Sentinel Lymph Node Biopsy (SLNB) clinical trials

Audit of Targeted Sentinel Node Biopsy (TSNB) in Patients With Limited Nodal Disease Undergoing Primary Surgery

Skipping breast surgery after complete response

This trial looks at whether some people with breast cancer can safely avoid breast surgery after they respond completely to treatment before surgery. If you have no remaining cancer in the tissue and lymph node tests, this study checks whether the “watch-and-wait” approach is feasible and safe.

Sentinel node biopsy after chemo for initial node-positive breast cancer

This trial checks whether a less invasive sentinel lymph node biopsy (removing just a few nodes) can safely replace full lymph node removal for people whose breast cancer and underarm lymph nodes responded well to chemotherapy. It is for patients who initially had 1 to 3 involved nodes and now appear cancer-free in the armpit.

Blue dye sentinel node mapping for early ovarian cancer

This study is testing a blue dye called Patent Blue to see if it can help surgeons find sentinel lymph nodes (the first nodes cancer might spread to) during surgery for early-stage ovarian cancer. The goal is to reduce the need for more extensive lymph node removal, possibly leading to fewer side effects.

Sentinel node biopsy for high-risk skin cancer of the head and neck

This trial is testing whether a procedure called sentinel lymph node biopsy (SLNB) can help manage high-risk skin cancer on the head and neck that has not spread to lymph nodes. It is for people whose skin cancer is considered high-risk due to features like size, depth, or location, and who are able to have surgery.

Targeted removal of only suspicious lymph nodes for early breast cancer

This trial is testing a targeted surgical approach to remove only the suspicious lymph nodes under the arm for people with early-stage, hormone receptor positive, HER2 negative breast cancer. The goal is to see if this less extensive surgery is safe and effective when there is limited lymph node involvement.

Lymph node biopsy after chemo for inflammatory breast cancer

This trial is testing if a less invasive sentinel lymph node biopsy can replace more extensive lymph node removal in women with inflammatory breast cancer who have had chemotherapy and whose nodes appear cancer-free. This could help avoid unnecessary side effects.

Repeat lymph node biopsy for recurrent breast cancer

This study tests whether repeating a specific lymph node biopsy (sentinel lymph node biopsy) is safe and useful in people whose breast cancer has come back in the same breast. It may help doctors better understand whether lymph nodes are involved and guide next steps after surgery.

Sentinel node biopsy for head and neck skin cancer

This study checks whether a “sentinel lymph node biopsy” can help find if skin cancer in the head or neck has spread to nearby lymph nodes. It uses special dye/medicine and imaging, then removes the cancer and the sentinel node soon after scanning.

Personalized neck radiation using a lymph node sentinel biopsy

This Phase 3 trial tests whether guiding neck radiation by checking the “sentinel” lymph node can target treatment more precisely in certain larynx, hypopharynx, or oropharynx cancers. It aims to improve control while potentially reducing unnecessary radiation to areas that don’t need it.

Check nodes in early mouth cancer using a biopsy or planned neck surgery

This trial studies two ways to check whether early oral cavity cancer has spread to nearby neck lymph nodes. It compares sentinel node biopsy versus limited elective neck dissection to see which approach is more useful for people with node-negative tongue or inner-cheek cancers.

Test a sentinel lymph node biopsy in early ovarian cancer

This trial studies whether taking a sample from the sentinel lymph node during surgery can help with staging early ovarian cancer. It may help doctors find spread to lymph nodes more accurately while limiting unnecessary lymph node removal in some cases.

Immune cells from lymph nodes for HER2-negative breast cancer

This trial tests whether taking immune cells from your lymph nodes and giving them back to you can help shrink breast cancer that has not responded fully to initial chemotherapy. It is for women with HER2-negative breast cancer who have had stable disease after two cycles of a standard chemotherapy combination.

SHINE: Using a special dye to find lymph nodes after breast cancer chemo

This study tests whether a special dye called indocyanine green (ICG) can help find sentinel lymph nodes during breast cancer surgery after chemotherapy. It may offer a safer and more effective way to check if cancer has spread.

Study of immune cells from lymph nodes for HER2-negative breast cancer

This trial tests whether using a patient's own immune cells from lymph nodes near the tumor, given as a treatment before surgery, can help shrink HER2-negative breast cancer. It is for people whose cancer has not responded fully to two cycles of initial chemotherapy.

Skipping armpit surgery for breast cancer patients

This trial tests whether it's safe to skip armpit surgery in older women with small, low-risk breast cancers. If you qualify, you would have a mastectomy without removing lymph nodes from your armpit.

Magnetic tracer for sentinel node biopsy in breast cancer

This study tests a magnetic tracer call Magtrace to help find and remove the first lymph node (sentinel node) during breast cancer surgery. The goal is to see if it works well for people having breast-conserving surgery.

Light-guided re-surgery for recurrent breast cancer

This trial uses a special light and dye to help surgeons find and remove lymph nodes that might contain cancer cells, in women whose breast cancer has come back in the same area after previous surgery.

ICG dye to find sentinel nodes in breast cancer surgery

This trial tests using a green dye called ICG (indocyanine green) during breast cancer surgery to find the first lymph nodes (sentinel nodes) that cancer may have spread to. It aims to help doctors locate these nodes more accurately, and is for people with early-stage breast cancer that has not yet spread to the lymph nodes.

Quick test for breast cancer spread to lymph nodes using a new probe

This trial uses a special probe that lights up cancer cells to quickly check if breast cancer has spread to nearby lymph nodes. It may help doctors decide how much surgery is needed.

Finding sentinel nodes during mastectomy with dye

This trial tests if a special dye (indocyanine green) can find the first lymph nodes (sentinel nodes) during mastectomy. It may help improve staging for women with early breast cancer who need or choose mastectomy.

Using a green dye to map lymph nodes in breast cancer surgery

This trial tests if an injection of indocyanine green dye can help surgeons find and remove only the key lymph nodes in the armpit during breast cancer surgery. It aims to reduce the need for more extensive lymph node removal.

Skipping lymph node surgery in early breast cancer

This trial tests whether older women with early-stage, slow-growing breast cancer can safely skip removal of underarm lymph nodes during surgery. The goal is to reduce surgery-related side effects while maintaining safety.

Sentinel node biopsy versus watchful waiting after PET

This trial studies whether taking a sample from the sentinel lymph node (a first lymph node that can be involved) improves care compared with observation, after a breast cancer PET scan of the armpit area. It may help people with certain early breast cancers avoid unnecessary procedures if the lymph nodes look negative on scans.