Clinical trials
Lidocaine clinical trials
Below are recruiting lidocaine clinical trials, each written for real people, not researchers. We’re tracking 133 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07675616Recruiting
Comparing two drugs for numbing the eye before tear-duct surgery
This trial tests whether adding dexmedetomidine or magnesium sulfate to lidocaine makes numbing the eye more effective for tear-duct surgery. The goal is to find which combination provides better pain control during surgery.
CairoAges 18 years+ - NCT06427707RecruitingPhase 2/Phase 3
Adding propofol or ketamine to magnesium and lidocaine for nasal surgery
This trial tests whether adding propofol or ketamine to a standard combination of magnesium and lidocaine improves pain control and recovery for people having nasal surgery. It aims to find a better way to manage anesthesia and reduce side effects.
Cairo, Cairo GovernorateAges 18–60 - NCT07648784Recruiting
Pain Relief Comparison for Lower Leg Surgery
This trial tests different combinations of two numbing medicines (lidocaine and bupivacaine) given through the spine to manage pain during lower limb surgery. The goal is to find which mixture works best and lasts longest.
Karachi, SindhAges 20–60 - NCT07268495Recruiting
Lidocaine spray to reduce pain after fibroid surgery
This trial tests if spraying lidocaine (a numbing medicine) inside the belly along with lidocaine given through an IV can lower pain after surgery to remove uterine fibroids. It may help you have less pain and recover more comfortably.
Yinchuan, NingxiaAges 18–65 - NCT07062367Recruiting
Anesthesia options for laparoscopic hysterectomy and brain health
This study compares three ways to give anesthesia during laparoscopic hysterectomy: one type of gas (sevoflurane) with or without a lidocaine IV drip, versus a different IV anesthesia (propofol). The goal is to see which approach best protects pressure inside your head and oxygen levels in your brain during surgery.
Tanta, El-GharbiaAges 18–65 - NCT07700108RecruitingPhase 2
Pain relief for epidural needle insertion in pregnant women
This study compares two ways to numb the skin before placing an epidural needle: a lidocaine patch placed on the back versus a lidocaine injection under the skin. The goal is to find which method is more comfortable for pregnant women during labor or cesarean delivery.
Columbus, OhioAges 18 years+ - NCT07193836Enrolling by invitation
Lidocaine for easier recovery after laparoscopic surgery
This study tests whether giving lidocaine (a numbing medicine) through an IV can help you wake up more smoothly and with less discomfort after laparoscopic gallbladder or gynecologic surgery. If you are generally healthy and having one of these specific surgeries, you may be a good fit.
Yinchuan, NingxiaAges 18–70 - NCT07327905Recruiting
Lidocaine or dexmedetomidine for pain during weight-loss surgery
This trial compares two medicines given through an IV during sleeve gastrectomy (weight-loss surgery) to see which provides better pain control. It may help patients have a smoother recovery with less discomfort.
AlexandriaAges 20–50 - NCT07141589Recruiting
Comparing pain relievers added to numbing for eye surgery
This study compares two medicines (fentanyl and ketorolac) added to the numbing injection used during eye surgery. The goal is to see which one works better to reduce pain and make the surgery more comfortable.
CairoAges 18 years+ - NCT07661758RecruitingPhase 3
Lidocaine to prevent headache after C-section
This trial tests if giving lidocaine through an IV can prevent the headache that sometimes happens after spinal anesthesia during a planned C-section. If you are having a planned C-section with spinal anesthesia and meet other health requirements, this study might help reduce your risk of post-procedure headache.
Tanta, Gharbia GovernorateAges 18 years+ - NCT06768580Recruiting
Melatonin or lidocaine to prevent confusion after hip replacement
This trial tests if giving either oral melatonin or lidocaine during surgery can reduce the chance of confusion (delirium) in older adults after total hip replacement. It compares these two approaches to standard care.
Tanta, El-GharbiaAges 65 years+ - NCT06910644Recruiting
Pain relief after mastectomy: dexmedetomidine vs lidocaine
This trial tests whether adding dexmedetomidine or lidocaine to anesthesia during mastectomy helps reduce long-term pain after surgery. It's for women with breast cancer undergoing mastectomy with lymph node removal.
