Clinical trials
Liver Metastases From Colorectal Cancer clinical trials
Below are recruiting liver metastases from colorectal cancer clinical trials, each written for real people, not researchers. We’re tracking 271 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06185556RecruitingPhase 2/Phase 3
New treatments for liver tumors near blood vessels or bile ducts
This trial tests two procedures—irreversible electroporation and stereotactic body radiotherapy—for people whose colorectal cancer has spread to the liver (1–3 tumors near major blood vessels or bile ducts) and can't be surgically removed or treated with heat. The goal is to see if these approaches can safely destroy those hard-to-reach tumors.
Amsterdam, North HollandAges 18 years+ - NCT06191120Recruiting
FAPI PET scan for aggressive colorectal cancer liver metastases
This trial uses a special PET scan (FAPI) to detect a specific, more aggressive type of colorectal cancer (CMS4) in people who have liver tumors that can be surgically removed. The goal is to see if the scan can help doctors choose the best treatment for you.
Utrecht, UtrechtAges 18 years+ - NCT06200831Recruiting
Same surgery or two surgeries for colorectal cancer with liver spread
This trial compares having one surgery to remove both the colon tumor and liver tumors at the same time versus having two separate surgeries. It aims to find which approach is safer and works better for patients whose cancer has spread only to the liver.
OsloAges 18–80 - NCT06207656RecruitingPhase 2
Targeted therapy for BRAF V600E mutated colorectal cancer
This trial tests if combining three targeted drugs (cetuximab, encorafenib, and binimetinib) before surgery can shrink or control cancer in people with a specific BRAF V600E mutation and a stable (MSS) tumor. It focuses on colorectal cancer that is either already able to be removed or could become removable with treatment.
MadridAges 18 years+ - NCT06208397Recruiting
MRI study to understand liver tumor growth patterns
This trial uses MRI scans to study how colorectal cancer that has spread to the liver grows. It may help doctors choose better treatments.
Shenyang, LiaoningAges 18–80 - NCT06225843RecruitingPhase 2
Testing a new drug combo before liver surgery for colorectal cancer
This trial is for people with colorectal cancer that has spread to the liver. It tests whether adding a new drug (sotevtamab) to standard chemotherapy (FOLFOX) before surgery can help shrink tumors and improve outcomes.
Montreal, QuebecAges 18 years+ - NCT06253871RecruitingPhase 1
Study of IAM1363 for HER2 Cancers
This trial tests a new oral drug called IAM1363 for people with HER2-altered cancers that have stopped responding to previous treatments. The goal is to see if the drug is safe and how well it works against these cancers.
La Jolla, CaliforniaAges 18 years+ - NCT06275958RecruitingPhase 3
Lower starting chemo dose for older adults with metastatic colorectal cancer
This study tests whether starting with a lower dose of chemotherapy works as well as the standard dose for people aged 70 and older with metastatic colorectal cancer. The goal is to find a treatment that is effective but gentler, with fewer side effects.
's-HertogenboschAges 70 years+ - NCT06280495RecruitingPhase 2/Phase 3
Targeted drugs plus chemo before surgery for colon cancer with liver spread
This trial tests whether adding two targeted drugs (serplulimab and bevacizumab) to standard chemotherapy before surgery can improve outcomes for people with colorectal cancer that has spread to the liver. It is for those whose cancer has certain genetic features and is considered resectable.
Guangzhou, GuangdongAges 18–75 - NCT06287723Recruiting
Blood test for cancer DNA after liver surgery in colorectal cancer
This study uses a simple blood test (liquid biopsy) to look for tiny bits of cancer DNA after surgery for colorectal cancer that spread to the liver. It aims to see if this test can find cancer earlier than standard scans, which may help guide future treatment decisions.
MontpellierAges 18 years+ - NCT06300463RecruitingPhase 2
Immunotherapy combinations for colorectal cancer with liver tumors
This trial tests combinations of immunotherapy drugs for people with colorectal cancer that has spread to the liver and is scheduled for surgery. The goal is to see if these treatments are safe and effective before and after the operation.
New York, New YorkAges 18 years+ - NCT07341737RecruitingPhase 1/Phase 2
SL-28 for advanced solid tumors that haven’t responded to treatment
This trial tests a new drug, SL-28, for people with advanced solid tumors that haven’t responded to or cannot be treated with standard therapies. It aims to find a safe dose and see if the drug can help shrink or slow the growth of your cancer.
