Clinical trials
Liver Metastases From Colorectal Cancer clinical trials
Below are recruiting liver metastases from colorectal cancer clinical trials, each written for real people, not researchers. We’re tracking 271 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06337084RecruitingPhase 1
Imaging test for solid tumors using MNPR-101-DFO*-89Zr
This study tests whether a new imaging agent, MNPR-101-DFO*-89Zr, can find solid tumors and measure their uPAR levels. It might help doctors better understand your cancer and guide future treatment decisions.
North Melbourne, VictoriaAges 18 years+ - NCT06336902RecruitingPhase 1
Immunotherapy plus fasting diet and vitamin C for KRAS-mutated colorectal cancer
This trial tests a combination of two immunotherapy drugs (botensilimab and balstilimab) plus a fasting-mimicking diet and high-dose vitamin C for people with a specific type of advanced colorectal cancer (KRAS-mutated). It aims to see if this approach can help when standard treatments have stopped working.
Fullerton, CaliforniaAges 18 years+ - NCT06356584RecruitingPhase 2
A drug combination with or without radiation for advanced colorectal cancer
This trial tests a new drug combo (fruquintinib and sintilimab) with or without radiation for people with colorectal cancer that has spread to the liver and has not responded to earlier treatments.
Jinan, ShandongAges 18–75 - NCT06356714RecruitingPhase 2
Nocardia cell wall skeleton plus current therapy for colorectal cancer
This trial tests adding an investigational drug (Nocardia rubra cell wall skeleton) to the current treatment for people with advanced colorectal cancer that is stable but showing early signs of getting worse. It aims to see if this combination can help delay further progression.
Nanjing, JiangsuAges 18 years+ - NCT06385418RecruitingPhase 2
Colon chemotherapy for colorectal cancer
This trial tests putting a chemo drug (fluorouracil) directly into the colon through a tube. It's for people with colorectal cancer who are already getting other cancer treatment, to see if adding local chemo helps shrink the main tumor.
Nanjing, JiangsuAges 18–75 - NCT06440005RecruitingPhase 1
Testing AGX101 for advanced solid tumors
This study tests a new drug called AGX101 for people with advanced solid tumors that have not responded to other treatments. The goal is to see if it is safe and if it can shrink tumors or slow their growth.
Los Angeles, CaliforniaAges 18 years+ - NCT06449937Recruiting
Local liver treatment for colorectal cancer that has spread
This trial tests whether treating liver tumors with surgery or ablation can help people whose colorectal cancer has spread to the liver and other organs. It may be an option if you've had only 1 or 2 types of chemotherapy and your non-liver metastases are stable.
Chuzhou, AnhuiAges 18–80 - NCT06501482RecruitingPhase 3
FOLFIRI after liver surgery for colorectal cancer
This trial tests whether adding FOLFIRI chemotherapy after surgery for liver metastases from colorectal cancer can reduce the risk of the cancer coming back. It's for people whose liver tumors responded well to the same chemotherapy before surgery.
Paris, Île-de-France RegionAges 18 years+ - NCT06509126RecruitingPhase 3
Panitumumab with Chemo: Continuous or Intermittent for Advanced CRC
This trial compares giving panitumumab plus FOLFIRI (two chemotherapy drugs) either continuously or with breaks, as a first treatment for left-sided colorectal cancer that has spread. It's for people whose tumors have certain genetic markers (RAS/BRAF wild-type) and haven't had treatments for advanced disease before.
NaplesAges 18–100 - NCT06543836RecruitingPhase 2
Targeted therapy plus immunotherapy for advanced colorectal cancer
This trial tests a combination of a targeted therapy pill (TKI) and an immunotherapy (PD-1 inhibitor) for people with advanced colorectal cancer that has stopped responding to standard treatments. It uses a blood test to tailor the treatment, aiming to be more effective with fewer side effects.
Beijing, Beijing MunicipalityAges 18–80 - NCT06545630RecruitingPhase 1
Personalized immune cell vaccine for colorectal cancer with liver spread
This trial tests a personalized vaccine made from your own immune cells (dendritic cells) that are trained to recognize colorectal cancer. It is for people who had surgery for colorectal cancer that spread to the liver and are now at high risk for the cancer returning.
Chengdu, Chengdu/SichuanAges 18–75 - NCT06555003RecruitingPhase 3
DEBIRI plus chemo vs. chemo alone for liver metastases
This trial tests if a treatment called DEBIRI (tiny beads delivering chemo directly to the liver) plus standard chemotherapy works better than chemotherapy alone for colorectal cancer that has spread to the liver and can't be fully removed by surgery.
