Clinical trials
Liver Cancer clinical trials
Below are recruiting liver cancer clinical trials, each written for real people, not researchers. We’re tracking 366 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06717295Recruiting
Blood test to find cancer early and track treatment
This study uses a blood test that looks at your platelets and immune cells to find common cancers early, and for certain cancers, to monitor how well treatment is working.
RosarioAges 40–75 - NCT05492136Recruiting
Radiofrequency during liver surgery to reduce cancer coming back
This study looks at whether using radiofrequency (a heat-based treatment used during surgery) during liver surgery can lower the chances that cancer returns locally. It includes people with colorectal cancer that has spread to the liver and people with liver cancer (HCC).
BarcelonaAges 18 years+ - NCT06287723Recruiting
Blood test for cancer DNA after liver surgery in colorectal cancer
This study uses a simple blood test (liquid biopsy) to look for tiny bits of cancer DNA after surgery for colorectal cancer that spread to the liver. It aims to see if this test can find cancer earlier than standard scans, which may help guide future treatment decisions.
MontpellierAges 18 years+ - NCT05588388RecruitingPhase 2
Testing bevacizumab with chemo and immunotherapy for small cell lung cancer
This Phase 2 trial studies whether adding bevacizumab to chemo plus immunotherapy (including atezolizumab) can improve outcomes in extensive-stage small cell lung cancer (ES-SCLC) that has spread to the liver. It may help by blocking tumor blood vessel growth while boosting anti-cancer immune and treatment effects.
Los Angeles, CaliforniaAges Any age - NCT05398380Recruiting
Liver transplant for colorectal liver cancer that can’t be removed
This trial studies liver transplantation for certain people with colorectal cancer that has spread only to the liver and cannot be removed with surgery. It aims to improve outcomes for carefully selected patients whose cancer is controlled on chemotherapy and who meet specific safety and scan requirements.
Barcelona, BarcelonaAges 18–70 - NCT03488953Recruiting
Two-step liver surgery using a living donor transplant
This study looks at a specialized liver transplant approach using a living donor, for people with colorectal cancer that has spread only to the liver and cannot be removed by standard surgery. It’s meant for cases where chemotherapy has helped stop or shrink the tumors, to improve the chance of successful treatment.
JenaAges 18 years+ - NCT06111105Recruiting
Comparing blood tests to guide colon cancer treatment
This study compares different blood tests to find the best way to detect tiny bits of cancer DNA after surgery for stage III colorectal cancer. It aims to help doctors decide if additional chemotherapy is needed to prevent the cancer from coming back.
Graz, StyriaAges 18 years+ - NCT06478108RecruitingPhase 2/Phase 3
Software-guided multi-immunotherapy for solid tumors
This trial tests a new software-guided approach to deliver multiple immunotherapy drugs directly into the liver for people with solid tumors. It aims to see if this method can shrink tumors and improve survival.
Guangzhou, GuangdongAges 18–75 - NCT06873659RecruitingPhase 1
Testing SON-DP for advanced solid tumors
This trial tests a new drug called SON-DP for people with advanced solid tumors that haven't responded to standard treatments. It aims to see if the drug is safe and helps shrink or control the cancer.
Beijing, Beijing MunicipalityAges 18–75 - NCT07298577Enrolling by invitation
Using blood test and ultrasound to find early liver cancer in Asia
This study tests whether adding a simple blood test (GAAD score) to a routine liver ultrasound can find early-stage liver cancer sooner in people with chronic liver conditions. It aims to improve detection in Asian populations at risk.
Bangkok Noi, BangkokAges 18 years+ - NCT04868149RecruitingPhase 3
Laparoscopic versus open ALPPS to regrow liver before surgery
This study compares two ways of doing a staged liver surgery (ALPPS) to help regrow enough liver for people with certain liver cancers. It looks at outcomes and how well the remaining liver grows after surgery, using different surgical approaches.
Hong KongAges 18 years+ - NCT04115254Recruiting
MRI-guided focused radiation for certain tumors
This study tests a type of high-precision radiation guided by MRI pictures to treat certain cancers. It may help doctors deliver radiation more accurately while avoiding nearby healthy tissue, but you must be able to safely complete an MRI scan and meet tumor-size and health requirements.
