Clinical trials
Liver clinical trials
Below are recruiting liver clinical trials, each written for real people, not researchers. We’re tracking 1,219 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05705219Recruiting
3D ultrasound scan to guide treatment decisions in liver cancer
This study tests whether a special 3D ultrasound scan (using contrast) can help support decisions for people with colorectal cancer that has spread to the liver. If you have planned new cancer treatment, the scan may add information to help doctors guide care.
Palo Alto, CaliforniaAges 18 years+ - NCT05692024RecruitingPhase 1/Phase 2
Coffee and gut bacteria study after colon or rectal cancer
This early-phase study tests whether a coffee-related approach can change gut bacteria and blood “metabolites” after treatment for stage I–III colon or rectal cancer. The goal is to learn if these changes could help improve health after standard cancer treatment.
Boston, MassachusettsAges 18 years+ - NCT05600933Enrolling by invitation
Providing tumor samples to find new treatment targets
This study collects tumor tissue and related blood tests from people who already need a biopsy or surgery as part of their usual care. Researchers use the samples to learn what drives the tumor and how the tumor environment may affect treatment, which could help develop future therapies.
Bethesda, MarylandAges 18 years+ - NCT05556642Recruiting
Liver tumor registry for children with relapsed cancer
This study collects information and may collect fresh tumor tissue to better understand and model relapsed or hard-to-treat liver tumors. Joining could help researchers develop future treatments and more personalized research for affected patients.
Cincinnati, OhioAges Any age - NCT05098197RecruitingEarly Phase 1
Study of TIL cell therapy for advanced liver, bile, or pancreas cancer
This trial studies a treatment called TIL therapy, which uses your own immune cells grown from a tumor sample, to treat advanced cancers of the liver/bile ducts or pancreas. It’s mainly for people whose standard treatments have already failed (or none exist), and who can safely provide tumor tissue for the cell preparation.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05526144RecruitingPhase 2
Thyroid hormone treatment for fatty liver in Veterans
This trial tests whether thyroid hormone can improve nonalcoholic steatohepatitis (fatty liver with inflammation) in Veterans. You may be asked to have a medically needed liver biopsy, and the study also focuses on safety in people with related conditions like diabetes and heart risks.
Columbia, MissouriAges 18–75 - NCT05519475RecruitingPhase 2
Gene-silencing medicine trial for adults with MASH and liver scarring
This Phase 2 study tests a gene-silencing treatment to improve chronic liver disease called MASH, especially in people with certain genetic risk. You may be eligible if you have MASH with moderate-to-advanced scarring and specific test results, and if other liver causes and recent substance/alcohol issues don’t apply.
Chandler, ArizonaAges 18–75 - NCT05517811Recruiting
Blood clotting tests before and after surgery for cancer
This study looks at how cancer and surgery affect blood clotting. It may help doctors understand and prevent blood clots in patients having surgery for certain cancers.
Aurora, ColoradoAges 18–99 - NCT05040360RecruitingPhase 2
Chemotherapy after surgery for high-risk pancreatic NET tumors
This Phase 2 trial studies whether giving chemotherapy after surgery can lower cancer recurrence risk in people with high-risk pancreatic neuroendocrine tumors (NETs). It may help you by testing an added treatment after the tumor has been removed.
Anchorage, AlaskaAges 18 years+ - NCT05486572Recruiting
Ultrasound or MRI to help prevent liver cancer deaths
This study compares ultrasound scans versus MRI scans to see which one better helps prevent deaths from liver cancer in people with cirrhosis. You may be assigned to one of the two imaging tests and follow-up visits to track whether liver cancer develops or is caught early.
Birmingham, AlabamaAges 18–75 - NCT05463796Recruiting
Prevention and early detection for people at high cancer risk
This study looks at surveillance (watching closely), prevention, and early “interception” steps to lower the chance that cancer will develop or be found later. It is for people with genetic risk, past cancer treatment exposures, strong family history, or certain early pre-cancer or high-risk conditions.
