Clinical trials
Lymph Node Metastasis clinical trials
Below are recruiting lymph node metastasis clinical trials, each written for real people, not researchers. We’re tracking 112 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06621823Recruiting
Robotic ultrasound to check lymph nodes during gynecologic cancer surgery
This trial tests a new robotic ultrasound tool to see if it can better find cancer in lymph nodes during surgery. It may help doctors decide exactly which nodes to remove, avoiding unnecessary surgery.
RomaAges 18–99 - NCT06883084Enrolling by invitation
How lymph node changes affect rectal cancer outcomes
This trial looks at how much the lymph nodes respond to chemoradiation before surgery in people with locally advanced rectal cancer. It aims to understand if that response can predict long-term results and guide future treatment choices.
Ages 18–65 - NCT06527027Recruiting
New ways to assess lymph nodes in cancer patients
This trial compares three methods (LN-RADS, RECIST 1.1, and Node-RADS) to see which best evaluates lymph nodes in people with cancer. It may help doctors make more accurate decisions about your lymph nodes using CT or MRI scans.
KrakowAges 18 years+ - NCT05839912Recruiting
Surgery study for melanoma in one lymph node basin
This trial tests whether removing a clinically involved lymph node basin (via a specific lymph node excision surgery) after certain melanoma findings is helpful. It mainly aims to see effects on outcomes and on arm/leg swelling (lymphedema) after surgery.
Atlanta, GeorgiaAges 18 years+ - NCT06389786Recruiting
Using a new PET scan to find cancer spread before prostate surgery
This trial tests a special PET/MRI scan that may help doctors see if prostate cancer has spread to nearby lymph nodes before surgery. It could help guide treatment decisions for men with high-risk prostate cancer.
Jacksonville, FloridaAges 30–85 - NCT06264167Recruiting
Ultrasound for groin lymph nodes in vulvar cancer
This trial tests whether using ultrasound of the groin can help find cancer spread in the lymph nodes of women with early-stage vulvar cancer. The goal is to see if ultrasound can replace or reduce the need for more invasive surgery.
Brisbane, QueenslandAges 18 years+ - NCT06252129Recruiting
Improving Lymph Node Removal During Lung Cancer Surgery
This trial studies a better way to remove and examine lymph nodes from lung cancer surgery specimens. It aims to improve how doctors check for cancer spread, which may help guide your treatment after surgery.
Boston, MassachusettsAges 18 years+ - NCT05935150Recruiting
Skipping lymph node surgery in early breast cancer
This trial studies whether you can safely avoid a lymph node biopsy in the armpit for early breast cancer when scans and exams look negative. It may reduce surgery-related side effects while still keeping cancer care on track.
Nanjing, JiangsuAges 18–70 - NCT07415356Recruiting
Adaptive radiation for lymph node tumors that have spread
This trial tests a new way to deliver targeted radiation for cancer that has spread to lymph nodes in the belly or pelvis. The radiation dose is adjusted during each session to better hit the tumor while protecting healthy tissue.
Rotterdam, South HollandAges 18 years+ - NCT06652672Recruiting
Sentinel Node and Organ-Sparing Surgery for Early Colon Cancer
This trial tests a less invasive surgery approach for early-stage colon cancer. It uses a special dye to find and remove only the first lymph node (sentinel node) while removing just the part of the colon with the tumor, possibly avoiding a bigger surgery.
AmersfoortAges 18 years+ - NCT06146946Recruiting
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Beijing, Beijing MunicipalityAges 18–75 - NCT07049276Recruiting
Lymph node surgery for melanoma with immunotherapy
This trial tests if a specific type of lymph node surgery, combined with a short course of immunotherapy (medicines that help your immune system fight cancer), works better for melanoma that has spread to nearby lymph nodes. It's for people whose melanoma can be removed and who are healthy enough for treatment.
Los Angeles, CaliforniaAges 18 years+ - NCT03385018Recruiting
Laparoscopic total stomach surgery trial for stomach cancer
This trial studies whether a minimally invasive (laparoscopic) removal of the entire stomach, along with lymph node removal, can be done safely and effectively for certain stomach cancers. It may be an option if your cancer is in the stomach, has limited spread to nearby lymph nodes, and can be fully removed.
