabbage Leaf for Knee Osteoarthritis Pain
This study tests whether applying cabbage leaves to the knee can reduce pain in people with knee osteoarthritis. If you have had knee pain for at least 6 months and are not allergic to cabbage, you may be able to join.
Şirnak, MerkezAges 18–80 - NCT07731737Recruiting
Biofeedback vs foam roller for knee osteoarthritis
This trial compares two non-surgical therapies—pressure biofeedback and foam rolling—to see which better reduces pain, improves muscle function, and boosts quality of life in people with early-stage knee osteoarthritis.
LahoreAges 45–65 - NCT07425457Recruiting
Cold nerve treatment before knee replacement surgery
This trial tests a cold therapy on nerves before knee replacement to reduce pain. It may help you recover with less discomfort after surgery.
AthensAges 18 years+ - NCT07671482Recruiting
Kinesio vs McConnell taping for knee pain relief
This study compares two types of taping (Kinesio and McConnell) to see which works better for people with pain behind the kneecap (patellofemoral pain syndrome). You may help researchers learn how to best relieve knee pain during daily activities.
Beirut, BeirutAges 18–50 - NCT06709963Recruiting
Brain stimulation for older adults with chronic back or knee pain
This study tests a type of brain stimulation called intermittent theta burst stimulation to see if it can reduce pain and improve thinking in older adults with long-term back or knee pain. The treatment involves a non-invasive procedure that uses magnetic pulses to stimulate the brain.
Hong KongAges 60–85 - NCT06637709Recruiting
Pain after osteoarthritis treatment: a 24-month study
This study looks at why some people still have pain after knee surgery or other treatments for osteoarthritis. It tests a marker in the blood to see if it relates to ongoing pain. You would be followed for 24 months.
Roma, RomaAges 18–99 - NCT06915363Recruiting
BioPoly implant for knee cartilage repair
This trial tests a BioPoly implant to repair a small damaged cartilage spot in your knee. If you have a specific type of cartilage injury that didn't get better with other treatments, this implant may help relieve pain and improve function.
Fort Wayne, IndianaAges 30–65 - NCT07080892Recruiting
Comparing two ways to give a knee nerve block for pain after knee replacement
This study compares two different ways of giving a nerve block (called iPACK) to see which works better for pain after total knee replacement. The goal is to find the best spot for the injection to help you feel more comfortable after surgery.
BratislavaAges 18–80 - NCT06781463Recruiting
Knee arthritis treatment registry
This study tracks patients with knee arthritis who undergo a procedure called genicular artery embolization (GAE), a minimally invasive option for those not ready for or not eligible for knee replacement. The goal is to see how well GAE works for pain relief.
Chicago, IllinoisAges 18 years+ - NCT07367126Recruiting
Nerve pain in knee osteoarthritis: Pain and function study
This study looks at nerve-related pain in people with knee osteoarthritis and how it affects their pain level and daily function. It may help understand if nerve pain is a key factor in your knee OA symptoms.
IstanbulAges 40–70 - NCT07532070Recruiting
Exercise and Therapy for Chronic Pain and Sleep Problems
This study tests whether exercise, talk therapy for sleep problems, or both together can help people with long-term back, hip, or knee pain who also struggle with sleep. You'll attend video appointments and try one of these approaches for several weeks.
San Antonio, NevadaAges 18 years+ - NCT06239649Recruiting
Nerve block before knee replacement for faster recovery
This trial tests whether a numbing injection (nerve block) around the knee before surgery can help you recover faster and feel less pain after a total knee replacement. It is for people with knee osteoarthritis who are ready for their first knee replacement surgery.
Denizli, PamukkaleAges 40–85 - NCT07464080Recruiting
Brain imaging study for knee replacement patients
This study uses advanced brain scans to understand how pain and recovery change after knee replacement surgery. It may help researchers develop better ways to manage pain after surgery.
Ottawa, OntarioAges 18 years+ - NCT07733518Recruiting
Exercise comparison for knee osteoarthritis
This trial compares two types of exercise—eccentric training and low-load blood flow restriction training—to see which is better for reducing pain and improving function in people with knee osteoarthritis.
Rawalpindi, Punjab ProvinceAges 40–70 - NCT05816798RecruitingPhase 2/Phase 3
Laser treatment to reduce chronic knee pain before weight-surgery
This trial tests whether photobiomodulation (a type of laser/light therapy) can reduce chronic pain in both knees for people preparing for bariatric (weight-loss) surgery. If you have knee pain that limits daily life, the treatment may help you feel better while you’re in the pre-surgery rehabilitation period.
Goiânia, GoiásAges 18–70 - NCT07712419Recruiting
Predicting response to knee nerve block with ultrasound
This study is testing if a type of ultrasound can help predict how well a nerve block injection will work for people with severe knee osteoarthritis. It may help doctors choose the best treatment for your pain.
IstanbulAges 45 years+
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Common questions
- Are there clinical trials for knee pain arthritis?
- Yes. Clin2 currently lists 86 recruiting knee pain arthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee pain arthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee pain arthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.