Boston, MassachusettsAges Any age - NCT05470205RecruitingPhase 3
Noninvasive blood-pressure measurement to estimate liver portal pressure
This Phase 3 study tests a noninvasive ultrasound-based method to estimate portal hypertension, which is high blood pressure in the liver’s blood vessels. It aims to help doctors measure how severe the liver circulation problem is without needing invasive pressure testing.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05428267Recruiting
Sexual function study for people with cirrhosis
This study looks at sexual dysfunction in people who have cirrhosis (scarring of the liver). It may help researchers understand causes and better care for sexual problems in this condition.
ParisAges 18 years+ - NCT05424003RecruitingPhase 2
Semaglutide to prevent weight gain after liver transplant
This trial tests semaglutide (a diabetes/weight-loss medicine) to help prevent weight gain after liver transplant. It is also looking at blood sugar and safety while you continue your transplant medicines.
Richmond, VirginiaAges 18–75 - NCT05428358Recruiting
MRI helps choose which pancreatic cancer patients can have surgery
This trial studies whether adding an MRI scan improves the selection of people with pancreatic cancer who may benefit from surgery. It focuses on patients without liver spread and with tumors that are borderline or likely removable.
AalborgAges 18–99 - NCT05433948Enrolling by invitation
Testing ways to diagnose mild brain changes in liver disease
This study looks at how well simple brain tests can detect early (minimal) thinking changes related to liver cirrhosis. It may help doctors spot these changes sooner and diagnose the condition more accurately.
EsbjergAges 18–90 - NCT05305287RecruitingPhase 4
Measuring liver energy use in people with diabetes and fatty liver disease
This study looks at how the liver uses energy (mitochondria) in people with type 2 diabetes and fatty liver disease. By understanding this, researchers may find better ways to treat liver problems.
San Antonio, TexasAges 18–80 - NCT04530760Recruiting
Study of breathing problems in people with liver scarring on a ventilator
This study looks at whether people with cirrhosis who are on a breathing machine have increased pressure in the belly and small unnoticed breathing mist (microaspiration). It may help doctors better monitor and prevent breathing complications while patients are being mechanically ventilated.
LilleAges 18–99 - NCT05213598Recruiting
Biomarker study for liver disease after Fontan surgery
This study looks for blood and/or test markers that can better show how severe liver disease is in people who had the Fontan heart procedure. It also involves medical imaging and/or a liver biopsy or related procedures to help evaluate those markers.
Bethesda, MarylandAges 18–100 - NCT05181826Recruiting
Blood collection study for cancer and benign diseases
This study collects blood samples from people with different health conditions (cancer, diabetes, liver disease, etc.) and from healthy volunteers. The goal is to find markers in the blood that could help detect or monitor diseases.
Redondo Beach, CaliforniaAges 18 years+ - NCT05185505Enrolling by invitationPhase 4
Immunotherapy before liver transplant for advanced liver cancer
This trial tests whether giving a combination of two immunotherapy drugs before a liver transplant can help people with advanced liver cancer (beyond standard size limits) receive a transplant successfully. The treatment aims to shrink the tumor and improve outcomes.
Houston, TexasAges 18 years+ - NCT05184790Recruiting
Using imaging during radiation therapy to improve AI planning
This study tests how well an artificial intelligence system can use special X-ray images taken during certain radiation treatments to improve care. You may qualify if you’re having radiation for specific conditions and your treatment center uses the required imaging steps.
Saint Leonards, New South WalesAges 18 years+ - NCT05168163RecruitingPhase 2
Atezolizumab plus targeted drug for advanced liver cancer
This Phase 2 study tests whether atezolizumab combined with a multi-targeted (“multi-kinase”) inhibitor can treat advanced liver cancer that cannot be cured with surgery or local procedures. It focuses on people whose cancer has already grown despite a first-line treatment using atezolizumab plus bevacizumab.
Scottsdale, ArizonaAges 18 years+ - NCT05166499Recruiting
Amino acids to help rebuild muscle in liver cirrhosis
This trial tests whether a special amino-acid supplement can help reverse muscle loss in people with cirrhosis (scarring of the liver). It may help maintain or improve muscle strength and overall function, but eligibility depends on your liver status and overall health.
Cleveland, OhioAges 21–65
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Common questions
- Are there clinical trials for liver?
- Yes. Clin2 currently lists 1,219 recruiting liver studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a liver trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a liver trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.