Clinical trials
Lung Cancer (Locally Advanced or Metastatic) clinical trials
Below are recruiting lung cancer (locally advanced or metastatic) clinical trials, each written for real people, not researchers. We’re tracking 5,796 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03137095Recruiting
Study how chemotherapy affects brain function in breast cancer
This study looks at changes in thinking and brain function in people with early to locally advanced breast cancer before and during chemotherapy. You may also be offered a brain MRI in a separate optional part of the research to learn more about brain changes.
Rochester, New YorkAges 21 years+ - NCT03051464RecruitingPhase 2/Phase 3
Testing two ways to boost radiation to prevent rectal surgery
This study looks at whether two different added “boosts” of radiation can work as well for rectal cancer patients, aiming to avoid or reduce the need for rectal cancer surgery. You would receive a specific combination of radiation (including brachytherapy) and chemotherapy, and your tumor’s location and size will determine if you can take part.
Dallas, TexasAges 18–80 - NCT03161522RecruitingPhase 2
Chemo alone versus with radiation or surgery for limited spread
This study tests whether adding radiation or surgery to chemotherapy can improve outcomes for people whose esophageal or stomach cancer has spread to only a few places. If your cancer is “oligometastatic” (up to 3 spots), the trial helps doctors see which approach gives the best control.
Houston, TexasAges 18–79 - NCT02338167Recruiting
Study for pregnant women with breast cancer
This study is for adults with breast cancer who are pregnant and are either newly diagnosed (early) or have locally advanced or metastatic disease. It aims to better understand how breast cancer treatment should be managed during pregnancy.
Böblingen, Baden-WurttembergAges 18–99 - NCT01915225Recruiting
Collecting solid tumor samples during cancer biopsy or surgery
This trial collects tissue (samples) from people who are already scheduled for biopsy or surgery for certain solid cancers. It aims to improve future testing and research while checking that taking the sample is safe and doesn’t add extra risk.
Bethesda, MarylandAges 2 years+ - NCT01742143Recruiting
Helping underserved patients finish cancer treatment and feel better
This study tests a support program (ICCAN) designed to help people from underserved communities better complete chemotherapy or radiation and improve quality of life. It may help by connecting patients with practical resources and support during treatment.
Basking Ridge, New JerseyAges 21–80 - NCT06223568RecruitingPhase 2
Chemotherapy with or without vaccine for HPV-related throat cancer
This trial compares standard chemotherapy alone versus chemotherapy combined with an investigational vaccine (PRGN-2009) before surgery for newly diagnosed HPV-positive oropharyngeal (throat) cancer. The goal is to see if adding the vaccine improves outcomes.
Bethesda, MarylandAges 18–120 - NCT07877376Recruiting
How thinking problems affect pain in breast cancer survivors
This study looks at whether mild memory or thinking issues after breast cancer treatment are linked to ongoing pain. If you join, you will help doctors understand this connection, which may lead to better pain care.
Boulogne-Billancourt, IDEAges 35–65 - NCT06007924RecruitingPhase 2
Study of two drugs for advanced thyroid cancer
This trial tests two oral medications, avutometinib and defactinib, for people with advanced thyroid cancer that has specific genetic changes. The goal is to see if these drugs can shrink tumors or slow their growth.
Basking Ridge, New JerseyAges 18 years+ - NCT07203729RecruitingPhase 2
A new drug for advanced breast cancer with severe symptoms
This trial tests a new drug called SHR-A1811 (a type of targeted therapy) for people with advanced breast cancer that is HER2-low and is causing severe symptoms (visceral crisis). The drug is given alone and aims to control the cancer and relieve symptoms.
Beijing, Beijing MunicipalityAges 18–75 - NCT03541928RecruitingPhase 2
Gene therapy with standard treatment for high-risk prostate cancer
This trial combines gene therapy with hormone therapy, radiation, and possibly surgery to treat high-risk prostate cancer. It aims to improve outcomes by adding gene therapy to standard treatments and will require additional biopsies.
Houston, TexasAges 18 years+ - NCT05035147RecruitingPhase 4
Albumin-bound paclitaxel plus gemcitabine for advanced pancreatic cancer
This trial studies a chemotherapy combination (albumin-bound paclitaxel and gemcitabine) as first treatment for pancreatic cancer that cannot be removed by surgery. It aims to improve outcomes by testing how well this treatment works in people with locally advanced or metastatic disease.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT05491395Recruiting
Radiation after mastectomy with breast implant reconstruction
This trial studies a radiation schedule given after breast cancer surgery when your breast was rebuilt right away with a prosthesis (implant or similar). It aims to see whether this “hypofractionated” (fewer, larger treatment sessions) radiation approach is appropriate for patients who need additional (adjuvant) radiation to reduce recurrence risk.