Tehran, Tehran ProvinceAges 18 years+ - NCT06566755RecruitingPhase 3
New drug combo for a common type of colorectal cancer
This trial tests a combination of a new immunotherapy (cadonilimab) with standard chemotherapy (capecitabine, oxaliplatin) and bevacizumab for people with metastatic colorectal cancer that has a RAS mutation or is located on the right side of the colon. The goal is to see if this combination works better than the current standard of care as a first treatment.
Shenyang, LiaoningAges 18–75 - NCT07159048Recruiting
Heat therapy for liver cancer that hasn't spread
This trial tests a new heat-based treatment for liver cancer (hepatocellular carcinoma or tumors that started elsewhere and spread to the liver). It may be an option if your tumors are small (5 cm or less), you have no more than 5 tumors in the liver, and the cancer hasn't spread to other organs.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06607458RecruitingPhase 2
Liver-focused chemo for metastatic colorectal cancer
This trial tests giving high-dose melphalan directly into the liver's blood supply, followed by standard cancer therapy, for people whose colorectal cancer has spread mainly to the liver. The goal is to see if this approach is safer and works better than standard treatment alone.
Duarte, CaliforniaAges 18 years+ - NCT06617169RecruitingPhase 1
Radioactive drug for solid tumors after prior study
This trial tests a new radioactive drug called MNPR-101-PCTA-177Lu for people with solid tumors who already completed a previous study (MNPR-101-D001). It aims to find the safest and most effective dose by carefully monitoring how your body handles the treatment.
North Melbourne, VictoriaAges 18 years+ - NCT06630624RecruitingPhase 1/Phase 2
IP-001 with ablation for colorectal liver metastases
This trial tests whether adding the drug IP-001 to tumor ablation (microwave or irreversible electroporation) helps control colorectal cancer that has spread to the liver. The goal is to find the best dose and see how the immune system responds.
Amsterdam, North HollandAges 18 years+ - NCT06640166RecruitingPhase 2
Encorafenib + Cetuximab with FOLFIRI after progression
This trial tests adding a new chemotherapy regimen (FOLFIRI) to the combination of Encorafenib and Cetuximab for people with a specific type of advanced colorectal cancer that has started growing again after initial treatment with Encorafenib and Cetuximab. The goal is to see if the new combination can help control the cancer longer.
MilanAges 18 years+ - NCT06696768RecruitingPhase 1
New drug plus chemo for advanced colorectal cancer
This trial tests a new targeted drug (CA-4948) plus a standard chemotherapy combo (FOLFOX and bevacizumab) for people with colorectal cancer that has spread. The goal is to see if this combination works better than standard treatment alone.
Gainesville, FloridaAges 18 years+ - NCT06698146Recruiting
Liver transplant for colorectal cancer that spread to the liver
This trial tests a special approach for colorectal cancer that has spread to the liver: first removing the liver tumor, then doing a partial liver transplant, and later removing more liver tissue. The goal is to see if this can help people who otherwise have limited options.
Chicago, IllinoisAges 18 years+ - NCT07224724Recruiting
Exosome liquid biopsy for colorectal cancer spread
This study uses a blood test to detect if colorectal cancer that has spread to the liver has also spread to other parts of the body. It may help doctors better understand how the cancer is moving and guide treatment decisions.
Duarte, CaliforniaAges 18 years+ - NCT06728072RecruitingPhase 2
Adding antibiotics to first chemo for advanced colorectal cancer
This trial tests whether adding a short course of antibiotics to your standard first chemotherapy for stage 4 colorectal cancer can improve treatment. The antibiotics target certain gut bacteria that might affect how well the chemo works.
Richmond, VirginiaAges 18 years+ - NCT06763029RecruitingPhase 2
Study of three drugs for advanced colorectal cancer after first treatment
This trial tests a combination of three drugs (irinotecan liposomes, cetuximab, and vemurafenib) for people with advanced colorectal cancer that has a specific genetic change (BRAF V600E mutation) and did not respond to first treatment. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06787625Recruiting
Growing tumor models from colorectal cancer and liver metastases
This study takes samples from colorectal cancer that has spread to the liver and grows them in the lab. The goal is to create models that can help researchers understand the cancer better and find new treatments.
RomeAges 18 years+
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Common questions
- Are there clinical trials for liver metastases from colorectal cancer?
- Yes. Clin2 currently lists 271 recruiting liver metastases from colorectal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a liver metastases from colorectal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a liver metastases from colorectal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.