Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04651673Enrolling by invitation
Knee brace program for adults with knee osteoarthritis pain
This trial looks at using a prescribed knee brace to help relieve knee pain and symptoms from knee osteoarthritis. You may be able to join if your knee braces are being provided through participating clinics and you can consent and complete study questionnaires.
Hässleholm, Skåne CountyAges 18–100 - NCT07879014Recruiting
Quiet knee protocol after knee replacement surgery
This study tests a special recovery plan after knee replacement surgery. It aims to see if this plan helps reduce pain and improve movement. You may be able to join if you are having one knee replaced due to arthritis.
Jacksonville, FloridaAges 18–100 - NCT03949400Recruiting
Exercise therapy and a soft knee brace for knee arthritis
This study tests whether an exercise program plus education, along with a soft brace, helps improve symptoms and function in adults with knee osteoarthritis. It may help people who have knee pain by combining movement training with daily support.
Aalborg, NothernAges 18 years+ - NCT04858347Recruiting
Study of a specific knee implant and recovery outcomes
This trial looks at how well a particular knee replacement (a GEMINI SL fixed-bearing prosthesis) works and how people function after surgery. It may help doctors learn what to expect for recovery and long-term results with this implant.
Cali, Valle del Cauca DepartmentAges 18–80 - NCT04364334Recruiting
Knee care registry for people treated at UMC Utrecht
This study is a “registry,” meaning researchers collect information about your knee care over time. It may help improve understanding and care for people who receive knee treatment at UMC Utrecht.
UtrechtAges Any age - NCT06094660Recruiting
Nerve blocking for knee arthritis pain
This study tests two treatments for knee arthritis pain when knee replacement isn't an option: a nerve block using heat (radiofrequency ablation) or a chemical injection (phenol), compared to standard care. It aims to find a better way to reduce pain and improve daily function.
Hoorn, North HollandAges 35–90 - NCT06127719Recruiting
Surgery wait time and knee replacement quality of life
This study looks at how waiting for knee replacement surgery affects your quality of life. It may help doctors understand how to improve care for people waiting for surgery.
Hoorn, North HollandAges 18–100 - NCT06166628Recruiting
Comparing two procedures for knee osteoarthritis pain
This study compares two minimally invasive procedures—embolization (blocking blood flow) and nerve ablation (blocking pain signals)—to see which works better for knee osteoarthritis pain. If you have long-lasting knee pain and are considering knee replacement surgery, this trial may help find another option.
Kingston, OntarioAges 40 years+ - NCT07871487Recruiting
Brain protein changes after hip or knee replacement surgery
This study looks at whether having hip or knee replacement surgery with spinal anesthesia affects certain proteins in the brain that are linked to memory and thinking. It compares people having surgery with people who have arthritis but are not having surgery, to help understand if the surgery causes any short-term brain changes.
UppsalaAges 55–75 - NCT06433648Recruiting
Powered knee study for above-knee amputee walkers
This study looks at how a powered (motorized) prosthetic knee joint affects walking in people with one above-knee amputation. It aims to find out if the powered knee makes walking easier or more natural.
Chicago, IllinoisAges 18–95 - NCT07838012Recruiting
Early home cycling after knee replacement surgery
This study tests whether starting gentle cycling at home soon after knee replacement surgery is safe and helpful. It aims to see if patients can use a stationary bike to speed up recovery.
Silkeborg, Central JutlandAges 18 years+ - NCT05653102Recruiting
Collecting data on a knee replacement system after surgery
This study collects real-world health and surgery records to better understand how the Truliant total knee replacement performs. It may help doctors and patients by improving future guidance on this knee system’s safety and effectiveness.
Aurora, ColoradoAges 18 years+ - NCT06451510Recruiting
Knee osteoarthritis study in Northern Sweden
This trial studies knee osteoarthritis in people from Norrbotten, Sweden, who broke their tibial plateau between 2001 and 2015. It aims to understand how the injury affects the knee over time.
Luleå, Norrbotten CountyAges 18 years+ - NCT07795008Recruiting
MRI for sports knee injuries
This study uses MRI to look at knee injuries caused by sports. It aims to better understand these injuries and help guide treatment. You may join if your knee injury is sports-related and you haven't had knee surgery or arthritis.
Sohag, Sohag GovernorateAges Any age - NCT07786207Recruiting
Knee cartilage repair registry study
This trial is a registry that collects information from people having knee cartilage repair surgery to learn more about how well these surgeries work over time. You may join if you are scheduled for this type of surgery and can complete online questionnaires.
Parker, ColoradoAges 18 years+ - NCT05120492Recruiting
Program for severe knee arthritis and extreme weight
This feasibility study tests a practical approach to help people with very severe knee arthritis and very high body weight. It aims to find an effective and safe way to manage both conditions together in real-world care.
Halifax, Nova ScotiaAges 18–65 - NCT06608134RecruitingEarly Phase 1
Umbilical cord injection for knee osteoarthritis pain
This trial tests whether a special injection made from umbilical cord tissue can safely help with knee osteoarthritis pain. If you have moderate knee arthritis and haven't had recent injections or surgery, you may be able to join.
Scottsdale, ArizonaAges 30 years+ - NCT07733518Recruiting
Exercise comparison for knee osteoarthritis
This trial compares two types of exercise—eccentric training and low-load blood flow restriction training—to see which is better for reducing pain and improving function in people with knee osteoarthritis.
Rawalpindi, Punjab ProvinceAges 40–70 - NCT07721116Recruiting
AI Study of Knee Imaging and Treatment Results
This study uses artificial intelligence (AI) to better understand knee images from healthy people and those with knee arthritis. It aims to predict how well knee injections might work for you.
Taipei, TaiwanAges 18 years+ - NCT07712419Recruiting
Predicting response to knee nerve block with ultrasound
This study is testing if a type of ultrasound can help predict how well a nerve block injection will work for people with severe knee osteoarthritis. It may help doctors choose the best treatment for your pain.
IstanbulAges 45 years+ - NCT07706569Recruiting
Fetuin-A and COMP levels in knee osteoarthritis
This study looks at two substances in the blood (fetuin-A and COMP) to see if they are linked to knee osteoarthritis severity. Results may help understand the disease better.
AntalyaAges Any age - NCT07703293Recruiting
Testing nerve branches for chronic knee pain relief
This study tests a procedure targeting specific nerve branches in the thigh to treat long-lasting knee pain from osteoarthritis. It may help people who haven't found relief from standard treatments like pain relievers or physical therapy.
AnkaraAges 45–80 - NCT06171204Recruiting
Knee arthritis treatment with your own cells
This trial tests a treatment using your own cells (stromal vascular fraction) to repair knee joint damage and reduce pain. It may help people with knee arthritis, tendon injuries, or persistent knee pain.
Ghent, Oost-VlaanderenAges 18–90 - NCT07653841Recruiting
Balance vs. strength training for knee osteoarthritis
This study compares two types of exercise programs (a balance-focused training and a progressive strengthening program) added to usual physical therapy. The goal is to see which works better for reducing knee pain and improving daily function in people with knee osteoarthritis.
Islamabad, ICTAges 40–70
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.