Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 813 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05391828Recruiting
Testing a new knee robot and app support for knee arthritis
This study looks at whether a robot-assisted knee replacement plus remote tracking with an Apple Watch and a smartphone app helps people do better after surgery. You may be eligible if you’re an adult getting a planned (not replacement) knee surgery for arthritis and can use the required devices.
New York, New YorkAges 18 years+ - NCT05381818Recruiting
Breathing muscle training before joint surgery
This trial tests whether strengthening breathing muscles before total joint surgery can lower the chance of lung complications after the operation. It may help people who already have breathing problems or a history of smoking.
Jacksonville, FloridaAges 18–100 - NCT05323474Recruiting
Rehab program after ACL surgery to return to competitive sport
This study tests an “optimized” rehabilitation plan after ACL reconstruction to help people safely return to competitive sports. It’s for people who had an ACL surgery and still want to play sports that involve cutting, pivoting, or contact.
Challes-les-EauxAges 18–25 - NCT05344001Recruiting
Study links past sports injuries and low activity to later health
This study looks at how an earlier sports injury and time spent being inactive may relate to later health problems. It mainly needs specific age groups and either current/former collegiate athletes or non-athlete comparison participants.
Milwaukee, WisconsinAges 18–64 - NCT05124652Recruiting
Testing a prosthetic socket that adjusts automatically
This trial is testing a prosthetic socket that can automatically adjust to help fit better and feel more comfortable. It may help people with below-knee (transtibial) amputations who currently struggle with socket fit or comfort.
Seattle, WashingtonAges 18 years+ - NCT05112302Enrolling by invitation
Virtual reality during orthopedic anesthesia
This study tests whether using virtual reality during hip or knee surgery (while you’re receiving a nerve block for anesthesia) helps make the experience more comfortable. You’d try the VR during your procedure, and the team will compare outcomes with usual care.
Jackson, FloridaAges 18 years+ - NCT05073263Recruiting
Full versus partial weight bearing after FCL ligament repair
This study compares two rehab plans: doing full weight bearing versus partial weight bearing during the first 6 weeks after fibular collateral ligament (FCL) reconstruction. It may help figure out which approach is safer and better for healing and recovery.
Edina, MinnesotaAges 14–59 - NCT04816773Enrolling by invitation
Long-term follow-up for specific knee replacement parts
This study follows people for up to 10 years after a knee replacement done with specific manufacturer parts. It helps the company and doctors understand how well these knee implants work and whether they cause any long-term problems.
Fremont, CaliforniaAges 21 years+ - NCT04660955Enrolling by invitation
10-year follow-up MRI after ACL surgery in young athletes
This study uses an MRI scan to look at knees 10 years after ACL reconstruction. It helps researchers understand how the knee changes over time after sports-related ACL injury, and how well reconstruction lasts.
Cleveland, OhioAges 22–45 - NCT04554212Recruiting
Blood flow restriction therapy after kneecap instability
This trial tests whether a special exercise method called blood flow restriction training can help people recover faster and get back to running and pivoting activities after a kneecap (patella) that slips out of place. It may help strengthen the knee while you go through physical therapy.
Lexington, KentuckyAges 14–40 - NCT04576078RecruitingPhase 2
Nefopam for less pain after knee replacement surgery
This Phase 2 study tests whether oral nefopam can reduce pain after total knee replacement done with spinal anesthesia. It looks at whether this medicine works better than the usual post-surgery pain plan and how safely it can be used.
Lyon, LyonAges 18–75 - NCT04389749Recruiting
Continuous passive motion after certain hip or leg fractures
This trial studies whether a device that gently moves your leg helps recovery after surgery for specific hip or knee fractures. It may help with healing and getting you back to moving more comfortably sooner, compared with not using the device.
Cincinnati, OhioAges 18 years+ - NCT04109638Recruiting
PEMF therapy to reduce pain after shoulder or knee surgery
This trial studies whether PEMF, a type of non-surgical device that uses pulsed electromagnetic fields, can reduce pain after shoulder or knee surgery. If you join, you’ll also be expected to do post-surgery physical therapy exercises and report your pain and function.
Redwood City, CaliforniaAges 18 years+ - NCT03908931Recruiting
Study of knee cartilage repair results
This study looks at how well certain types of knee cartilage repair work, using clinical check-ins and imaging (scans). You may be able to help researchers understand which method restores knee surface cartilage best.
Le ChesnayAges 18 years+ - NCT03747146Recruiting
Enhanced recovery plan for knee replacement pain control
This study tests an “enhanced recovery” approach for people getting total knee replacement, focused on better pain control using regional anesthesia and a home pain medicine plan. It may help you recover more comfortably and follow the care plan more smoothly after surgery.
New York, New YorkAges 18–65 - NCT03484325Enrolling by invitation
Patient registry for joint replacement and related surgeries
This trial is a “registry,” meaning it collects information from people who choose certain elective joint surgeries. It may help doctors better understand outcomes and safety after procedures like hip and knee operations.
Houston, TexasAges 18–100 - NCT02993029Recruiting
Fluoride scan–guided treatment for painful knee arthritis
This trial studies a targeted treatment using a fluoride-related injection to help reduce pain from knee osteoarthritis. To join, you need a painful osteoarthritis knee and a specific bone-scan finding (SUV above 10) on an imaging test.
Shanghai, Shanghai MunicipalityAges 40 years+ - NCT02918734Recruiting
ACL surgery: compare two ways to secure the tendon graft
This study looks at two surgical methods to attach the tendon graft during ACL reconstruction, using either an Endobutton or metal interference screws. It may help patients by improving how securely the graft is fixed and how well recovery goes.
TrondheimAges 18–55 - NCT02771496Recruiting
Study of knee cartilage injury diagnosis using imaging
This study looks at people with a specific knee cartilage problem called osteochondritis dissecans (or a focal cartilage defect). It uses X-rays or MRI scans to confirm the diagnosis, which helps researchers understand the condition and how it’s identified.
Philadelphia, PennsylvaniaAges Any age - NCT02604563Recruiting
Aging, blood changes, and health in older adults
This study examines why some older adults develop changes in their blood cells that may affect their health. Researchers will look for links between these blood changes, aging, and common health problems in older people.
St Louis, MissouriAges 50 years+ - NCT02503228Enrolling by invitation
Registry study of a preserved bone-cartilage graft
This registry study follows people who get a preserved graft to repair damaged bone and cartilage in a joint. It helps doctors understand how well the graft is preserved and how patients do after surgery over time.
Columbia, MissouriAges 13 years+
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 813 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.