Barretos, São PauloAges 18 years+ - NCT05547529RecruitingPhase 3
Chemo and radiation before surgery versus chemo alone for esophageal cancer
This trial studies whether adding radiation to chemotherapy before surgery works better for people with operable (resectable) squamous cell esophageal cancer. It aims to improve outcomes by comparing two different treatment plans before the operation.
MoscowAges 18–70 - NCT05620732Recruiting
CAR-T treatment for advanced stomach or pancreatic cancer
This trial tests a customized immune-cell treatment (CAR-T) for advanced stomach or pancreatic cancer that cannot be removed by surgery. It aims to use cells engineered to target a specific tumor marker to shrink cancer or slow its growth.
Shenzhen, GuangdongAges 18–75 - NCT05241236Recruiting
Laser ablation guided by MRI and ultrasound for prostate cancer
This trial looks at a treatment that uses MRI and ultrasound to guide a laser to destroy prostate cancer. It may help men with low- or intermediate-risk prostate cancer who do not have spread beyond the prostate.
Miami Lakes, FloridaAges 50 years+ - NCT04690439Recruiting
Light therapy to treat breast cancer–related arm swelling
This trial studies whether a noninvasive light-based treatment (photobiomodulation) can reduce breast cancer–related lymphedema, which is swelling in the arm or chest area due to lymph fluid buildup. If you qualify, you’ll be asked to follow a set treatment and follow-up schedule to see if symptoms improve safely.
Hasselt, LimburgAges 18 years+ - NCT05797077RecruitingPhase 3
After-surgery blood test–guided therapy for colon cancer liver spread
This Phase 3 trial tests whether an added “maintenance” treatment after liver surgery can help prevent colorectal cancer from coming back. It is only for people whose blood test (ctDNA) still shows signs of cancer after their operation.
Guangzhou, GuangdongAges 18–75 - NCT05815082RecruitingPhase 3
ctDNA-guided chemo after liver surgery for colon cancer
This trial checks whether giving chemotherapy after surgery only for people whose blood test (ctDNA) shows no remaining cancer can help prevent the cancer from coming back. It is for people with colon cancer that has spread to the liver who had the tumor fully removed.
Guangzhou, GuangdongAges 18–75 - NCT04370496Recruiting
Testing minimally invasive endoscopic stapler surgery for early cervix cancer
This trial tests how safe a specific minimally invasive surgery tool (an endoscopic stapler) is for people with early-stage cervical cancer. If you qualify, you would get surgery to remove the cervix area using a minimally invasive approach and the study will track safety outcomes.
SeoulAges 20 years+ - NCT05937958Recruiting
MR-guided linac boost for gynecologic cancers when brachytherapy isn’t possible
This study tests a targeted radiation “boost” delivered using an MRI-guided machine for certain gynecologic cancers when the usual treatment (brachytherapy) can’t be done. It may help improve control of the cancer while still aiming for cure.
OdenseAges 18 years+ - NCT06039631RecruitingPhase 2
Immuno-chemo before surgery and organ-sparing treatment for throat cancer
This trial tests whether adding immunotherapy before surgery, followed by either radiation or organ-preserving surgery, can improve outcomes for people with locally advanced laryngeal or hypopharyngeal cancer. It may help avoid complete removal of the voice box.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06082180RecruitingPhase 3
Preventive neck lymph node removal in low-risk thyroid cancer
This trial is for people with low-risk papillary thyroid cancer. It compares two surgical approaches: one that removes just the thyroid gland, and another that also removes some lymph nodes in the center of the neck as a preventive measure. The goal is to see if removing these lymph nodes helps prevent the cancer from coming back.
Beijing, Beijing MunicipalityAges 18–70 - NCT05494060RecruitingPhase 2
Adjuvant chemo plus immunotherapy for ctDNA-positive stomach cancer
This trial tests whether adding an anti-cancer immune treatment and another targeted drug to standard chemotherapy after surgery can lower the chance of cancer coming back. It is for people whose blood test (ctDNA) shows leftover cancer-related DNA after surgery.
Nanjing, JiangsuAges 18–75
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Common questions
- Are there clinical trials for lung cancer (locally advanced or metastatic)?
- Yes. Clin2 currently lists 5,796 recruiting lung cancer (locally advanced or metastatic) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lung cancer (locally advanced or metastatic) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lung cancer (locally advanced or metastatic) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Locally Advanced or Metastatic Breast Cancer
- Locally Advanced Non-Small Cell Lung Cancer
- Advanced or Metastatic Non-small Cell Lung Cancer
- Colorectal Cancer (Locally Advanced or Metastatic)
- Liver Cancer (Locally Advanced or Metastatic)
- NSCLC (Advanced Non-small Cell Lung Cancer)
- Non Small Cell Lung Cancer Metastatic
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.