Lymph Node Disease clinical trials

Audit of Targeted Sentinel Node Biopsy (TSNB) in Patients With Limited Nodal Disease Undergoing Primary Surgery

Lymph node surgery for high-risk upper tract cancer

This trial compares removing the kidney and ureter alone versus also removing nearby lymph nodes for high-risk upper tract urothelial cancer. It aims to see if the extra step helps improve outcomes.

Using lymph node T cells for advanced solid tumors

This trial tests a new treatment using T cells taken from your lymph nodes to fight advanced solid tumors that have not responded to standard therapies. The goal is to see if this approach can help shrink tumors or slow their growth.

Study of tiny cancer spread found in sentinel lymph nodes

This trial studies whether very small deposits of cancer (called micrometastasis or isolated tumor cells) are found in sentinel lymph nodes in early endometrial or cervical cancer. The goal is to better understand what these findings may mean for cancer spread and treatment planning.

Mediastinal node removal versus sparing nodes for early lung nodule

This trial compares two surgical approaches for people with a single small, noncancer-looking lung nodule (a GGN) that is diagnosed as very early lung cancer. It aims to see whether removing mediastinal lymph nodes—or leaving them alone—can lead to better outcomes with less harm.

Sentinel node biopsy versus full node removal in early uterine cancer

This study compares two ways to check lymph nodes during surgery for early-stage endometrial (uterine) cancer: sentinel node biopsy versus removing more lymph nodes. It may help find whether the less extensive approach can stage the cancer accurately with fewer side effects.

Skipping axillary lymph node surgery after treatment response

This study looks at whether some breast cancer patients can safely skip a surgery that removes lymph nodes in the armpit after their initial (pre-surgery) treatment shows the armpit is likely clear. It may reduce surgical side effects if the armpit truly responds well.

Comparing a new ultrasound tool to the standard scope

This study compares a new, possibly easier-to-use ultrasound tool (EndoSound Vision System) to the standard echoendoscope for looking at organs like the pancreas, bile duct, or lymph nodes. If you are already scheduled for an endoscopic ultrasound, you may be able to join.

Comparing injection techniques for cervical lymph node mapping in endometrial cancer

This trial tests two different injection methods in the cervix to help map lymph nodes for endometrial cancer. The goal is to find which technique works better for staging, using a dye that helps surgeons see the lymph nodes during surgery.

Lymph node spread in early esophageal cancer

This trial looks at how early-stage esophageal cancer spreads to lymph nodes. It uses CT scans and pathology reports to understand patterns, which may help guide future treatment decisions.

Quick test for breast cancer spread to lymph nodes using a new probe

This trial uses a special probe that lights up cancer cells to quickly check if breast cancer has spread to nearby lymph nodes. It may help doctors decide how much surgery is needed.

Kidney removal with or without lymph node removal for high risk kidney cancer

This study is for people with high-risk kidney cancer who are having their whole kidney removed. It compares surgery alone versus surgery plus removing lymph nodes from the tumor area to see if removing the nodes helps control the cancer better.

Registry for people with Castleman disease worldwide

This trial is a worldwide registry that collects basic medical information from people diagnosed with Castleman disease. It helps researchers learn about real-world care and outcomes across different ages and care settings.

Comparing lymph node removal approaches in aggressive prostate cancer

This trial compares two surgical approaches for removing lymph nodes during prostate cancer surgery in men with high-risk disease on one side of the prostate. The goal is to determine whether removing lymph nodes from both sides or just one side provides better outcomes.

Skipping lymph node surgery in early breast cancer

This trial studies whether you can safely avoid a lymph node biopsy in the armpit for early breast cancer when scans and exams look negative. It may reduce surgery-related side effects while still keeping cancer care on track.

Rectal cancer surgery trial: Skipping certain lymph node removal

This trial is testing whether a more limited surgery for mid and low rectal cancer can be safe, by avoiding removal of lymph nodes near the main artery. It may be a good fit if your tumor is in the lower rectum, hasn't spread far, and you are in generally good health.

Comparing limited vs. full lymph node removal during prostate surgery

This trial compares two types of lymph node removal during prostate cancer surgery to see if removing fewer lymph nodes is just as effective. It is for men with prostate cancer that has not spread beyond the pelvis.

Avoiding armpit lymph node removal in breast cancer

This trial tests whether it is safe to skip removing lymph nodes from the armpit when cancer has spread there but has been found by ultrasound. If you have breast cancer that has spread to armpit lymph nodes and are not getting chemotherapy before surgery, this study may be an option.

Surgery study for melanoma in one lymph node basin

This trial tests whether removing a clinically involved lymph node basin (via a specific lymph node excision surgery) after certain melanoma findings is helpful. It mainly aims to see effects on outcomes and on arm/leg swelling (lymphedema) after surgery.

Experimental cell therapy for advanced HER2-negative breast cancer

This study tests a new treatment for advanced HER2-negative breast cancer. Doctors will take immune cells from lymph nodes near your tumor, grow them in a lab, and then give them back to you along with chemotherapy and immunotherapy. This approach aims to help your body fight the cancer more effectively.

Immune cells from lymph nodes for advanced HER2-negative breast cancer

This trial tests a treatment using your own immune cells taken from lymph nodes near the tumor. The cells are grown in a lab and given back to you to fight cancer, along with another drug chosen by your doctor.

Nerve block for pain relief in groin lymph node surgery

This trial tests a special ultrasound-guided nerve block to reduce pain during and after groin lymph node removal. It may help patients undergoing this type of cancer surgery have less pain and use fewer painkillers.

Lymph node surgery for melanoma with immunotherapy

This trial tests if a specific type of lymph node surgery, combined with a short course of immunotherapy (medicines that help your immune system fight cancer), works better for melanoma that has spread to nearby lymph nodes. It's for people whose melanoma can be removed and who are healthy enough for treatment.

Immune cell therapy for advanced solid tumors

This trial tests a new immune cell treatment made from your own lymph nodes for advanced solid tumors that haven't responded to standard therapies or have no good treatment options. It aims to see if this personalized cell therapy is safe and can help shrink tumors.