CairoAges 18–75 - NCT06960317Recruiting
Numbing injection for IUD placement pain
This study tests whether a numbing injection (lidocaine) in the cervix can reduce pain during IUD placement. It's for women who have never had a vaginal birth and are getting their first IUD.
La Jolla, CaliforniaAges 18–50 - NCT07034300RecruitingPhase 4
Comparing lidocaine with and without dexmedetomidine for arm surgery
This trial tests whether adding dexmedetomidine to lidocaine works better for numbing the arm during surgery. Patients get numbing medicine through a special IV in the arm while the surgery is happening.
Lahore, Punjab ProvinceAges 18–60 - NCT07061847RecruitingPhase 2
Lidocaine infusion for severe chronic migraines
This trial tests if a lidocaine infusion into an artery in the head can reduce severe chronic daily headaches. It is for people who have tried multiple treatments without enough relief.
Great Neck, New YorkAges 18–75 - NCT07073846RecruitingPhase 4
Lidocaine and dexmedetomidine for pain after weight-loss surgery
This study tests whether adding two medicines (lidocaine and dexmedetomidine) to your anesthesia during weight-loss surgery can reduce pain, swelling, and stress on the body. It might help you have a smoother recovery.
Mexico City, Mexico CityAges 18–60 - NCT07108764Recruiting
Medicine to prevent confusion after abdominal surgery in seniors
This trial tests giving either lidocaine or dexmedetomidine during abdominal surgery to see if it helps keep the brain healthy and lowers the chance of waking up confused or agitated. It is for older adults having planned abdominal surgery who are otherwise in fairly good health.
Tanta, El-GharbiaAges 65 years+ - NCT07294118RecruitingPhase 2
Lidocaine and steroids for pain after brain bleed
This trial tests whether giving a numbing medicine (lidocaine) and steroids into the artery that covers the brain can help reduce pain after a brain bleed. It may be an option for people with a specific type of bleeding who have not had certain brain surgeries or procedures.
Galveston, TexasAges 18–100 - NCT07390851Recruiting
Magnesium with lidocaine for jaw and neck muscle trigger points
This trial tests whether adding magnesium to lidocaine makes trigger point injections more effective for jaw, face, or upper shoulder pain. The results will be measured by pain scales and muscle activity tests.
Giza, Giza GovernorateAges 18–70 - NCT06785987Enrolling by invitationPhase 4
Lidocaine Drip During Thyroid Surgery with Nerve Monitoring
This study tests whether giving a continuous lidocaine drip during open thyroid surgery can improve pain control and recovery. Lidocaine is a numbing medicine, and researchers want to see if it helps without interfering with the nerve monitor used during surgery.
Kaohsiung, TaiwanAges 20–75 - NCT07780760Recruiting
Numbing throat spray to ease pain after tonsil removal in children
This study tests whether a numbing mist sprayed into the throat before surgery can reduce sore throat pain children feel after having their tonsils removed. It compares two numbing medicines to see if one works better than the other.
Al FayyumAges 3–15 - NCT07566286Recruiting
Safety Study of Restylane Lyft for Chin Enhancement
This study tests the safety of a dermal filler (Restylane Lyft) used to enhance and reshape the chin. If you're interested in chin augmentation, this trial may help you receive the treatment while contributing to safety data.
Westport, ConnecticutAges 22 years+ - NCT05072314RecruitingPhase 3
Lidocaine drip after breast surgery to improve long-term pain
This Phase 3 study tests whether a long-running lidocaine (a numbing medicine) drip given around the time of breast surgery can improve long-term post-surgery pain and recovery. It may help people who have pain after mastectomy or breast-conserving surgery.
Kingswood, New South WalesAges 18 years+ - NCT05885230Recruiting
Pain relief after heart surgery: nerve block vs lidocaine drip
This trial compares two ways to manage pain after open-heart surgery: an ultrasound-guided nerve block (PIFB) versus lidocaine given through a vein. The goal is to see which method works better and helps you recover more comfortably.
Banī Suwayf, e\EYGPTAges 18–75
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Common questions
- Are there clinical trials for lidocaine?
- Yes. Clin2 currently lists 133 recruiting lidocaine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lidocaine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lidocaine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.