Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 816 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06124482Recruiting
Study of a new knee replacement implant
This trial tests a new knee replacement implant called the FHK®-CK. It is for people who need a new knee due to arthritis or to replace a failed knee implant.
BeaumontAges 18 years+ - NCT05876143Recruiting
Study of a knee implant with patient follow-up surveys
This trial follows people who already have (or are receiving) a specific partial knee implant to see how they do over time using questionnaires after surgery. It may help improve care for future patients with knee arthritis who get this type of implant.
Pierre-BéniteAges 18 years+ - NCT07597538Recruiting
How Hip Replacement Changes Knee Position and Function
This study examines whether getting a hip replacement changes how your knee aligns and functions. Researchers will compare knee imaging before and after your surgery to understand this connection.
Asyut, Asyut GovernorateAges Any age - NCT07544264Recruiting
Five-Year Knee Replacement Outcomes Study
This study follows patients who receive a new knee joint replacement for severe knee arthritis or similar conditions. Researchers will track how well the artificial knee works and how patients recover over 5 years to ensure the replacement lasts and improves quality of life.
BolognaAges 50–85 - NCT07489963Recruiting
Does keeping the posterior cruciate ligament help after knee replacement?
This trial compares two ways of doing robotic-assisted knee replacement: one that keeps the posterior cruciate ligament (a natural knee stabilizer) and one that doesn't. Researchers will see if saving the ligament leads to better knee function a year after surgery.
BordeauxAges 18 years+ - NCT07183475Recruiting
Returning to sports after knee replacement
This study looks at how well people can get back to sports after having a knee replacement. If you have had a knee replacement and are active in sports, you may be able to join to help researchers learn more about recovery.
Munich, BavariaAges 18–85 - NCT06218238Recruiting
Testing the Ossur Power Knee for above-knee amputees
This study tests a new bionic knee called the Ossur Power Knee for people with an above-knee amputation. It looks at how well the knee helps with walking and balance, which may lead to better mobility.
Chicago, IllinoisAges 45–75 - NCT07454356Recruiting
Device to help knee bending after replacement
This study tests a non-surgical device called Knee Flexionater to help people who have limited knee bending after total knee replacement. The goal is to improve knee motion and avoid a second surgery.
Houston, TexasAges 40 years+ - NCT06569836Recruiting
Study on digital program for chronic knee pain
This trial tests a digital program to help people manage chronic knee pain. If you are 55 or older and have had knee pain recently, this study may be a good fit.
Hong KongAges 55 years+ - NCT05653102Recruiting
Collecting data on a knee replacement system after surgery
This study collects real-world health and surgery records to better understand how the Truliant total knee replacement performs. It may help doctors and patients by improving future guidance on this knee system’s safety and effectiveness.
Aurora, ColoradoAges 18 years+ - NCT07351968RecruitingPhase 1
Study of HRS-2129 for knee osteoarthritis pain
This trial tests an investigational drug, HRS-2129, for people with knee osteoarthritis who have moderate to severe pain. It aims to see if the drug is safe and effective at reducing pain.
Nanjing, JiangsuAges 18–80 - NCT07324954RecruitingPhase 1
Methylene blue for knee replacement surgery
This study tests if using a blue dye called methylene blue during knee replacement surgery can help doctors see and clean out infections better. It may help people having a first-time knee replacement or those with an infected knee replacement.
Miami, FloridaAges 18 years+ - NCT06293352Recruiting
Comparing two antibiotic spacers for knee infection
This trial compares two types of antibiotic spacers for people with a long-term knee replacement infection. It tests whether a spacer made entirely of antibiotic cement or one with a metal core works better to treat the infection before a new knee replacement.
Chicago, IllinoisAges 18 years+ - NCT07584915Enrolling by invitationPhase 4
Pain Relief Method Comparison for Knee Replacement Surgery
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Los Angeles, CaliforniaAges 18 years+ - NCT07319546Recruiting
Faster recovery after first knee replacement
This study tests a faster, more active recovery program for people having their first total knee replacement. It may help you get back to daily activities sooner after surgery.
Dali, YunnanAges 50–80 - NCT07003932Recruiting
Remote monitoring after knee replacement surgery
This trial tests a remote monitoring program for people having knee replacement surgery. It uses a smartphone app to track your recovery, so you can stay in touch with your care team without needing extra clinic visits.
Oslo, Please SelectAges 50 years+ - NCT06969222Recruiting
Robotic knee replacement study with a special implant
This study tests a robot-assisted knee replacement using a new type of implant designed to move more like a natural knee. It may help people with arthritis or other knee joint problems who need a total knee replacement.
Larissa, ThessalyAges 18–95 - NCT07348614RecruitingPhase 4
Knee manipulation: best numbing method for less pain
This study tests different numbing techniques to see which works best for pain during a knee manipulation procedure. It may help you have less pain and a smoother recovery.
Durham, North CarolinaAges 18–75 - NCT06608745Recruiting
Computer-assisted vs standard knee replacement study
This trial compares a computer-assisted technique to the standard method for total knee replacement. It aims to see if the computer-assisted approach leads to better clinical and functional outcomes.
BolognaAges 45 years+ - NCT07491575Recruiting
Evaluation of the 5C MEDic knee replacement system
This study tests a new knee replacement system (the 5C® MEDic Knee) in people having knee surgery at Leuven University Hospital. It aims to see how well the implant works for conditions like arthritis, fractures, or revision of a previous knee replacement.
Leuven, Vlaams-BrabantAges 18 years+ - NCT06171204Recruiting
Knee arthritis treatment with your own cells
This trial tests a treatment using your own cells (stromal vascular fraction) to repair knee joint damage and reduce pain. It may help people with knee arthritis, tendon injuries, or persistent knee pain.
Ghent, Oost-VlaanderenAges 18–90 - NCT07721116Recruiting
AI Study of Knee Imaging and Treatment Results
This study uses artificial intelligence (AI) to better understand knee images from healthy people and those with knee arthritis. It aims to predict how well knee injections might work for you.
Taipei, TaiwanAges 18 years+ - NCT07712419Recruiting
Predicting response to knee nerve block with ultrasound
This study is testing if a type of ultrasound can help predict how well a nerve block injection will work for people with severe knee osteoarthritis. It may help doctors choose the best treatment for your pain.
IstanbulAges 45 years+ - NCT07706569Recruiting
Fetuin-A and COMP levels in knee osteoarthritis
This study looks at two substances in the blood (fetuin-A and COMP) to see if they are linked to knee osteoarthritis severity. Results may help understand the disease better.
AntalyaAges Any age
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 816 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.