Adelaide, South AustraliaAges 18 years+ - NCT06638502RecruitingPhase 1/Phase 2
Testing HRX215 for liver recovery after surgery
This trial tests a drug called HRX215 to see if it is safe and helps the liver recover after surgery to remove colon cancer tumors that have spread to the liver. It is for people who are having either a minor or major liver resection and have a low risk of liver failure.
Baltimore, MarylandAges 18–75 - NCT06337084RecruitingPhase 1
Imaging test for solid tumors using MNPR-101-DFO*-89Zr
This study tests whether a new imaging agent, MNPR-101-DFO*-89Zr, can find solid tumors and measure their uPAR levels. It might help doctors better understand your cancer and guide future treatment decisions.
North Melbourne, VictoriaAges 18 years+ - NCT06336902RecruitingPhase 1
Immunotherapy plus fasting diet and vitamin C for KRAS-mutated colorectal cancer
This trial tests a combination of two immunotherapy drugs (botensilimab and balstilimab) plus a fasting-mimicking diet and high-dose vitamin C for people with a specific type of advanced colorectal cancer (KRAS-mutated). It aims to see if this approach can help when standard treatments have stopped working.
Fullerton, CaliforniaAges 18 years+ - NCT06356584RecruitingPhase 2
A drug combination with or without radiation for advanced colorectal cancer
This trial tests a new drug combo (fruquintinib and sintilimab) with or without radiation for people with colorectal cancer that has spread to the liver and has not responded to earlier treatments.
Jinan, ShandongAges 18–75 - NCT06356714RecruitingPhase 2
Nocardia cell wall skeleton plus current therapy for colorectal cancer
This trial tests adding an investigational drug (Nocardia rubra cell wall skeleton) to the current treatment for people with advanced colorectal cancer that is stable but showing early signs of getting worse. It aims to see if this combination can help delay further progression.
Nanjing, JiangsuAges 18 years+ - NCT06369259RecruitingPhase 2
Study of avutometinib, defactinib, and cetuximab for advanced colorectal cancer
This trial tests a combination of three drugs for people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if combining these drugs can shrink tumors or slow cancer growth.
Houston, TexasAges 18 years+ - NCT06385418RecruitingPhase 2
Colon chemotherapy for colorectal cancer
This trial tests putting a chemo drug (fluorouracil) directly into the colon through a tube. It's for people with colorectal cancer who are already getting other cancer treatment, to see if adding local chemo helps shrink the main tumor.
Nanjing, JiangsuAges 18–75 - NCT06440005RecruitingPhase 1
Testing AGX101 for advanced solid tumors
This study tests a new drug called AGX101 for people with advanced solid tumors that have not responded to other treatments. The goal is to see if it is safe and if it can shrink tumors or slow their growth.
Los Angeles, CaliforniaAges 18 years+ - NCT06449937Recruiting
Local liver treatment for colorectal cancer that has spread
This trial tests whether treating liver tumors with surgery or ablation can help people whose colorectal cancer has spread to the liver and other organs. It may be an option if you've had only 1 or 2 types of chemotherapy and your non-liver metastases are stable.
Chuzhou, AnhuiAges 18–80 - NCT06501482RecruitingPhase 3
FOLFIRI after liver surgery for colorectal cancer
This trial tests whether adding FOLFIRI chemotherapy after surgery for liver metastases from colorectal cancer can reduce the risk of the cancer coming back. It's for people whose liver tumors responded well to the same chemotherapy before surgery.
Paris, Île-de-France RegionAges 18 years+ - NCT06509126RecruitingPhase 3
Panitumumab with Chemo: Continuous or Intermittent for Advanced CRC
This trial compares giving panitumumab plus FOLFIRI (two chemotherapy drugs) either continuously or with breaks, as a first treatment for left-sided colorectal cancer that has spread. It's for people whose tumors have certain genetic markers (RAS/BRAF wild-type) and haven't had treatments for advanced disease before.
NaplesAges 18–100 - NCT06543836RecruitingPhase 2
Targeted therapy plus immunotherapy for advanced colorectal cancer
This trial tests a combination of a targeted therapy pill (TKI) and an immunotherapy (PD-1 inhibitor) for people with advanced colorectal cancer that has stopped responding to standard treatments. It uses a blood test to tailor the treatment, aiming to be more effective with fewer side effects.
Beijing, Beijing MunicipalityAges 18–80
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Common questions
- Are there clinical trials for liver metastases from colorectal cancer?
- Yes. Clin2 currently lists 271 recruiting liver metastases from colorectal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a liver metastases from colorectal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a liver metastases from colorectal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.