Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 837 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04814082Recruiting
Compare two knee implant types for walking and function
This study compares two designs of knee replacement implants to see how they affect walking, function, and outcomes after surgery. You may be randomly assigned to one of the implant types used for your specific, approved knee replacement.
Baltimore, MarylandAges 18–75 - NCT03048201Recruiting
Total Knee Replacement Registry Study for a Specific Knee Implant
This study tracks outcomes for people getting a total knee replacement using a specific knee implant system. It may help doctors understand which patients do best and how the implant performs over time.
Rancho Mirage, CaliforniaAges 22 years+ - NCT07575555Recruiting
Lipedema's role in knee arthritis in women
This study compares women with knee arthritis who do or don't have lipedema (a condition causing painful fat buildup, usually in the legs) to understand how lipedema affects knee joint health. Results may help doctors better treat knee arthritis in women with lipedema.
Izmir, İzmirAges 30–65 - NCT07522489Recruiting
New knee replacement surgery guidance methods compared
This study compares two ways doctors use computer guidance during robotic knee replacement surgery for severe knee arthritis. The trial tests whether both methods work equally well or if one is better for patient recovery and results.
Warsaw, MazovianAges 18 years+ - NCT05290818Recruiting
Robotic vs standard knee replacement for inner-joint wear
This trial compares robotic-assisted knee replacement with the usual (non-robotic) approach for people with severe arthritis on the inner (medial) side of the knee. It aims to see which method works better for pain and function while matching the right knee anatomy for certain implant types.
Edinburgh, LothianAges 50–75 - NCT06839807Recruiting
Testing a new device for knee replacement loosening
This study tests a new device (AtMoves Knee System) to help diagnose if a knee replacement is loose. It is for people who have had a knee replacement and have symptoms that might mean the implant is loose, but standard tests have not given a clear answer.
Nijmegen, GelderlandAges 18 years+ - NCT06010979Recruiting
Knee replacement with digital help study
This study looks at knee replacement surgery done with digital tools like robots or computer guidance. It may help people with knee arthritis find better ways to have surgery and recover.
Beijing, Beijing MunicipalityAges Any age - NCT06968143Recruiting
Patient Satisfaction With Smart Knee Implants Trial
This trial looks at how satisfied patients are with a new 'smart' knee implant that tracks motion and function. If you are getting a total knee replacement, you might be able to join and help compare the smart implant with standard implants.
Chicago, IllinoisAges 18 years+ - NCT07121556Recruiting
Fat tissue vs fat tissue plus gel for knee osteoarthritis
This trial compares two injections for knee arthritis: one uses your own fat tissue, the other adds a lubricating gel. Researchers want to see if the combination helps pain and function more than fat tissue alone.
BolognaAges 18–75 - NCT07552415Recruiting
Joint Immobilization After Knee Replacement Revision Surgery
This study tests whether keeping your knee still for a period after revision knee replacement surgery helps improve how well you can bend and straighten it. Researchers want to see if immobilization (using a brace or cast) helps you regain better movement compared to standard care.
New York, New YorkAges 18 years+ - NCT06880497Recruiting
Comparing knee sounds after two types of knee replacement
This study compares how much noise the knee makes (and how it feels to the patient) after two different kinds of total knee replacement surgery. It aims to help patients know what to expect after surgery.
AuxerreAges 18 years+ - NCT06203756Enrolling by invitation
Robotic-Assisted Knee Replacement Outcomes Study
This study tests a robotic-assisted system for knee replacement surgery. It aims to see how well patients do with the robotic help.
Flagstaff, ArizonaAges Any age - NCT04095637Recruiting
Compare two types of partial knee replacement surgeries
This study compares two implant types used for a partial knee replacement (only the inside/medial part) for people with “wear-and-tear” arthritis in that compartment. It looks to see which option leads to better outcomes after surgery and follow-up.
LondonAges 40–80 - NCT03286868Recruiting
Tested knee replacement alignment during knee surgery
This study looks at how a specific computer/measurement approach (“Verasense”) helps position the knee during total knee replacement for people with knee arthritis. It may help improve how the new knee fits and aligns as you recover.
Halifax, Nova ScotiaAges 21–80 - NCT04247672Recruiting
Study of knee replacement outcomes using a specific knee implant
This study follows people who need knee replacement for “end-stage” knee osteoarthritis and will receive a specific knee implant system as part of routine care. It aims to measure how well the knee replacement works for patients over time, which may help improve future care.
Hoofddorp, North HollandAges 21–90 - NCT04275362Recruiting
Walking analysis after a specific knee replacement design
This study looks at how people walk after receiving a particular total knee replacement design. It compares movement patterns (gait analysis) to help understand how well the knee works in real life.
Phoenix, ArizonaAges 50 years+ - NCT05980442Recruiting
Navigation vs robotic-arm assisted knee replacement
This study compares two different high-tech tools used during total knee replacement surgery: one that uses a navigation system (OrthoPilot) and one that uses a robotic arm (MAKO). The goal is to see if one method leads to better results. If you're having a total knee replacement, this trial could help your surgeon choose the best approach.
Ulm, Baden-WurttembergAges 18–90 - NCT06194838Recruiting
Mechanical vs. powered knee for above-knee amputees
This study compares a non-powered (mechanical) knee to a powered (battery-assisted) knee for people with above-knee amputations who walk at a moderate level (K2). It will help find out which knee type works better for your daily activities and mobility.
Austin, TexasAges 18 years+ - NCT06264076Recruiting
Ligament balancing in knee replacement
This trial tests a new method of balancing the ligaments during total knee replacement. If you are generally healthy and need a first-time knee replacement due to arthritis, you may be eligible.
Bærums verk, AkershusAges 40 years+ - NCT06915363Recruiting
BioPoly implant for knee cartilage repair
This trial tests a BioPoly implant to repair a small damaged cartilage spot in your knee. If you have a specific type of cartilage injury that didn't get better with other treatments, this implant may help relieve pain and improve function.
Fort Wayne, IndianaAges 30–65 - NCT06676189Recruiting
Comparing two types of plastic knee implants for replacement
This study compares two different types of plastic knee implants (polyethylene) used in total knee replacement surgery. The goal is to see which one works best for patients with knee arthritis.
Clermont-FerrandAges 18–90 - NCT06726629Recruiting
Italian Knee Questionnaire Study
This study is testing a new Italian version of a questionnaire that measures how your knee feels and works after knee replacement. The goal is to make sure the questionnaire is accurate for Italian-speaking patients.
BolognaAges 18–85 - NCT06859164RecruitingPhase 2
Knee artery treatment for chronic osteoarthritis pain
This trial tests a procedure called genicular artery embolization to reduce pain in people with knee osteoarthritis that hasn't improved with other treatments. The goal is to see if blocking certain blood vessels can relieve pain and help you avoid or delay knee replacement surgery.
Chicago, IllinoisAges 40–80 - NCT06891807Recruiting
Robotic vs augmented reality knee replacement
This study compares two advanced technologies for total knee replacement: a robot that uses a CT scan for guidance versus an augmented reality system that uses no scan. The goal is to see which approach leads to better outcomes for patients with osteoarthritis.
Sint-Martens-Latem, Oost-VlaanderenAges 18–85
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 837 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.