Boston, MassachusettsAges 18 years+ - NCT04912765RecruitingPhase 2
New immune vaccine plus nivolumab for liver cancer
This trial studies whether an individualized “neoantigen” cancer vaccine given to immune cells (dendritic cells) plus nivolumab can improve outcomes in people with liver cancer and/or colorectal cancer that has spread only to the liver. It focuses on tumors that can be removed with curative surgery (with or without local ablation) and on people with good enough liver and overall health.
SingaporeAges 21 years+ - NCT06475352RecruitingPhase 2
Tailoring chemo dose for GI cancer patients low in a liver enzyme
This trial tests whether adjusting the dose of chemotherapy drugs (5-FU or capecitabine plus oxaliplatin) based on a liver enzyme test can improve safety and effectiveness for people with gastrointestinal cancer who are starting this type of chemo for the first time.
AmiensAges 18 years+ - NCT02185443RecruitingPhase 2
SBRT radiation for liver metastases that can’t be surgically removed
This trial studies stereotactic body radiation therapy (high-precision radiation given in a few sessions) for liver metastases when surgery isn’t possible. It may help shrink or control tumors in the liver and delay progression in people whose cancer has not spread outside the liver (or only to areas treated with a curative plan).
São Paulo, São PauloAges 18 years+ - NCT05181826Recruiting
Blood collection study for cancer and benign diseases
This study collects blood samples from people with different health conditions (cancer, diabetes, liver disease, etc.) and from healthy volunteers. The goal is to find markers in the blood that could help detect or monitor diseases.
Redondo Beach, CaliforniaAges 18 years+ - NCT06681818Recruiting
New method to measure liver regrowth after surgery
This study tests a new way to measure how well your liver grows back and heals after part of it is removed. The goal is to predict and prevent complications after surgery.
Englewood, New JerseyAges 18 years+ - NCT05248581Recruiting
Living donor liver transplant for unresectable colon cancer spread
This trial looks at using a living donor liver transplant for people whose colon or rectal cancer has spread to the liver in a way that can’t be removed with standard surgery. It may help if you might otherwise have limited options because your liver surgery would be too risky.
Rochester, New YorkAges 18 years+ - NCT07070362Recruiting
Digital early warning system for lung injury after liver surgery
This trial tests a digital early warning system to detect acute lung injury after liver surgery. It may help doctors catch breathing problems early so they can treat them faster.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05098197RecruitingEarly Phase 1
Study of TIL cell therapy for advanced liver, bile, or pancreas cancer
This trial studies a treatment called TIL therapy, which uses your own immune cells grown from a tumor sample, to treat advanced cancers of the liver/bile ducts or pancreas. It’s mainly for people whose standard treatments have already failed (or none exist), and who can safely provide tumor tissue for the cell preparation.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04657042Recruiting
4D MRI scans to guide lung or liver cancer radiation
This trial tests whether special “4D” MRI scans can improve precision radiation planning for people with lung or liver cancer. You may get MRI scan data to better account for tumor movement, alongside your usual radiation treatment.
Charlottesville, VirginiaAges 18–82 - NCT04731558RecruitingPhase 4
Blood clot prevention before versus after liver surgery
This study compares two approaches to preventing blood clots around the time of liver surgery. If you’re having planned liver surgery, it may help doctors choose the safest timing and method for clot prevention.
HelsinkiAges 18 years+ - NCT04745390Recruiting
Testing a tailored radiation dose plan for liver tumors
This study compares a standard radiation dose plan versus a plan that adjusts the dose based on how the tumor responds to radiation-related measurements. It aims to improve how well stereotactic body radiation therapy (SBRT) treats liver cancer while keeping side effects manageable.
London, OntarioAges 18 years+ - NCT05199259Recruiting
Blood test study for people at risk for or with liver cancer
This trial tests a new blood test to help detect liver cancer (HCC) or confirm it’s not present in people with cirrhosis who are being monitored. It may help improve how doctors screen for liver cancer and decide who needs further imaging or treatment.
Escondido, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for liver cancer?
- Yes. Clin2 currently lists 366 recruiting liver cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a liver cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a liver cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.