SeoulAges 20–80 - NCT04109079Recruiting
Best surgery plan for breast cancer lymph nodes after chemotherapy
This study looks at the safest and most useful way to remove and check breast-cancer lymph nodes in the armpit after you finish chemotherapy given before surgery. It may help you avoid unnecessary surgery while still getting accurate information about how well the treatment worked.
DublinAges 18 years+ - NCT03796559Recruiting
Magnetic marker helps find breast cancer lymph nodes
This study uses a tiny magnetic marker (called Magseed) placed in a breast cancer–affected underarm lymph node, then tracks whether surgeons can find and remove the correct nodes after chemotherapy. It may help reduce the chance of missing cancer in the underarm while aiming for more accurate surgery.
Houston, TexasAges 18 years+ - NCT05981014RecruitingPhase 1/Phase 2
Immune cells from lymph nodes for HER2-negative breast cancer
This trial tests whether taking immune cells from your lymph nodes and giving them back to you can help shrink breast cancer that has not responded fully to initial chemotherapy. It is for women with HER2-negative breast cancer who have had stable disease after two cycles of a standard chemotherapy combination.
Guangzhou, GuangdongAges 18–70 - NCT06121570RecruitingPhase 1
Study of immune cells from lymph nodes for HER2-negative breast cancer
This trial tests whether using a patient's own immune cells from lymph nodes near the tumor, given as a treatment before surgery, can help shrink HER2-negative breast cancer. It is for people whose cancer has not responded fully to two cycles of initial chemotherapy.
Guangzhou, GuangdongAges 18–70 - NCT05918510Recruiting
Blood and tumor study for virus markers in throat cancer
This study looks at virus-related markers and tiny gene regulators (microRNAs) in tumor tissue from people with certain throat cancers caused by human papilloma virus (HPV). It’s observational, meaning it does not change your treatment, but results may help doctors better understand these cancers and how they behave.
RomeAges 18 years+ - NCT06091423RecruitingPhase 2
XELOX plus fruquintinib and sintilimab for stomach cancer with liver or lymph node spread
This trial tests a combination of chemotherapy (XELOX), a targeted therapy (fruquintinib), and an immunotherapy (sintilimab) to shrink stomach cancer that has spread only to the liver or retroperitoneal lymph nodes. The goal is to make the cancer removable by surgery.
NanjinAges 18–75 - NCT06286631Recruiting
Predicting lymph node spread in thyroid cancer with a new scale
This trial is testing a new scale to predict if thyroid cancer has spread to nearby lymph nodes. It may help doctors decide on the best treatment for you.
Xi'an, ShaanxiAges 16–80 - NCT06684418Recruiting
AI to find hidden cancer spread in early lung cancer
This trial uses artificial intelligence to predict if early-stage lung cancer has spread to nearby lymph nodes. It aims to help doctors make better treatment decisions for patients with stage 1 lung cancer.
ShanghaiAges 18 years+ - NCT07353294Enrolling by invitationPhase 1
Propranolol plus immunotherapy and chemo before bladder cancer surgery
This trial tests adding a blood pressure medication (propranolol) to a combination of immunotherapy (tislelizumab) and chemotherapy before surgery for bladder cancer that has spread to lymph nodes. It aims to see if this can help shrink the tumor before it is removed.
Guangzhou, GuangdongAges 18 years+ - NCT07357571Recruiting
Can ultrasound help predict lymph node spread in early thyroid cancer?
This trial uses contrast-enhanced ultrasound before surgery to see if it can predict whether cancer has spread to lymph nodes in patients with early-stage papillary thyroid cancer. The goal is to improve treatment planning without unnecessary surgery.
Guangdong, GuangzhouAges Any age - NCT06876753Recruiting
Advanced liver cancer: TACE with immunotherapy and anti-angiogenesis
This trial is for people with advanced liver cancer (HCC) that has spread outside the liver. It tests whether combining a TACE procedure with immunotherapy and anti-angiogenesis drugs can improve outcomes. You must not have had prior systemic therapy and must have received TACE in a specific time window around starting these drugs.
Nanjing, JiangsuAges 18–80
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Common questions
- Are there clinical trials for lymph node metastasis?
- Yes. Clin2 currently lists 112 recruiting lymph node metastasis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lymph node metastasis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lymph node metastasis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.